KEGG   ENZYME: 4.4.1.10
Entry
EC 4.4.1.10                 Enzyme                                 

Name
cysteine lyase;
cysteine (sulfite) lyase;
L-cysteine hydrogen-sulfide-lyase (adding sulfite)
Class
Lyases;
Carbon-sulfur lyases;
Carbon-sulfur lyases (only sub-subclass identified to date)
Sysname
L-cysteine hydrogen-sulfide-lyase (adding sulfite; L-cysteate-forming)
Reaction(IUBMB)
L-cysteine + sulfite = L-cysteate + hydrogen sulfide [RN:R00901]
Reaction(KEGG)
R00901
Substrate
L-cysteine [CPD:C00097];
sulfite [CPD:C00094]
Product
L-cysteate [CPD:C00506];
hydrogen sulfide [CPD:C00283]
Comment
A pyridoxal-phosphate protein. Can use a second molecule of cysteine (producing lanthionine), or other alkyl thiols, as a replacing agent.
History
EC 4.4.1.10 created 1972
Pathway
ec00270  Cysteine and methionine metabolism
ec00430  Taurine and hypotaurine metabolism
ec01100  Metabolic pathways
Reference
1  [PMID:5813025]
  Authors
Tolosa EA, Chepurnova NK, Khomutov RM, Severin ES.
  Title
Reactions catalysed by cysteine lyase from the yolk sac of chicken embryo.
  Journal
Biochim Biophys Acta 171:369-71 (1969)
DOI:10.1016/0005-2744(69)90174-0
Other DBs
ExplorEnz - The Enzyme Database: 4.4.1.10
IUBMB Enzyme Nomenclature: 4.4.1.10
ExPASy - ENZYME nomenclature database: 4.4.1.10
BRENDA, the Enzyme Database: 4.4.1.10
CAS: 9079-86-1
LinkDB

KEGG   REACTION: R00901
Entry
R00901                      Reaction                               

Name
L-cysteine hydrogen-sulfide-lyase (adding sulfite; L-cysteate-forming)
Definition
L-Cysteine + Sulfite <=> Hydrogen sulfide + L-Cysteate
Equation
Reaction class
RC02814  C00097_C00283
RC02824  C00097_C00506
Enzyme
Pathway
rn00270  Cysteine and methionine metabolism
rn00430  Taurine and hypotaurine metabolism
rn01100  Metabolic pathways
Other DBs
RHEA: 20919
LinkDB

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