KEGG   DRUG: Naproxen
Entry
D00118                      Drug                                   

Name
Naproxen (JP17/USP/INN);
Naprosyn (TN)
Product
  Generic
NAPROXEN (A-S Medication Solutions), NAPROXEN (A-S Medication Solutions), NAPROXEN (A-S Medication Solutions), NAPROXEN (A-S Medication Solutions), NAPROXEN (A-S Medication Solutions), NAPROXEN (A-S Medication Solutions), NAPROXEN (A-S Medication Solutions), NAPROXEN (A-S Medication Solutions), NAPROXEN (A-S Medication Solutions), NAPROXEN (A-S Medication Solutions), NAPROXEN (A-S Medication Solutions), NAPROXEN (A-S Medication Solutions), NAPROXEN (American Health Packaging), NAPROXEN (American Health Packaging), NAPROXEN (Amneal Pharmaceuticals LLC), NAPROXEN (Amneal Pharmaceuticals of New York LLC), NAPROXEN (Aphena Pharma Solutions - Tennessee), NAPROXEN (Aphena Pharma Solutions - Tennessee), NAPROXEN (Asclemed USA), NAPROXEN (Aurobindo Pharma Limited), NAPROXEN (AvKARE), NAPROXEN (AvKARE), NAPROXEN (AvPAK), NAPROXEN (Bryant Ranch Prepack), NAPROXEN (Bryant Ranch Prepack), NAPROXEN (Bryant Ranch Prepack), NAPROXEN (Bryant Ranch Prepack), NAPROXEN (Bryant Ranch Prepack), NAPROXEN (Cadila Healthcare Limited), NAPROXEN (Cipla USA), NAPROXEN (Cipla USA), NAPROXEN (Clinical Solutions Wholesale), NAPROXEN (DIRECT RX), NAPROXEN (DIRECT RX), NAPROXEN (Denton Pharma), NAPROXEN (Denton Pharma), NAPROXEN (Denton Pharma), NAPROXEN (Direct RX), NAPROXEN (DirectRX), NAPROXEN (Direct_Rx), NAPROXEN (Direct_Rx), NAPROXEN (Direct_Rx), NAPROXEN (Direct_Rx), NAPROXEN (Direct_Rx), NAPROXEN (Exelan Pharmaceuticals), NAPROXEN (Lake Erie Medical DBA Quality Care Products LLC), NAPROXEN (Lake Erie Medical DBA Quality Care Products LLC), NAPROXEN (McKesson Corporation dba SKY Packaging), NAPROXEN (Medsource Pharmaceuticals), NAPROXEN (NCS HealthCare of KY), NAPROXEN (NuCare Pharmaceuticals), NAPROXEN (NuCare Pharmaceuticals), NAPROXEN (NuCare Pharmaceuticals), NAPROXEN (NuCare Pharmaceuticals), NAPROXEN (NuCare Pharmaceuticals), NAPROXEN (NuCare Pharmaceuticals), NAPROXEN (NuCare Pharmaceuticals), NAPROXEN (NuCare Pharmaceuticals), NAPROXEN (PD-Rx Pharmaceuticals), NAPROXEN (PD-Rx Pharmaceuticals), NAPROXEN (PD-Rx Pharmaceuticals), NAPROXEN (PD-Rx Pharmaceuticals), NAPROXEN (PD-Rx Pharmaceuticals), NAPROXEN (PD-Rx Pharmaceuticals), NAPROXEN (PD-Rx Pharmaceuticals), NAPROXEN (Palmetto Pharmaceuticals), NAPROXEN (Preferred Pharmaceuticals), NAPROXEN (Preferred Pharmaceuticals), NAPROXEN (Preferred Pharmaceuticals), NAPROXEN (Preferred Pharmaceuticals), NAPROXEN (Preferred Pharmaceuticals), NAPROXEN (Preferred Pharmaceuticals), NAPROXEN (Preferred Pharmaceuticals), NAPROXEN (Preferred Pharmaceuticals), NAPROXEN (Proficient Rx LP), NAPROXEN (Proficient Rx LP), NAPROXEN (Proficient Rx LP), NAPROXEN (Proficient Rx LP), NAPROXEN (Proficient Rx LP), NAPROXEN (QPharma), NAPROXEN (QPharma), NAPROXEN (REMEDYREPACK), NAPROXEN (REMEDYREPACK), NAPROXEN (REMEDYREPACK), NAPROXEN (REMEDYREPACK), NAPROXEN (REMEDYREPACK), NAPROXEN (REMEDYREPACK), NAPROXEN (REMEDYREPACK), NAPROXEN (RedPharm Drug), NAPROXEN (RedPharm Drug), NAPROXEN (RedPharm Drug), NAPROXEN (RedPharm Drug), NAPROXEN (RedPharm Drug), NAPROXEN (ScieGen Pharmaceuticals), NAPROXEN (St. Mary's Medical Park Pharmacy), NAPROXEN (St. Mary's Medical Park Pharmacy), NAPROXEN (TIME CAP LABORATORIES), NAPROXEN (Teva Pharmaceuticals USA), NAPROXEN (Unit Dose Services), NAPROXEN (Unit Dose Services), NAPROXEN (Unit Dose Services), NAPROXEN (Virtus Pharmaceuticals), NAPROXEN (Zydus Pharmaceuticals (USA)), NAPROXEN (medsource pharmaceuticals), NAPROXEN (medsource pharmaceuticals), NAPROXEN (medsource pharmaceuticals), NAPROXEN SODIUM (Glenmark Pharmaceuticals Limited)
Formula
C14H14O3
Exact mass
230.0943
Mol weight
230.2592
Structure
Simcomp
Class
Anti-inflammatory
 DG01908  Anti-inflammatory drug, propionic acid derivatives
 DG01504  Nonsteroidal anti-inflammatory drug (NSAID)
  DG01908  Anti-inflammatory drug, propionic acid derivatives
Remark
Same as: C01517
Therapeutic category: 1149
ATC code: G02CC02 M01AE02 M02AA12
Chemical structure group: DG00455
Product (DG00455): D00118<JP/US> D00970<US>
Product (mixture): D11576<US>
Efficacy
Analgesic, Anti-inflammatory, Antipyretic, COX inhibitor
  Disease
Rheumatoid arthritis [DS:H00630]
Ankylosing spondylitis [DS:H01674]
Polyarticular juvenile idiopathic arthritis [DS:H01672]
Acute gout [DS:H01532]
Comment
Propionic acid derivative
Target
PTGS1 (COX1) [HSA:5742] [KO:K00509]
PTGS2 (COX2) [HSA:5743] [KO:K11987]
  Pathway
hsa00590  Arachidonic acid metabolism
Interaction
Structure map
map07048  Antimigraines
map07114  Naphthalene family
map07219  Cyclooxygenase inhibitors
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 G GENITO URINARY SYSTEM AND SEX HORMONES
  G02 OTHER GYNECOLOGICALS
   G02C OTHER GYNECOLOGICALS
    G02CC Antiinflammatory products for vaginal administration
     G02CC02 Naproxen
      D00118  Naproxen (JP17/USP/INN) <JP/US>
 M MUSCULO-SKELETAL SYSTEM
  M01 ANTIINFLAMMATORY AND ANTIRHEUMATIC PRODUCTS
   M01A ANTIINFLAMMATORY AND ANTIRHEUMATIC PRODUCTS, NON-STEROIDS
    M01AE Propionic acid derivatives
     M01AE02 Naproxen
      D00118  Naproxen (JP17/USP/INN) <JP/US>
  M02 TOPICAL PRODUCTS FOR JOINT AND MUSCULAR PAIN
   M02A TOPICAL PRODUCTS FOR JOINT AND MUSCULAR PAIN
    M02AA Antiinflammatory preparations, non-steroids for topical use
     M02AA12 Naproxen
      D00118  Naproxen (JP17/USP/INN) <JP/US>
USP drug classification [BR:br08302]
 Analgesics
  Nonsteroidal Anti-inflammatory Drugs
   Naproxen
    D00118  Naproxen (JP17/USP/INN)
Therapeutic category of drugs in Japan [BR:br08301]
 1  Agents affecting nervous system and sensory organs
  11  Agents affecting central nervous system
   114  Antipyretics and analgesics, anti-inflammatory agents
    1149  Others
     D00118  Naproxen (JP17/USP/INN)
Target-based classification of drugs [BR:br08310]
 Enzymes
  Oxidoreductases (EC1)
   Prostaglandin synthase
    PTGS1 (COX1)
     D00118  Naproxen (JP17/USP/INN) <JP/US>
    PTGS2 (COX2)
     D00118  Naproxen (JP17/USP/INN) <JP/US>
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D00118  Naproxen
Other DBs
CAS: 22204-53-1
PubChem: 7847186
ChEBI: 7476
ChEMBL: CHEMBL154
DrugBank: DB00788
PDB-CCD: NPS[PDBj]
LigandBox: D00118
NIKKAJI: J9.289D
LinkDB
KCF data

ATOM        17
            1   C8y C    24.6254  -20.0866
            2   C8y C    24.6254  -21.4127
            3   C8x C    25.8119  -19.3887
            4   C8x C    23.5087  -19.3887
            5   C8x C    23.5087  -22.1106
            6   C8x C    25.8119  -22.1106
            7   C8y C    26.9983  -20.0866
            8   C8x C    22.3222  -20.0866
            9   C8y C    22.3222  -21.4127
            10  C8x C    26.9983  -21.3429
            11  C1c C    28.1848  -19.3887
            12  O2a O    21.1358  -22.1106
            13  C6a C    29.3015  -20.0866
            14  C1a C    28.1848  -18.0626
            15  C1a C    19.4607  -21.0637
            16  O6a O    30.6974  -19.1793
            17  O6a O    29.3015  -21.4127
BOND        18
            1     1   2 2
            2     1   3 1
            3     1   4 1
            4     2   5 1
            5     2   6 1
            6     3   7 2
            7     4   8 2
            8     5   9 2
            9     6  10 2
            10    7  11 1
            11    9  12 1
            12   11  13 1
            13   11  14 1 #Down
            14   12  15 1
            15   13  16 1
            16   13  17 2
            17    7  10 1
            18    8   9 1

» Japanese version   » Back

KEGG   DRUG: Naproxen sodium
Entry
D00970                      Drug                                   

Name
Naproxen sodium (USP);
Anaprox (TN)
Product
  Generic
NAPROXEN SODIUM (A-S Medication Solutions), NAPROXEN SODIUM (Actavis Pharma), NAPROXEN SODIUM (Alvogen), NAPROXEN SODIUM (Amneal Pharmaceuticals of New York LLC), NAPROXEN SODIUM (Aurobindo Pharma Limited), NAPROXEN SODIUM (AvKARE), NAPROXEN SODIUM (AvKARE), NAPROXEN SODIUM (AvPAK), NAPROXEN SODIUM (Bryant Ranch Prepack), NAPROXEN SODIUM (DIRECT RX), NAPROXEN SODIUM (DIRECT RX), ANAPROX (DIRECT RX), NAPROXEN (DIRECT RX), NAPROXEN SODIUM (Direct_Rx), NAPROXEN SODIUM (Dr. Reddy's Laboratories), NAPROXEN SODIUM (Lake Erie Medical DBA Quality Care Products LLC), NAPROXEN SODIUM (Medsource Pharmaceuticals), NAPROXEN SODIUM (NuCare Pharmaceuticals), NAPROXEN SODIUM (PD-Rx Pharmaceuticals), NAPROXEN SODIUM (Preferred Pharmaceuticals), NAPROXEN SODIUM (Preferred Pharmaceuticals), NAPROXEN SODIUM (Proficient Rx LP), NAPROXEN SODIUM (REMEDYREPACK), NAPROXEN SODIUM (REMEDYREPACK), NAPROXEN SODIUM (SA3), NAPROXEN SODIUM (ScieGen Pharmaceuticals)
Formula
C14H13O3. Na
Exact mass
252.0762
Mol weight
252.241
Structure
Simcomp
Class
Anti-inflammatory
 DG01908  Anti-inflammatory drug, propionic acid derivatives
 DG01504  Nonsteroidal anti-inflammatory drug (NSAID)
  DG01908  Anti-inflammatory drug, propionic acid derivatives
Remark
ATC code: G02CC02 M01AE02 M02AA12
Chemical structure group: DG00455
Product (DG00455): D00118<JP/US> D00970<US>
Product (mixture): D11577<US>
Efficacy
Analgesic, Anti-inflammatory, Antipyretic, COX inhibitor
  Disease
Rheumatoid arthritis [DS:H00630]
Ankylosing spondylitis [DS:H01674]
Polyarticular juvenile idiopathic arthritis [DS:H01672]
Acute gout [DS:H01532]
Comment
Propionic acid derivative
Target
PTGS1 (COX1) [HSA:5742] [KO:K00509]
PTGS2 (COX2) [HSA:5743] [KO:K11987]
  Pathway
hsa00590  Arachidonic acid metabolism
Interaction
Structure map
map07048  Antimigraines
map07114  Naphthalene family
map07219  Cyclooxygenase inhibitors
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 G GENITO URINARY SYSTEM AND SEX HORMONES
  G02 OTHER GYNECOLOGICALS
   G02C OTHER GYNECOLOGICALS
    G02CC Antiinflammatory products for vaginal administration
     G02CC02 Naproxen
      D00970  Naproxen sodium (USP) <US>
 M MUSCULO-SKELETAL SYSTEM
  M01 ANTIINFLAMMATORY AND ANTIRHEUMATIC PRODUCTS
   M01A ANTIINFLAMMATORY AND ANTIRHEUMATIC PRODUCTS, NON-STEROIDS
    M01AE Propionic acid derivatives
     M01AE02 Naproxen
      D00970  Naproxen sodium (USP) <US>
  M02 TOPICAL PRODUCTS FOR JOINT AND MUSCULAR PAIN
   M02A TOPICAL PRODUCTS FOR JOINT AND MUSCULAR PAIN
    M02AA Antiinflammatory preparations, non-steroids for topical use
     M02AA12 Naproxen
      D00970  Naproxen sodium (USP) <US>
USP drug classification [BR:br08302]
 Analgesics
  Nonsteroidal Anti-inflammatory Drugs
   Naproxen
    D00970  Naproxen sodium (USP)
Target-based classification of drugs [BR:br08310]
 Enzymes
  Oxidoreductases (EC1)
   Prostaglandin synthase
    PTGS1 (COX1)
     D00970  Naproxen sodium (USP) <US>
    PTGS2 (COX2)
     D00970  Naproxen sodium (USP) <US>
Rx-to-OTC switch list in the USA [br08315.html]
 D00970
Other DBs
CAS: 26159-34-2
PubChem: 7848033
ChEBI: 7477
ChEMBL: CHEMBL1200806
LigandBox: D00970
NIKKAJI: J17.059C
LinkDB
KCF data

ATOM        18
            1   C8y C    23.5997  -20.0988
            2   C8y C    23.5997  -21.4993
            3   C8x C    24.7901  -19.3985
            4   C8x C    22.3393  -19.3985
            5   C8x C    22.3393  -22.1995
            6   C8x C    24.7901  -22.1995
            7   C8y C    25.9806  -20.0988
            8   C8x C    21.1489  -20.0988
            9   C8y C    21.1489  -21.4993
            10  C8x C    25.9806  -21.4993
            11  C1c C    27.2410  -19.3985
            12  O2a O    19.9584  -22.1995
            13  C6a C    28.4314  -20.0988
            14  C1a C    27.2410  -17.9980
            15  C1a C    18.6980  -21.4993
            16  O6a O    28.4314  -21.4993
            17  O6a O    29.6219  -19.3985 #-
            18  Z   Na   31.5125  -19.3985 #+
BOND        18
            1     1   2 2
            2     1   3 1
            3     1   4 1
            4     2   5 1
            5     2   6 1
            6     3   7 2
            7     4   8 2
            8     5   9 2
            9     6  10 2
            10    7  11 1
            11    9  12 1
            12   11  13 1
            13   11  14 1 #Down
            14   12  15 1
            15   13  16 2
            16   13  17 1
            17    7  10 1
            18    8   9 1

» Japanese version   » Back

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