KEGG   ENZYME: 1.2.1.57
Entry
EC 1.2.1.57                 Enzyme                                 

Name
butanal dehydrogenase
Class
Oxidoreductases;
Acting on the aldehyde or oxo group of donors;
With NAD+ or NADP+ as acceptor
Sysname
butanal:NAD(P)+ oxidoreductase (CoA-acylating)
Reaction(IUBMB)
butanal + CoA + NAD(P)+ = butanoyl-CoA + NAD(P)H + H+ [RN:R01172 R01173]
Reaction(KEGG)
R01172 R01173
Substrate
butanal [CPD:C01412];
CoA [CPD:C00010];
NAD+ [CPD:C00003];
NADP+ [CPD:C00006]
Product
butanoyl-CoA [CPD:C00136];
NADH [CPD:C00004];
NADPH [CPD:C00005];
H+ [CPD:C00080]
Comment
Also acts on acetaldehyde, but more slowly.
History
EC 1.2.1.57 created 1992
Pathway
ec00650  Butanoate metabolism
ec01100  Metabolic pathways
Reference
1  [PMID:3384801]
  Authors
Palosaari NR, Rogers P.
  Title
Purification and properties of the inducible coenzyme A-linked butyraldehyde dehydrogenase from Clostridium acetobutylicum.
  Journal
J Bacteriol 170:2971-6 (1988)
DOI:10.1128/JB.170.7.2971-2976.1988
Other DBs
ExplorEnz - The Enzyme Database: 1.2.1.57
IUBMB Enzyme Nomenclature: 1.2.1.57
ExPASy - ENZYME nomenclature database: 1.2.1.57
BRENDA, the Enzyme Database: 1.2.1.57
CAS: 116412-25-0
LinkDB

KEGG   REACTION: R01172
Entry
R01172                      Reaction                               

Name
butanal:NAD+ oxidoreductase (CoA-acylating)
Definition
Butanal + CoA + NAD+ <=> Butanoyl-CoA + NADH + H+
Equation
Comment
NADP+ (ec 1.2.1.57, see R01173)
Reaction class
RC00001  C00003_C00004
RC00004  C00010_C00136
RC00184  C00136_C01412
Enzyme
1.2.1.10        1.2.1.57        1.2.1.87
Pathway
rn00650  Butanoate metabolism
rn01100  Metabolic pathways
rn01120  Microbial metabolism in diverse environments
Orthology
K00132  acetaldehyde dehydrogenase (acetylating) [EC:1.2.1.10]
K04072  acetaldehyde dehydrogenase / alcohol dehydrogenase [EC:1.2.1.10 1.1.1.1]
K04073  acetaldehyde dehydrogenase [EC:1.2.1.10]
K18366  acetaldehyde/propanal dehydrogenase [EC:1.2.1.10 1.2.1.87]
Other DBs
RHEA: 22971
LinkDB

KEGG   REACTION: R01173
Entry
R01173                      Reaction                               

Name
butanal:NADP+ oxidoreductase (CoA-acylating)
Definition
Butanal + CoA + NADP+ <=> Butanoyl-CoA + NADPH + H+
Equation
Comment
NAD+ (see R01172)
Reaction class
RC00001  C00005_C00006
RC00004  C00010_C00136
RC00184  C00136_C01412
Enzyme
Pathway
rn00650  Butanoate metabolism
rn01100  Metabolic pathways
Other DBs
RHEA: 22975
LinkDB

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