KEGG   ENZYME: 1.8.4.3
Entry
EC 1.8.4.3                  Enzyme                                 

Name
glutathione---CoA-glutathione transhydrogenase;
glutathione-coenzyme A glutathione disulfide transhydrogenase;
glutathione-coenzyme A glutathione disulfide transhydrogenase;
glutathione coenzyme A-glutathione transhydrogenase;
glutathione:coenzyme A-glutathione transhydrogenase;
coenzyme A:oxidized-glutathione oxidoreductase;
coenzyme A:glutathione-disulfide oxidoreductase
Class
Oxidoreductases;
Acting on a sulfur group of donors;
With a disulfide as acceptor
Sysname
CoA:glutathione-disulfide oxidoreductase
Reaction(IUBMB)
CoA + glutathione disulfide = CoA-glutathione + glutathione [RN:R01111]
Reaction(KEGG)
R01111;
(other) R02409 R04860
Substrate
CoA [CPD:C00010];
glutathione disulfide [CPD:C00127]
Product
CoA-glutathione [CPD:C00920];
glutathione [CPD:C00051]
History
EC 1.8.4.3 created 1972
Pathway
ec00270  Cysteine and methionine metabolism
ec00480  Glutathione metabolism
ec01100  Metabolic pathways
Reference
1  [PMID:5924646]
  Authors
Chang SH, Wilken DR.
  Title
Participation of the unsymmetrical disulfide of coenzyme A and glutathione in an enzymatic sulfhydryl-disulfide interchange. I. Partial purification and properties of the bovine kidney enzyme.
  Journal
J Biol Chem 241:4251-60 (1966)
Other DBs
ExplorEnz - The Enzyme Database: 1.8.4.3
IUBMB Enzyme Nomenclature: 1.8.4.3
ExPASy - ENZYME nomenclature database: 1.8.4.3
BRENDA, the Enzyme Database: 1.8.4.3
CAS: 37256-48-7
LinkDB

KEGG   REACTION: R01111
Entry
R01111                      Reaction                               

Name
coenzyme A:glutathione-disulfide oxidoreductase
Definition
CoA + Glutathione disulfide <=> CoA-glutathione + Glutathione
Equation
Reaction class
RC00011  C00010_C00920  C00051_C00127
Enzyme
Pathway
rn00480  Glutathione metabolism
rn01100  Metabolic pathways
Other DBs
RHEA: 13128
LinkDB

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