| Entry |
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| Name |
3,4-dihydroxyphenylacetaldehyde synthase;
DHPAA synthase
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| Class |
Lyases;
Carbon-carbon lyases;
Carboxy-lyases
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| Sysname |
L-dopa carboxy-lyase (oxidative-deaminating)
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| Reaction(IUBMB) |
L-dopa + O2 + H2O = 3,4-dihydroxyphenylacetaldehyde + CO2 + NH3 + H2O2 [RN: R11916]
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| Reaction(KEGG) |
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| Substrate |
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| Product |
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| Comment |
A pyridoxal 5'-phosphate protein. The enzyme, isolated from the mosquito Aedes aegypti, catalyses the production of 3,4-dihydroxylphenylacetaldehyde directly from L-dopa. Dopamine is not formed as an intermediate (cf. EC 4.1.1.28, aromatic-L-amino-acid decarboxylase). The enzyme is specific for L-dopa and does not react with other aromatic amino acids with the exception of a low activity with alpha-methyl-L-dopa.
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| History |
EC 4.1.1.107 created 2017
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| Pathway |
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| Orthology |
| K01618 | 3,4-dihydroxyphenylacetaldehyde synthase |
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| Genes |
» show all
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| Reference |
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| Authors |
Vavricka C, Han Q, Huang Y, Erickson SM, Harich K, Christensen BM, Li J |
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| Title |
From L-dopa to dihydroxyphenylacetaldehyde: a toxic biochemical pathway plays a vital physiological function in insects. |
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| Journal |
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| Sequence |
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| Other DBs |
| ExPASy - ENZYME nomenclature database: | 4.1.1.107 |
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| LinkDB |
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