KEGG   ENZYME: 4.2.1.74
Entry
EC 4.2.1.74                 Enzyme                                 

Name
long-chain-enoyl-CoA hydratase;
long-chain enoyl coenzyme A hydratase
Class
Lyases;
Carbon-oxygen lyases;
Hydro-lyases
Sysname
long-chain-(3S)-3-hydroxyacyl-CoA hydro-lyase
Reaction(IUBMB)
a long-chain (3S)-3-hydroxyacyl-CoA = a long-chain trans-2-enoyl-CoA + H2O [RN:R02685]
Reaction(KEGG)
Substrate
long-chain (3S)-3-hydroxyacyl-CoA
Product
long-chain trans-2-enoyl-CoA;
H2O [CPD:C00001]
Comment
Acts in the reverse direction. The best substrate is oct-3-enoyl-CoA. Unlike EC 4.2.1.17 enoyl-CoA hydratase, it does not act on crotonoyl-CoA.
History
EC 4.2.1.74 created 1981
Pathway
ec00062  Fatty acid elongation
ec00071  Fatty acid degradation
ec01100  Metabolic pathways
Reference
1  [PMID:833142]
  Authors
Fong JC, Schulz H.
  Title
Purification and properties of pig heart crotonase and the presence of short chain and long chain enoyl coenzyme A hydratases in pig and guinea pig tissues.
  Journal
J Biol Chem 252:542-7 (1977)
Reference
2  [PMID:4828315]
  Authors
Schulz H.
  Title
Long chain enoyl coenzyme A hydratase from pig heart.
  Journal
J Biol Chem 249:2704-9 (1974)
Other DBs
ExplorEnz - The Enzyme Database: 4.2.1.74
IUBMB Enzyme Nomenclature: 4.2.1.74
ExPASy - ENZYME nomenclature database: 4.2.1.74
BRENDA, the Enzyme Database: 4.2.1.74
CAS: 62009-81-8
LinkDB

KEGG   REACTION: R04740
Entry
R04740                      Reaction                               

Name
(S)-3-Hydroxytetradecanoyl-CoA hydro-lyase
Definition
(S)-3-Hydroxytetradecanoyl-CoA <=> trans-Tetradec-2-enoyl-CoA + H2O
Equation
Reaction class
RC01095  C05260_C05273
Enzyme
4.2.1.17        4.2.1.74
Pathway
rn00062  Fatty acid elongation
rn00071  Fatty acid degradation
rn01100  Metabolic pathways
rn01212  Fatty acid metabolism
Module
M00085  Fatty acid elongation in mitochondria
M00087  beta-Oxidation
Orthology
K01692  enoyl-CoA hydratase [EC:4.2.1.17]
K01782  3-hydroxyacyl-CoA dehydrogenase / enoyl-CoA hydratase / 3-hydroxybutyryl-CoA epimerase [EC:1.1.1.35 4.2.1.17 5.1.2.3]
K01825  3-hydroxyacyl-CoA dehydrogenase / enoyl-CoA hydratase / 3-hydroxybutyryl-CoA epimerase / enoyl-CoA isomerase [EC:1.1.1.35 4.2.1.17 5.1.2.3 5.3.3.8]
K07511  enoyl-CoA hydratase [EC:4.2.1.17]
K07514  enoyl-CoA hydratase / 3-hydroxyacyl-CoA dehydrogenase / 3,2-trans-enoyl-CoA isomerase [EC:4.2.1.17 1.1.1.35 5.3.3.8]
K07515  enoyl-CoA hydratase / long-chain 3-hydroxyacyl-CoA dehydrogenase [EC:4.2.1.17 1.1.1.211]
K10527  enoyl-CoA hydratase/3-hydroxyacyl-CoA dehydrogenase [EC:4.2.1.17 1.1.1.35 1.1.1.211]
K13767  enoyl-CoA hydratase [EC:4.2.1.17]
Other DBs
RHEA: 31174
LinkDB

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