| Entry |
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| Name |
maleylpyruvate hydrolase;
hbzF (gene name)
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| Class |
Hydrolases;
Acting on carbon-carbon bonds;
In ketonic substances
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| Sysname |
(2Z)-4,6-dioxohept-2-enedioate acylhydrolase
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| Reaction(IUBMB) |
3-maleylpyruvate + H2O = maleate + pyruvate [RN: R11257]
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| Reaction(KEGG) |
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| Substrate |
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| Product |
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| Comment |
The enzyme, characterized from the bacterium Pseudomonas alcaligenes NCIMB 9867, catalyses the hydrolysis of 3-maleylpyruvate, the ring-cleavage product of gentisate. The enzyme can also act on a number of maleylpyruvate derivatives, such as (2E)-2-methyl-4,6-dioxohept-2-enedioate and (2E)-3-methyl-4,6-dioxohept-2-enedioate. Activated by Mn2+. May be identical to EC 3.7.1.5, acylpyruvate hydrolase.
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| History |
EC 3.7.1.23 created 2016
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| Pathway |
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| Orthology |
| K20758 | maleylpyruvate hydrolase |
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| Reference |
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| Authors |
Hopper DJ, Chapman PJ, Dagley S |
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| Title |
The enzymic degradation of alkyl-substituted gentisates, maleates and malates. |
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| Journal |
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| Reference |
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| Authors |
Bayly RC, Chapman PJ, Dagley S, Di Berardino D |
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| Title |
Purification and some properties of maleylpyruvate hydrolase and fumarylpyruvate hydrolase from Pseudomonas alcaligenes. |
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| Journal |
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| Reference |
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| Authors |
Liu K, Liu TT, Zhou NY |
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| Title |
HbzF catalyzes direct hydrolysis of maleylpyruvate in the gentisate pathway of Pseudomonas alcaligenes NCIMB 9867. |
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| Journal |
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| Sequence |
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| Other DBs |
| ExplorEnz - The Enzyme Database: | 3.7.1.23 |
| ExPASy - ENZYME nomenclature database: | 3.7.1.23 |
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| LinkDB |
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