KEGG   ENZYME: 1.8.4.4
Entry
EC 1.8.4.4                  Enzyme                                 

Name
glutathione---cystine transhydrogenase;
GSH-cystine transhydrogenase;
NADPH-dependent GSH-cystine transhydrogenase
Class
Oxidoreductases;
Acting on a sulfur group of donors;
With a disulfide as acceptor
Sysname
glutathione:cystine oxidoreductase
Reaction(IUBMB)
2 glutathione + cystine = glutathione disulfide + 2 cysteine [RN:R01109]
Reaction(KEGG)
R01109 > R01113
Substrate
glutathione [CPD:C00051];
cystine [CPD:C01420]
Product
glutathione disulfide [CPD:C00127];
cysteine [CPD:C00736]
History
EC 1.8.4.4 created 1972
Pathway
ec00270  Cysteine and methionine metabolism
ec00480  Glutathione metabolism
ec01100  Metabolic pathways
Reference
1  [PMID:5646485]
  Authors
Nagai S, Black S.
  Title
A thiol-disulfide transhydrogenase from yeast.
  Journal
J Biol Chem 243:1942-7 (1968)
Other DBs
ExplorEnz - The Enzyme Database: 1.8.4.4
IUBMB Enzyme Nomenclature: 1.8.4.4
ExPASy - ENZYME nomenclature database: 1.8.4.4
BRENDA, the Enzyme Database: 1.8.4.4
CAS: 37256-49-8
LinkDB

KEGG   REACTION: R01109
Entry
R01109                      Reaction                               

Name
Glutathione:cystine oxidoreductase
Definition
Cystine + 2 Glutathione <=> Glutathione disulfide + 2 Cysteine
Equation
C01420 + 2 C00051 <=> C00127 + 2 C00736
Reaction class
RC00011  C00051_C00127  C00736_C01420
Enzyme
Pathway
rn00480  Glutathione metabolism
rn01100  Metabolic pathways
Other DBs
RHEA: 12616
LinkDB

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