| Entry |
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| Name |
aldehyde oxidase;
quinoline oxidase;
retinal oxidase
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| Class |
Oxidoreductases;
Acting on the aldehyde or oxo group of donors;
With oxygen as acceptor
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| Sysname |
aldehyde:oxygen oxidoreductase
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| Reaction(IUBMB) |
an aldehyde + H2O + O2 = a carboxylate + H2O2 [RN: R00635]
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| Reaction(KEGG) |
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| Substrate |
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| Product |
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| Comment |
Contains molybdenum, [2Fe-2S] centres and FAD. The enzyme from liver exhibits a broad substrate specificity, and is involved in the metabolism of xenobiotics, including the oxidation of N-heterocycles and aldehydes and the reduction of N-oxides, nitrosamines, hydroxamic acids, azo dyes, nitropolycyclic aromatic hydrocarbons, and sulfoxides [4,6].
The enzyme is also responsible for the oxidation of retinal, an activity that was initially attributed to a distinct enzyme (EC 1.2.3.11, retinal oxidase) [5,7].
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| History |
EC 1.2.3.1 created 1961, modified 2002, modified 2004, modified 2012
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| Pathway |
| ec00280 | Valine, leucine and isoleucine degradation |
| ec00760 | Nicotinate and nicotinamide metabolism |
| ec00982 | Drug metabolism - cytochrome P450 |
| ec01120 | Microbial metabolism in diverse environments |
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| Orthology |
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| Genes |
» show all
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| Reference |
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| Authors |
Gordon AH, Green DE, Subrahmanyan V |
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| Title |
Liver aldehyde oxidase. |
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| Journal |
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| Reference |
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| Authors |
KNOX WE |
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| Title |
The quinine-oxidizing enzyme and liver aldehyde oxidase. |
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| Journal |
J Biol Chem 163:699-711 (1946) |
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| Reference |
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| Authors |
MAHLER HR, MACKLER B, GREEN DE. |
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| Title |
Studies on metalloflavoproteins. III. Aldehyde oxidase: a molybdoflavoprotein. |
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| Journal |
J Biol Chem 210:465-80 (1954) |
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| Reference |
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| Authors |
Krenitsky TA, Neil SM, Elion GB, Hitchings GH |
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| Title |
A comparison of the specificities of xanthine oxidase and aldehyde oxidase. |
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| Journal |
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| Reference |
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| Authors |
Tomita S, Tsujita M, Ichikawa Y |
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| Title |
Retinal oxidase is identical to aldehyde oxidase. |
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| Journal |
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| Reference |
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| Authors |
Yoshihara S, Tatsumi K |
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| Title |
Purification and characterization of hepatic aldehyde oxidase in male and female mice. |
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| Journal |
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| Reference |
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| Authors |
Huang DY, Furukawa A, Ichikawa Y |
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| Title |
Molecular cloning of retinal oxidase/aldehyde oxidase cDNAs from rabbit and mouse livers and functional expression of recombinant mouse retinal oxidase cDNA in Escherichia coli. |
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| Journal |
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| Sequence |
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| Reference |
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| Authors |
Uchida H, Kondo D, Yamashita A, Nagaosa Y, Sakurai T, Fujii Y, Fujishiro K, Aisaka K, Uwajima T. |
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| Title |
Purification and characterization of an aldehyde oxidase from Pseudomonas sp. KY 4690. |
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| Journal |
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| Other DBs |
| ExplorEnz - The Enzyme Database: | 1.2.3.1 |
| ExPASy - ENZYME nomenclature database: | 1.2.3.1 |
| UM-BBD (Biocatalysis/Biodegradation Database): | 1.2.3.1 |
| BRENDA, the Enzyme Database: | 1.2.3.1 |
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| LinkDB |
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