KEGG ENZYME: 5.3.2.1

ENZYME: 5.3.2.1

Entry

EC 5.3.2.1 Enzyme

Name

phenylpyruvate tautomerase;
phenylpyruvic keto-enol isomerase

Class

Isomerases;
Intramolecular oxidoreductases;
Interconverting keto- and enol-groups

Sysname

phenylpyruvate keto---enol-isomerase

Reaction(IUBMB)

keto-phenylpyruvate = enol-phenylpyruvate [RN:R01378]

Reaction(KEGG)

R01378;
(other) R03342

Substrate

keto-phenylpyruvate [CPD:C00166]

Product

enol-phenylpyruvate [CPD:C02763]

Comment

Also acts on other arylpyruvates.

History

EC 5.3.2.1 created 1961

Pathway

ec00350

Tyrosine metabolism

ec00360

Phenylalanine metabolism

ec01100

Metabolic pathways

Orthology

K07253

phenylpyruvate tautomerase

Genes

HSA:

4282(MIF)

PTR:	748716(MIF)

PPS:	100995773(MIF)

GGO:	101146189(MIF)

PON:	100438837(MIF)

NLE:	100581032(MIF)

MCC:	574298(MIF)

MCF:	101867092(MIF)

CSAB:

103223031(MIF)

RRO:	104667415(MIF)

RBB:	108540422(MIF)

CJC:	100392923(MIF)

SBQ:	101038492(MIF)

MMU:	17319(Mif)

MCAL:

110303158(Mif)

MPAH:

110326780(Mif)

RNO:	103694877 81683(Mif)

MUN:	110558690(Mif)

CGE:	100766328(Mif)

NGI:	103740066(Mif)

HGL:	101725992(Mif)

CCAN:

109690506 109690507

OCU:	100338701(MIF)

TUP:	102489547(MIF)

VVP:	112907528(MIF)

AML:	100480443(MIF)

UAH:	113247035(MIF)

ORO:	101376805(MIF)

ELK:

111142602

FCA:	101090298(MIF)

PTG:	102955799(MIF)

PPAD:

109259716(MIF)

AJU:	106988287(MIF)

BTA:	280858(MIF)

BIU:	109570988(MIF)

BBUB:

102403512(MIF)

CHX:	108637839(MIF)

OAS:	780466(MIF)

SSC:	397412(MIF)

CFR:	102518568(MIF)

CDK:	105095204(MIF)

BACU:

103014799

LVE:	103073098(MIF)

OOR:	101276106(MIF)

DLE:	111163021(MIF)

PCAD:

112064089

ECB:	100053618(MIF)

EPZ:	103541501(MIF)

EAI:	106847116(MIF)

MNA:	107530480(MIF)

DRO:	112310715(MIF)

PALE:

102882544(MIF)

RAY:	107501246(MIF)

MJV:	108389703(MIF)

LAV:	104845409(MIF)

TMU:

101348711

MDO:	100014737(MIF)

SHR:	116420904(MIF)

PCW:	110201782(MIF)

OAA:	100081817(MIF)

GGA:	100857237(MIF)

MGP:	100551273(MIF)

CJO:	107321446(MIF)

NMEL:

110406243(MIF)

APLA:

101796948 101804212(MIF)

ACYG:

106031298 106031440

TGU:	100190143 100232372

LSR:	110481382(MIF)

SCAN:

103818237(MIF) 103818238

GFR:	102039032 102044154

FAB:	101807041(MIF)

PHI:	102103863 102111823

PMAJ:

107211438 107211468

CCAE:

111936762(MIF)

CCW:	104688587 104688767

ETL:	114061538 114061539

FPG:	101916004(MIF)

FCH:	102049665(MIF)

CLV:	102092102 110359817(MIF)

EGZ:	104130100(MIF)

NNI:	104011431(MIF)

ACUN:

113486319(MIF)

PADL:

103922605(MIF)

AAM:	106486278 106486297

ASN:

102383931

AMJ:	102572055 102572281(MIF)

PSS:	102445441 102446381

CMY:	102947909 102948142

CPIC:

101933859 101934100

PVT:	110081964(MIF)

PMUR:

107291844(MIF)

PMUA:

114587021(MIF)

GJA:	107108555(MIF)

XLA:	399041(mif.L)

XTR:	100134996(mif)

NPR:	108794801(MIF)

DRE:	751093(mif)

SRX:	107749729 107750392

SANH:

107668577 107680670

SGH:	107594906 107594949

CCAR:

109102592

IPU:	100305114(mif)

PHYP:

113542806(mif)

AMEX:

103031017(mif)

EEE:	113570789(mif)

TRU:	115246418 503499(mif)

LCO:	104922620(mif)

NCC:	104961162(mif)

MZE:	101480066(mif)

ONL:	100705586(mif)

OLA:	101160246(mif)

XMA:	102232566(mif)

XCO:	114138982(mif)

PRET:

103471348(mif)

CVG:	107101020(mif)

NFU:	107372730(mif)

KMR:	108243064(mif)

ALIM:

106536652(mif)

AOCE:

111578098 111583658

CSEM:

103390923(mif)

POV:	109642286(mif)

LCF:	108885537(mif)

SDU:	111232407(mif)

SLAL:

111662789(mif)

HCQ:	109524441(mif) 109524442

BPEC:

110162381(mif)

MALB:

109957277(mif)

SASA:

100136498(mif) 100196518(mif)

OTW:	112220788 112256110

SALP:

111965412 112069058

ELS:	105025208(mif)

SFM:	108930909(mif)

PKI:	111859339(mif)

LCM:	102367089(MIF)

CMK:	103190732(mif)

RTP:	109919405(mif)

BFO:	118425486 118426506

CIN:	100175627 100183461

SPU:	105440032 105444560 577624 762494

APLC:

110976984 110976985 110979298 110980696

SKO:

100369257

TCA:	100142248 656105

DPA:

109537033

ATD:

109602756

BMOR:

101743564 692890(Mif)

BMAN:

114246772 114247038

DPL:	KGM_203325 KGM_206951

PMAC:

106714533 106717204

PRAP:

110993229 111003327

HAW:	110373655 110374504 110376561

TNL:

113494362

PXY:

105388160

API:	100144890 100161225 100162394 100164929 100165124 100570612 103309364

DNX:	107161760 107165403 107171358 107171635 107171636 107173839

AGS:	114122934 114131014 114131726 114132070 114132306 114132313

RMD:	113549713 113551009 113552179 113553129 113554219 113560834

BTAB:

109031233

ZNE:

110836479

DPX:	DAPPUDRAFT_308977

PVM:	113803303 113803305

TUT:

DPTE:

CSCU:

PTEP:

CEL:	CELE_Y56A3A.3(mif-1)

CBR:	CBG13302(Cbr-mif-1)

BMY:

Bm1_28435

LOA:	LOAG_08159

NAI:	NECAME_06445 NECAME_08442

TSP:	Tsp_06335 Tsp_06336

HRO:	HELRODRAFT_147095 HELRODRAFT_180615

LGI:	LOTGIDRAFT_176471 LOTGIDRAFT_231585

PCAN:

112559495 112561180 112568008

CRG:	105319375 105343631

MYI:	110458563 110458573 110458584

OBI:	106879456 106881859

LAK:	106150929 106153859 106153864

NVE:

EPA:

PDAM:

SPIS:

HMG:

TAD:	TRIADDRAFT_53604

ATH:

AT5G57170

ALY:	9302262 9302263 9306977 9312166

CRB:	17876610 17886287

CSAT:

104709013 104711711 104726269 104734043 104761793 104768294 104780999 104791410

EUS:	EUTSA_v10010841mg EUTSA_v10015052mg

BRP:	103841091 103845155

BNA:	106364820 106364847 106370341 106416472 106440092 106448248

BOE:	106303958 106311128 106315787 106334590

RSZ:	108809731 108810056 108825487 108845748

THJ:	104806117 104817772

CPAP:

110811091

CIT:	102607528 102630667 102631169

CIC:	CICLE_v10009962mg CICLE_v10013125mg CICLE_v10013158mg

TCC:	18589402 18597450 18597451

GRA:	105786590 105790896 105799984

GHI:	107890930 107924291 107937047 107938969 107939691 107958088

GAB:	108452611 108461669 108462181

DZI:	111295008 111295499 111304280 111312093

EGR:	104426349 104426350 104426351 104426393 104427838 104435924

GMX:	100305839 100306650

GSJ:	114381349 114395024 114395206 114416543 114416568 114419127

PVU:	PHAVU_003G141000g PHAVU_008G092400g PHAVU_008G092500g

VRA:	106754874 106765688

VAR:	108322114 108347027

VUN:	114177312 114183504 114184157

CCAJ:

109802349 109802604 109809139 109818158

MTR:	MTR_4g014040 MTR_4g127360 MTR_7g059460

CAM:	101503432 101506823 101509336

LJA:	Lj0g3v0322299.1(Lj0g3v0322299.1) Lj4g3v2139180.1(Lj4g3v2139180.1)

ADU:	107475370 107475372 107485033 107495472 107496390

AIP:	107625807 107625809 107637980 107642812

LANG:

109325198 109352671 109361572 109362073

FVE:	101295703 101306351

RCN:	112191418 112191523 112197438

PPER:

18774386 18789679

PMUM:

103323646 103342903

PAVI:

110758344 110767303

MDM:	103412348 103419406 103433707 103451003 114819951

PXB:	103929361 103950459 103962144 103962145

ZJU:	107428926 107431054 107431060

CSV:	101203411 101208581 101215141

CMO:	103494235 103502167 103502168

MCHA:

111006808 111013854 111013868 111013871

CMAX:

111466128 111471895 111478343

CMOS:

111432434 111432436 111433078 111453099

CPEP:

111782212 111792312 111803070

RCU:	8263125 8263126 8279554

JCU:	105631082 105648086 105648087

HBR:	110633729 110633740 110636501 110650961 110667767

MESC:

110616665 110620055 110620357 110623510 110623511

POP:	18110655 7460405 7474727 7487340 7487343 7488724 7488725

PEU:	105119464 105119465 105121898 105121902 105122555 105131372 105141313 105141315

JRE:	109003088 109013656

QSU:	112012605 112015170 112015179

VVI:	100251764 100256897 100266836

SLY:	101253800 101255350

SPEN:

107026310 107032411

SOT:	102582498 102602878

CANN:

107844958 107877786

NTA:	107762576 107771315 107775000 107788402 107816944

NSY:	104212826 104231564 104236053 104246674

NTO:	104086153 104093135 104101288

NAU:	109228691 109233313 109233400 109235695

INI:	109159053 109181050 109181365 109191680

SIND:

105173900 105174616

OEU:	111366312 111387590 111399315 111408036

HAN:	110877608 110886173 110915213 110916340

LSV:	111878214 111878217 111890767 111914392

CCAV:

112506795 112507106 112517292

DCR:	108193498 108217932 108219355

BVG:	104892565 104892566 104898774

SOE:	110786692 110794754

CQI:	110684583 110710765 110733874 110734720

NNU:	104597256 104602505 104609064

PSOM:

113298891 113310569 113322445 113329228 113340649 113358665

OSA:	4341957 4349563 4351273

DOSA:

Os06t0699500-01(Os06g0699500) Os11t0107500-01(Os11g0107500) Os12t0107500-01(Os12g0107500)

OBR:	102704815 102717469 102720003

BDI:	100834365 100841922 100846149

ATS:	109734531(LOC109734531) 109735416(LOC109735416)

SBI:	8055497 8063823 8079974

ZMA:	100284350(cl405_1) 100284546

SITA:

101764466 101765900 101774678

PDA:	103696432 103717501 103722612

EGU:	105050858 105057162

MUS:	103974496 103984178 103986889 103992538

DCT:	110110165 110113531

PEQ:	110023443 110033913

AOF:	109843024 109849899

ATR:

18440677

SMO:	SELMODRAFT_117499 SELMODRAFT_147673 SELMODRAFT_76736

PPP:

112290375

CRE:	CHLREDRAFT_170481

VCN:	VOLCADRAFT_83092

MNG:

MNEG_7054

CSL:	COCSUDRAFT_57937

CVR:	CHLNCDRAFT_136510

OLU:	OSTLU_17653

OTA:	OT_ostta12g02430

BPG:	Bathy07g02340

MPP:	MICPUCDRAFT_9312

CME:	CYME_CMT251C

GSL:	Gasu_17280

PBL:	PAAG_01158

PBN:	PADG_03671

AJE:	HCAG_05903

BGH:	BDBG_03359

PPL:	POSPLDRAFT_105444 POSPLDRAFT_28475 POSPLDRAFT_88655

TVS:	TRAVEDRAFT_138052 TRAVEDRAFT_36441 TRAVEDRAFT_46171

DSQ:	DICSQDRAFT_104168

PCO:	PHACADRAFT_207427 PHACADRAFT_261823

SHS:	STEHIDRAFT_108811

HIR:	HETIRDRAFT_470362

PSQ:	PUNSTDRAFT_122774 PUNSTDRAFT_69339 PUNSTDRAFT_88614

ADL:	AURDEDRAFT_116659 AURDEDRAFT_133858 AURDEDRAFT_138911 AURDEDRAFT_173029

FME:	FOMMEDRAFT_104675

GTR:	GLOTRDRAFT_120269

LBC:	LACBIDRAFT_324849

MRR:	Moror_5129 Moror_5555 Moror_715

CCI:	CC1G_10833

SCM:	SCHCODRAFT_106144 SCHCODRAFT_232893 SCHCODRAFT_232894

ABP:	AGABI1DRAFT111593(AGABI1DRAFT_111593) AGABI1DRAFT69253(AGABI1DRAFT_69253)

ABV:	AGABI2DRAFT200279(AGABI2DRAFT_200279) AGABI2DRAFT217233(AGABI2DRAFT_217233)

CPUT:

CONPUDRAFT_144997 CONPUDRAFT_150320 CONPUDRAFT_70300 CONPUDRAFT_80073

SLA:	SERLADRAFT_397185 SERLADRAFT_397187 SERLADRAFT_474679

SRE:	PTSG_12443

EIV:	EIN_113870 EIN_174020

PYO:	PY17X_1446500

PCB:	PCHAS_144620(PC000788.00.0)

PBE:	PBANKA_1444000

PKN:	PKH_144610

PCY:	PCYB_145500

TGO:	TGME49_290040

NGD:	NGA_2067700(MIF)

AAF:	AURANDRAFT_30541

PIF:	PITG_16205 PITG_16206

PSOJ:

PHYSODRAFT_247002 PHYSODRAFT_285242 PHYSODRAFT_285243 PHYSODRAFT_295775

EHX:	EMIHUDRAFT_358508 EMIHUDRAFT_360168

GTT:	GUITHDRAFT_76592 GUITHDRAFT_83763

LIF:	LINJ_33_1840(MIF1)

LDO:	LDBPK_331840

LMI:	LMXM_32_1740

LBZ:	LBRM_33_2010

LPAN:

LPMP_331830

TVA:	TVAG_101850 TVAG_219770

GLA:	GL50803_0012091

MCA:

MCA2795

METU:

GNH96_00580

MMT:	Metme_0569

MDN:	JT25_012665

MDH:	AYM39_02460

MKO:	MKLM6_0534

METL:

U737_22220

MAH:	MEALZ_0491(MIF)

MBUR:

MMAI:

MMOB:

MEJ:

MEC:

THIS:

TMB:	Thimo_1880

MPUR:

MARPU_14525

TEE:

Tel_09965

TSY:	THSYN_03235

TTP:	E6P07_03845

TGR:

Tgr7_1126

TKM:

TK90_0504

TNI:	TVNIR_3391

TTI:	THITH_02825

TVR:

APRS:

SLIM:

TBN:

REV:	HUE57_15620

ENM:

EBS_0375

DDN:	DND132_0930

DFL:

DFE_0354

DMS:	E8L03_19315

DEJ:	AWY79_09500

PPRF:

PSEL:

DBA:

DAL:

DOV:	DSCO28_55940

DWD:	DSCW_22500

DALK:

DSCA_43460

MAGQ:

MGMAQ_1296

DEX:	HWD60_06260

MAES:

Ga0123461_0564

MFN:	Ga0123462_1699

TPD:	Teth39_1610

TIT:

Thit_0686

TMT:	Tmath_0739

TBO:	Thebr_1650

TWI:	Thewi_0839

TKI:	TKV_c07050

TTM:

Tthe_1010

TTO:	Thethe_00962

TXY:	Thexy_1717

TSH:

Tsac_1471

HAS:	Halsa_0970

SYW:

SYNW0376

SYD:	Syncc9605_1073

SYE:	Syncc9902_1470

SYX:	SynWH7803_0947

SYP:	SYNPCC7002_A0567

CYA:

CYA_2597

CYB:

CYB_0558

SYND:

KR52_11595

SYH:	Syncc8109_1600

SYV:	AWQ23_02995

SYL:	AWQ21_02975

SYNC:

CB0101_02095

CYI:	CBM981_0145

CMP:	Cha6605_1431

LEP:	Lepto7376_1667

LEN:	LEP3755_14590

LET:	O77CONTIG1_02474

HHG:	XM38_023300

PSEU:

Pse7367_1549

PMM:

PMM1167

PMT:

PMT_0503

PMN:	PMN2A_0714

PMI:	PMT9312_1267

PMB:	A9601_13581

PMF:	P9303_17651

PMG:	P9301_13671

PMH:	P9215_13791

PME:	NATL1_15511

PRC:

PRM:

AMR:

THEU:

GLP:	Glo7428_1654

GEE:	GM3708_3155

MAR:

MAE_29020

MPK:

VL20_5280

MIQ:	B5D77_21225

MVZ:	myaer102_05040

CSN:	Cyast_1911

CYL:	AA637_09210

HAO:	PCC7418_2439

CYT:

cce_2084

CWA:	CwatDRAFT_5612

CYP:	PCC8801_2603

CYH:	Cyan8802_3503

CYC:	PCC7424_3169

CYJ:	Cyan7822_2502

CYN:	Cyan7425_4718

TER:

Tery_1915

MIC:	Mic7113_1717

ARP:	NIES39_H00420 NIES39_H00430

OXY:	HCG48_05330

LFS:	HFV01_17870 HFV01_17875

GEI:	GEI7407_0030

OAC:	Oscil6304_5465

MPRO:

BJP34_26070

NOS:	Nos7107_4337

NOP:	Nos7524_1812

ACY:	Anacy_1558

CSG:	Cylst_4922

CALO:

Cal7507_0789

CALT:

Cal6303_5502

CALH:

IJ00_02520

RIV:	Riv7116_1527

TOQ:	HCG51_07840

NCN:	BZZ01_27075

CTHE:

Chro_4899

PLP:	Ple7327_2175

SCS:	Sta7437_1222

STAN:

STA3757_23340

CER:	RGRSB_1926

OBG:	Verru16b_01893

VBH:	CMV30_02210

CAA:

Caka_1114

MIN:

Minf_2366

MKC:

kam1_115

VBS:	EGM51_11025

SSM:	Spirs_1314

BLQ:	L21SP5_01065

MBAS:

PMO:

ASAC:

Reference

1 [PMID:5824560]

Authors

Blasi F, Fragomele F, Covelli I.

Title

Thyroidal phenylpyruvate tautomerase. Isolation and characterization.

Journal

J Biol Chem 244:4864-70 (1969)

Reference

Authors

Knox, W.E.

Title

p-Hydroxyphenylpyruvate enol-keto tautomerase.

Journal

Methods Enzymol 2:289-295 (1955)

Reference

3 [PMID:13416270]

Authors

KNOX WE, PITT BM.

Title

Enzymic catalysis of the keto-enol tautomerization of phenylpyruvic acids.

Journal

J Biol Chem 225:675-88 (1957)

Other DBs

ExplorEnz - The Enzyme Database:

5.3.2.1

IUBMB Enzyme Nomenclature:

5.3.2.1

ExPASy - ENZYME nomenclature database:

5.3.2.1

BRENDA, the Enzyme Database:

5.3.2.1

CAS:

9023-54-5

LinkDB

DBGET integrated database retrieval system