KEGG   ENZYME: 1.8.4.1
Entry
EC 1.8.4.1                  Enzyme                                 

Name
glutathione---homocystine transhydrogenase
Class
Oxidoreductases;
Acting on a sulfur group of donors;
With a disulfide as acceptor
Sysname
glutathione:homocystine oxidoreductase
Reaction(IUBMB)
2 glutathione + homocystine = glutathione disulfide + 2 homocysteine [RN:R01110]
Reaction(KEGG)
R01110 > R01292
Substrate
glutathione [CPD:C00051];
homocystine [CPD:C01817]
Product
glutathione disulfide [CPD:C00127];
homocysteine [CPD:C00155]
Comment
The reactions catalysed by this enzyme and by others in this subclass may be similar to those catalysed by EC 2.5.1.18 glutathione transferase.
History
EC 1.8.4.1 created 1961
Pathway
ec00270  Cysteine and methionine metabolism
ec00480  Glutathione metabolism
ec01100  Metabolic pathways
Reference
1  [PMID:13271447]
  Authors
RACKER E.
  Title
Glutathione-homocystine transhydrogenase.
  Journal
J Biol Chem 217:867-74 (1955)
Other DBs
ExplorEnz - The Enzyme Database: 1.8.4.1
IUBMB Enzyme Nomenclature: 1.8.4.1
ExPASy - ENZYME nomenclature database: 1.8.4.1
BRENDA, the Enzyme Database: 1.8.4.1
CAS: 9029-40-7
LinkDB

KEGG   REACTION: R01110
Entry
R01110                      Reaction                               

Name
glutathione:homocystine oxidoreductase
Definition
Homocystine + 2 Glutathione <=> Glutathione disulfide + 2 Homocysteine
Equation
C20788 + 2 C00051 <=> C00127 + 2 C05330
Reaction class
RC00011  C00051_C00127
Enzyme
Pathway
rn00480  Glutathione metabolism
rn01100  Metabolic pathways
Other DBs
RHEA: 11467
LinkDB

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