| Entry |
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| Name |
leucine transaminase;
L-leucine aminotransferase;
leucine 2-oxoglutarate transaminase;
leucine aminotransferase;
leucine-alpha-ketoglutarate transaminase
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| Class |
Transferases;
Transferring nitrogenous groups;
Transaminases
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| Sysname |
L-leucine:2-oxoglutarate aminotransferase
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| Reaction(IUBMB) |
L-leucine + 2-oxoglutarate = 4-methyl-2-oxopentanoate + L-glutamate [RN: R01090]
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| Reaction(KEGG) |
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| Substrate |
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| Product |
4-methyl-2-oxopentanoate [CPD: C00233];
L-glutamate [CPD: C00025]
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| Comment |
A pyridoxal-phosphate protein. This enzyme differs from EC 2.6.1.42, branched-chain-amino-acid transaminase, in that it does not act on L-valine or L-isoleucine, although it does act on L-methionine. The mitochondrial form from rat liver differs in physical characteristics from the cytoplasmic form.
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| History |
EC 2.6.1.6 created 1961, modified 1982
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| Pathway |
| ec00280 | Valine, leucine and isoleucine degradation |
| ec00290 | Valine, leucine and isoleucine biosynthesis |
| ec00770 | Pantothenate and CoA biosynthesis |
| ec01110 | Biosynthesis of secondary metabolites |
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| Reference |
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| Authors |
Aki K, Ogawa K, Ichihara A. |
|---|
| Title |
Transaminases of branched chain amino acids. IV. Purification and properties of two enzymes from rat liver. |
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| Journal |
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| Reference |
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| Authors |
Ikeda T, Konishi Y, Ichihara A. |
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| Title |
Transaminase of branched chain amino acids. XI. Leucine (methionine) transaminase of rat liver mitochondria. |
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| Journal |
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| Other DBs |
| ExplorEnz - The Enzyme Database: | 2.6.1.6 |
| ExPASy - ENZYME nomenclature database: | 2.6.1.6 |
| BRENDA, the Enzyme Database: | 2.6.1.6 |
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| LinkDB |
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