KEGG   ENZYME: 1.4.9.2
Entry
EC 1.4.9.2                  Enzyme                                 

Name
aralkylamine dehydrogenase (azurin);
aromatic amine dehydrogenase;
arylamine dehydrogenase;
tyramine dehydrogenase;
aralkylamine:(acceptor) oxidoreductase (deaminating)
Class
Oxidoreductases;
Acting on the CH-NH2 group of donors;
With a copper protein as acceptor
Sysname
aralkylamine:azurin oxidoreductase (deaminating)
Reaction(IUBMB)
ArCH2NH2 + H2O + 2 azurin = ArCHO + NH3 + 2 reduced azurin
Reaction(KEGG)
(other) R02382 R02612 R04300
Substrate
ArCH2NH2;
H2O [CPD:C00001];
azurin
Product
ArCHO;
NH3 [CPD:C00014];
reduced azurin [CPD:C05358]
Comment
Phenazine methosulfate can act as acceptor. Acts on aromatic amines and, more slowly, on some long-chain aliphatic amines, but not on methylamine or ethylamine
History
EC 1.4.9.2 created 1986 as EC 1.4.99.4, transferred 2011 to EC 1.4.9.2
Pathway
ec00350  Tyrosine metabolism
ec00360  Phenylalanine metabolism
ec00950  Isoquinoline alkaloid biosynthesis
ec01100  Metabolic pathways
ec01110  Biosynthesis of secondary metabolites
Orthology
K13371  aralkylamine dehydrogenase light chain
K13372  aralkylamine dehydrogenase heavy chain
Genes
AFA: UZ73_08875 UZ73_08890
AFQ: AFA_01705 AFA_01720
AAQU: D3M96_01565 D3M96_01580
Reference
1  [PMID:6830237]
  Authors
Iwaki M, Yagi T, Horiike K, Saeki Y, Ushijima T, Nozaki M.
  Title
Crystallization and properties of aromatic amine dehydrogenase from Pseudomonas sp.
  Journal
Arch Biochem Biophys 220:253-62 (1983)
DOI:10.1016/0003-9861(83)90408-3
Reference
2  [PMID:7547967]
  Authors
Hyun YL, Davidson VL
  Title
Electron transfer reactions between aromatic amine dehydrogenase and azurin.
  Journal
Biochemistry 34:12249-54 (1995)
DOI:10.1021/bi00038a020
Reference
3  [PMID:10506161]
  Authors
Hyun YL, Zhu Z, Davidson VL
  Title
Gated and ungated electron transfer reactions from aromatic amine dehydrogenase to azurin.
  Journal
J Biol Chem 274:29081-6 (1999)
DOI:10.1074/jbc.274.41.29081
Reference
4  [PMID:15234267]
  Authors
Davidson VL
  Title
Electron transfer in quinoproteins.
  Journal
Arch Biochem Biophys 428:32-40 (2004)
DOI:10.1016/j.abb.2004.03.022
Reference
5  [PMID:17087503]
  Authors
Sukumar N, Chen ZW, Ferrari D, Merli A, Rossi GL, Bellamy HD, Chistoserdov A, Davidson VL, Mathews FS
  Title
Crystal structure of an electron transfer complex between aromatic amine dehydrogenase and azurin from Alcaligenes faecalis.
  Journal
Biochemistry 45:13500-10 (2006)
DOI:10.1021/bi0612972
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 1.4.9.2
IUBMB Enzyme Nomenclature: 1.4.9.2
ExPASy - ENZYME nomenclature database: 1.4.9.2
BRENDA, the Enzyme Database: 1.4.9.2
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