KEGG   DRUG: Cytarabine
Entry
D00168                      Drug                                   

Name
Cytarabine (JP17/USP/INN);
ARA-C;
Depocyt (TN)
Product
  Generic
Formula
C9H13N3O5
Exact mass
243.0855
Mol weight
243.2166
Structure
Simcomp
Class
Antineoplastic
 DG01958  Nucleic acid derivative, antineoplastic
  DG01439  Arabinofuranosyl type antineoplastic
 DG01439  Arabinofuranosyl type antineoplastic
 DG02018  Antimetabolite
  DG01958  Nucleic acid derivative, antineoplastic
   DG01439  Arabinofuranosyl type antineoplastic
Remark
Same as: C02961
Therapeutic category: 4224
ATC code: L01BC01
Chemical structure group: DG00686
Product (DG00686): D00168<JP/US> D03046<JP>
Product (mixture): D11390<US>
Efficacy
Antineoplastic, Antimetabolite, Antiviral, DNA polymerase inhibitor
  Disease
Lymphomatous meningitis [DS:H01668]
Acute myeloid leukemia [DS:H00003]
Chronic myelocytic leukemia [DS:H00004]
Comment
Active metabolite: Cytarabine-5;-triphosphate (ara-CTP)
Target
DNA polymerase
Interaction
Structure map
map07041  Antineoplastics - antimetabolic agents
map07046  Immunosuppressive agents
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 L ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS
  L01 ANTINEOPLASTIC AGENTS
   L01B ANTIMETABOLITES
    L01BC Pyrimidine analogues
     L01BC01 Cytarabine
      D00168  Cytarabine (JP17/USP/INN) <JP/US>
Therapeutic category of drugs in Japan [BR:br08301]
 4  Agents affecting cellular function
  42  Antineoplastics
   422  Antimetabolites
    4224  Cytosines
     D00168  Cytarabine (JP17/USP/INN)
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D00168  Cytarabine
New drug approvals in Europe [br08329.html]
 European public assessment reports (EPAR) authorised medicine
  D00168
Prodrugs [br08324.html]
 D00168
Other DBs
CAS: 147-94-4
PubChem: 7847236
ChEBI: 28680
ChEMBL: CHEMBL803
DrugBank: DB00987
PDB-CCD: AR3[PDBj]
LigandBox: D00168
NIKKAJI: J2.958K
LinkDB
KCF data

ATOM        17
            1   C1y C    22.3986  -17.4645
            2   N4y N    23.7916  -16.8812
            3   O2x O    21.2637  -16.6396
            4   C1y C    21.9658  -18.7927
            5   C8y C    25.0030  -17.5661
            6   C8x C    23.7682  -15.4827
            7   C1y C    20.1286  -17.4645
            8   C1y C    20.5616  -18.7927
            9   O1a O    22.7848  -19.9278
            10  N5x N    26.2080  -16.8485
            11  O5x O    25.0208  -18.9659
            12  C8x C    24.9731  -14.7651
            13  C1b C    18.7947  -17.0317
            14  O1a O    19.7425  -19.9278
            15  C8y C    26.1901  -15.4486
            16  O1a O    17.7591  -17.9735
            17  N1a N    27.3966  -14.7369
BOND        18
            1     1   2 1 #Up
            2     1   3 1
            3     1   4 1
            4     2   5 1
            5     2   6 1
            6     3   7 1
            7     4   8 1
            8     4   9 1 #Up
            9     5  10 1
            10    5  11 2
            11    6  12 2
            12    7  13 1 #Up
            13    8  14 1 #Down
            14   10  15 2
            15   13  16 1
            16   15  17 1
            17    7   8 1
            18   12  15 1

» Japanese version   » Back

KEGG   DRUG: Cytarabine hydrochloride
Entry
D03637                      Drug                                   

Name
Cytarabine hydrochloride (USAN)
Formula
C9H13N3O5. HCl
Exact mass
279.0622
Mol weight
279.6776
Structure
Simcomp
Class
Antineoplastic
 DG01958  Nucleic acid derivative, antineoplastic
  DG01439  Arabinofuranosyl type antineoplastic
 DG01439  Arabinofuranosyl type antineoplastic
 DG02018  Antimetabolite
  DG01958  Nucleic acid derivative, antineoplastic
   DG01439  Arabinofuranosyl type antineoplastic
Remark
ATC code: L01BC01
Chemical structure group: DG00686
Product (DG00686): D00168<JP/US> D03046<JP>
Efficacy
Antineoplastic, Antimetabolite, Antiviral
Comment
Arabinofuranosyl derivative
Target
DNA polymerase
Interaction
Structure map
map07041  Antineoplastics - antimetabolic agents
map07046  Immunosuppressive agents
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 L ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS
  L01 ANTINEOPLASTIC AGENTS
   L01B ANTIMETABOLITES
    L01BC Pyrimidine analogues
     L01BC01 Cytarabine
      D03637  Cytarabine hydrochloride (USAN)
Other DBs
CAS: 69-74-9
PubChem: 17397740
ChEMBL: CHEMBL1256472
DrugBank: DB00987
LigandBox: D03637
NIKKAJI: J237.286J
LinkDB
KCF data

ATOM        18
            1   C1y C    23.1685  -16.8344
            2   N4y N    24.5093  -16.4132
            3   O2x O    22.0336  -16.0095
            4   C1y C    22.7357  -18.1626
            5   C8y C    25.7140  -17.1098
            6   C8x C    24.4994  -15.0145
            7   C1y C    20.8985  -16.8344
            8   C1y C    21.3315  -18.1626
            9   O1a O    23.5547  -19.2977
            10  N5x N    26.9259  -16.4039
            11  O5x O    25.7182  -18.5096
            12  C8x C    25.7113  -14.3086
            13  C1b C    19.5646  -16.4016
            14  O1a O    20.5124  -19.2977
            15  C8y C    26.9216  -15.0039
            16  O1a O    18.5290  -17.3434
            17  N1a N    28.1349  -14.3039
            18  X   Cl   29.2599  -18.8299
BOND        18
            1     1   2 1 #Up
            2     1   3 1
            3     1   4 1
            4     2   5 1
            5     2   6 1
            6     3   7 1
            7     4   8 1
            8     4   9 1 #Up
            9     5  10 1
            10    5  11 2
            11    6  12 2
            12    7  13 1 #Up
            13    8  14 1 #Down
            14   10  15 2
            15   13  16 1
            16   15  17 1
            17    7   8 1
            18   12  15 1

» Japanese version   » Back

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