KEGG   DRUG: Co-Trimoxazole
Entry
D00285            Mixture   Drug                                   

Name
Co-Trimoxazole (BAN);
Sulfamethoxazole and trimethoprim;
Bactrim (TN);
Septra (TN)
Product
  Generic
SULFAMETH/TRIMETH-DS (DIRECT RX), SULFAMETH/TRIMETH-DS (DirectRX), SULFAMETH/TRIMETH-DS (Direct_Rx), SULFAMETH/TRIMETH-DS (Direct_Rx), SULFAMETH/TRIMETH-DS (Direct_Rx), SULFAMETH/TRIMETH-DS (Direct_Rx), SULFAMETHOXAZOLE AND TRIMETHOPRIM (A-S Medication Solutions), SULFAMETHOXAZOLE AND TRIMETHOPRIM (A-S Medication Solutions), SULFAMETHOXAZOLE AND TRIMETHOPRIM (A-S Medication Solutions), SULFAMETHOXAZOLE AND TRIMETHOPRIM (A-S Medication Solutions), SULFAMETHOXAZOLE AND TRIMETHOPRIM (A-S Medication Solutions), SULFAMETHOXAZOLE AND TRIMETHOPRIM (A-S Medication Solutions), SULFAMETHOXAZOLE AND TRIMETHOPRIM (A-S Medication Solutions), SULFAMETHOXAZOLE AND TRIMETHOPRIM (A-S Medication Solutions), SULFAMETHOXAZOLE AND TRIMETHOPRIM (A-S Medication Solutions), SULFAMETHOXAZOLE AND TRIMETHOPRIM (A-S Medication Solutions), SULFAMETHOXAZOLE AND TRIMETHOPRIM (A-S Medication Solutions), SULFAMETHOXAZOLE AND TRIMETHOPRIM (A-S Medication Solutions), SULFAMETHOXAZOLE AND TRIMETHOPRIM (A-S Medication Solutions), SULFAMETHOXAZOLE AND TRIMETHOPRIM (ANI Pharmaceuticals), SULFAMETHOXAZOLE AND TRIMETHOPRIM (ATLANTIC BIOLOGICALS CORP.), SULFAMETHOXAZOLE AND TRIMETHOPRIM (American Health Packaging), SULFAMETHOXAZOLE AND TRIMETHOPRIM (American Health Packaging), SULFAMETHOXAZOLE AND TRIMETHOPRIM (Amneal Pharmaceuticals LLC), SULFAMETHOXAZOLE AND TRIMETHOPRIM (Amneal Pharmaceuticals of New York LLC), SULFAMETHOXAZOLE AND TRIMETHOPRIM (Asclemed USA), SULFAMETHOXAZOLE AND TRIMETHOPRIM (Atlantic Biologicals Corps), SULFAMETHOXAZOLE AND TRIMETHOPRIM (Aurobindo Pharma Limited), SULFAMETHOXAZOLE AND TRIMETHOPRIM (Aurobindo Pharma Limited), SULFAMETHOXAZOLE AND TRIMETHOPRIM (AvKARE), SULFAMETHOXAZOLE AND TRIMETHOPRIM (AvPAK), SULFAMETHOXAZOLE AND TRIMETHOPRIM (Bryant Ranch Prepack), SULFAMETHOXAZOLE AND TRIMETHOPRIM (Bryant Ranch Prepack), SULFAMETHOXAZOLE AND TRIMETHOPRIM (Bryant Ranch Prepack), SULFAMETHOXAZOLE AND TRIMETHOPRIM (Bryant Ranch Prepack), SULFAMETHOXAZOLE AND TRIMETHOPRIM (Cardinal Health), SULFAMETHOXAZOLE AND TRIMETHOPRIM (Cardinal Health), SULFAMETHOXAZOLE AND TRIMETHOPRIM (Clinical Solutions Wholesale), SULFAMETHOXAZOLE AND TRIMETHOPRIM (Contract Pharmacy Services-PA), SULFAMETHOXAZOLE AND TRIMETHOPRIM (Cronus Pharma LLC), SULFAMETHOXAZOLE AND TRIMETHOPRIM (Denton Pharma), SULFAMETHOXAZOLE AND TRIMETHOPRIM (Denton Pharma), SULFAMETHOXAZOLE AND TRIMETHOPRIM (Denton Pharma), SULFAMETHOXAZOLE AND TRIMETHOPRIM (Denton Pharma), SULFAMETHOXAZOLE AND TRIMETHOPRIM (Direct_Rx), SULFAMETHOXAZOLE AND TRIMETHOPRIM (Direct_Rx), SULFAMETHOXAZOLE AND TRIMETHOPRIM (Golden State Medical Supply), SULFAMETHOXAZOLE AND TRIMETHOPRIM (Hi-Tech Pharmacal), SULFAMETHOXAZOLE AND TRIMETHOPRIM (KAISER FOUNDATION HOSPITALS), SULFAMETHOXAZOLE AND TRIMETHOPRIM (Lake Erie Medical DBA Quality Care Products LLC), SULFAMETHOXAZOLE AND TRIMETHOPRIM (Lannett Company), SULFAMETHOXAZOLE AND TRIMETHOPRIM (Major Pharmaceuticals), SULFAMETHOXAZOLE AND TRIMETHOPRIM (McKesson Corporation dba SKY Packaging), SULFAMETHOXAZOLE AND TRIMETHOPRIM (Medsource Pharmaceuticals), SULFAMETHOXAZOLE AND TRIMETHOPRIM (Mylan Institutional), SULFAMETHOXAZOLE AND TRIMETHOPRIM (Mylan Institutional LLC), SULFAMETHOXAZOLE AND TRIMETHOPRIM (NCS HealthCare of KY), SULFAMETHOXAZOLE AND TRIMETHOPRIM (NuCare Pharmaceuticals), SULFAMETHOXAZOLE AND TRIMETHOPRIM (NuCare Pharmaceuticals), SULFAMETHOXAZOLE AND TRIMETHOPRIM (NuCare Pharmaceuticals), SULFAMETHOXAZOLE AND TRIMETHOPRIM (NuCare Pharmaceuticals), SULFAMETHOXAZOLE AND TRIMETHOPRIM (NuCare Pharmaceuticals), SULFAMETHOXAZOLE AND TRIMETHOPRIM (NuCare Pharmaceuticals), SULFAMETHOXAZOLE AND TRIMETHOPRIM (NuCare Pharmaceuticals), SULFAMETHOXAZOLE AND TRIMETHOPRIM (NuCare Pharmaceuticals), SULFAMETHOXAZOLE AND TRIMETHOPRIM (NuCare Pharmaceuticals), SULFAMETHOXAZOLE AND TRIMETHOPRIM (PD-Rx Pharmaceuticals), SULFAMETHOXAZOLE AND TRIMETHOPRIM (PD-Rx Pharmaceuticals), SULFAMETHOXAZOLE AND TRIMETHOPRIM (PD-Rx Pharmaceuticals), SULFAMETHOXAZOLE AND TRIMETHOPRIM (PD-Rx Pharmaceuticals), SULFAMETHOXAZOLE AND TRIMETHOPRIM (PD-Rx Pharmaceuticals), SULFAMETHOXAZOLE AND TRIMETHOPRIM (PD-Rx Pharmaceuticals), SULFAMETHOXAZOLE AND TRIMETHOPRIM (Preferred Pharmaceuticals), SULFAMETHOXAZOLE AND TRIMETHOPRIM (Preferred Pharmaceuticals), SULFAMETHOXAZOLE AND TRIMETHOPRIM (Preferred Pharmaceuticals), SULFAMETHOXAZOLE AND TRIMETHOPRIM (Preferred Pharmaceuticals), SULFAMETHOXAZOLE AND TRIMETHOPRIM (Preferred Pharmaceuticals), SULFAMETHOXAZOLE AND TRIMETHOPRIM (Proficient Rx LP), SULFAMETHOXAZOLE AND TRIMETHOPRIM (Proficient Rx LP), SULFAMETHOXAZOLE AND TRIMETHOPRIM (Proficient Rx LP), SULFAMETHOXAZOLE AND TRIMETHOPRIM (Proficient Rx LP), SULFAMETHOXAZOLE AND TRIMETHOPRIM (QPharma), SULFAMETHOXAZOLE AND TRIMETHOPRIM (REMEDYREPACK), SULFAMETHOXAZOLE AND TRIMETHOPRIM (REMEDYREPACK), SULFAMETHOXAZOLE AND TRIMETHOPRIM (REMEDYREPACK), SULFAMETHOXAZOLE AND TRIMETHOPRIM (REMEDYREPACK), SULFAMETHOXAZOLE AND TRIMETHOPRIM (RedPharm Drug), SULFAMETHOXAZOLE AND TRIMETHOPRIM (RedPharm Drug), SULFAMETHOXAZOLE AND TRIMETHOPRIM (RedPharm Drug), SULFAMETHOXAZOLE AND TRIMETHOPRIM (RedPharm Drug), SULFAMETHOXAZOLE AND TRIMETHOPRIM (RedPharm Drug), SULFAMETHOXAZOLE AND TRIMETHOPRIM (RedPharm Drug), SULFAMETHOXAZOLE AND TRIMETHOPRIM (RedPharm Drug), SULFAMETHOXAZOLE AND TRIMETHOPRIM (RedPharm Drug), SULFAMETHOXAZOLE AND TRIMETHOPRIM (Rising Health), SULFAMETHOXAZOLE AND TRIMETHOPRIM (Somerset Therapeutics), SULFAMETHOXAZOLE AND TRIMETHOPRIM (St. Mary's Medical Park Pharmacy), SULFAMETHOXAZOLE AND TRIMETHOPRIM (Sun Pharmaceutical Industries), SULFAMETHOXAZOLE AND TRIMETHOPRIM (Teva Parenteral Medicines), SULFAMETHOXAZOLE AND TRIMETHOPRIM (Teva Parenteral Medicines), SULFAMETHOXAZOLE AND TRIMETHOPRIM (Unit Dose Services), SULFAMETHOXAZOLE AND TRIMETHOPRIM (Unit Dose Services), SULFAMETHOXAZOLE AND TRIMETHOPRIM (Vista Pharmaceuticals), SULFAMETHOX-TMP DS (PharmPak)
Formula
C14H18N4O3. C10H11N3O3S
Exact mass
543.19
Mol weight
543.5954
Structure
Component
Sulfamethoxazole [DR:D00447], Trimethoprim [DR:D00145]
Class
Metabolizing enzyme inhibitor
 DG01641  CYP2C8 inhibitor
 DG01643  CYP2C9 inhibitor
Remark
Therapeutic category: 6290 6419
ATC code: J01EE01
Product: D00285<JP/US>
Efficacy
Antibacterial
  Disease
Shigellosis [DS:H00299]
Pneumocystis jiroveci pneumonia [DS:H01521]
Comment
Sulfamethoxazole is an inhibitor of CYP2C9.
Trimethoprim is an inhibitor of CYP2C8 as well as OCT2 transporter.
Interaction
CYP inhibition: CYP2C8 [HSA:1558], CYP2C9 [HSA:1559]
Transporter inhibition: SLC22A2 [HSA:6582]
Structure map
map07016  Sulfonamide derivatives - sulfa drugs
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 J ANTIINFECTIVES FOR SYSTEMIC USE
  J01 ANTIBACTERIALS FOR SYSTEMIC USE
   J01E SULFONAMIDES AND TRIMETHOPRIM
    J01EE Combinations of sulfonamides and trimethoprim, incl. derivatives
     J01EE01 Sulfamethoxazole and trimethoprim
      D00285  Co-Trimoxazole (BAN) <JP/US>
USP drug classification [BR:br08302]
 Antibacterials
  Antibacterials, Other
   Sulfamethoxazole/ Trimethoprim
    D00285  Co-Trimoxazole (BAN)
Therapeutic category of drugs in Japan [BR:br08301]
 6  Agents against pathologic organisms and parasites
  62  Chemotherapeutics
   629  Miscellaneous
    6290  Miscellaneous
     D00285  Co-Trimoxazole (BAN)
  64  Parasitics (systemic)
   641  Antiprotozoans
    6419  Others
     D00285  Co-Trimoxazole (BAN)
Drug metabolizing enzymes and transporters [br08309.html]
 Drug metabolizing enzymes
  D00285
 Drug transporters
  D00285
Pharmacogenomic biomarkers [br08341.html]
 Polymorphisms and mutations affecting drug response
  D00285
Other DBs
CAS: 8064-90-2
PubChem: 7847351
ChEBI: 3770
ChEMBL: CHEMBL58061
LigandBox: D00285
NIKKAJI: J410.873F
LinkDB
KCF data

ATOM        38
            1   C8y C    17.7985  -15.4832
            2   C8x C    16.6120  -16.2509
            3   C8x C    17.7985  -14.0874
            4   C1b C    18.9850  -16.1811
            5   C8y C    15.3558  -15.5530
            6   C8y C    16.5422  -13.4593
            7   C8y C    20.1714  -15.4832
            8   C8y C    15.3558  -14.1572
            9   O2a O    14.1694  -16.2509
            10  O2a O    16.5422  -12.0635
            11  C8y C    21.4276  -16.1113
            12  C8x C    20.1714  -14.0176
            13  O2a O    14.0996  -13.4593
            14  C1a C    12.9132  -15.6228
            15  N5x N    22.6140  -15.4134
            16  N1a N    21.4276  -17.5072
            17  N5x N    21.3578  -13.3197
            18  C8y C    22.6140  -14.0176
            19  N1a N    23.8005  -13.2499
            20  C1a C    14.0525  -12.0643
            21  C1a C    17.7452  -11.3556
            22  C8y C    32.5183  -13.0378
            23  N1b N    31.3319  -13.7357
            24  N5x N    32.5678  -11.7075
            25  C8x C    33.8111  -13.5108
            26  S4a S    30.1453  -13.0378
            27  O2x O    33.9412  -11.3333
            28  C8y C    34.7188  -12.4690
            29  C8y C    28.9589  -13.7357
            30  O3c O    28.9589  -12.0608
            31  O3c O    31.4016  -12.0608
            32  C1a C    36.0513  -12.4473
            33  C8x C    28.9589  -15.1315
            34  C8x C    27.7725  -13.0378
            35  C8x C    27.7725  -15.8294
            36  C8x C    26.5861  -13.7357
            37  C8y C    26.5861  -15.1315
            38  N1a N    25.3996  -15.8294
BOND        40
            1     1   2 2
            2     1   3 1
            3     1   4 1
            4     2   5 1
            5     3   6 2
            6     4   7 1
            7     5   8 2
            8     5   9 1
            9     6  10 1
            10    7  11 2
            11    7  12 1
            12    8  13 1
            13    9  14 1
            14   11  15 1
            15   11  16 1
            16   12  17 2
            17   15  18 2
            18   18  19 1
            19    6   8 1
            20   17  18 1
            21   13  20 1
            22   10  21 1
            23   22  23 1
            24   22  24 2
            25   22  25 1
            26   23  26 1
            27   24  27 1
            28   25  28 2
            29   26  29 1
            30   26  30 2
            31   26  31 2
            32   28  32 1
            33   29  33 1
            34   29  34 2
            35   33  35 2
            36   34  36 1
            37   35  37 1
            38   37  38 1
            39   27  28 1
            40   36  37 2

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