KEGG   DRUG: NorethindroneHelp
Entry
D00182                      Drug                                   

Name
Norethindrone (USP);
Norethisterone (JP17);
Camila (TN);
Micronor (TN);
Primolut-N (TN)
Product
  Generic
Formula
C20H26O2
Exact mass
298.1933
Mol weight
298.4192
Structure
Mol fileKCF fileDB search
Simcomp SIMCOMP
Class
Other
 DG01666  Progesterone receptor agonist
 DG02004  Progesterone
Remark
Same as: C05028
Therapeutic category: 2479
ATC code: G03AC01 G03DC02
Chemical structure group: DG00456
Product (DG00456): D00182<JP/US> D00953<US>
Product (mixture): D04483<JP/US> D09188<JP/US>
Efficacy
Contraceptive, Progesterone receptor agonist
Comment
Progestin, Estren derivative
Target
NR3C3 (PGR) [HSA:5241] [KO:K08556]
  Pathway
hsa04114  Oocyte meiosis
hsa04914  Progesterone-mediated oocyte maturation
hsa04915  Estrogen signaling pathway
Interaction
Drug interaction
Structure map
map07226  Progesterone, androgen and estrogen receptor agonists/antagonists
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 G GENITO URINARY SYSTEM AND SEX HORMONES
  G03 SEX HORMONES AND MODULATORS OF THE GENITAL SYSTEM
   G03A HORMONAL CONTRACEPTIVES FOR SYSTEMIC USE
    G03AC Progestogens
     G03AC01 Norethisterone
      D00182  Norethindrone (USP) <JP/US>
   G03D PROGESTOGENS
    G03DC Estren derivatives
     G03DC02 Norethisterone
      D00182  Norethindrone (USP) <JP/US>
USP drug classification [BR:br08302]
 Contraceptives
  Oral Progestins
   Norethindrone
    D00182  Norethindrone (USP)
 Hormonal Agents, Stimulant/Replacement/Modifying (Sex Hormones/Modifiers)
  Progestins
   Norethindrone
    D00182  Norethindrone (USP)
Therapeutic category of drugs in Japan [BR:br08301]
 2  Agents affecting individual organs
  24  Hormones
   247  Estrogen and progesterone preparations
    2479  Others
     D00182  Norethindrone (USP); Norethisterone (JP17)
Target-based classification of drugs [BR:br08310]
 Nuclear receptors
  Estrogen like receptors
   3-Ketosteroid receptor
    NR3C3 (PGR)
     D00182  Norethindrone (USP) <JP/US>
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D00182  Norethisterone
BRITE hierarchy
Other DBs
CAS: 68-22-4
PubChem: 7847250
ChEBI: 7627
ChEMBL: CHEMBL1162 CHEMBL2136460 CHEMBL266115
DrugBank: DB00717
PDB-CCD: NDR[PDBj]
LigandBox: D00182
NIKKAJI: J1.416H
LinkDB All DBs
KCF data Show

ATOM        22
            1   C1y C    26.8452  -17.3412
            2   C1z C    26.8512  -15.9656
            3   C1y C    25.6547  -18.0321
            4   C1x C    29.2262  -17.3473
            5   C1z C    28.0417  -15.2747
            6   C1x C    25.6484  -15.2810
            7   C1a C    26.8019  -14.4420
            8   C1y C    24.4702  -17.3536
            9   C1x C    25.5970  -19.4015
            10  C1x C    29.2324  -15.9718
            11  C3b C    29.1954  -14.5962
            12  O1a O    28.0357  -13.5161
            13  C1x C    24.5279  -15.9779
            14  C1y C    23.2921  -18.0384
            15  C1x C    24.4826  -20.0800
            16  C3a C    30.3488  -13.9116
            17  C2y C    23.2921  -19.3954
            18  C1x C    22.1200  -17.3720
            19  C2x C    22.1200  -20.0800
            20  C1x C    20.9542  -18.0384
            21  C5x C    20.9542  -19.3954
            22  O5x O    19.7884  -20.0616
BOND        25
            1     1   2 1
            2     1   3 1
            3     1   4 1
            4     2   5 1
            5     2   6 1
            6     2   7 1 #Up
            7     3   8 1
            8     3   9 1
            9     4  10 1
            10    5  11 1 #Down
            11    5  12 1 #Up
            12    6  13 1
            13    8  14 1
            14    9  15 1
            15   11  16 3
            16   14  17 1
            17   14  18 1
            18   17  19 2
            19   18  20 1
            20   19  21 1
            21   21  22 2
            22    5  10 1
            23    8  13 1
            24   15  17 1
            25   20  21 1

» Japanese version   » Back

KEGG   DRUG: Norethindrone acetateHelp
Entry
D00953                      Drug                                   

Name
Norethindrone acetate (USP);
Norethisterone acetate (JAN);
Aygestin (TN)
Product
  Generic
Formula
C22H28O3
Exact mass
340.2038
Mol weight
340.4559
Structure
Mol fileKCF fileDB search
Simcomp SIMCOMP
Class
Other
 DG01666  Progesterone receptor agonist
 DG02004  Progesterone
Remark
Same as: C08152
ATC code: G03AC01 G03DC02
Chemical structure group: DG00456
Product (DG00456): D00182<JP/US> D00953<US>
Product (mixture): D04483<JP/US> D09188<JP/US>
Efficacy
Contraceptive, Progesterone receptor agonist
Comment
Progestin
Target
NR3C3 (PGR) [HSA:5241] [KO:K08556]
  Pathway
hsa04114  Oocyte meiosis
hsa04914  Progesterone-mediated oocyte maturation
hsa04915  Estrogen signaling pathway
Interaction
Drug interaction
Structure map
map07226  Progesterone, androgen and estrogen receptor agonists/antagonists
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 G GENITO URINARY SYSTEM AND SEX HORMONES
  G03 SEX HORMONES AND MODULATORS OF THE GENITAL SYSTEM
   G03A HORMONAL CONTRACEPTIVES FOR SYSTEMIC USE
    G03AC Progestogens
     G03AC01 Norethisterone
      D00953  Norethindrone acetate (USP) <US>
   G03D PROGESTOGENS
    G03DC Estren derivatives
     G03DC02 Norethisterone
      D00953  Norethindrone acetate (USP) <US>
USP drug classification [BR:br08302]
 Contraceptives
  Oral Progestins
   Norethindrone
    D00953  Norethindrone acetate (USP)
 Hormonal Agents, Stimulant/Replacement/Modifying (Sex Hormones/Modifiers)
  Progestins
   Norethindrone
    D00953  Norethindrone acetate (USP)
Target-based classification of drugs [BR:br08310]
 Nuclear receptors
  Estrogen like receptors
   3-Ketosteroid receptor
    NR3C3 (PGR)
     D00953  Norethindrone acetate (USP) <US>
BRITE hierarchy
Other DBs
CAS: 51-98-9
PubChem: 7848016
ChEBI: 7628
ChEMBL: CHEMBL1201146 CHEMBL1357114
DrugBank: DB00717
LigandBox: D00953
NIKKAJI: J1.910K
LinkDB All DBs
KCF data Show

ATOM        25
            1   C1z C    26.8820  -17.0674
            2   C1z C    28.0682  -16.3895
            3   C1y C    26.8705  -18.4405
            4   C1x C    25.7075  -16.3836
            5   C1a C    26.8762  -15.7000
            6   C1x C    29.2545  -17.0791
            7   O7a O    28.0567  -15.0162
            8   C3b C    29.2487  -15.7000
            9   C1y C    25.6842  -19.1184
            10  C1x C    29.2429  -18.3822
            11  C1x C    24.5155  -17.0557
            12  C7a C    28.0567  -13.6548
            13  C3a C    30.4292  -15.0105
            14  C1y C    24.5038  -18.4231
            15  C1x C    25.6842  -20.4917
            16  C1a C    29.2429  -12.9710
            17  O6a O    26.8762  -12.9769
            18  C1y C    23.3175  -19.1009
            19  C1x C    24.4921  -21.1696
            20  C2y C    23.3118  -20.4800
            21  C1x C    22.1371  -18.4172
            22  C2x C    22.1371  -21.1636
            23  C1x C    20.9508  -19.1009
            24  C5x C    20.9508  -20.4800
            25  O5x O    19.7588  -21.1579
BOND        28
            1     1   2 1
            2     1   3 1
            3     1   4 1
            4     1   5 1 #Up
            5     2   6 1
            6     2   7 1 #Up
            7     2   8 1 #Down
            8     3   9 1
            9     3  10 1
            10    4  11 1
            11    7  12 1
            12    8  13 3
            13    9  14 1
            14    9  15 1
            15   12  16 1
            16   12  17 2
            17   14  18 1
            18   15  19 1
            19   18  20 1
            20   18  21 1
            21   20  22 2
            22   21  23 1
            23   22  24 1
            24   24  25 2
            25    6  10 1
            26   11  14 1
            27   19  20 1
            28   23  24 1

» Japanese version   » Back

KEGG   DRUG: Norethisterone enantateHelp
Entry
D08285                      Drug                                   

Name
Norethisterone enantate;
Noristerat (TN)
Formula
C27H38O3
Exact mass
410.2821
Mol weight
410.5888
Structure
Mol fileKCF fileDB search
Simcomp SIMCOMP
Class
Other
 DG01666  Progesterone receptor agonist
 DG02004  Progesterone
Remark
Same as: C14486
ATC code: G03AC01 G03DC02
Chemical structure group: DG00456
Product (DG00456): D00182<JP/US> D00953<US>
Efficacy
Contraceptive, Progesterone receptor agonist
Comment
Progestin
Target
NR3C3 (PGR) [HSA:5241] [KO:K08556]
  Pathway
hsa04114  Oocyte meiosis
hsa04914  Progesterone-mediated oocyte maturation
hsa04915  Estrogen signaling pathway
Interaction
Drug interaction
Structure map
map07226  Progesterone, androgen and estrogen receptor agonists/antagonists
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 G GENITO URINARY SYSTEM AND SEX HORMONES
  G03 SEX HORMONES AND MODULATORS OF THE GENITAL SYSTEM
   G03A HORMONAL CONTRACEPTIVES FOR SYSTEMIC USE
    G03AC Progestogens
     G03AC01 Norethisterone
      D08285  Norethisterone enantate
   G03D PROGESTOGENS
    G03DC Estren derivatives
     G03DC02 Norethisterone
      D08285  Norethisterone enantate
Target-based classification of drugs [BR:br08310]
 Nuclear receptors
  Estrogen like receptors
   3-Ketosteroid receptor
    NR3C3 (PGR)
     D08285  Norethisterone enantate
BRITE hierarchy
Other DBs
CAS: 3836-23-5
PubChem: 96024972
ChEBI: 34894
ChEMBL: CHEMBL3187229
LigandBox: D08285
NIKKAJI: J59.376A
LinkDB All DBs
KCF data Show

ATOM        30
            1   C1z C    23.5200  -17.9200
            2   C1z C    24.6400  -17.2900
            3   C1y C    23.4500  -19.3200
            4   C1x C    22.3300  -17.2900
            5   C1a C    23.4500  -16.5900
            6   C1x C    25.8300  -17.9900
            7   O7a O    24.6400  -15.8900
            8   C3b C    25.8300  -16.5900
            9   C1y C    22.2600  -20.0200
            10  C1x C    25.8300  -19.3200
            11  C1x C    21.1400  -17.9200
            12  C7a C    24.6400  -14.5600
            13  C3a C    27.0200  -15.8900
            14  C1y C    21.1400  -19.3200
            15  C1x C    22.2600  -21.3500
            16  C1b C    25.8300  -13.8600
            17  O6a O    23.4500  -13.8600
            18  C1y C    19.9500  -20.0200
            19  C1x C    21.0700  -22.0500
            20  C2y C    19.9500  -21.3500
            21  C1x C    18.7600  -19.3200
            22  C2x C    18.7600  -22.0500
            23  C1x C    17.5700  -20.0200
            24  C5x C    17.5700  -21.3500
            25  O5x O    16.3800  -22.0500
            26  C1b C    27.0900  -14.5600
            27  C1b C    28.2800  -13.8600
            28  C1b C    29.4700  -14.5600
            29  C1b C    30.7300  -13.8600
            30  C1a C    31.9200  -14.5600
BOND        33
            1     1   2 1
            2     1   3 1
            3     1   4 1
            4     1   5 1 #Up
            5     2   6 1
            6     2   7 1 #Up
            7     2   8 1 #Down
            8     3   9 1
            9     3  10 1
            10    4  11 1
            11    7  12 1
            12    8  13 3
            13    9  14 1
            14    9  15 1
            15   12  16 1
            16   12  17 2
            17   14  18 1
            18   15  19 1
            19   18  20 1
            20   18  21 1
            21   20  22 2
            22   21  23 1
            23   22  24 1
            24   24  25 2
            25    6  10 1
            26   11  14 1
            27   19  20 1
            28   23  24 1
            29   16  26 1
            30   26  27 1
            31   27  28 1
            32   28  29 1
            33   29  30 1

» Japanese version   » Back

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