KEGG   ENZYME: 4.3.1.22
Entry
EC 4.3.1.22                 Enzyme                                 

Name
3,4-dihydroxyphenylalanine reductive deaminase;
reductive deaminase;
DOPA-reductive deaminase;
DOPARDA
Class
Lyases;
Carbon-nitrogen lyases;
Ammonia-lyases
Sysname
3,4-dihydroxy-L-phenylalanine ammonia-lyase (3,4-dihydroxyphenylpropanoate-forming)
Reaction(IUBMB)
L-dopa + NADH = 3,4-dihydroxyphenylpropanoate + NAD+ + NH3 [RN:R08846]
Reaction(KEGG)
R08846
Substrate
L-dopa [CPD:C00355];
NADH [CPD:C00004]
Product
3,4-dihydroxyphenylpropanoate [CPD:C10447];
NAD+ [CPD:C00003];
NH3 [CPD:C00014]
Comment
Forms part of the L-phenylalanine-catabolism pathway in the anoxygenic phototrophic bacterium Rhodobacter sphaeroides OU5. NADPH is oxidized more slowly than NADH.
History
EC 4.3.1.22 created 2007
Pathway
ec00350  Tyrosine metabolism
Reference
1  [PMID:17616348]
  Authors
Ranjith NK, Sasikala Ch, Ramana ChV.
  Title
Catabolism of L-phenylalanine and L-tyrosine by Rhodobacter sphaeroides OU5 occurs through 3,4-dihydroxyphenylalanine.
  Journal
Res Microbiol 158:506-11 (2007)
DOI:10.1016/j.resmic.2007.04.008
Other DBs
ExplorEnz - The Enzyme Database: 4.3.1.22
IUBMB Enzyme Nomenclature: 4.3.1.22
ExPASy - ENZYME nomenclature database: 4.3.1.22
BRENDA, the Enzyme Database: 4.3.1.22
LinkDB

KEGG   REACTION: R08846
Entry
R08846                      Reaction                               

Name
3,4-dihydroxy-L-phenylalanine ammonia-lyase (3,4-dihydroxyphenylpropanoate-forming)
Definition
3,4-Dihydroxy-L-phenylalanine + NADH + H+ <=> 3,4-Dihydroxyphenylpropanoate + NAD+ + Ammonia
Equation
Reaction class
RC00001  C00003_C00004
RC02368  C00355_C10447
Enzyme
Pathway
rn00350  Tyrosine metabolism
Other DBs
RHEA: 24763
LinkDB

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