KEGG   DRUG: DexamethasoneHelp
Entry
D00292                      Drug                                   

Name
Dexamethasone (JP17/USP/INN);
Decadron (TN);
Maxidex (TN)
Product
  Generic
DEXAMETHASONE (A-S Medication Solutions), DEXAMETHASONE (A-S Medication Solutions), DEXAMETHASONE (A-S Medication Solutions), DEXAMETHASONE (A-S Medication Solutions), DEXAMETHASONE (Bryant Ranch Prepack), DEXAMETHASONE (Bryant Ranch Prepack), DEXAMETHASONE (Bryant Ranch Prepack), DEXAMETHASONE (Bryant Ranch Prepack), DEXAMETHASONE (Cardinal Health), DEXAMETHASONE (Direct Rx), DEXAMETHASONE (Fera Pharmaceuticals), HIDEX 6-DAY (Gentex Pharma), DEXAMETHASONE (Lake Erie Medical DBA Quality Care Products LLC), DEXABLISS (Levins Pharmaceuticals), DEXAMETHASONE (Morton Grove Pharmaceuticals), DEXAMETHASONE (NuCare Pharmaceuticals), DEXAMETHASONE (PD-Rx Pharmaceuticals), DEXAMETHASONE (PD-Rx Pharmaceuticals), DEXAMETHASONE (PD-Rx Pharmaceuticals), DEXAMETHASONE (Par Pharmaceutical), DXEVO (Phlight Pharma), DECADRON (Pragma Pharmaceuticals), DEXAMETHASONE (Preferred Pharmaceuticals), DEXAMETHASONE (Preferred Pharmaceuticals), DEXAMETHASONE (Proficient Rx LP), DEXAMETHASONE (Proficient Rx LP), TAPERDEX 6-DAY (Proficient Rx LP), TAPERDEX 12-DAY (Proficient Rx LP), TAPERDEX 6-DAY (Quality Care Products), DEXAMETHASONE (REMEDYREPACK), DEXAMETHASONE (RedPharm Drug), DEXAMETHASONE (RedPharm Drug), DEXAMETHASONE (Rising Pharmaceuticals), DEXAMETHASONE (STI Pharma LLC), DEXAMETHASONE (Xspire Pharma), TAPERDEX 6-DAY (Xspire Pharma), TAPERDEX 7-DAY (Xspire Pharma), TAPERDEX 12-DAY (Xspire Pharma), DEXAMETHASONE 6-DAY (Xspire Pharma), DEXAMETHASONE (medsource pharmaceuticals), DEXAMETHASONE (Larken Laboratories), DEXAMETHASONE (Larken Laboratories), DXEVO (Skylar Laboratories), DEXAMETHASONE INTENSOL (West-Ward Pharmaceuticals Corp.)
Formula
C22H29FO5
Exact mass
392.1999
Mol weight
392.4611
Structure
Mol fileKCF fileDB search
Simcomp SIMCOMP
Class
Anti-inflammatory
 DG01955  Corticosteroid
  DG02068  Glucocorticoid
Metabolizing enzyme substrate
 DG02913  CYP3A4 substrate
Metabolizing enzyme inducer
 DG01635  CYP3A4 inducer
Remark
Same as: C15643
Therapeutic category: 1315 2399 2454 2646
ATC code: A01AC02 C05AA09 D07AB19 D07XB05 D10AA03 H02AB02 R01AD03 S01BA01 S01CB01 S02BA06 S03BA01
Chemical structure group: DG00011
Product (DG00011): D00292<JP/US> D00975<JP/US> D01510<JP> D01615<JP> D01632<JP> D01948<JP> D07073<JP>
Product (mixture): D08733<JP> D10296<US> D11177<US> D11178<US>
Efficacy
Anti-inflammatory, Antipruritic, Glucocorticoid receptor agonist
  Disease
Diabetic macular edema [DS:H01651]
Asthma [DS:H00079]
Atopic dermatitis [DS:H01358]
Contact dermatitis [DS:H01357]
Allergic rhinitis [DS:H01360]
Bullous dermatitis herpetiformis [DS:H01362]
Mycosis fungoides [DS:H01463]
Pemphigus [DS:H01648]
Erythema multiforme [DS:H01695]
Stevens-Johnson syndrome [DS:H01694]
Congenital adrenal hyperplasia [DS:H00216]
Ulcerative colitis [DS:H01466]
Acquired (autoimmune) hemolytic anemia [DS:H01585]
Congenital (erythroid) hypoplastic anemia; Diamond-Blackfan anemia [DS:H00237]
Pure red cell aplasia [DS:H01586]
Multiple sclerosis [DS:H01490]
Temporal arteritis [DS:H01698]
Nephrotic syndrome [DS:H01657]
Pulmonary tuberculosis [DS:H00342]
Acute gouty arthritis [DS:H01532]
Ankylosing spondylitis [DS:H01674]
Psoriatic arthritis [DS:H01507]
Rheumatoid arthritis [DS:H00630]
Juvenile rheumatoid arthritis [DS:H01672]
Dermatomyositis and polymyositis [DS:H01604]
Systemic lupus erythematosus [DS:H00080]
Target
NR3C1 (GR) [HSA:2908] [KO:K05771]
  Pathway
hsa04080  Neuroactive ligand-receptor interaction
Metabolism
Enzyme: CYP3A4 [HSA:1576]
Interaction
CYP induction: CYP3A4 [HSA:1576]
Drug interaction
Structure map
map07043  Antineoplastics - hormones
map07046  Immunosuppressive agents
map07225  Glucocorticoid and mineralocorticoid receptor agonists/antagonists
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 A ALIMENTARY TRACT AND METABOLISM
  A01 STOMATOLOGICAL PREPARATIONS
   A01A STOMATOLOGICAL PREPARATIONS
    A01AC Corticosteroids for local oral treatment
     A01AC02 Dexamethasone
      D00292  Dexamethasone (JP17/USP/INN) <JP/US>
 C CARDIOVASCULAR SYSTEM
  C05 VASOPROTECTIVES
   C05A AGENTS FOR TREATMENT OF HEMORRHOIDS AND ANAL FISSURES FOR TOPICAL USE
    C05AA Corticosteroids
     C05AA09 Dexamethasone
      D00292  Dexamethasone (JP17/USP/INN) <JP/US>
 D DERMATOLOGICALS
  D07 CORTICOSTEROIDS, DERMATOLOGICAL PREPARATIONS
   D07A CORTICOSTEROIDS, PLAIN
    D07AB Corticosteroids, moderately potent (group II)
     D07AB19 Dexamethasone
      D00292  Dexamethasone (JP17/USP/INN) <JP/US>
   D07X CORTICOSTEROIDS, OTHER COMBINATIONS
    D07XB Corticosteroids, moderately potent, other combinations
     D07XB05 Dexamethasone
      D00292  Dexamethasone (JP17/USP/INN) <JP/US>
  D10 ANTI-ACNE PREPARATIONS
   D10A ANTI-ACNE PREPARATIONS FOR TOPICAL USE
    D10AA Corticosteroids, combinations for treatment of acne
     D10AA03 Dexamethasone
      D00292  Dexamethasone (JP17/USP/INN) <JP/US>
 H SYSTEMIC HORMONAL PREPARATIONS, EXCL. SEX HORMONES AND INSULINS
  H02 CORTICOSTEROIDS FOR SYSTEMIC USE
   H02A CORTICOSTEROIDS FOR SYSTEMIC USE, PLAIN
    H02AB Glucocorticoids
     H02AB02 Dexamethasone
      D00292  Dexamethasone (JP17/USP/INN) <JP/US>
 R RESPIRATORY SYSTEM
  R01 NASAL PREPARATIONS
   R01A DECONGESTANTS AND OTHER NASAL PREPARATIONS FOR TOPICAL USE
    R01AD Corticosteroids
     R01AD03 Dexamethasone
      D00292  Dexamethasone (JP17/USP/INN) <JP/US>
 S SENSORY ORGANS
  S01 OPHTHALMOLOGICALS
   S01B ANTIINFLAMMATORY AGENTS
    S01BA Corticosteroids, plain
     S01BA01 Dexamethasone
      D00292  Dexamethasone (JP17/USP/INN) <JP/US>
   S01C ANTIINFLAMMATORY AGENTS AND ANTIINFECTIVES IN COMBINATION
    S01CB Corticosteroids/antiinfectives/mydriatics in combination
     S01CB01 Dexamethasone
      D00292  Dexamethasone (JP17/USP/INN) <JP/US>
  S02 OTOLOGICALS
   S02B CORTICOSTEROIDS
    S02BA Corticosteroids
     S02BA06 Dexamethasone
      D00292  Dexamethasone (JP17/USP/INN) <JP/US>
  S03 OPHTHALMOLOGICAL AND OTOLOGICAL PREPARATIONS
   S03B CORTICOSTEROIDS
    S03BA Corticosteroids
     S03BA01 Dexamethasone
      D00292  Dexamethasone (JP17/USP/INN) <JP/US>
USP drug classification [BR:br08302]
 Hormonal Agents, Stimulant/Replacement/Modifying (Adrenal)
  Dexamethasone
   D00292  Dexamethasone (JP17/USP/INN)
 Inflammatory Bowel Disease Agents
  Glucocorticoids
   Dexamethasone
    D00292  Dexamethasone (JP17/USP/INN)
 Ophthalmic Agents
  Ophthalmic Anti-inflammatories
   Glucocorticoids, Ophthalmic
    Dexamethasone
     D00292  Dexamethasone (JP17/USP/INN)
Therapeutic category of drugs in Japan [BR:br08301]
 1  Agents affecting nervous system and sensory organs
  13  Agents affecting sensory organs
   131  Ophthalmic agents
    1315  Ophthalmic cortisones
     D00292  Dexamethasone (JP17/USP/INN)
 2  Agents affecting individual organs
  23  Digestive organ agents
   239  Miscellaneous
    2399  Others
     D00292  Dexamethasone (JP17/USP/INN)
  24  Hormones
   245  Adrenal hormone preparations
    2454  Fluorinated adrenocorticotropic hormones
     D00292  Dexamethasone (JP17/USP/INN)
  26  Epidermides
   264  Analgesics, anti-itchings, astringents, anti-inflammatory agents
    2646  Adrenocorticotropic hormones
     D00292  Dexamethasone (JP17/USP/INN)
Classification of Japanese OTC drugs [BR:br08313]
 Agents for integumentary system
  57 Analgesic, antipruritic, astringent, and anti-inflammatory remedies (incl. gel patches)
   D00292  Dexamethasone (JP17/USP/INN)
Risk category of Japanese OTC drugs [BR:br08312]
 Designated second-class OTC drugs
  Inorganic and organic chemicals
   Dexamethasone
    D00292  Dexamethasone (JP17/USP/INN)
 Second-class OTC drugs
  Inorganic and organic chemicals
   Dexamethasone
    D00292  Dexamethasone (JP17/USP/INN)
Target-based classification of drugs [BR:br08310]
 Nuclear receptors
  Estrogen like receptors
   3-Ketosteroid receptor
    NR3C1 (GR)
     D00292  Dexamethasone (JP17/USP/INN) <JP/US>
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D00292  Dexamethasone
New drug approvals in Europe [br08329.html]
 European public assessment reports (EPAR) authorised medicine
  D00292
Drug metabolizing enzymes and transporters [br08309.html]
 Drug metabolizing enzymes
  D00292
Topical steroids potency [br08317.html]
 Classification in Japan
  D00292
Rx-to-OTC switch list in Japan [br08314.html]
 D00292
BRITE hierarchy
Other DBs
CAS: 50-02-2
PubChem: 7847358
ChEBI: 41879
ChEMBL: CHEMBL1698267 CHEMBL1723662 CHEMBL378081 CHEMBL384467
DrugBank: DB01234
PDB-CCD: DEX[PDBj]
LigandBox: D00292
NIKKAJI: J1.356K
LinkDB All DBs
KCF data Show

ATOM        28
            1   C2x C     6.5292  -16.7310
            2   C5x C     6.5292  -18.0917
            3   C2x C     7.7075  -18.7720
            4   C2y C     8.8859  -18.0917
            5   C1z C     8.8859  -16.7310
            6   C2x C     7.7075  -16.0507
            7   C1x C    10.0643  -18.7720
            8   C1x C    11.2426  -18.0917
            9   C1y C    11.2426  -16.7310
            10  C1z C    10.0643  -16.0507
            11  C1y C    12.4210  -16.0507
            12  C1z C    12.4210  -14.6900
            13  C1x C    11.2426  -14.0097
            14  C1y C    10.0643  -14.6900
            15  C1x C    14.7777  -16.0507
            16  C1y C    14.7777  -14.6900
            17  C1z C    13.5994  -14.0097
            18  C1a C     8.8859  -15.3703
            19  O1a O     8.8879  -14.0109
            20  C1a C    12.4210  -13.3294
            21  C1a C    15.9436  -14.0168
            22  C5a C    13.5994  -12.3089
            23  X   F    10.0643  -17.4113
            24  O1a O    14.7777  -13.1194
            25  O5x O     5.3509  -18.7720
            26  O5a O    14.7817  -11.6263
            27  C1b C    12.4249  -11.6308
            28  O1a O    11.2650  -12.3007
BOND        31
            1     1   2 1
            2     2   3 1
            3     3   4 2
            4     4   5 1
            5     5   6 1
            6     1   6 2
            7     4   7 1
            8     7   8 1
            9     8   9 1
            10    9  10 1
            11    5  10 1
            12    9  11 1
            13   11  12 1
            14   12  13 1
            15   13  14 1
            16   10  14 1
            17   11  15 1
            18   15  16 1
            19   16  17 1
            20   12  17 1
            21    5  18 1 #Up
            22   14  19 1 #Up
            23   12  20 1 #Up
            24   16  21 1 #Down
            25   17  22 1 #Up
            26   10  23 1 #Down
            27   17  24 1 #Down
            28    2  25 2
            29   22  26 2
            30   22  27 1
            31   27  28 1

» Japanese version   » Back

KEGG   DRUG: Dexamethasone sodium phosphateHelp
Entry
D00975                      Drug                                   

Name
Dexamethasone sodium phosphate (JAN/USP);
Dalalone (TN);
Maxidex (TN)
Product
  Generic
DEXAMETHASONE SODIUM PHOSPHATE (A-S Medication Solutions), DEXAMETHASONE SODIUM PHOSPHATE (A-S Medication Solutions), DEXAMETHASONE SODIUM PHOSPHATE (A-S Medication Solutions), DEXAMETHASONE SODIUM PHOSPHATE (Amneal Pharmaceuticals LLC), DEXAMETHASONE SODIUM PHOSPHATE (Amneal Pharmaceuticals LLC), DEXAMETHASONE SODIUM PHOSPHATE (Asclemed USA), DEXAMETHASONE SODIUM PHOSPHATE (AuroMedics Pharma LLC), DEXAMETHASONE SODIUM PHOSPHATE (AuroMedics Pharma LLC), DEXAMETHASONE SODIUM PHOSPHATE (Bausch & Lomb Incorporated), DEXAMETHASONE SODIUM PHOSPHATE (Cardinal Health), DEXAMETHASONE SODIUM PHOSPHATE (Cardinal Health), DEXAMETHASONE SODIUM PHOSPHATE (Cardinal Health), DEXAMETHASONE SODIUM PHOSPHATE (Civica), DEXAMETHASONE SODIUM PHOSPHATE (Fresenius Kabi USA), DEXAMETHASONE SODIUM PHOSPHATE (Fresenius Kabi USA), DEXAMETHASONE SODIUM PHOSPHATE (Fresenius Kabi USA), DEXAMETHASONE SODIUM PHOSPHATE (Fresenius Kabi USA), DEXAMETHASONE SODIUM PHOSPHATE (Fresenius Kabi USA), DEXAMETHASONE SODIUM PHOSPHATE (Fresenius Kabi USA), DEXAMETHASONE SODIUM PHOSPHATE (General Injectables & Vaccines), DEXAMETHASONE SODIUM PHOSPHATE (General Injectables & Vaccines), DEXAMETHASONE SODIUM PHOSPHATE (General Injectables and Vaccines), DEXAMETHASONE SODIUM PHOSPHATE (General Injectables and Vaccines), DEXAMETHASONE SODIUM PHOSPHATE (General Injectables and Vaccines), DEXAMETHASONE SODIUM PHOSPHATE (HF Acquisition Co LLC), DEXAMETHASONE SODIUM PHOSPHATE (HF Acquisition Co LLC), DEXAMETHASONE SODIUM PHOSPHATE (HF Acquisition Co LLC), DEXAMETHASONE SODIUM PHOSPHATE (HF Acquisition Co LLC), DEXAMETHASONE SODIUM PHOSPHATE (HF Acquisition Co LLC), DEXAMETHASONE SODIUM PHOSPHATE (Hikma Pharmaceuticals USA), VIADOX (IT3 Medical LLC), CORTAREN CORTICOSTEROID/ANTI-INFLAMMATORY SYSTEM (IT3 Medical LLC), NEUROMAQUEL NEUROMA/ANTI-INFLAMMATORY SYSTEM (IT3 Medical LLC), DEXAMETHASONE SODIUM PHOSPHATE (Medical Purchasing Solutions), DEXAMETHASONE SODIUM PHOSPHATE (Medical Purchasing Solutions), DEXAMETHASONE SODIUM PHOSPHATE (Medical Purchasing Solutions), DEXAMETHASONE SODIUM PHOSPHATE (Medical Purchasing Solutions), DEXAMETHASONE SODIUM PHOSPHATE (Medical Purchasing Solutions), DEXAMETHASONE SODIUM PHOSPHATE (Medical Purchasing Solutions), DEXAMETHASONE SODIUM PHOSPHATE (Medical Purchasing Solutions), DEXAMETHASONE SODIUM PHOSPHATE (Medical Purchasing Solutions), DEXAMETHASONE SODIUM PHOSPHATE (Medical Purchasing Solutions), DEXAMETHASONE SODIUM PHOSPHATE (Medical Purchasing Solutions), DEXAMETHASONE SODIUM PHOSPHATE (Medical Purchasing Solutions), DEXAMETHASONE SODIUM PHOSPHATE (Mylan Institutional LLC), DEXAMETHASONE SODIUM PHOSPHATE (NuCare Pharmaceuticals), READYSHARP DEXAMETHASONE (Preferred Pharmaceuticals), DEXAMETHASONE SODIUM PHOSPHATE (REMEDYREPACK), DEXAMETHASONE SODIUM PHOSPHATE (Somerset Therapeutics), DEXAMETHASONE SODIUM PHOSPHATE (Somerset Therapeutics), DEXAMETHASONE SODIUM PHOSPHATE (Somerset Therapeutics), READYSHARP DEXAMETHASONE (Terrain Pharmaceuticals)
Formula
C22H28FO8P. 2Na
Exact mass
516.1301
Mol weight
516.4046
Structure
Mol fileKCF fileDB search
Simcomp SIMCOMP
Class
Anti-inflammatory
 DG01955  Corticosteroid
  DG02068  Glucocorticoid
Metabolizing enzyme substrate
 DG02913  CYP3A4 substrate
Metabolizing enzyme inducer
 DG01635  CYP3A4 inducer
Remark
Same as: C08175
Therapeutic category: 1315 1329 2454
ATC code: A01AC02 C05AA09 D07AB19 D07XB05 D10AA03 H02AB02 R01AD03 S01BA01 S01CB01 S02BA06 S03BA01
Chemical structure group: DG00011
Product (DG00011): D00292<JP/US> D00975<JP/US> D01510<JP> D01615<JP> D01632<JP> D01948<JP> D07073<JP>
Efficacy
Anti-inflammatory, Glucocorticoid receptor agonist
  Disease
Primary or secondary adrenocortical insufficiency [DS:H01598]
Congenital adrenal hyperplasia [DS:H00216]
Rheumatoid arthritis [DS:H00630]
Juvenile rheumatoid arthritis [DS:H01672]
Acute gouty arthritis [DS:H01532]
Psoriatic arthritis [DS:H01507]
Ankylosing spondylitis [DS:H01674]
Systemic lupus erythematosus [DS:H00080]
Pemphigus [DS:H01648]
Severe erythema multiforme [DS:H01695]
Stevens-Johnson syndrome [DS:H01694]
Seborrheic dermatitis [DS:H01652]
Psoriasis [DS:H01656]
Mycosis fungoides [DS:H01463]
Bronchial asthma [DS:H00079]
Contact dermatitis [DS:H01357]
Atopic dermatitis [DS:H01358]
Seasonal or perennial allergic rhinitis [DS:H01360]
Herpes zoster ophthalmicus [DS:H00366]
Optic neuritis [DS:H01717]
Ulcerative colitis [DS:H01466]
Pulmonary tuberculosis [DS:H00342]
Acquired (autoimmune) hemolytic anemia [DS:H01585]
Nephrotic syndrome [DS:H01657]
Target
NR3C1 (GR) [HSA:2908] [KO:K05771]
  Pathway
hsa04080  Neuroactive ligand-receptor interaction
Metabolism
Enzyme: CYP3A4 [HSA:1576]
Interaction
CYP induction: CYP3A4 [HSA:1576]
Drug interaction
Structure map
map07225  Glucocorticoid and mineralocorticoid receptor agonists/antagonists
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 A ALIMENTARY TRACT AND METABOLISM
  A01 STOMATOLOGICAL PREPARATIONS
   A01A STOMATOLOGICAL PREPARATIONS
    A01AC Corticosteroids for local oral treatment
     A01AC02 Dexamethasone
      D00975  Dexamethasone sodium phosphate (JAN/USP) <JP/US>
 C CARDIOVASCULAR SYSTEM
  C05 VASOPROTECTIVES
   C05A AGENTS FOR TREATMENT OF HEMORRHOIDS AND ANAL FISSURES FOR TOPICAL USE
    C05AA Corticosteroids
     C05AA09 Dexamethasone
      D00975  Dexamethasone sodium phosphate (JAN/USP) <JP/US>
 D DERMATOLOGICALS
  D07 CORTICOSTEROIDS, DERMATOLOGICAL PREPARATIONS
   D07A CORTICOSTEROIDS, PLAIN
    D07AB Corticosteroids, moderately potent (group II)
     D07AB19 Dexamethasone
      D00975  Dexamethasone sodium phosphate (JAN/USP) <JP/US>
   D07X CORTICOSTEROIDS, OTHER COMBINATIONS
    D07XB Corticosteroids, moderately potent, other combinations
     D07XB05 Dexamethasone
      D00975  Dexamethasone sodium phosphate (JAN/USP) <JP/US>
  D10 ANTI-ACNE PREPARATIONS
   D10A ANTI-ACNE PREPARATIONS FOR TOPICAL USE
    D10AA Corticosteroids, combinations for treatment of acne
     D10AA03 Dexamethasone
      D00975  Dexamethasone sodium phosphate (JAN/USP) <JP/US>
 H SYSTEMIC HORMONAL PREPARATIONS, EXCL. SEX HORMONES AND INSULINS
  H02 CORTICOSTEROIDS FOR SYSTEMIC USE
   H02A CORTICOSTEROIDS FOR SYSTEMIC USE, PLAIN
    H02AB Glucocorticoids
     H02AB02 Dexamethasone
      D00975  Dexamethasone sodium phosphate (JAN/USP) <JP/US>
 R RESPIRATORY SYSTEM
  R01 NASAL PREPARATIONS
   R01A DECONGESTANTS AND OTHER NASAL PREPARATIONS FOR TOPICAL USE
    R01AD Corticosteroids
     R01AD03 Dexamethasone
      D00975  Dexamethasone sodium phosphate (JAN/USP) <JP/US>
 S SENSORY ORGANS
  S01 OPHTHALMOLOGICALS
   S01B ANTIINFLAMMATORY AGENTS
    S01BA Corticosteroids, plain
     S01BA01 Dexamethasone
      D00975  Dexamethasone sodium phosphate (JAN/USP) <JP/US>
   S01C ANTIINFLAMMATORY AGENTS AND ANTIINFECTIVES IN COMBINATION
    S01CB Corticosteroids/antiinfectives/mydriatics in combination
     S01CB01 Dexamethasone
      D00975  Dexamethasone sodium phosphate (JAN/USP) <JP/US>
  S02 OTOLOGICALS
   S02B CORTICOSTEROIDS
    S02BA Corticosteroids
     S02BA06 Dexamethasone
      D00975  Dexamethasone sodium phosphate (JAN/USP) <JP/US>
  S03 OPHTHALMOLOGICAL AND OTOLOGICAL PREPARATIONS
   S03B CORTICOSTEROIDS
    S03BA Corticosteroids
     S03BA01 Dexamethasone
      D00975  Dexamethasone sodium phosphate (JAN/USP) <JP/US>
USP drug classification [BR:br08302]
 Hormonal Agents, Stimulant/Replacement/Modifying (Adrenal)
  Dexamethasone
   D00975  Dexamethasone sodium phosphate (JAN/USP)
 Inflammatory Bowel Disease Agents
  Glucocorticoids
   Dexamethasone
    D00975  Dexamethasone sodium phosphate (JAN/USP)
 Ophthalmic Agents
  Ophthalmic Anti-inflammatories
   Glucocorticoids, Ophthalmic
    Dexamethasone
     D00975  Dexamethasone sodium phosphate (JAN/USP)
Therapeutic category of drugs in Japan [BR:br08301]
 1  Agents affecting nervous system and sensory organs
  13  Agents affecting sensory organs
   131  Ophthalmic agents
    1315  Ophthalmic cortisones
     D00975  Dexamethasone sodium phosphate (JAN/USP)
   132  Otic and nasal agents
    1329  Others
     D00975  Dexamethasone sodium phosphate (JAN/USP)
 2  Agents affecting individual organs
  24  Hormones
   245  Adrenal hormone preparations
    2454  Fluorinated adrenocorticotropic hormones
     D00975  Dexamethasone sodium phosphate (JAN/USP)
Target-based classification of drugs [BR:br08310]
 Nuclear receptors
  Estrogen like receptors
   3-Ketosteroid receptor
    NR3C1 (GR)
     D00975  Dexamethasone sodium phosphate (JAN/USP) <JP/US>
Drug metabolizing enzymes and transporters [br08309.html]
 Drug metabolizing enzymes
  D00975
BRITE hierarchy
Other DBs
CAS: 2392-39-4
PubChem: 7848038
ChEBI: 4462
ChEMBL: CHEMBL2021430
DrugBank: DB01234
LigandBox: D00975
NIKKAJI: J7.881F
LinkDB All DBs
KCF data Show

ATOM        34
            1   C1y C    20.5509  -18.6771
            2   C1y C    19.3622  -19.3588
            3   C1z C    20.5626  -17.2961
            4   C1x C    22.9399  -18.7004
            5   C1z C    18.1794  -18.6655
            6   C1x C    19.3622  -20.7281
            7   C1z C    21.7686  -16.6144
            8   C1x C    19.3855  -16.6144
            9   C1a C    20.5567  -15.9269
            10  C1y C    22.9514  -17.3253
            11  C1z C    16.9908  -19.3471
            12  C1y C    18.1910  -17.2961
            13  X   F    18.1677  -20.0289
            14  C1x C    18.1677  -21.4098
            15  C5a C    21.7745  -15.2451
            16  O1a O    23.0913  -16.2589
            17  C1a C    24.2741  -17.1681
            18  C2y C    16.9849  -20.7222
            19  C2x C    15.8021  -18.6596
            20  C1a C    16.9791  -17.9662
            21  O1a O    17.0025  -16.6028
            22  C1b C    22.9573  -14.5575
            23  O5a O    20.5743  -14.5575
            24  C2x C    15.8021  -21.4040
            25  C2x C    14.6135  -19.3471
            26  O2b O    24.1401  -15.2334
            27  C5x C    14.6135  -20.7222
            28  P1b P    25.2763  -14.4585
            29  O5x O    13.4190  -21.3981
            30  O1c O    26.4534  -15.1461
            31  O1c O    26.4068  -13.6836 #-
            32  O1c O    24.5014  -13.3223 #-
            33  Z   Na   28.9880  -14.9538 #+
            34  Z   Na   28.9181  -18.1935 #+
BOND        35
            1     1   2 1
            2     1   3 1
            3     1   4 1
            4     2   5 1
            5     2   6 1
            6     3   7 1
            7     3   8 1
            8     3   9 1 #Up
            9     4  10 1
            10    5  11 1
            11    5  12 1
            12    5  13 1 #Down
            13    6  14 1
            14    7  15 1 #Up
            15    7  16 1 #Down
            16   10  17 1 #Down
            17   11  18 1
            18   11  19 1
            19   11  20 1 #Up
            20   12  21 1 #Up
            21   15  22 1
            22   15  23 2
            23   18  24 2
            24   19  25 2
            25   22  26 1
            26   24  27 1
            27   26  28 1
            28   27  29 2
            29   28  30 2
            30   28  31 1
            31   28  32 1
            32    7  10 1
            33    8  12 1
            34   14  18 1
            35   25  27 1

» Japanese version   » Back

KEGG   DRUG: Dexamethasone metasulfobenzoate sodiumHelp
Entry
D01510                      Drug                                   

Name
Dexamethasone metasulfobenzoate sodium (JAN);
Dexamethazone metasulfobenzoate sodium;
Dexapos;
Santeson (TN)
Formula
C29H32FO9S. Na
Exact mass
598.1649
Mol weight
598.6122
Structure
Mol fileKCF fileDB search
Simcomp SIMCOMP
Class
Anti-inflammatory
 DG01955  Corticosteroid
  DG02068  Glucocorticoid
Metabolizing enzyme substrate
 DG02913  CYP3A4 substrate
Metabolizing enzyme inducer
 DG01635  CYP3A4 inducer
Remark
Same as: C12961
Therapeutic category: 1315 1329
ATC code: A01AC02 C05AA09 D07AB19 D07XB05 D10AA03 H02AB02 R01AD03 S01BA01 S01CB01 S02BA06 S03BA01
Chemical structure group: DG00011
Product (DG00011): D00292<JP/US> D00975<JP/US> D01510<JP> D01615<JP> D01632<JP> D01948<JP> D07073<JP>
Efficacy
Anti-inflammatory, Glucocorticoid receptor agonist
Target
NR3C1 (GR) [HSA:2908] [KO:K05771]
  Pathway
hsa04080  Neuroactive ligand-receptor interaction
Metabolism
Enzyme: CYP3A4 [HSA:1576]
Interaction
CYP induction: CYP3A4 [HSA:1576]
Drug interaction
Structure map
map07225  Glucocorticoid and mineralocorticoid receptor agonists/antagonists
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 A ALIMENTARY TRACT AND METABOLISM
  A01 STOMATOLOGICAL PREPARATIONS
   A01A STOMATOLOGICAL PREPARATIONS
    A01AC Corticosteroids for local oral treatment
     A01AC02 Dexamethasone
      D01510  Dexamethasone metasulfobenzoate sodium (JAN) <JP>
 C CARDIOVASCULAR SYSTEM
  C05 VASOPROTECTIVES
   C05A AGENTS FOR TREATMENT OF HEMORRHOIDS AND ANAL FISSURES FOR TOPICAL USE
    C05AA Corticosteroids
     C05AA09 Dexamethasone
      D01510  Dexamethasone metasulfobenzoate sodium (JAN) <JP>
 D DERMATOLOGICALS
  D07 CORTICOSTEROIDS, DERMATOLOGICAL PREPARATIONS
   D07A CORTICOSTEROIDS, PLAIN
    D07AB Corticosteroids, moderately potent (group II)
     D07AB19 Dexamethasone
      D01510  Dexamethasone metasulfobenzoate sodium (JAN) <JP>
   D07X CORTICOSTEROIDS, OTHER COMBINATIONS
    D07XB Corticosteroids, moderately potent, other combinations
     D07XB05 Dexamethasone
      D01510  Dexamethasone metasulfobenzoate sodium (JAN) <JP>
  D10 ANTI-ACNE PREPARATIONS
   D10A ANTI-ACNE PREPARATIONS FOR TOPICAL USE
    D10AA Corticosteroids, combinations for treatment of acne
     D10AA03 Dexamethasone
      D01510  Dexamethasone metasulfobenzoate sodium (JAN) <JP>
 H SYSTEMIC HORMONAL PREPARATIONS, EXCL. SEX HORMONES AND INSULINS
  H02 CORTICOSTEROIDS FOR SYSTEMIC USE
   H02A CORTICOSTEROIDS FOR SYSTEMIC USE, PLAIN
    H02AB Glucocorticoids
     H02AB02 Dexamethasone
      D01510  Dexamethasone metasulfobenzoate sodium (JAN) <JP>
 R RESPIRATORY SYSTEM
  R01 NASAL PREPARATIONS
   R01A DECONGESTANTS AND OTHER NASAL PREPARATIONS FOR TOPICAL USE
    R01AD Corticosteroids
     R01AD03 Dexamethasone
      D01510  Dexamethasone metasulfobenzoate sodium (JAN) <JP>
 S SENSORY ORGANS
  S01 OPHTHALMOLOGICALS
   S01B ANTIINFLAMMATORY AGENTS
    S01BA Corticosteroids, plain
     S01BA01 Dexamethasone
      D01510  Dexamethasone metasulfobenzoate sodium (JAN) <JP>
   S01C ANTIINFLAMMATORY AGENTS AND ANTIINFECTIVES IN COMBINATION
    S01CB Corticosteroids/antiinfectives/mydriatics in combination
     S01CB01 Dexamethasone
      D01510  Dexamethasone metasulfobenzoate sodium (JAN) <JP>
  S02 OTOLOGICALS
   S02B CORTICOSTEROIDS
    S02BA Corticosteroids
     S02BA06 Dexamethasone
      D01510  Dexamethasone metasulfobenzoate sodium (JAN) <JP>
  S03 OPHTHALMOLOGICAL AND OTOLOGICAL PREPARATIONS
   S03B CORTICOSTEROIDS
    S03BA Corticosteroids
     S03BA01 Dexamethasone
      D01510  Dexamethasone metasulfobenzoate sodium (JAN) <JP>
USP drug classification [BR:br08302]
 Hormonal Agents, Stimulant/Replacement/Modifying (Adrenal)
  Dexamethasone
   D01510  Dexamethasone metasulfobenzoate sodium (JAN)
 Inflammatory Bowel Disease Agents
  Glucocorticoids
   Dexamethasone
    D01510  Dexamethasone metasulfobenzoate sodium (JAN)
 Ophthalmic Agents
  Ophthalmic Anti-inflammatories
   Glucocorticoids, Ophthalmic
    Dexamethasone
     D01510  Dexamethasone metasulfobenzoate sodium (JAN)
Therapeutic category of drugs in Japan [BR:br08301]
 1  Agents affecting nervous system and sensory organs
  13  Agents affecting sensory organs
   131  Ophthalmic agents
    1315  Ophthalmic cortisones
     D01510  Dexamethasone metasulfobenzoate sodium (JAN)
   132  Otic and nasal agents
    1329  Others
     D01510  Dexamethasone metasulfobenzoate sodium (JAN)
Target-based classification of drugs [BR:br08310]
 Nuclear receptors
  Estrogen like receptors
   3-Ketosteroid receptor
    NR3C1 (GR)
     D01510  Dexamethasone metasulfobenzoate sodium (JAN) <JP>
Drug metabolizing enzymes and transporters [br08309.html]
 Drug metabolizing enzymes
  D01510
BRITE hierarchy
Other DBs
CAS: 3936-02-5
PubChem: 7848573
ChEBI: 32132
ChEMBL: CHEMBL3186892
DrugBank: DB01234
LigandBox: D01510
NIKKAJI: J217.774I
LinkDB All DBs
KCF data Show

ATOM        41
            1   Z   Na   24.7006  -23.8099 #+
            2   C2x C     8.3300  -30.9400
            3   C5x C     8.3300  -32.2700
            4   C2x C     9.4500  -32.9700
            5   C2y C    10.6400  -32.2700
            6   C1z C    10.6400  -30.9400
            7   C2x C     9.4500  -30.3100
            8   C1x C    11.7600  -32.9700
            9   C1x C    12.9500  -32.2700
            10  C1y C    12.9500  -30.9400
            11  C1z C    11.7600  -30.3100
            12  C1y C    14.0700  -30.3100
            13  C1z C    14.0700  -28.9800
            14  C1x C    12.9500  -28.2800
            15  C1y C    11.7600  -28.9800
            16  C1x C    16.3800  -30.3100
            17  C1y C    16.3800  -28.9800
            18  C1z C    15.2600  -28.2800
            19  C1a C    10.6400  -29.6100
            20  O1a O    10.6400  -28.2800
            21  C1a C    14.0700  -27.6500
            22  C1a C    17.5700  -28.2800
            23  X   F    11.7600  -31.6400
            24  O1a O    16.2400  -27.3000
            25  O5x O     7.1400  -32.9700
            26  C5a C    15.2387  -26.8802
            27  O5a O    14.0320  -26.2076
            28  C1b C    16.4560  -26.1523
            29  O7a O    17.6860  -26.8374
            30  C7a C    18.9174  -26.1013
            31  C8y C    20.1306  -26.7776
            32  O6a O    18.8962  -24.7100
            33  C8x C    21.3390  -26.0551
            34  C8y C    22.5639  -26.7375
            35  C8x C    20.1517  -28.2100
            36  C8x C    22.5854  -28.1393
            37  C8x C    21.4017  -28.8472
            38  S4a S    23.7467  -26.0301
            39  O1d O    24.4231  -27.2564
            40  O1d O    23.1004  -24.7896
            41  O1d O    24.9409  -25.3373 #-
BOND        44
            1     2   3 1
            2     3   4 1
            3     4   5 2
            4     5   6 1
            5     6   7 1
            6     2   7 2
            7     5   8 1
            8     8   9 1
            9     9  10 1
            10   10  11 1
            11    6  11 1
            12   10  12 1
            13   12  13 1
            14   13  14 1
            15   14  15 1
            16   11  15 1
            17   12  16 1
            18   16  17 1
            19   17  18 1
            20   13  18 1
            21    6  19 1 #Up
            22   15  20 1 #Up
            23   13  21 1 #Up
            24   17  22 1 #Down
            25   11  23 1 #Down
            26   18  24 1 #Down
            27    3  25 2
            28   18  26 1 #Up
            29   26  27 2
            30   26  28 1
            31   28  29 1
            32   29  30 1
            33   30  31 1
            34   30  32 2
            35   31  33 2
            36   33  34 1
            37   31  35 1
            38   34  36 2
            39   36  37 1
            40   37  35 2
            41   34  38 1
            42   38  39 2
            43   38  40 2
            44   38  41 1

» Japanese version   » Back

KEGG   DRUG: Dexamethasone palmitateHelp
Entry
D01615                      Drug                                   

Name
Dexamethasone palmitate (JAN);
Dexamethasone 21-palmitate;
Limethason (TN)
Formula
C38H59FO6
Exact mass
630.4296
Mol weight
630.8699
Structure
Mol fileKCF fileDB search
Simcomp SIMCOMP
Class
Anti-inflammatory
 DG01955  Corticosteroid
  DG02068  Glucocorticoid
Metabolizing enzyme substrate
 DG02913  CYP3A4 substrate
Metabolizing enzyme inducer
 DG01635  CYP3A4 inducer
Remark
Therapeutic category: 2454
ATC code: A01AC02 C05AA09 D07AB19 D07XB05 D10AA03 H02AB02 R01AD03 S01BA01 S01CB01 S02BA06 S03BA01
Chemical structure group: DG00011
Product (DG00011): D00292<JP/US> D00975<JP/US> D01510<JP> D01615<JP> D01632<JP> D01948<JP> D07073<JP>
Efficacy
Anti-inflammatory, Antirheumatic, Glucocorticoid receptor agonist
Target
NR3C1 (GR) [HSA:2908] [KO:K05771]
  Pathway
hsa04080  Neuroactive ligand-receptor interaction
Metabolism
Enzyme: CYP3A4 [HSA:1576]
Interaction
CYP induction: CYP3A4 [HSA:1576]
Drug interaction
Structure map
map07225  Glucocorticoid and mineralocorticoid receptor agonists/antagonists
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 A ALIMENTARY TRACT AND METABOLISM
  A01 STOMATOLOGICAL PREPARATIONS
   A01A STOMATOLOGICAL PREPARATIONS
    A01AC Corticosteroids for local oral treatment
     A01AC02 Dexamethasone
      D01615  Dexamethasone palmitate (JAN) <JP>
 C CARDIOVASCULAR SYSTEM
  C05 VASOPROTECTIVES
   C05A AGENTS FOR TREATMENT OF HEMORRHOIDS AND ANAL FISSURES FOR TOPICAL USE
    C05AA Corticosteroids
     C05AA09 Dexamethasone
      D01615  Dexamethasone palmitate (JAN) <JP>
 D DERMATOLOGICALS
  D07 CORTICOSTEROIDS, DERMATOLOGICAL PREPARATIONS
   D07A CORTICOSTEROIDS, PLAIN
    D07AB Corticosteroids, moderately potent (group II)
     D07AB19 Dexamethasone
      D01615  Dexamethasone palmitate (JAN) <JP>
   D07X CORTICOSTEROIDS, OTHER COMBINATIONS
    D07XB Corticosteroids, moderately potent, other combinations
     D07XB05 Dexamethasone
      D01615  Dexamethasone palmitate (JAN) <JP>
  D10 ANTI-ACNE PREPARATIONS
   D10A ANTI-ACNE PREPARATIONS FOR TOPICAL USE
    D10AA Corticosteroids, combinations for treatment of acne
     D10AA03 Dexamethasone
      D01615  Dexamethasone palmitate (JAN) <JP>
 H SYSTEMIC HORMONAL PREPARATIONS, EXCL. SEX HORMONES AND INSULINS
  H02 CORTICOSTEROIDS FOR SYSTEMIC USE
   H02A CORTICOSTEROIDS FOR SYSTEMIC USE, PLAIN
    H02AB Glucocorticoids
     H02AB02 Dexamethasone
      D01615  Dexamethasone palmitate (JAN) <JP>
 R RESPIRATORY SYSTEM
  R01 NASAL PREPARATIONS
   R01A DECONGESTANTS AND OTHER NASAL PREPARATIONS FOR TOPICAL USE
    R01AD Corticosteroids
     R01AD03 Dexamethasone
      D01615  Dexamethasone palmitate (JAN) <JP>
 S SENSORY ORGANS
  S01 OPHTHALMOLOGICALS
   S01B ANTIINFLAMMATORY AGENTS
    S01BA Corticosteroids, plain
     S01BA01 Dexamethasone
      D01615  Dexamethasone palmitate (JAN) <JP>
   S01C ANTIINFLAMMATORY AGENTS AND ANTIINFECTIVES IN COMBINATION
    S01CB Corticosteroids/antiinfectives/mydriatics in combination
     S01CB01 Dexamethasone
      D01615  Dexamethasone palmitate (JAN) <JP>
  S02 OTOLOGICALS
   S02B CORTICOSTEROIDS
    S02BA Corticosteroids
     S02BA06 Dexamethasone
      D01615  Dexamethasone palmitate (JAN) <JP>
  S03 OPHTHALMOLOGICAL AND OTOLOGICAL PREPARATIONS
   S03B CORTICOSTEROIDS
    S03BA Corticosteroids
     S03BA01 Dexamethasone
      D01615  Dexamethasone palmitate (JAN) <JP>
USP drug classification [BR:br08302]
 Hormonal Agents, Stimulant/Replacement/Modifying (Adrenal)
  Dexamethasone
   D01615  Dexamethasone palmitate (JAN)
 Inflammatory Bowel Disease Agents
  Glucocorticoids
   Dexamethasone
    D01615  Dexamethasone palmitate (JAN)
 Ophthalmic Agents
  Ophthalmic Anti-inflammatories
   Glucocorticoids, Ophthalmic
    Dexamethasone
     D01615  Dexamethasone palmitate (JAN)
Therapeutic category of drugs in Japan [BR:br08301]
 2  Agents affecting individual organs
  24  Hormones
   245  Adrenal hormone preparations
    2454  Fluorinated adrenocorticotropic hormones
     D01615  Dexamethasone palmitate (JAN)
Target-based classification of drugs [BR:br08310]
 Nuclear receptors
  Estrogen like receptors
   3-Ketosteroid receptor
    NR3C1 (GR)
     D01615  Dexamethasone palmitate (JAN) <JP>
Drug metabolizing enzymes and transporters [br08309.html]
 Drug metabolizing enzymes
  D01615
BRITE hierarchy
Other DBs
CAS: 14899-36-6
PubChem: 7848678
ChEBI: 31471
DrugBank: DB01234
LigandBox: D01615
NIKKAJI: J265.157B
LinkDB All DBs
KCF data Show

ATOM        45
            1   C1z C    11.5428  -18.6613
            2   C1y C    12.6894  -19.3399
            3   C1z C    10.3788  -19.3282
            4   C1y C    11.5545  -17.3219
            5   X   F    11.5136  -19.9425
            6   C1y C    13.8535  -18.6790
            7   C1x C    12.6894  -20.6736
            8   C2y C    10.3730  -20.6619
            9   C2x C     9.2263  -18.6556
            10  C1a C    10.3670  -17.8307
            11  C1x C    12.7128  -16.6667
            12  O1a O    10.3962  -16.6491
            13  C1z C    13.8653  -17.3393
            14  C1x C    16.1525  -18.7081
            15  C1x C    11.5311  -21.3406
            16  C2x C     9.2263  -21.3348
            17  C2x C     8.0622  -19.3282
            18  C1z C    15.0234  -16.6959
            19  C1a C    13.8944  -16.0113
            20  C1y C    16.1700  -17.3685
            21  C5x C     8.0622  -20.6619
            22  C5a C    15.0351  -14.7947
            23  O1a O    16.6673  -15.7423
            24  C1a C    17.3401  -16.7133
            25  O5x O     6.9039  -21.3348
            26  C1b C    16.1875  -14.1043
            27  O5a O    13.8944  -14.1863
            28  O7a O    17.3516  -14.7537
            29  C7a C    18.5545  -14.0501
            30  C1b C    19.7633  -14.7498
            31  C1b C    20.9720  -14.0501
            32  C1b C    22.1807  -14.7498
            33  C1b C    23.3894  -14.0501
            34  C1b C    24.5981  -14.7498
            35  C1b C    25.8068  -14.0501
            36  C1b C    27.0155  -14.7498
            37  C1b C    28.2242  -14.0501
            38  C1b C    29.4330  -14.7498
            39  C1b C    30.6417  -14.0501
            40  C1b C    31.8504  -14.7498
            41  C1b C    33.0591  -14.0501
            42  C1b C    34.2678  -14.7498
            43  C1b C    35.4765  -14.0501
            44  C1a C    36.6852  -14.7498
            45  O6a O    18.5772  -12.6721
BOND        48
            1    18  23 1 #Down
            2    20  24 1 #Down
            3    21  25 2
            4    22  26 1
            5    22  27 2
            6    26  28 1
            7     8  15 1
            8    11  13 1
            9    17  21 1
            10   18  20 1
            11    1   2 1
            12    1   3 1
            13    1   4 1
            14    1   5 1 #Down
            15    2   6 1
            16   28  29 1
            17    2   7 1
            18   29  30 1
            19    3   8 1
            20   30  31 1
            21    3   9 1
            22   31  32 1
            23    3  10 1 #Up
            24   32  33 1
            25    4  11 1
            26   33  34 1
            27    4  12 1 #Up
            28   34  35 1
            29    6  13 1
            30   35  36 1
            31    6  14 1
            32   36  37 1
            33    7  15 1
            34   37  38 1
            35    8  16 2
            36   38  39 1
            37    9  17 2
            38   39  40 1
            39   13  18 1
            40   40  41 1
            41   13  19 1 #Up
            42   41  42 1
            43   14  20 1
            44   42  43 1
            45   16  21 1
            46   43  44 1
            47   18  22 1 #Up
            48   29  45 2

» Japanese version   » Back

KEGG   DRUG: Dexamethasone dipropionateHelp
Entry
D01632                      Drug                                   

Name
Dexamethasone dipropionate (USAN);
Dexamethasone propionate (JAN);
Hifmeta (TN)
Formula
C28H37FO7
Exact mass
504.2523
Mol weight
504.5876
Structure
Mol fileKCF fileDB search
Simcomp SIMCOMP
Class
Anti-inflammatory
 DG01955  Corticosteroid
  DG02068  Glucocorticoid
Other
 DG01590  Androgen receptor agonist
  DG01605  Anabolic steroid
Metabolizing enzyme substrate
 DG02913  CYP3A4 substrate
Metabolizing enzyme inducer
 DG01635  CYP3A4 inducer
Remark
Therapeutic category: 2646
ATC code: A01AC02 C05AA09 D07AB19 D07XB05 D10AA03 H02AB02 R01AD03 S01BA01 S01CB01 S02BA06 S03BA01
Chemical structure group: DG00011
Product (DG00011): D00292<JP/US> D00975<JP/US> D01510<JP> D01615<JP> D01632<JP> D01948<JP> D07073<JP>
Efficacy
Anti-inflammatory, Glucocorticoid receptor agonist
Target
NR3C1 (GR) [HSA:2908] [KO:K05771]
  Pathway
hsa04080  Neuroactive ligand-receptor interaction
Metabolism
Enzyme: CYP3A4 [HSA:1576]
Interaction
CYP induction: CYP3A4 [HSA:1576]
Drug interaction
Structure map
map07225  Glucocorticoid and mineralocorticoid receptor agonists/antagonists
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 A ALIMENTARY TRACT AND METABOLISM
  A01 STOMATOLOGICAL PREPARATIONS
   A01A STOMATOLOGICAL PREPARATIONS
    A01AC Corticosteroids for local oral treatment
     A01AC02 Dexamethasone
      D01632  Dexamethasone dipropionate (USAN) <JP>
 C CARDIOVASCULAR SYSTEM
  C05 VASOPROTECTIVES
   C05A AGENTS FOR TREATMENT OF HEMORRHOIDS AND ANAL FISSURES FOR TOPICAL USE
    C05AA Corticosteroids
     C05AA09 Dexamethasone
      D01632  Dexamethasone dipropionate (USAN) <JP>
 D DERMATOLOGICALS
  D07 CORTICOSTEROIDS, DERMATOLOGICAL PREPARATIONS
   D07A CORTICOSTEROIDS, PLAIN
    D07AB Corticosteroids, moderately potent (group II)
     D07AB19 Dexamethasone
      D01632  Dexamethasone dipropionate (USAN) <JP>
   D07X CORTICOSTEROIDS, OTHER COMBINATIONS
    D07XB Corticosteroids, moderately potent, other combinations
     D07XB05 Dexamethasone
      D01632  Dexamethasone dipropionate (USAN) <JP>
  D10 ANTI-ACNE PREPARATIONS
   D10A ANTI-ACNE PREPARATIONS FOR TOPICAL USE
    D10AA Corticosteroids, combinations for treatment of acne
     D10AA03 Dexamethasone
      D01632  Dexamethasone dipropionate (USAN) <JP>
 H SYSTEMIC HORMONAL PREPARATIONS, EXCL. SEX HORMONES AND INSULINS
  H02 CORTICOSTEROIDS FOR SYSTEMIC USE
   H02A CORTICOSTEROIDS FOR SYSTEMIC USE, PLAIN
    H02AB Glucocorticoids
     H02AB02 Dexamethasone
      D01632  Dexamethasone dipropionate (USAN) <JP>
 R RESPIRATORY SYSTEM
  R01 NASAL PREPARATIONS
   R01A DECONGESTANTS AND OTHER NASAL PREPARATIONS FOR TOPICAL USE
    R01AD Corticosteroids
     R01AD03 Dexamethasone
      D01632  Dexamethasone dipropionate (USAN) <JP>
 S SENSORY ORGANS
  S01 OPHTHALMOLOGICALS
   S01B ANTIINFLAMMATORY AGENTS
    S01BA Corticosteroids, plain
     S01BA01 Dexamethasone
      D01632  Dexamethasone dipropionate (USAN) <JP>
   S01C ANTIINFLAMMATORY AGENTS AND ANTIINFECTIVES IN COMBINATION
    S01CB Corticosteroids/antiinfectives/mydriatics in combination
     S01CB01 Dexamethasone
      D01632  Dexamethasone dipropionate (USAN) <JP>
  S02 OTOLOGICALS
   S02B CORTICOSTEROIDS
    S02BA Corticosteroids
     S02BA06 Dexamethasone
      D01632  Dexamethasone dipropionate (USAN) <JP>
  S03 OPHTHALMOLOGICAL AND OTOLOGICAL PREPARATIONS
   S03B CORTICOSTEROIDS
    S03BA Corticosteroids
     S03BA01 Dexamethasone
      D01632  Dexamethasone dipropionate (USAN) <JP>
USP drug classification [BR:br08302]
 Hormonal Agents, Stimulant/Replacement/Modifying (Adrenal)
  Dexamethasone
   D01632  Dexamethasone dipropionate (USAN)
 Inflammatory Bowel Disease Agents
  Glucocorticoids
   Dexamethasone
    D01632  Dexamethasone dipropionate (USAN)
 Ophthalmic Agents
  Ophthalmic Anti-inflammatories
   Glucocorticoids, Ophthalmic
    Dexamethasone
     D01632  Dexamethasone dipropionate (USAN)
Therapeutic category of drugs in Japan [BR:br08301]
 2  Agents affecting individual organs
  26  Epidermides
   264  Analgesics, anti-itchings, astringents, anti-inflammatory agents
    2646  Adrenocorticotropic hormones
     D01632  Dexamethasone dipropionate (USAN); Dexamethasone propionate (JAN)
Target-based classification of drugs [BR:br08310]
 Nuclear receptors
  Estrogen like receptors
   3-Ketosteroid receptor
    NR3C1 (GR)
     D01632  Dexamethasone dipropionate (USAN) <JP>
Drug metabolizing enzymes and transporters [br08309.html]
 Drug metabolizing enzymes
  D01632
Topical steroids potency [br08317.html]
 Classification in Japan
  D01632
BRITE hierarchy
Other DBs
CAS: 55541-30-5
PubChem: 7848695
ChEBI: 135805 31470
ChEMBL: CHEMBL1697788
DrugBank: DB01234
LigandBox: D01632
NIKKAJI: J67.048K
LinkDB All DBs
KCF data Show

ATOM        36
            1   C2x C    18.6476  -17.5714
            2   C5x C    18.6476  -18.9149
            3   C2x C    19.8111  -19.5866
            4   C2y C    20.9746  -18.9149
            5   C1z C    20.9746  -17.5714
            6   C2x C    19.8111  -16.8996
            7   C1x C    22.1382  -19.5866
            8   C1x C    23.3015  -18.9149
            9   C1y C    23.3015  -17.5714
            10  C1z C    22.1382  -16.8996
            11  C1y C    24.4651  -16.8996
            12  C1z C    24.4651  -15.5561
            13  C1x C    23.3015  -14.8844
            14  C1y C    22.1382  -15.5561
            15  C1x C    26.7921  -16.8996
            16  C1y C    26.7921  -15.5561
            17  C1z C    25.6286  -14.8844
            18  C1a C    20.9746  -16.2278
            19  O1a O    20.9765  -14.8856
            20  C1a C    24.4651  -14.2127
            21  C1a C    27.9432  -14.8914
            22  C5a C    25.6286  -13.2051
            23  X   F    22.1382  -18.2431
            24  O7a O    27.3464  -13.7974
            25  O5x O    17.4842  -19.5866
            26  O5a O    26.7961  -12.5311
            27  C1b C    24.4690  -12.5355
            28  O7a O    23.3237  -13.1970
            29  C7a C    28.7322  -13.7974
            30  O6a O    29.4335  -15.0127
            31  C1b C    29.4307  -12.5875
            32  C1a C    30.8165  -12.5875
            33  C7a C    22.1401  -12.5134
            34  C1b C    20.9300  -13.2121
            35  O6a O    22.1409  -11.0989
            36  C1a C    19.7253  -12.5168
BOND        39
            1     1   2 1
            2     2   3 1
            3     3   4 2
            4     4   5 1
            5     5   6 1
            6     1   6 2
            7     4   7 1
            8     7   8 1
            9     8   9 1
            10    9  10 1
            11    5  10 1
            12    9  11 1
            13   11  12 1
            14   12  13 1
            15   13  14 1
            16   10  14 1
            17   11  15 1
            18   15  16 1
            19   16  17 1
            20   12  17 1
            21    5  18 1 #Up
            22   14  19 1 #Up
            23   12  20 1 #Up
            24   16  21 1 #Down
            25   17  22 1 #Up
            26   10  23 1 #Down
            27   17  24 1 #Down
            28    2  25 2
            29   22  26 2
            30   22  27 1
            31   27  28 1
            32   24  29 1
            33   29  30 2
            34   29  31 1
            35   31  32 1
            36   28  33 1
            37   33  34 1
            38   33  35 2
            39   34  36 1

» Japanese version   » Back

KEGG   DRUG: Dexamethasone valerateHelp
Entry
D01948                      Drug                                   

Name
Dexamethasone valerate (JAN);
Dexamethasone 17-valerate;
DV-17;
Voalla ointment (TN)
Formula
C27H37FO6
Exact mass
476.2574
Mol weight
476.5775
Structure
Mol fileKCF fileDB search
Simcomp SIMCOMP
Class
Anti-inflammatory
 DG01955  Corticosteroid
  DG02068  Glucocorticoid
Metabolizing enzyme substrate
 DG02913  CYP3A4 substrate
Metabolizing enzyme inducer
 DG01635  CYP3A4 inducer
Remark
Therapeutic category: 2646
ATC code: A01AC02 C05AA09 D07AB19 D07XB05 D10AA03 H02AB02 R01AD03 S01BA01 S01CB01 S02BA06 S03BA01
Chemical structure group: DG00011
Product (DG00011): D00292<JP/US> D00975<JP/US> D01510<JP> D01615<JP> D01632<JP> D01948<JP> D07073<JP>
Efficacy
Anti-inflammatory, Glucocorticoid receptor agonist
Target
NR3C1 (GR) [HSA:2908] [KO:K05771]
  Pathway
hsa04080  Neuroactive ligand-receptor interaction
Metabolism
Enzyme: CYP3A4 [HSA:1576]
Interaction
CYP induction: CYP3A4 [HSA:1576]
Drug interaction
Structure map
map07225  Glucocorticoid and mineralocorticoid receptor agonists/antagonists
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 A ALIMENTARY TRACT AND METABOLISM
  A01 STOMATOLOGICAL PREPARATIONS
   A01A STOMATOLOGICAL PREPARATIONS
    A01AC Corticosteroids for local oral treatment
     A01AC02 Dexamethasone
      D01948  Dexamethasone valerate (JAN) <JP>
 C CARDIOVASCULAR SYSTEM
  C05 VASOPROTECTIVES
   C05A AGENTS FOR TREATMENT OF HEMORRHOIDS AND ANAL FISSURES FOR TOPICAL USE
    C05AA Corticosteroids
     C05AA09 Dexamethasone
      D01948  Dexamethasone valerate (JAN) <JP>
 D DERMATOLOGICALS
  D07 CORTICOSTEROIDS, DERMATOLOGICAL PREPARATIONS
   D07A CORTICOSTEROIDS, PLAIN
    D07AB Corticosteroids, moderately potent (group II)
     D07AB19 Dexamethasone
      D01948  Dexamethasone valerate (JAN) <JP>
   D07X CORTICOSTEROIDS, OTHER COMBINATIONS
    D07XB Corticosteroids, moderately potent, other combinations
     D07XB05 Dexamethasone
      D01948  Dexamethasone valerate (JAN) <JP>
  D10 ANTI-ACNE PREPARATIONS
   D10A ANTI-ACNE PREPARATIONS FOR TOPICAL USE
    D10AA Corticosteroids, combinations for treatment of acne
     D10AA03 Dexamethasone
      D01948  Dexamethasone valerate (JAN) <JP>
 H SYSTEMIC HORMONAL PREPARATIONS, EXCL. SEX HORMONES AND INSULINS
  H02 CORTICOSTEROIDS FOR SYSTEMIC USE
   H02A CORTICOSTEROIDS FOR SYSTEMIC USE, PLAIN
    H02AB Glucocorticoids
     H02AB02 Dexamethasone
      D01948  Dexamethasone valerate (JAN) <JP>
 R RESPIRATORY SYSTEM
  R01 NASAL PREPARATIONS
   R01A DECONGESTANTS AND OTHER NASAL PREPARATIONS FOR TOPICAL USE
    R01AD Corticosteroids
     R01AD03 Dexamethasone
      D01948  Dexamethasone valerate (JAN) <JP>
 S SENSORY ORGANS
  S01 OPHTHALMOLOGICALS
   S01B ANTIINFLAMMATORY AGENTS
    S01BA Corticosteroids, plain
     S01BA01 Dexamethasone
      D01948  Dexamethasone valerate (JAN) <JP>
   S01C ANTIINFLAMMATORY AGENTS AND ANTIINFECTIVES IN COMBINATION
    S01CB Corticosteroids/antiinfectives/mydriatics in combination
     S01CB01 Dexamethasone
      D01948  Dexamethasone valerate (JAN) <JP>
  S02 OTOLOGICALS
   S02B CORTICOSTEROIDS
    S02BA Corticosteroids
     S02BA06 Dexamethasone
      D01948  Dexamethasone valerate (JAN) <JP>
  S03 OPHTHALMOLOGICAL AND OTOLOGICAL PREPARATIONS
   S03B CORTICOSTEROIDS
    S03BA Corticosteroids
     S03BA01 Dexamethasone
      D01948  Dexamethasone valerate (JAN) <JP>
USP drug classification [BR:br08302]
 Hormonal Agents, Stimulant/Replacement/Modifying (Adrenal)
  Dexamethasone
   D01948  Dexamethasone valerate (JAN)
 Inflammatory Bowel Disease Agents
  Glucocorticoids
   Dexamethasone
    D01948  Dexamethasone valerate (JAN)
 Ophthalmic Agents
  Ophthalmic Anti-inflammatories
   Glucocorticoids, Ophthalmic
    Dexamethasone
     D01948  Dexamethasone valerate (JAN)
Therapeutic category of drugs in Japan [BR:br08301]
 2  Agents affecting individual organs
  26  Epidermides
   264  Analgesics, anti-itchings, astringents, anti-inflammatory agents
    2646  Adrenocorticotropic hormones
     D01948  Dexamethasone valerate (JAN)
Target-based classification of drugs [BR:br08310]
 Nuclear receptors
  Estrogen like receptors
   3-Ketosteroid receptor
    NR3C1 (GR)
     D01948  Dexamethasone valerate (JAN) <JP>
Drug metabolizing enzymes and transporters [br08309.html]
 Drug metabolizing enzymes
  D01948
Topical steroids potency [br08317.html]
 Classification in Japan
  D01948
BRITE hierarchy
Other DBs
CAS: 33755-46-3
PubChem: 7849010
ChEMBL: CHEMBL1378167
DrugBank: DB01234
LigandBox: D01948
NIKKAJI: J67.028F
LinkDB All DBs
KCF data Show

ATOM        34
            1   C2x C    14.8604  -19.2419
            2   C5x C    14.8604  -20.6015
            3   C2x C    16.0379  -21.2814
            4   C2y C    17.2153  -20.6015
            5   C1z C    17.2153  -19.2419
            6   C2x C    16.0379  -18.5620
            7   C1x C    18.3928  -21.2814
            8   C1x C    19.5703  -20.6015
            9   C1y C    19.5703  -19.2419
            10  C1z C    18.3928  -18.5620
            11  C1y C    20.7478  -18.5620
            12  C1z C    20.7478  -17.2024
            13  C1x C    19.5703  -16.5225
            14  C1y C    18.3928  -17.2024
            15  C1x C    23.1028  -18.5620
            16  C1y C    23.1028  -17.2024
            17  C1z C    21.9253  -16.5225
            18  C5a C    21.9306  -14.8129
            19  C1b C    20.7531  -14.1331
            20  O1a O    19.5756  -14.7195
            21  O5a O    23.1236  -14.1271
            22  O7a O    23.1363  -15.8333
            23  C7a C    24.9581  -15.8333
            24  O6a O    25.6590  -17.0472
            25  C1b C    25.6590  -14.6193
            26  C1b C    27.0609  -14.6193
            27  C1b C    27.7612  -13.4063
            28  C1a C    29.1566  -13.4063
            29  C1a C    24.5273  -17.1841
            30  X   F    18.4084  -19.9867
            31  O5x O    13.6486  -21.3012
            32  C1a C    17.1938  -17.8381
            33  O1a O    17.1832  -16.5039
            34  C1a C    20.7438  -15.8762
BOND        37
            1     1   2 1
            2     2   3 1
            3     3   4 2
            4     4   5 1
            5     5   6 1
            6     1   6 2
            7     4   7 1
            8     7   8 1
            9     8   9 1
            10    9  10 1
            11    5  10 1
            12    9  11 1
            13   11  12 1
            14   12  13 1
            15   13  14 1
            16   10  14 1
            17   11  15 1
            18   15  16 1
            19   16  17 1
            20   12  17 1
            21   17  18 1 #Up
            22   18  19 1
            23   19  20 1
            24   18  21 2
            25   17  22 1 #Down
            26   22  23 1
            27   23  24 2
            28   23  25 1
            29   25  26 1
            30   26  27 1
            31   27  28 1
            32   16  29 1 #Down
            33   10  30 1 #Down
            34    2  31 2
            35    5  32 1 #Up
            36   14  33 1 #Up
            37   12  34 1 #Up

» Japanese version   » Back

KEGG   DRUG: Dexamethasone acetateHelp
Entry
D02174                      Drug                                   

Name
Dexamethasone acetate (JAN/USP);
Decadronal (TN)
Formula
C24H31FO6. H2O
Exact mass
452.221
Mol weight
452.513
Structure
Mol fileKCF fileDB search
Simcomp SIMCOMP
Class
Anti-inflammatory
 DG01955  Corticosteroid
  DG02068  Glucocorticoid
Metabolizing enzyme substrate
 DG02913  CYP3A4 substrate
Metabolizing enzyme inducer
 DG01635  CYP3A4 inducer
Remark
ATC code: A01AC02 C05AA09 D07AB19 D07XB05 D10AA03 H02AB02 R01AD03 S01BA01 S01CB01 S02BA06 S03BA01
Chemical structure group: DG00011
Product (DG00011): D00292<JP/US> D00975<JP/US> D01510<JP> D01615<JP> D01632<JP> D01948<JP> D07073<JP>
Efficacy
Anti-inflammatory, Glucocorticoid receptor agonist
Target
NR3C1 (GR) [HSA:2908] [KO:K05771]
  Pathway
hsa04080  Neuroactive ligand-receptor interaction
Metabolism
Enzyme: CYP3A4 [HSA:1576]
Interaction
CYP induction: CYP3A4 [HSA:1576]
Drug interaction
Structure map
map07225  Glucocorticoid and mineralocorticoid receptor agonists/antagonists
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 A ALIMENTARY TRACT AND METABOLISM
  A01 STOMATOLOGICAL PREPARATIONS
   A01A STOMATOLOGICAL PREPARATIONS
    A01AC Corticosteroids for local oral treatment
     A01AC02 Dexamethasone
      D02174  Dexamethasone acetate (JAN/USP)
 C CARDIOVASCULAR SYSTEM
  C05 VASOPROTECTIVES
   C05A AGENTS FOR TREATMENT OF HEMORRHOIDS AND ANAL FISSURES FOR TOPICAL USE
    C05AA Corticosteroids
     C05AA09 Dexamethasone
      D02174  Dexamethasone acetate (JAN/USP)
 D DERMATOLOGICALS
  D07 CORTICOSTEROIDS, DERMATOLOGICAL PREPARATIONS
   D07A CORTICOSTEROIDS, PLAIN
    D07AB Corticosteroids, moderately potent (group II)
     D07AB19 Dexamethasone
      D02174  Dexamethasone acetate (JAN/USP)
   D07X CORTICOSTEROIDS, OTHER COMBINATIONS
    D07XB Corticosteroids, moderately potent, other combinations
     D07XB05 Dexamethasone
      D02174  Dexamethasone acetate (JAN/USP)
  D10 ANTI-ACNE PREPARATIONS
   D10A ANTI-ACNE PREPARATIONS FOR TOPICAL USE
    D10AA Corticosteroids, combinations for treatment of acne
     D10AA03 Dexamethasone
      D02174  Dexamethasone acetate (JAN/USP)
 H SYSTEMIC HORMONAL PREPARATIONS, EXCL. SEX HORMONES AND INSULINS
  H02 CORTICOSTEROIDS FOR SYSTEMIC USE
   H02A CORTICOSTEROIDS FOR SYSTEMIC USE, PLAIN
    H02AB Glucocorticoids
     H02AB02 Dexamethasone
      D02174  Dexamethasone acetate (JAN/USP)
 R RESPIRATORY SYSTEM
  R01 NASAL PREPARATIONS
   R01A DECONGESTANTS AND OTHER NASAL PREPARATIONS FOR TOPICAL USE
    R01AD Corticosteroids
     R01AD03 Dexamethasone
      D02174  Dexamethasone acetate (JAN/USP)
 S SENSORY ORGANS
  S01 OPHTHALMOLOGICALS
   S01B ANTIINFLAMMATORY AGENTS
    S01BA Corticosteroids, plain
     S01BA01 Dexamethasone
      D02174  Dexamethasone acetate (JAN/USP)
   S01C ANTIINFLAMMATORY AGENTS AND ANTIINFECTIVES IN COMBINATION
    S01CB Corticosteroids/antiinfectives/mydriatics in combination
     S01CB01 Dexamethasone
      D02174  Dexamethasone acetate (JAN/USP)
  S02 OTOLOGICALS
   S02B CORTICOSTEROIDS
    S02BA Corticosteroids
     S02BA06 Dexamethasone
      D02174  Dexamethasone acetate (JAN/USP)
  S03 OPHTHALMOLOGICAL AND OTOLOGICAL PREPARATIONS
   S03B CORTICOSTEROIDS
    S03BA Corticosteroids
     S03BA01 Dexamethasone
      D02174  Dexamethasone acetate (JAN/USP)
Classification of Japanese OTC drugs [BR:br08313]
 Agents for integumentary system
  57 Analgesic, antipruritic, astringent, and anti-inflammatory remedies (incl. gel patches)
   D02174  Dexamethasone acetate (JAN/USP)
Risk category of Japanese OTC drugs [BR:br08312]
 Designated second-class OTC drugs
  Inorganic and organic chemicals
   Dexamethasone acetate
    D02174  Dexamethasone acetate (JAN/USP)
 Second-class OTC drugs
  Inorganic and organic chemicals
   Dexamethasone acetate
    D02174  Dexamethasone acetate (JAN/USP)
Target-based classification of drugs [BR:br08310]
 Nuclear receptors
  Estrogen like receptors
   3-Ketosteroid receptor
    NR3C1 (GR)
     D02174  Dexamethasone acetate (JAN/USP)
Drug metabolizing enzymes and transporters [br08309.html]
 Drug metabolizing enzymes
  D02174
BRITE hierarchy
Other DBs
CAS: 55812-90-3
PubChem: 7849235
DrugBank: DB01234
LigandBox: D02174
LinkDB All DBs
KCF data Show

ATOM        32
            1   C2x C    17.7128  -16.5491
            2   C5x C    17.7128  -17.9064
            3   C2x C    18.8882  -18.5850
            4   C2y C    20.0636  -17.9064
            5   C1z C    20.0636  -16.5491
            6   C2x C    18.8882  -15.8705
            7   C1x C    21.2391  -18.5850
            8   C1x C    22.4144  -17.9064
            9   C1y C    22.4144  -16.5491
            10  C1z C    21.2391  -15.8705
            11  C1y C    23.5899  -15.8705
            12  C1z C    23.5899  -14.5132
            13  C1x C    22.4144  -13.8346
            14  C1y C    21.2391  -14.5132
            15  C1x C    25.9407  -15.8705
            16  C1y C    25.9407  -14.5132
            17  C1z C    24.7653  -13.8346
            18  C1a C    20.0636  -15.1918
            19  O1a O    20.0656  -13.8358
            20  C1a C    23.5899  -13.1560
            21  C1a C    27.1036  -13.8417
            22  C5a C    24.7653  -12.1381
            23  X   F    21.2391  -17.2277
            24  O1a O    25.9407  -12.9465
            25  O5x O    16.5375  -18.5850
            26  O5a O    25.9447  -11.4572
            27  C1b C    23.5938  -11.4617
            28  O7a O    22.4368  -12.1299
            29  C7a C    21.2411  -11.4393
            30  C1a C    20.0186  -12.1452
            31  O6a O    21.2419  -10.0104
            32  O0  O    28.9100  -16.8700
BOND        34
            1     1   2 1
            2     2   3 1
            3     3   4 2
            4     4   5 1
            5     5   6 1
            6     1   6 2
            7     4   7 1
            8     7   8 1
            9     8   9 1
            10    9  10 1
            11    5  10 1
            12    9  11 1
            13   11  12 1
            14   12  13 1
            15   13  14 1
            16   10  14 1
            17   11  15 1
            18   15  16 1
            19   16  17 1
            20   12  17 1
            21    5  18 1 #Up
            22   14  19 1 #Up
            23   12  20 1 #Up
            24   16  21 1 #Down
            25   17  22 1 #Up
            26   10  23 1 #Down
            27   17  24 1 #Down
            28    2  25 2
            29   22  26 2
            30   22  27 1
            31   27  28 1
            32   28  29 1
            33   29  30 1
            34   29  31 2

» Japanese version   » Back

KEGG   DRUG: Dexamethasone acefurateHelp
Entry
D02591                      Drug                                   

Name
Dexamethasone acefurate (USAN/INN)
Formula
C29H33FO8
Exact mass
528.2159
Mol weight
528.5659
Structure
Mol fileKCF fileDB search
Simcomp SIMCOMP
Class
Anti-inflammatory
 DG01955  Corticosteroid
  DG02068  Glucocorticoid
Metabolizing enzyme substrate
 DG02913  CYP3A4 substrate
Metabolizing enzyme inducer
 DG01635  CYP3A4 inducer
Remark
ATC code: A01AC02 C05AA09 D07AB19 D07XB05 D10AA03 H02AB02 R01AD03 S01BA01 S01CB01 S02BA06 S03BA01
Chemical structure group: DG00011
Product (DG00011): D00292<JP/US> D00975<JP/US> D01510<JP> D01615<JP> D01632<JP> D01948<JP> D07073<JP>
Efficacy
Anti-inflammatory, Glucocorticoid receptor agonist
Target
NR3C1 (GR) [HSA:2908] [KO:K05771]
  Pathway
hsa04080  Neuroactive ligand-receptor interaction
Metabolism
Enzyme: CYP3A4 [HSA:1576]
Interaction
CYP induction: CYP3A4 [HSA:1576]
Drug interaction
Structure map
map07225  Glucocorticoid and mineralocorticoid receptor agonists/antagonists
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 A ALIMENTARY TRACT AND METABOLISM
  A01 STOMATOLOGICAL PREPARATIONS
   A01A STOMATOLOGICAL PREPARATIONS
    A01AC Corticosteroids for local oral treatment
     A01AC02 Dexamethasone
      D02591  Dexamethasone acefurate (USAN/INN)
 C CARDIOVASCULAR SYSTEM
  C05 VASOPROTECTIVES
   C05A AGENTS FOR TREATMENT OF HEMORRHOIDS AND ANAL FISSURES FOR TOPICAL USE
    C05AA Corticosteroids
     C05AA09 Dexamethasone
      D02591  Dexamethasone acefurate (USAN/INN)
 D DERMATOLOGICALS
  D07 CORTICOSTEROIDS, DERMATOLOGICAL PREPARATIONS
   D07A CORTICOSTEROIDS, PLAIN
    D07AB Corticosteroids, moderately potent (group II)
     D07AB19 Dexamethasone
      D02591  Dexamethasone acefurate (USAN/INN)
   D07X CORTICOSTEROIDS, OTHER COMBINATIONS
    D07XB Corticosteroids, moderately potent, other combinations
     D07XB05 Dexamethasone
      D02591  Dexamethasone acefurate (USAN/INN)
  D10 ANTI-ACNE PREPARATIONS
   D10A ANTI-ACNE PREPARATIONS FOR TOPICAL USE
    D10AA Corticosteroids, combinations for treatment of acne
     D10AA03 Dexamethasone
      D02591  Dexamethasone acefurate (USAN/INN)
 H SYSTEMIC HORMONAL PREPARATIONS, EXCL. SEX HORMONES AND INSULINS
  H02 CORTICOSTEROIDS FOR SYSTEMIC USE
   H02A CORTICOSTEROIDS FOR SYSTEMIC USE, PLAIN
    H02AB Glucocorticoids
     H02AB02 Dexamethasone
      D02591  Dexamethasone acefurate (USAN/INN)
 R RESPIRATORY SYSTEM
  R01 NASAL PREPARATIONS
   R01A DECONGESTANTS AND OTHER NASAL PREPARATIONS FOR TOPICAL USE
    R01AD Corticosteroids
     R01AD03 Dexamethasone
      D02591  Dexamethasone acefurate (USAN/INN)
 S SENSORY ORGANS
  S01 OPHTHALMOLOGICALS
   S01B ANTIINFLAMMATORY AGENTS
    S01BA Corticosteroids, plain
     S01BA01 Dexamethasone
      D02591  Dexamethasone acefurate (USAN/INN)
   S01C ANTIINFLAMMATORY AGENTS AND ANTIINFECTIVES IN COMBINATION
    S01CB Corticosteroids/antiinfectives/mydriatics in combination
     S01CB01 Dexamethasone
      D02591  Dexamethasone acefurate (USAN/INN)
  S02 OTOLOGICALS
   S02B CORTICOSTEROIDS
    S02BA Corticosteroids
     S02BA06 Dexamethasone
      D02591  Dexamethasone acefurate (USAN/INN)
  S03 OPHTHALMOLOGICAL AND OTOLOGICAL PREPARATIONS
   S03B CORTICOSTEROIDS
    S03BA Corticosteroids
     S03BA01 Dexamethasone
      D02591  Dexamethasone acefurate (USAN/INN)
Target-based classification of drugs [BR:br08310]
 Nuclear receptors
  Estrogen like receptors
   3-Ketosteroid receptor
    NR3C1 (GR)
     D02591  Dexamethasone acefurate (USAN/INN)
Drug metabolizing enzymes and transporters [br08309.html]
 Drug metabolizing enzymes
  D02591
BRITE hierarchy
Other DBs
CAS: 83880-70-0
PubChem: 17396762
ChEMBL: CHEMBL1697787 CHEMBL290547
DrugBank: DB01234
LigandBox: D02591
LinkDB All DBs
KCF data Show

ATOM        38
            1   C2x C    18.2728  -16.5491
            2   C5x C    18.2728  -17.9064
            3   C2x C    19.4482  -18.5850
            4   C2y C    20.6236  -17.9064
            5   C1z C    20.6236  -16.5491
            6   C2x C    19.4482  -15.8705
            7   C1x C    21.7991  -18.5850
            8   C1x C    22.9744  -17.9064
            9   C1y C    22.9744  -16.5491
            10  C1z C    21.7991  -15.8705
            11  C1y C    24.1499  -15.8705
            12  C1z C    24.1499  -14.5132
            13  C1x C    22.9744  -13.8346
            14  C1y C    21.7991  -14.5132
            15  C1x C    26.5007  -15.8705
            16  C1y C    26.5007  -14.5132
            17  C1z C    25.3253  -13.8346
            18  C1a C    20.6236  -15.1918
            19  O1a O    20.6256  -13.8358
            20  C1a C    24.1499  -13.1560
            21  C1a C    27.6636  -13.8417
            22  C5a C    25.3253  -12.1381
            23  X   F    21.7991  -17.2277
            24  O7a O    27.0607  -12.7365
            25  O5x O    17.0975  -18.5850
            26  O5a O    26.5047  -11.4572
            27  C1b C    24.1538  -11.4617
            28  O7a O    22.9968  -12.1299
            29  C7a C    28.4607  -12.7365
            30  O6a O    29.1691  -13.9642
            31  C8y C    29.1663  -11.5142
            32  C8x C    30.5663  -11.5142
            33  C8x C    30.9989  -10.1827
            34  C8x C    29.8663   -9.3598
            35  O2x O    28.7337  -10.1827
            36  C7a C    21.8011  -11.4393
            37  C1a C    20.5786  -12.1452
            38  O6a O    21.8019  -10.0104
BOND        42
            1     1   2 1
            2     2   3 1
            3     3   4 2
            4     4   5 1
            5     5   6 1
            6     1   6 2
            7     4   7 1
            8     7   8 1
            9     8   9 1
            10    9  10 1
            11    5  10 1
            12    9  11 1
            13   11  12 1
            14   12  13 1
            15   13  14 1
            16   10  14 1
            17   11  15 1
            18   15  16 1
            19   16  17 1
            20   12  17 1
            21    5  18 1 #Up
            22   14  19 1 #Up
            23   12  20 1 #Up
            24   16  21 1 #Down
            25   17  22 1 #Up
            26   10  23 1 #Down
            27   17  24 1 #Down
            28    2  25 2
            29   22  26 2
            30   22  27 1
            31   27  28 1
            32   24  29 1
            33   29  30 2
            34   29  31 1
            35   31  32 2
            36   32  33 1
            37   33  34 2
            38   34  35 1
            39   31  35 1
            40   28  36 1
            41   36  37 1
            42   36  38 2

» Japanese version   » Back

KEGG   DRUG: Dexamethasone beloxilHelp
Entry
D02592                      Drug                                   

Name
Dexamethasone beloxil (USAN)
Formula
C29H35FO5
Exact mass
482.2469
Mol weight
482.5836
Structure
Mol fileKCF fileDB search
Simcomp SIMCOMP
Class
Anti-inflammatory
 DG01955  Corticosteroid
  DG02068  Glucocorticoid
Metabolizing enzyme substrate
 DG02913  CYP3A4 substrate
Metabolizing enzyme inducer
 DG01635  CYP3A4 inducer
Remark
ATC code: A01AC02 C05AA09 D07AB19 D07XB05 D10AA03 H02AB02 R01AD03 S01BA01 S01CB01 S02BA06 S03BA01
Chemical structure group: DG00011
Product (DG00011): D00292<JP/US> D00975<JP/US> D01510<JP> D01615<JP> D01632<JP> D01948<JP> D07073<JP>
Efficacy
Anti-inflammatory, Glucocorticoid receptor agonist
Target
NR3C1 (GR) [HSA:2908] [KO:K05771]
  Pathway
hsa04080  Neuroactive ligand-receptor interaction
Metabolism
Enzyme: CYP3A4 [HSA:1576]
Interaction
CYP induction: CYP3A4 [HSA:1576]
Drug interaction
Structure map
map07225  Glucocorticoid and mineralocorticoid receptor agonists/antagonists
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 A ALIMENTARY TRACT AND METABOLISM
  A01 STOMATOLOGICAL PREPARATIONS
   A01A STOMATOLOGICAL PREPARATIONS
    A01AC Corticosteroids for local oral treatment
     A01AC02 Dexamethasone
      D02592  Dexamethasone beloxil (USAN)
 C CARDIOVASCULAR SYSTEM
  C05 VASOPROTECTIVES
   C05A AGENTS FOR TREATMENT OF HEMORRHOIDS AND ANAL FISSURES FOR TOPICAL USE
    C05AA Corticosteroids
     C05AA09 Dexamethasone
      D02592  Dexamethasone beloxil (USAN)
 D DERMATOLOGICALS
  D07 CORTICOSTEROIDS, DERMATOLOGICAL PREPARATIONS
   D07A CORTICOSTEROIDS, PLAIN
    D07AB Corticosteroids, moderately potent (group II)
     D07AB19 Dexamethasone
      D02592  Dexamethasone beloxil (USAN)
   D07X CORTICOSTEROIDS, OTHER COMBINATIONS
    D07XB Corticosteroids, moderately potent, other combinations
     D07XB05 Dexamethasone
      D02592  Dexamethasone beloxil (USAN)
  D10 ANTI-ACNE PREPARATIONS
   D10A ANTI-ACNE PREPARATIONS FOR TOPICAL USE
    D10AA Corticosteroids, combinations for treatment of acne
     D10AA03 Dexamethasone
      D02592  Dexamethasone beloxil (USAN)
 H SYSTEMIC HORMONAL PREPARATIONS, EXCL. SEX HORMONES AND INSULINS
  H02 CORTICOSTEROIDS FOR SYSTEMIC USE
   H02A CORTICOSTEROIDS FOR SYSTEMIC USE, PLAIN
    H02AB Glucocorticoids
     H02AB02 Dexamethasone
      D02592  Dexamethasone beloxil (USAN)
 R RESPIRATORY SYSTEM
  R01 NASAL PREPARATIONS
   R01A DECONGESTANTS AND OTHER NASAL PREPARATIONS FOR TOPICAL USE
    R01AD Corticosteroids
     R01AD03 Dexamethasone
      D02592  Dexamethasone beloxil (USAN)
 S SENSORY ORGANS
  S01 OPHTHALMOLOGICALS
   S01B ANTIINFLAMMATORY AGENTS
    S01BA Corticosteroids, plain
     S01BA01 Dexamethasone
      D02592  Dexamethasone beloxil (USAN)
   S01C ANTIINFLAMMATORY AGENTS AND ANTIINFECTIVES IN COMBINATION
    S01CB Corticosteroids/antiinfectives/mydriatics in combination
     S01CB01 Dexamethasone
      D02592  Dexamethasone beloxil (USAN)
  S02 OTOLOGICALS
   S02B CORTICOSTEROIDS
    S02BA Corticosteroids
     S02BA06 Dexamethasone
      D02592  Dexamethasone beloxil (USAN)
  S03 OPHTHALMOLOGICAL AND OTOLOGICAL PREPARATIONS
   S03B CORTICOSTEROIDS
    S03BA Corticosteroids
     S03BA01 Dexamethasone
      D02592  Dexamethasone beloxil (USAN)
Target-based classification of drugs [BR:br08310]
 Nuclear receptors
  Estrogen like receptors
   3-Ketosteroid receptor
    NR3C1 (GR)
     D02592  Dexamethasone beloxil (USAN)
Drug metabolizing enzymes and transporters [br08309.html]
 Drug metabolizing enzymes
  D02592
BRITE hierarchy
Other DBs
CAS: 150587-07-8
PubChem: 17396763
ChEMBL: CHEMBL2106699
DrugBank: DB01234
LigandBox: D02592
LinkDB All DBs
KCF data Show

ATOM        35
            1   C2x C    16.8028  -16.5491
            2   C5x C    16.8028  -17.9064
            3   C2x C    17.9782  -18.5850
            4   C2y C    19.1536  -17.9064
            5   C1z C    19.1536  -16.5491
            6   C2x C    17.9782  -15.8705
            7   C1x C    20.3291  -18.5850
            8   C1x C    21.5044  -17.9064
            9   C1y C    21.5044  -16.5491
            10  C1z C    20.3291  -15.8705
            11  C1y C    22.6799  -15.8705
            12  C1z C    22.6799  -14.5132
            13  C1x C    21.5044  -13.8346
            14  C1y C    20.3291  -14.5132
            15  C1x C    25.0307  -15.8705
            16  C1y C    25.0307  -14.5132
            17  C1z C    23.8553  -13.8346
            18  C1a C    19.1536  -15.1918
            19  O1a O    19.1556  -13.8358
            20  C1a C    22.6799  -13.1560
            21  C1a C    26.1936  -13.8417
            22  C5a C    23.8553  -11.0181
            23  X   F    20.3291  -17.2277
            24  O1a O    25.0307  -12.9465
            25  O5x O    15.6275  -18.5850
            26  O5a O    25.0347  -10.3372
            27  C1b C    22.6838  -10.3417
            28  O2a O    21.5268  -11.0099
            29  C1b C    20.3311  -10.3193
            30  C8y C    19.1086  -11.0252
            31  C8x C    17.9123  -10.3351
            32  C8x C    16.7001  -11.0355
            33  C8x C    16.7006  -12.4355
            34  C8x C    17.8969  -13.1256
            35  C8x C    19.1091  -12.4252
BOND        39
            1     1   2 1
            2     2   3 1
            3     3   4 2
            4     4   5 1
            5     5   6 1
            6     1   6 2
            7     4   7 1
            8     7   8 1
            9     8   9 1
            10    9  10 1
            11    5  10 1
            12    9  11 1
            13   11  12 1
            14   12  13 1
            15   13  14 1
            16   10  14 1
            17   11  15 1
            18   15  16 1
            19   16  17 1
            20   12  17 1
            21    5  18 1 #Up
            22   14  19 1 #Up
            23   12  20 1 #Up
            24   16  21 1 #Down
            25   17  22 1 #Up
            26   10  23 1 #Down
            27   17  24 1 #Down
            28    2  25 2
            29   22  26 2
            30   22  27 1
            31   27  28 1
            32   28  29 1
            33   29  30 1
            34   30  31 2
            35   31  32 1
            36   32  33 2
            37   33  34 1
            38   34  35 2
            39   30  35 1

» Japanese version   » Back

KEGG   DRUG: Dexamethasone cipecilateHelp
Entry
D07073                      Drug                                   

Name
Dexamethasone cipecilate (JAN/INN)
Formula
C33H43FO7
Exact mass
570.2993
Mol weight
570.6887
Structure
Mol fileKCF fileDB search
Simcomp SIMCOMP
Class
Anti-inflammatory
 DG01955  Corticosteroid
  DG02068  Glucocorticoid
Metabolizing enzyme substrate
 DG01892  CYP1A2 substrate
 DG02913  CYP3A4 substrate
 DG02970  CES substrate
Metabolizing enzyme inducer
 DG01635  CYP3A4 inducer
Remark
Therapeutic category: 1329
ATC code: A01AC02 C05AA09 D07AB19 D07XB05 D10AA03 H02AB02 R01AD03 S01BA01 S01CB01 S02BA06 S03BA01
Chemical structure group: DG00011
Product (DG00011): D00292<JP/US> D00975<JP/US> D01510<JP> D01615<JP> D01632<JP> D01948<JP> D07073<JP>
Efficacy
Antiallergic, Anti-inflammatory, Glucocorticoid receptor agonist
Target
NR3C1 (GR) [HSA:2908] [KO:K05771]
  Pathway
hsa04080  Neuroactive ligand-receptor interaction
Metabolism
Enzyme: CYP3A4 [HSA:1576], CYP1A2 [HSA:1544], CES [HSA:1066 8824 23491 221223]
Interaction
Drug interaction
Structure map
map07225  Glucocorticoid and mineralocorticoid receptor agonists/antagonists
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 A ALIMENTARY TRACT AND METABOLISM
  A01 STOMATOLOGICAL PREPARATIONS
   A01A STOMATOLOGICAL PREPARATIONS
    A01AC Corticosteroids for local oral treatment
     A01AC02 Dexamethasone
      D07073  Dexamethasone cipecilate (JAN/INN) <JP>
 C CARDIOVASCULAR SYSTEM
  C05 VASOPROTECTIVES
   C05A AGENTS FOR TREATMENT OF HEMORRHOIDS AND ANAL FISSURES FOR TOPICAL USE
    C05AA Corticosteroids
     C05AA09 Dexamethasone
      D07073  Dexamethasone cipecilate (JAN/INN) <JP>
 D DERMATOLOGICALS
  D07 CORTICOSTEROIDS, DERMATOLOGICAL PREPARATIONS
   D07A CORTICOSTEROIDS, PLAIN
    D07AB Corticosteroids, moderately potent (group II)
     D07AB19 Dexamethasone
      D07073  Dexamethasone cipecilate (JAN/INN) <JP>
   D07X CORTICOSTEROIDS, OTHER COMBINATIONS
    D07XB Corticosteroids, moderately potent, other combinations
     D07XB05 Dexamethasone
      D07073  Dexamethasone cipecilate (JAN/INN) <JP>
  D10 ANTI-ACNE PREPARATIONS
   D10A ANTI-ACNE PREPARATIONS FOR TOPICAL USE
    D10AA Corticosteroids, combinations for treatment of acne
     D10AA03 Dexamethasone
      D07073  Dexamethasone cipecilate (JAN/INN) <JP>
 H SYSTEMIC HORMONAL PREPARATIONS, EXCL. SEX HORMONES AND INSULINS
  H02 CORTICOSTEROIDS FOR SYSTEMIC USE
   H02A CORTICOSTEROIDS FOR SYSTEMIC USE, PLAIN
    H02AB Glucocorticoids
     H02AB02 Dexamethasone
      D07073  Dexamethasone cipecilate (JAN/INN) <JP>
 R RESPIRATORY SYSTEM
  R01 NASAL PREPARATIONS
   R01A DECONGESTANTS AND OTHER NASAL PREPARATIONS FOR TOPICAL USE
    R01AD Corticosteroids
     R01AD03 Dexamethasone
      D07073  Dexamethasone cipecilate (JAN/INN) <JP>
 S SENSORY ORGANS
  S01 OPHTHALMOLOGICALS
   S01B ANTIINFLAMMATORY AGENTS
    S01BA Corticosteroids, plain
     S01BA01 Dexamethasone
      D07073  Dexamethasone cipecilate (JAN/INN) <JP>
   S01C ANTIINFLAMMATORY AGENTS AND ANTIINFECTIVES IN COMBINATION
    S01CB Corticosteroids/antiinfectives/mydriatics in combination
     S01CB01 Dexamethasone
      D07073  Dexamethasone cipecilate (JAN/INN) <JP>
  S02 OTOLOGICALS
   S02B CORTICOSTEROIDS
    S02BA Corticosteroids
     S02BA06 Dexamethasone
      D07073  Dexamethasone cipecilate (JAN/INN) <JP>
  S03 OPHTHALMOLOGICAL AND OTOLOGICAL PREPARATIONS
   S03B CORTICOSTEROIDS
    S03BA Corticosteroids
     S03BA01 Dexamethasone
      D07073  Dexamethasone cipecilate (JAN/INN) <JP>
USP drug classification [BR:br08302]
 Hormonal Agents, Stimulant/Replacement/Modifying (Adrenal)
  Dexamethasone
   D07073  Dexamethasone cipecilate (JAN/INN)
 Inflammatory Bowel Disease Agents
  Glucocorticoids
   Dexamethasone
    D07073  Dexamethasone cipecilate (JAN/INN)
 Ophthalmic Agents
  Ophthalmic Anti-inflammatories
   Glucocorticoids, Ophthalmic
    Dexamethasone
     D07073  Dexamethasone cipecilate (JAN/INN)
Therapeutic category of drugs in Japan [BR:br08301]
 1  Agents affecting nervous system and sensory organs
  13  Agents affecting sensory organs
   132  Otic and nasal agents
    1329  Others
     D07073  Dexamethasone cipecilate (JAN/INN)
Target-based classification of drugs [BR:br08310]
 Nuclear receptors
  Estrogen like receptors
   3-Ketosteroid receptor
    NR3C1 (GR)
     D07073  Dexamethasone cipecilate (JAN/INN) <JP>
New drug approvals in Japan [br08318.html]
 Drugs with new active ingredients
  D07073
New drug approvals in the USA, Europe and Japan [br08328.html]
 Approval dates by FDA, EMA and PMDA
  D07073
Drug metabolizing enzymes and transporters [br08309.html]
 Drug metabolizing enzymes
  D07073
BRITE hierarchy
Other DBs
CAS: 132245-57-9
PubChem: 51091415
LigandBox: D07073
LinkDB All DBs
KCF data Show

ATOM        41
            1   C2x C    21.1400  -21.0000
            2   C5x C    21.1400  -22.3300
            3   C2x C    22.3300  -23.0300
            4   C2y C    23.5200  -22.3300
            5   C1z C    23.5200  -21.0000
            6   C2x C    22.3300  -20.3000
            7   C1x C    24.6400  -23.0300
            8   C1x C    25.8300  -22.3300
            9   C1y C    25.8300  -21.0000
            10  C1z C    24.6400  -20.3000
            11  C1y C    27.0200  -20.3000
            12  C1z C    27.0200  -18.9700
            13  C1x C    25.8300  -18.3400
            14  C1y C    24.6400  -18.9700
            15  C1x C    29.3300  -20.3000
            16  C1y C    29.3300  -18.9700
            17  C1z C    28.1400  -18.3400
            18  C1a C    23.5200  -19.6700
            19  C1a C    27.0200  -17.6400
            20  C1a C    30.4500  -18.3400
            21  C5a C    28.1400  -16.6600
            22  X   F    24.6400  -21.7000
            23  O7a O    29.8900  -17.2200
            24  O5x O    20.0200  -23.0300
            25  O5a O    29.3300  -15.9600
            26  C1b C    27.0200  -15.9600
            27  O7a O    25.8300  -16.6600
            28  C7a C    31.2200  -17.2200
            29  O6a O    31.9200  -18.4100
            30  C1y C    31.9200  -16.0300
            31  C7a C    24.6400  -15.9600
            32  O6a O    24.6400  -14.5600
            33  C1y C    23.4500  -16.6600
            34  C1x C    22.7500  -15.4700
            35  C1x C    21.3500  -15.4700
            36  C1x C    20.6500  -16.6600
            37  C1x C    21.3500  -17.8500
            38  C1x C    22.7500  -17.8500
            39  C1x C    33.3722  -15.8020
            40  C1x C    32.4961  -14.7350
            41  O1a O    24.6400  -17.5700
BOND        46
            1     1   2 1
            2     2   3 1
            3     3   4 2
            4     4   5 1
            5     5   6 1
            6     1   6 2
            7     4   7 1
            8     7   8 1
            9     8   9 1
            10    9  10 1
            11    5  10 1
            12    9  11 1
            13   11  12 1
            14   12  13 1
            15   13  14 1
            16   10  14 1
            17   11  15 1
            18   15  16 1
            19   16  17 1
            20   12  17 1
            21    5  18 1 #Up
            22   12  19 1 #Up
            23   16  20 1 #Down
            24   17  21 1 #Up
            25   10  22 1 #Down
            26   17  23 1 #Down
            27    2  24 2
            28   21  25 2
            29   21  26 1
            30   26  27 1
            31   23  28 1
            32   28  29 2
            33   28  30 1
            34   27  31 1
            35   31  32 2
            36   31  33 1
            37   33  34 1
            38   34  35 1
            39   35  36 1
            40   36  37 1
            41   37  38 1
            42   33  38 1
            43   30  39 1
            44   39  40 1
            45   40  30 1
            46   14  41 1 #Up

» Japanese version   » Back

KEGG   DRUG: Dexamethasone 21-acetateHelp
Entry
D07796                      Drug                                   

Name
Dexamethasone 21-acetate;
Dexamethasone acetate anhydrous;
Decaject-L.A. (TN)
Formula
C24H31FO6
Exact mass
434.2105
Mol weight
434.4977
Structure
Mol fileKCF fileDB search
Simcomp SIMCOMP
Class
Anti-inflammatory
 DG01955  Corticosteroid
  DG02068  Glucocorticoid
Metabolizing enzyme substrate
 DG02913  CYP3A4 substrate
Metabolizing enzyme inducer
 DG01635  CYP3A4 inducer
Remark
Same as: C08174
ATC code: A01AC02 C05AA09 D07AB19 D07XB05 D10AA03 H02AB02 R01AD03 S01BA01 S01CB01 S02BA06 S03BA01
Chemical structure group: DG00011
Product (DG00011): D00292<JP/US> D00975<JP/US> D01510<JP> D01615<JP> D01632<JP> D01948<JP> D07073<JP>
Efficacy
Anti-inflammatory, Glucocorticoid receptor agonist
Target
NR3C1 (GR) [HSA:2908] [KO:K05771]
  Pathway
hsa04080  Neuroactive ligand-receptor interaction
Metabolism
Enzyme: CYP3A4 [HSA:1576]
Interaction
CYP induction: CYP3A4 [HSA:1576]
Drug interaction
Structure map
map07225  Glucocorticoid and mineralocorticoid receptor agonists/antagonists
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 A ALIMENTARY TRACT AND METABOLISM
  A01 STOMATOLOGICAL PREPARATIONS
   A01A STOMATOLOGICAL PREPARATIONS
    A01AC Corticosteroids for local oral treatment
     A01AC02 Dexamethasone
      D07796  Dexamethasone 21-acetate
 C CARDIOVASCULAR SYSTEM
  C05 VASOPROTECTIVES
   C05A AGENTS FOR TREATMENT OF HEMORRHOIDS AND ANAL FISSURES FOR TOPICAL USE
    C05AA Corticosteroids
     C05AA09 Dexamethasone
      D07796  Dexamethasone 21-acetate
 D DERMATOLOGICALS
  D07 CORTICOSTEROIDS, DERMATOLOGICAL PREPARATIONS
   D07A CORTICOSTEROIDS, PLAIN
    D07AB Corticosteroids, moderately potent (group II)
     D07AB19 Dexamethasone
      D07796  Dexamethasone 21-acetate
   D07X CORTICOSTEROIDS, OTHER COMBINATIONS
    D07XB Corticosteroids, moderately potent, other combinations
     D07XB05 Dexamethasone
      D07796  Dexamethasone 21-acetate
  D10 ANTI-ACNE PREPARATIONS
   D10A ANTI-ACNE PREPARATIONS FOR TOPICAL USE
    D10AA Corticosteroids, combinations for treatment of acne
     D10AA03 Dexamethasone
      D07796  Dexamethasone 21-acetate
 H SYSTEMIC HORMONAL PREPARATIONS, EXCL. SEX HORMONES AND INSULINS
  H02 CORTICOSTEROIDS FOR SYSTEMIC USE
   H02A CORTICOSTEROIDS FOR SYSTEMIC USE, PLAIN
    H02AB Glucocorticoids
     H02AB02 Dexamethasone
      D07796  Dexamethasone 21-acetate
 R RESPIRATORY SYSTEM
  R01 NASAL PREPARATIONS
   R01A DECONGESTANTS AND OTHER NASAL PREPARATIONS FOR TOPICAL USE
    R01AD Corticosteroids
     R01AD03 Dexamethasone
      D07796  Dexamethasone 21-acetate
 S SENSORY ORGANS
  S01 OPHTHALMOLOGICALS
   S01B ANTIINFLAMMATORY AGENTS
    S01BA Corticosteroids, plain
     S01BA01 Dexamethasone
      D07796  Dexamethasone 21-acetate
   S01C ANTIINFLAMMATORY AGENTS AND ANTIINFECTIVES IN COMBINATION
    S01CB Corticosteroids/antiinfectives/mydriatics in combination
     S01CB01 Dexamethasone
      D07796  Dexamethasone 21-acetate
  S02 OTOLOGICALS
   S02B CORTICOSTEROIDS
    S02BA Corticosteroids
     S02BA06 Dexamethasone
      D07796  Dexamethasone 21-acetate
  S03 OPHTHALMOLOGICAL AND OTOLOGICAL PREPARATIONS
   S03B CORTICOSTEROIDS
    S03BA Corticosteroids
     S03BA01 Dexamethasone
      D07796  Dexamethasone 21-acetate
Target-based classification of drugs [BR:br08310]
 Nuclear receptors
  Estrogen like receptors
   3-Ketosteroid receptor
    NR3C1 (GR)
     D07796  Dexamethasone 21-acetate
Drug metabolizing enzymes and transporters [br08309.html]
 Drug metabolizing enzymes
  D07796
BRITE hierarchy
Other DBs
CAS: 1177-87-3
PubChem: 96024493
ChEBI: 4463
ChEMBL: CHEMBL1530428
LigandBox: D07796
NIKKAJI: J21.193A
LinkDB All DBs
KCF data Show

ATOM        31
            1   C2x C    22.2600  -21.7000
            2   C5x C    22.2600  -23.1000
            3   C2x C    23.4500  -23.7300
            4   C2y C    24.5700  -23.1000
            5   C1z C    24.5700  -21.7000
            6   C2x C    23.4500  -21.0700
            7   C1x C    25.7600  -23.7300
            8   C1x C    26.9500  -23.1000
            9   C1y C    26.9500  -21.7000
            10  C1z C    25.7600  -21.0700
            11  C1y C    28.1400  -21.0700
            12  C1z C    28.1400  -19.6700
            13  C1x C    26.9500  -19.0400
            14  C1y C    25.7600  -19.6700
            15  C1x C    30.4500  -21.0700
            16  C1y C    30.4500  -19.6700
            17  C1z C    29.3300  -19.0400
            18  C1a C    24.5700  -20.3700
            19  O1a O    24.6400  -19.0400
            20  C1a C    28.1400  -18.3400
            21  C1a C    31.6400  -19.0400
            22  C5a C    29.3300  -17.2900
            23  X   F    25.7600  -22.4000
            24  O1a O    30.4500  -18.1300
            25  O5x O    21.0700  -23.7300
            26  O5a O    30.4500  -16.6600
            27  C1b C    28.1400  -16.6600
            28  O7a O    26.9500  -17.2900
            29  C7a C    25.7600  -16.5900
            30  C1a C    24.5700  -17.2900
            31  O6a O    25.7600  -15.1900
BOND        34
            1     1   2 1
            2     2   3 1
            3     3   4 2
            4     4   5 1
            5     5   6 1
            6     1   6 2
            7     4   7 1
            8     7   8 1
            9     8   9 1
            10    9  10 1
            11    5  10 1
            12    9  11 1
            13   11  12 1
            14   12  13 1
            15   13  14 1
            16   10  14 1
            17   11  15 1
            18   15  16 1
            19   16  17 1
            20   12  17 1
            21    5  18 1 #Up
            22   14  19 1 #Up
            23   12  20 1 #Up
            24   16  21 1 #Down
            25   17  22 1 #Up
            26   10  23 1 #Down
            27   17  24 1 #Down
            28    2  25 2
            29   22  26 2
            30   22  27 1
            31   27  28 1
            32   28  29 1
            33   29  30 1
            34   29  31 2

» Japanese version   » Back

KEGG   DRUG: Dexamethasone isonicotinateHelp
Entry
D07797                      Drug                                   

Name
Dexamethasone isonicotinate;
Dexamethasone 21-isonicotinate;
Voren [veterinary] (TN)
Formula
C28H32FNO6
Exact mass
497.2214
Mol weight
497.5552
Structure
Mol fileKCF fileDB search
Simcomp SIMCOMP
Class
Anti-inflammatory
 DG01955  Corticosteroid
  DG02068  Glucocorticoid
Metabolizing enzyme substrate
 DG02913  CYP3A4 substrate
Metabolizing enzyme inducer
 DG01635  CYP3A4 inducer
Remark
ATC code: A01AC02 C05AA09 D07AB19 D07XB05 D10AA03 H02AB02 R01AD03 S01BA01 S01CB01 S02BA06 S03BA01
Chemical structure group: DG00011
Product (DG00011): D00292<JP/US> D00975<JP/US> D01510<JP> D01615<JP> D01632<JP> D01948<JP> D07073<JP>
Efficacy
Anti-inflammatory, Glucocorticoid receptor agonist
Target
NR3C1 (GR) [HSA:2908] [KO:K05771]
  Pathway
hsa04080  Neuroactive ligand-receptor interaction
Metabolism
Enzyme: CYP3A4 [HSA:1576]
Interaction
CYP induction: CYP3A4 [HSA:1576]
Drug interaction
Structure map
map07225  Glucocorticoid and mineralocorticoid receptor agonists/antagonists
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 A ALIMENTARY TRACT AND METABOLISM
  A01 STOMATOLOGICAL PREPARATIONS
   A01A STOMATOLOGICAL PREPARATIONS
    A01AC Corticosteroids for local oral treatment
     A01AC02 Dexamethasone
      D07797  Dexamethasone isonicotinate
 C CARDIOVASCULAR SYSTEM
  C05 VASOPROTECTIVES
   C05A AGENTS FOR TREATMENT OF HEMORRHOIDS AND ANAL FISSURES FOR TOPICAL USE
    C05AA Corticosteroids
     C05AA09 Dexamethasone
      D07797  Dexamethasone isonicotinate
 D DERMATOLOGICALS
  D07 CORTICOSTEROIDS, DERMATOLOGICAL PREPARATIONS
   D07A CORTICOSTEROIDS, PLAIN
    D07AB Corticosteroids, moderately potent (group II)
     D07AB19 Dexamethasone
      D07797  Dexamethasone isonicotinate
   D07X CORTICOSTEROIDS, OTHER COMBINATIONS
    D07XB Corticosteroids, moderately potent, other combinations
     D07XB05 Dexamethasone
      D07797  Dexamethasone isonicotinate
  D10 ANTI-ACNE PREPARATIONS
   D10A ANTI-ACNE PREPARATIONS FOR TOPICAL USE
    D10AA Corticosteroids, combinations for treatment of acne
     D10AA03 Dexamethasone
      D07797  Dexamethasone isonicotinate
 H SYSTEMIC HORMONAL PREPARATIONS, EXCL. SEX HORMONES AND INSULINS
  H02 CORTICOSTEROIDS FOR SYSTEMIC USE
   H02A CORTICOSTEROIDS FOR SYSTEMIC USE, PLAIN
    H02AB Glucocorticoids
     H02AB02 Dexamethasone
      D07797  Dexamethasone isonicotinate
 R RESPIRATORY SYSTEM
  R01 NASAL PREPARATIONS
   R01A DECONGESTANTS AND OTHER NASAL PREPARATIONS FOR TOPICAL USE
    R01AD Corticosteroids
     R01AD03 Dexamethasone
      D07797  Dexamethasone isonicotinate
 S SENSORY ORGANS
  S01 OPHTHALMOLOGICALS
   S01B ANTIINFLAMMATORY AGENTS
    S01BA Corticosteroids, plain
     S01BA01 Dexamethasone
      D07797  Dexamethasone isonicotinate
   S01C ANTIINFLAMMATORY AGENTS AND ANTIINFECTIVES IN COMBINATION
    S01CB Corticosteroids/antiinfectives/mydriatics in combination
     S01CB01 Dexamethasone
      D07797  Dexamethasone isonicotinate
  S02 OTOLOGICALS
   S02B CORTICOSTEROIDS
    S02BA Corticosteroids
     S02BA06 Dexamethasone
      D07797  Dexamethasone isonicotinate
  S03 OPHTHALMOLOGICAL AND OTOLOGICAL PREPARATIONS
   S03B CORTICOSTEROIDS
    S03BA Corticosteroids
     S03BA01 Dexamethasone
      D07797  Dexamethasone isonicotinate
Target-based classification of drugs [BR:br08310]
 Nuclear receptors
  Estrogen like receptors
   3-Ketosteroid receptor
    NR3C1 (GR)
     D07797  Dexamethasone isonicotinate
Drug metabolizing enzymes and transporters [br08309.html]
 Drug metabolizing enzymes
  D07797
BRITE hierarchy
Other DBs
CAS: 2265-64-7
PubChem: 96024494
ChEMBL: CHEMBL3186453
LigandBox: D07797
NIKKAJI: J15.020G
LinkDB All DBs
KCF data Show

ATOM        36
            1   C2x C     2.9299  -11.3320
            2   C5x C     2.9299  -12.6660
            3   C2x C     4.1235  -13.3682
            4   C2y C     5.3171  -12.6660
            5   C1z C     5.3171  -11.3320
            6   C2x C     4.1235  -10.7001
            7   C1x C     6.4405  -13.3682
            8   C1x C     7.6341  -12.6660
            9   C1y C     7.6341  -11.3320
            10  C1z C     6.4405  -10.7001
            11  C1y C     8.8277  -10.7001
            12  C1z C     8.8277   -9.2958
            13  C1x C     7.6341   -8.6639
            14  C1y C     6.4405   -9.2958
            15  C1x C    11.2150  -10.7001
            16  C1y C    11.2150   -9.2958
            17  C1z C    10.0214   -8.6639
            18  O1a O    11.0044   -7.6809
            19  X   F     6.4405  -11.9639
            20  O5x O     1.8064  -13.3682
            21  C1a C     8.8277   -7.9618
            22  C1a C     5.3171   -9.9979
            23  O1a O     5.5277   -8.3830
            24  C5a C    10.0214   -6.8384
            25  O5a O     8.8277   -6.1362
            26  C1a C    12.3971   -8.5841
            27  C1b C    11.2188   -6.1537
            28  O7a O    12.4168   -6.8523
            29  C7a C    13.6087   -6.1709
            30  C8y C    14.7919   -6.8608
            31  O6a O    13.6149   -4.7604
            32  C8x C    14.7859   -8.2599
            33  C8x C    15.9954   -8.9651
            34  N5x N    17.2108   -8.2703
            35  C8x C    17.2168   -6.8713
            36  C8x C    16.0074   -6.1661
BOND        40
            1     1   2 1
            2     2   3 1
            3     3   4 2
            4     4   5 1
            5     5   6 1
            6     1   6 2
            7     4   7 1
            8     7   8 1
            9     8   9 1
            10    9  10 1
            11    5  10 1
            12    9  11 1
            13   11  12 1
            14   12  13 1
            15   13  14 1
            16   10  14 1
            17   15  16 1
            18   16  17 1
            19   12  17 1
            20   17  18 1 #Down
            21   10  19 1 #Down
            22    2  20 2
            23   11  15 1
            24   12  21 1 #Up
            25    5  22 1 #Up
            26   14  23 1 #Up
            27   24  25 2
            28   17  24 1 #Up
            29   16  26 1 #Down
            30   24  27 1
            31   27  28 1
            32   28  29 1
            33   29  30 1
            34   29  31 2
            35   30  32 2
            36   32  33 1
            37   33  34 2
            38   34  35 1
            39   35  36 2
            40   30  36 1

» Japanese version   » Back

KEGG   DRUG: Dexamethasone sodium hemisulfateHelp
Entry
D07798                      Drug                                   

Name
Dexamethasone sodium hemisulfate;
Dexamethasone 21-sodium sulfate;
Colircusi Dexametasona (TN)
Formula
C22H28FO8S. Na
Exact mass
494.1387
Mol weight
494.5061
Structure
Mol fileKCF fileDB search
Simcomp SIMCOMP
Class
Anti-inflammatory
 DG01955  Corticosteroid
  DG02068  Glucocorticoid
Metabolizing enzyme substrate
 DG02913  CYP3A4 substrate
Metabolizing enzyme inducer
 DG01635  CYP3A4 inducer
Remark
ATC code: A01AC02 C05AA09 D07AB19 D07XB05 D10AA03 H02AB02 R01AD03 S01BA01 S01CB01 S02BA06 S03BA01
Chemical structure group: DG00011
Product (DG00011): D00292<JP/US> D00975<JP/US> D01510<JP> D01615<JP> D01632<JP> D01948<JP> D07073<JP>
Efficacy
Anti-inflammatory, Glucocorticoid receptor agonist
Target
NR3C1 (GR) [HSA:2908] [KO:K05771]
  Pathway
hsa04080  Neuroactive ligand-receptor interaction
Metabolism
Enzyme: CYP3A4 [HSA:1576]
Interaction
CYP induction: CYP3A4 [HSA:1576]
Drug interaction
Structure map
map07225  Glucocorticoid and mineralocorticoid receptor agonists/antagonists
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 A ALIMENTARY TRACT AND METABOLISM
  A01 STOMATOLOGICAL PREPARATIONS
   A01A STOMATOLOGICAL PREPARATIONS
    A01AC Corticosteroids for local oral treatment
     A01AC02 Dexamethasone
      D07798  Dexamethasone sodium hemisulfate
 C CARDIOVASCULAR SYSTEM
  C05 VASOPROTECTIVES
   C05A AGENTS FOR TREATMENT OF HEMORRHOIDS AND ANAL FISSURES FOR TOPICAL USE
    C05AA Corticosteroids
     C05AA09 Dexamethasone
      D07798  Dexamethasone sodium hemisulfate
 D DERMATOLOGICALS
  D07 CORTICOSTEROIDS, DERMATOLOGICAL PREPARATIONS
   D07A CORTICOSTEROIDS, PLAIN
    D07AB Corticosteroids, moderately potent (group II)
     D07AB19 Dexamethasone
      D07798  Dexamethasone sodium hemisulfate
   D07X CORTICOSTEROIDS, OTHER COMBINATIONS
    D07XB Corticosteroids, moderately potent, other combinations
     D07XB05 Dexamethasone
      D07798  Dexamethasone sodium hemisulfate
  D10 ANTI-ACNE PREPARATIONS
   D10A ANTI-ACNE PREPARATIONS FOR TOPICAL USE
    D10AA Corticosteroids, combinations for treatment of acne
     D10AA03 Dexamethasone
      D07798  Dexamethasone sodium hemisulfate
 H SYSTEMIC HORMONAL PREPARATIONS, EXCL. SEX HORMONES AND INSULINS
  H02 CORTICOSTEROIDS FOR SYSTEMIC USE
   H02A CORTICOSTEROIDS FOR SYSTEMIC USE, PLAIN
    H02AB Glucocorticoids
     H02AB02 Dexamethasone
      D07798  Dexamethasone sodium hemisulfate
 R RESPIRATORY SYSTEM
  R01 NASAL PREPARATIONS
   R01A DECONGESTANTS AND OTHER NASAL PREPARATIONS FOR TOPICAL USE
    R01AD Corticosteroids
     R01AD03 Dexamethasone
      D07798  Dexamethasone sodium hemisulfate
 S SENSORY ORGANS
  S01 OPHTHALMOLOGICALS
   S01B ANTIINFLAMMATORY AGENTS
    S01BA Corticosteroids, plain
     S01BA01 Dexamethasone
      D07798  Dexamethasone sodium hemisulfate
   S01C ANTIINFLAMMATORY AGENTS AND ANTIINFECTIVES IN COMBINATION
    S01CB Corticosteroids/antiinfectives/mydriatics in combination
     S01CB01 Dexamethasone
      D07798  Dexamethasone sodium hemisulfate
  S02 OTOLOGICALS
   S02B CORTICOSTEROIDS
    S02BA Corticosteroids
     S02BA06 Dexamethasone
      D07798  Dexamethasone sodium hemisulfate
  S03 OPHTHALMOLOGICAL AND OTOLOGICAL PREPARATIONS
   S03B CORTICOSTEROIDS
    S03BA Corticosteroids
     S03BA01 Dexamethasone
      D07798  Dexamethasone sodium hemisulfate
Target-based classification of drugs [BR:br08310]
 Nuclear receptors
  Estrogen like receptors
   3-Ketosteroid receptor
    NR3C1 (GR)
     D07798  Dexamethasone sodium hemisulfate
Drug metabolizing enzymes and transporters [br08309.html]
 Drug metabolizing enzymes
  D07798
BRITE hierarchy
Other DBs
CAS: 466-11-5
PubChem: 96024495
LigandBox: D07798
NIKKAJI: J196.186A
LinkDB All DBs
KCF data Show

ATOM        33
            1   Z   Na   21.3933  -25.5423 #+
            2   C2x C    10.0800  -25.7600
            3   C5x C    10.0800  -27.0900
            4   C2x C    11.2700  -27.7900
            5   C2y C    12.4600  -27.0900
            6   C1z C    12.4600  -25.7600
            7   C2x C    11.2700  -25.1300
            8   C1x C    13.5800  -27.7900
            9   C1x C    14.7700  -27.0900
            10  C1y C    14.7700  -25.7600
            11  C1z C    13.5800  -25.1300
            12  C1y C    15.9600  -25.1300
            13  C1z C    15.9600  -23.7300
            14  C1x C    14.7700  -23.1000
            15  C1y C    13.5800  -23.7300
            16  C1x C    18.3400  -25.1300
            17  C1y C    18.3400  -23.7300
            18  C1z C    17.1500  -23.1000
            19  O1a O    18.1300  -22.1200
            20  X   F    13.5800  -26.3900
            21  O5x O     8.9600  -27.7900
            22  C1a C    15.9600  -22.4000
            23  C1a C    12.4600  -24.4300
            24  O1a O    12.6700  -22.8200
            25  C1a C    19.6700  -23.1700
            26  C5a C    17.1500  -21.2800
            27  O5a O    15.9600  -20.5800
            28  C1b C    18.3653  -20.5849
            29  O2a O    19.5537  -21.2777
            30  S4a S    20.7501  -20.5935
            31  O1d O    21.3876  -21.8106
            32  O1d O    20.1631  -19.2955
            33  O1d O    21.9891  -19.9890 #-
BOND        35
            1     2   3 1
            2     3   4 1
            3     4   5 2
            4     5   6 1
            5     6   7 1
            6     2   7 2
            7     5   8 1
            8     8   9 1
            9     9  10 1
            10   10  11 1
            11    6  11 1
            12   10  12 1
            13   12  13 1
            14   13  14 1
            15   14  15 1
            16   11  15 1
            17   16  17 1
            18   17  18 1
            19   13  18 1
            20   18  19 1 #Down
            21   11  20 1 #Down
            22    3  21 2
            23   12  16 1
            24   13  22 1 #Up
            25    6  23 1 #Up
            26   15  24 1 #Up
            27   17  25 1 #Down
            28   26  27 2
            29   18  26 1 #Up
            30   26  28 1
            31   28  29 1
            32   29  30 1
            33   30  31 2
            34   30  32 2
            35   30  33 1

» Japanese version   » Back

KEGG   DRUG: Dexamethasone 21-tebutateHelp
Entry
D07799                      Drug                                   

Name
Dexamethasone 21-tebutate;
Dexamethasone tertiary butyl acetate;
Dexamedium [veterinary] (TN)
Formula
C28H39FO6
Exact mass
490.2731
Mol weight
490.6041
Structure
Mol fileKCF fileDB search
Simcomp SIMCOMP
Class
Anti-inflammatory
 DG01955  Corticosteroid
  DG02068  Glucocorticoid
Metabolizing enzyme substrate
 DG02913  CYP3A4 substrate
Metabolizing enzyme inducer
 DG01635  CYP3A4 inducer
Remark
ATC code: A01AC02 C05AA09 D07AB19 D07XB05 D10AA03 H02AB02 R01AD03 S01BA01 S01CB01 S02BA06 S03BA01
Chemical structure group: DG00011
Product (DG00011): D00292<JP/US> D00975<JP/US> D01510<JP> D01615<JP> D01632<JP> D01948<JP> D07073<JP>
Efficacy
Anti-inflammatory, Glucocorticoid receptor agonist
Target
NR3C1 (GR) [HSA:2908] [KO:K05771]
  Pathway
hsa04080  Neuroactive ligand-receptor interaction
Metabolism
Enzyme: CYP3A4 [HSA:1576]
Interaction
CYP induction: CYP3A4 [HSA:1576]
Drug interaction
Structure map
map07225  Glucocorticoid and mineralocorticoid receptor agonists/antagonists
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 A ALIMENTARY TRACT AND METABOLISM
  A01 STOMATOLOGICAL PREPARATIONS
   A01A STOMATOLOGICAL PREPARATIONS
    A01AC Corticosteroids for local oral treatment
     A01AC02 Dexamethasone
      D07799  Dexamethasone 21-tebutate
 C CARDIOVASCULAR SYSTEM
  C05 VASOPROTECTIVES
   C05A AGENTS FOR TREATMENT OF HEMORRHOIDS AND ANAL FISSURES FOR TOPICAL USE
    C05AA Corticosteroids
     C05AA09 Dexamethasone
      D07799  Dexamethasone 21-tebutate
 D DERMATOLOGICALS
  D07 CORTICOSTEROIDS, DERMATOLOGICAL PREPARATIONS
   D07A CORTICOSTEROIDS, PLAIN
    D07AB Corticosteroids, moderately potent (group II)
     D07AB19 Dexamethasone
      D07799  Dexamethasone 21-tebutate
   D07X CORTICOSTEROIDS, OTHER COMBINATIONS
    D07XB Corticosteroids, moderately potent, other combinations
     D07XB05 Dexamethasone
      D07799  Dexamethasone 21-tebutate
  D10 ANTI-ACNE PREPARATIONS
   D10A ANTI-ACNE PREPARATIONS FOR TOPICAL USE
    D10AA Corticosteroids, combinations for treatment of acne
     D10AA03 Dexamethasone
      D07799  Dexamethasone 21-tebutate
 H SYSTEMIC HORMONAL PREPARATIONS, EXCL. SEX HORMONES AND INSULINS
  H02 CORTICOSTEROIDS FOR SYSTEMIC USE
   H02A CORTICOSTEROIDS FOR SYSTEMIC USE, PLAIN
    H02AB Glucocorticoids
     H02AB02 Dexamethasone
      D07799  Dexamethasone 21-tebutate
 R RESPIRATORY SYSTEM
  R01 NASAL PREPARATIONS
   R01A DECONGESTANTS AND OTHER NASAL PREPARATIONS FOR TOPICAL USE
    R01AD Corticosteroids
     R01AD03 Dexamethasone
      D07799  Dexamethasone 21-tebutate
 S SENSORY ORGANS
  S01 OPHTHALMOLOGICALS
   S01B ANTIINFLAMMATORY AGENTS
    S01BA Corticosteroids, plain
     S01BA01 Dexamethasone
      D07799  Dexamethasone 21-tebutate
   S01C ANTIINFLAMMATORY AGENTS AND ANTIINFECTIVES IN COMBINATION
    S01CB Corticosteroids/antiinfectives/mydriatics in combination
     S01CB01 Dexamethasone
      D07799  Dexamethasone 21-tebutate
  S02 OTOLOGICALS
   S02B CORTICOSTEROIDS
    S02BA Corticosteroids
     S02BA06 Dexamethasone
      D07799  Dexamethasone 21-tebutate
  S03 OPHTHALMOLOGICAL AND OTOLOGICAL PREPARATIONS
   S03B CORTICOSTEROIDS
    S03BA Corticosteroids
     S03BA01 Dexamethasone
      D07799  Dexamethasone 21-tebutate
Target-based classification of drugs [BR:br08310]
 Nuclear receptors
  Estrogen like receptors
   3-Ketosteroid receptor
    NR3C1 (GR)
     D07799  Dexamethasone 21-tebutate
Drug metabolizing enzymes and transporters [br08309.html]
 Drug metabolizing enzymes
  D07799
BRITE hierarchy
Other DBs
CAS: 24668-75-5
PubChem: 96024496
LigandBox: D07799
NIKKAJI: J286.367G
LinkDB All DBs
KCF data Show

ATOM        35
            1   C2x C    10.9200  -21.4200
            2   C5x C    10.9200  -22.7500
            3   C2x C    12.1100  -23.4500
            4   C2y C    13.3000  -22.7500
            5   C1z C    13.3000  -21.4200
            6   C2x C    12.1100  -20.7900
            7   C1x C    14.4200  -23.4500
            8   C1x C    15.6100  -22.7500
            9   C1y C    15.6100  -21.4200
            10  C1z C    14.4200  -20.7900
            11  C1y C    16.8000  -20.7900
            12  C1z C    16.8000  -19.3900
            13  C1x C    15.6100  -18.7600
            14  C1y C    14.4200  -19.3900
            15  C1x C    19.1800  -20.7900
            16  C1y C    19.1800  -19.3900
            17  C1z C    17.9900  -18.7600
            18  O1a O    18.9700  -17.7800
            19  X   F    14.4200  -22.0500
            20  O5x O     9.8000  -23.4500
            21  C1a C    16.8000  -18.0600
            22  C1a C    13.3000  -20.0900
            23  O1a O    13.5100  -18.4800
            24  C1a C    20.5800  -18.8300
            25  C5a C    17.9900  -16.9400
            26  O5a O    16.8000  -16.2400
            27  C1b C    19.2053  -16.2449
            28  O7a O    20.3937  -16.9377
            29  C7a C    21.5901  -16.2535
            30  C1b C    22.7713  -16.9419
            31  O6a O    21.5855  -14.8402
            32  C1d C    23.9713  -16.2555
            33  C1a C    24.6652  -17.4375
            34  C1a C    25.1215  -15.4889
            35  C1a C    23.2199  -15.0394
BOND        38
            1     1   2 1
            2     2   3 1
            3     3   4 2
            4     4   5 1
            5     5   6 1
            6     1   6 2
            7     4   7 1
            8     7   8 1
            9     8   9 1
            10    9  10 1
            11    5  10 1
            12    9  11 1
            13   11  12 1
            14   12  13 1
            15   13  14 1
            16   10  14 1
            17   15  16 1
            18   16  17 1
            19   12  17 1
            20   17  18 1 #Down
            21   10  19 1 #Down
            22    2  20 2
            23   11  15 1
            24   12  21 1 #Up
            25    5  22 1 #Up
            26   14  23 1 #Up
            27   16  24 1 #Down
            28   25  26 2
            29   17  25 1 #Up
            30   25  27 1
            31   27  28 1
            32   28  29 1
            33   29  30 1
            34   29  31 2
            35   30  32 1
            36   32  33 1
            37   32  34 1
            38   32  35 1

» Japanese version   » Back

KEGG   DRUG: Dexamethasone 21-valerateHelp
Entry
D07800                      Drug                                   

Name
Dexamethasone 21-valerate;
Voalla (TN);
Zalucs (TN)
Formula
C27H37FO6
Exact mass
476.2574
Mol weight
476.5775
Structure
Mol fileKCF fileDB search
Simcomp SIMCOMP
Class
Anti-inflammatory
 DG01955  Corticosteroid
  DG02068  Glucocorticoid
Metabolizing enzyme substrate
 DG02913  CYP3A4 substrate
Metabolizing enzyme inducer
 DG01635  CYP3A4 inducer
Remark
ATC code: A01AC02 C05AA09 D07AB19 D07XB05 D10AA03 H02AB02 R01AD03 S01BA01 S01CB01 S02BA06 S03BA01
Chemical structure group: DG00011
Product (DG00011): D00292<JP/US> D00975<JP/US> D01510<JP> D01615<JP> D01632<JP> D01948<JP> D07073<JP>
Efficacy
Anti-inflammatory, Glucocorticoid receptor agonist
Target
NR3C1 (GR) [HSA:2908] [KO:K05771]
  Pathway
hsa04080  Neuroactive ligand-receptor interaction
Metabolism
Enzyme: CYP3A4 [HSA:1576]
Interaction
CYP induction: CYP3A4 [HSA:1576]
Drug interaction
Structure map
map07225  Glucocorticoid and mineralocorticoid receptor agonists/antagonists
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 A ALIMENTARY TRACT AND METABOLISM
  A01 STOMATOLOGICAL PREPARATIONS
   A01A STOMATOLOGICAL PREPARATIONS
    A01AC Corticosteroids for local oral treatment
     A01AC02 Dexamethasone
      D07800  Dexamethasone 21-valerate
 C CARDIOVASCULAR SYSTEM
  C05 VASOPROTECTIVES
   C05A AGENTS FOR TREATMENT OF HEMORRHOIDS AND ANAL FISSURES FOR TOPICAL USE
    C05AA Corticosteroids
     C05AA09 Dexamethasone
      D07800  Dexamethasone 21-valerate
 D DERMATOLOGICALS
  D07 CORTICOSTEROIDS, DERMATOLOGICAL PREPARATIONS
   D07A CORTICOSTEROIDS, PLAIN
    D07AB Corticosteroids, moderately potent (group II)
     D07AB19 Dexamethasone
      D07800  Dexamethasone 21-valerate
   D07X CORTICOSTEROIDS, OTHER COMBINATIONS
    D07XB Corticosteroids, moderately potent, other combinations
     D07XB05 Dexamethasone
      D07800  Dexamethasone 21-valerate
  D10 ANTI-ACNE PREPARATIONS
   D10A ANTI-ACNE PREPARATIONS FOR TOPICAL USE
    D10AA Corticosteroids, combinations for treatment of acne
     D10AA03 Dexamethasone
      D07800  Dexamethasone 21-valerate
 H SYSTEMIC HORMONAL PREPARATIONS, EXCL. SEX HORMONES AND INSULINS
  H02 CORTICOSTEROIDS FOR SYSTEMIC USE
   H02A CORTICOSTEROIDS FOR SYSTEMIC USE, PLAIN
    H02AB Glucocorticoids
     H02AB02 Dexamethasone
      D07800  Dexamethasone 21-valerate
 R RESPIRATORY SYSTEM
  R01 NASAL PREPARATIONS
   R01A DECONGESTANTS AND OTHER NASAL PREPARATIONS FOR TOPICAL USE
    R01AD Corticosteroids
     R01AD03 Dexamethasone
      D07800  Dexamethasone 21-valerate
 S SENSORY ORGANS
  S01 OPHTHALMOLOGICALS
   S01B ANTIINFLAMMATORY AGENTS
    S01BA Corticosteroids, plain
     S01BA01 Dexamethasone
      D07800  Dexamethasone 21-valerate
   S01C ANTIINFLAMMATORY AGENTS AND ANTIINFECTIVES IN COMBINATION
    S01CB Corticosteroids/antiinfectives/mydriatics in combination
     S01CB01 Dexamethasone
      D07800  Dexamethasone 21-valerate
  S02 OTOLOGICALS
   S02B CORTICOSTEROIDS
    S02BA Corticosteroids
     S02BA06 Dexamethasone
      D07800  Dexamethasone 21-valerate
  S03 OPHTHALMOLOGICAL AND OTOLOGICAL PREPARATIONS
   S03B CORTICOSTEROIDS
    S03BA Corticosteroids
     S03BA01 Dexamethasone
      D07800  Dexamethasone 21-valerate
Target-based classification of drugs [BR:br08310]
 Nuclear receptors
  Estrogen like receptors
   3-Ketosteroid receptor
    NR3C1 (GR)
     D07800  Dexamethasone 21-valerate
Drug metabolizing enzymes and transporters [br08309.html]
 Drug metabolizing enzymes
  D07800
BRITE hierarchy
Other DBs
CAS: 2600-31-9
PubChem: 96024497
LigandBox: D07800
NIKKAJI: J192.109F
LinkDB All DBs
KCF data Show

ATOM        34
            1   C2x C     7.7000  -22.4000
            2   C5x C     7.7000  -23.7300
            3   C2x C     8.8900  -24.4300
            4   C2y C    10.0800  -23.7300
            5   C1z C    10.0800  -22.4000
            6   C2x C     8.8900  -21.7700
            7   C1x C    11.2000  -24.4300
            8   C1x C    12.3900  -23.7300
            9   C1y C    12.3900  -22.4000
            10  C1z C    11.2000  -21.7700
            11  C1y C    13.5800  -21.7700
            12  C1z C    13.5800  -20.3700
            13  C1x C    12.3900  -19.7400
            14  C1y C    11.2000  -20.3700
            15  C1x C    15.9600  -21.7700
            16  C1y C    15.9600  -20.3700
            17  C1z C    14.7700  -19.7400
            18  O1a O    15.7500  -18.7600
            19  X   F    11.2000  -23.0300
            20  O5x O     6.5800  -24.4300
            21  C1a C    13.5800  -19.0400
            22  C1a C    10.0800  -21.0700
            23  O1a O    10.2900  -19.4600
            24  C1a C    17.3600  -19.8100
            25  C5a C    14.7700  -17.9200
            26  O5a O    13.5800  -17.2200
            27  C1b C    15.9853  -17.2249
            28  O7a O    17.1737  -17.9177
            29  C7a C    18.3701  -17.2335
            30  C1b C    19.5513  -17.9219
            31  O6a O    18.3156  -15.8202
            32  C1b C    20.7513  -17.2355
            33  C1b C    21.9308  -17.9229
            34  C1a C    23.1315  -17.2359
BOND        37
            1     1   2 1
            2     2   3 1
            3     3   4 2
            4     4   5 1
            5     5   6 1
            6     1   6 2
            7     4   7 1
            8     7   8 1
            9     8   9 1
            10    9  10 1
            11    5  10 1
            12    9  11 1
            13   11  12 1
            14   12  13 1
            15   13  14 1
            16   10  14 1
            17   15  16 1
            18   16  17 1
            19   12  17 1
            20   17  18 1 #Down
            21   10  19 1 #Down
            22    2  20 2
            23   11  15 1
            24   12  21 1 #Up
            25    5  22 1 #Up
            26   14  23 1 #Up
            27   16  24 1 #Down
            28   25  26 2
            29   17  25 1 #Up
            30   25  27 1
            31   27  28 1
            32   28  29 1
            33   29  30 1
            34   29  31 2
            35   30  32 1
            36   32  33 1
            37   33  34 1

» Japanese version   » Back

KEGG   DRUG: Dexamethasone phenylpropionateHelp
Entry
D07801                      Drug                                   

Name
Dexamethasone phenylpropionate;
Dexafort [veterinary] (TN)
Formula
C31H37FO6
Exact mass
524.2574
Mol weight
524.6203
Structure
Mol fileKCF fileDB search
Simcomp SIMCOMP
Class
Anti-inflammatory
 DG01955  Corticosteroid
  DG02068  Glucocorticoid
Metabolizing enzyme substrate
 DG02913  CYP3A4 substrate
Metabolizing enzyme inducer
 DG01635  CYP3A4 inducer
Remark
ATC code: A01AC02 C05AA09 D07AB19 D07XB05 D10AA03 H02AB02 R01AD03 S01BA01 S01CB01 S02BA06 S03BA01
Chemical structure group: DG00011
Product (DG00011): D00292<JP/US> D00975<JP/US> D01510<JP> D01615<JP> D01632<JP> D01948<JP> D07073<JP>
Efficacy
Anti-inflammatory, Glucocorticoid receptor agonist
Target
NR3C1 (GR) [HSA:2908] [KO:K05771]
  Pathway
hsa04080  Neuroactive ligand-receptor interaction
Metabolism
Enzyme: CYP3A4 [HSA:1576]
Interaction
CYP induction: CYP3A4 [HSA:1576]
Drug interaction
Structure map
map07225  Glucocorticoid and mineralocorticoid receptor agonists/antagonists
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 A ALIMENTARY TRACT AND METABOLISM
  A01 STOMATOLOGICAL PREPARATIONS
   A01A STOMATOLOGICAL PREPARATIONS
    A01AC Corticosteroids for local oral treatment
     A01AC02 Dexamethasone
      D07801  Dexamethasone phenylpropionate
 C CARDIOVASCULAR SYSTEM
  C05 VASOPROTECTIVES
   C05A AGENTS FOR TREATMENT OF HEMORRHOIDS AND ANAL FISSURES FOR TOPICAL USE
    C05AA Corticosteroids
     C05AA09 Dexamethasone
      D07801  Dexamethasone phenylpropionate
 D DERMATOLOGICALS
  D07 CORTICOSTEROIDS, DERMATOLOGICAL PREPARATIONS
   D07A CORTICOSTEROIDS, PLAIN
    D07AB Corticosteroids, moderately potent (group II)
     D07AB19 Dexamethasone
      D07801  Dexamethasone phenylpropionate
   D07X CORTICOSTEROIDS, OTHER COMBINATIONS
    D07XB Corticosteroids, moderately potent, other combinations
     D07XB05 Dexamethasone
      D07801  Dexamethasone phenylpropionate
  D10 ANTI-ACNE PREPARATIONS
   D10A ANTI-ACNE PREPARATIONS FOR TOPICAL USE
    D10AA Corticosteroids, combinations for treatment of acne
     D10AA03 Dexamethasone
      D07801  Dexamethasone phenylpropionate
 H SYSTEMIC HORMONAL PREPARATIONS, EXCL. SEX HORMONES AND INSULINS
  H02 CORTICOSTEROIDS FOR SYSTEMIC USE
   H02A CORTICOSTEROIDS FOR SYSTEMIC USE, PLAIN
    H02AB Glucocorticoids
     H02AB02 Dexamethasone
      D07801  Dexamethasone phenylpropionate
 R RESPIRATORY SYSTEM
  R01 NASAL PREPARATIONS
   R01A DECONGESTANTS AND OTHER NASAL PREPARATIONS FOR TOPICAL USE
    R01AD Corticosteroids
     R01AD03 Dexamethasone
      D07801  Dexamethasone phenylpropionate
 S SENSORY ORGANS
  S01 OPHTHALMOLOGICALS
   S01B ANTIINFLAMMATORY AGENTS
    S01BA Corticosteroids, plain
     S01BA01 Dexamethasone
      D07801  Dexamethasone phenylpropionate
   S01C ANTIINFLAMMATORY AGENTS AND ANTIINFECTIVES IN COMBINATION
    S01CB Corticosteroids/antiinfectives/mydriatics in combination
     S01CB01 Dexamethasone
      D07801  Dexamethasone phenylpropionate
  S02 OTOLOGICALS
   S02B CORTICOSTEROIDS
    S02BA Corticosteroids
     S02BA06 Dexamethasone
      D07801  Dexamethasone phenylpropionate
  S03 OPHTHALMOLOGICAL AND OTOLOGICAL PREPARATIONS
   S03B CORTICOSTEROIDS
    S03BA Corticosteroids
     S03BA01 Dexamethasone
      D07801  Dexamethasone phenylpropionate
Target-based classification of drugs [BR:br08310]
 Nuclear receptors
  Estrogen like receptors
   3-Ketosteroid receptor
    NR3C1 (GR)
     D07801  Dexamethasone phenylpropionate
Drug metabolizing enzymes and transporters [br08309.html]
 Drug metabolizing enzymes
  D07801
BRITE hierarchy
Other DBs
CAS: 1879-72-7
PubChem: 96024498
LigandBox: D07801
NIKKAJI: J199.699A
LinkDB All DBs
KCF data Show

ATOM        38
            1   C2x C    18.4100  -23.8700
            2   C5x C    18.4100  -25.2000
            3   C2x C    19.6700  -25.9000
            4   C2y C    20.8600  -25.2000
            5   C1z C    20.8600  -23.8700
            6   C2x C    19.6700  -23.2400
            7   C1x C    21.9800  -25.9000
            8   C1x C    23.1700  -25.2000
            9   C1y C    23.1700  -23.8700
            10  C1z C    21.9800  -23.2400
            11  C1y C    24.3600  -23.2400
            12  C1z C    24.3600  -21.8400
            13  C1x C    23.1700  -21.2100
            14  C1y C    21.9800  -21.8400
            15  C1x C    26.7400  -23.2400
            16  C1y C    26.7400  -21.8400
            17  C1z C    25.5500  -21.2100
            18  O1a O    26.5300  -20.2300
            19  X   F    21.9800  -24.5000
            20  O5x O    17.2900  -25.9000
            21  C1a C    24.3600  -20.5100
            22  C1a C    20.8600  -22.5400
            23  O1a O    21.0700  -20.9300
            24  C1a C    28.1400  -21.2800
            25  C5a C    25.5500  -19.3900
            26  O5a O    24.3600  -18.6900
            27  C1b C    26.7400  -18.6900
            28  O7a O    27.9300  -19.3900
            29  C7a C    29.1900  -18.6900
            30  C1b C    30.3100  -19.3900
            31  O6a O    29.1900  -17.2900
            32  C1b C    31.5700  -18.6900
            33  C8y C    32.7600  -19.3900
            34  C8x C    32.7486  -20.7900
            35  C8x C    33.9553  -21.4998
            36  C8x C    35.1734  -20.8097
            37  C8x C    35.1148  -19.4097
            38  C8x C    33.9781  -18.6999
BOND        42
            1     1   2 1
            2     2   3 1
            3     3   4 2
            4     4   5 1
            5     5   6 1
            6     1   6 2
            7     4   7 1
            8     7   8 1
            9     8   9 1
            10    9  10 1
            11    5  10 1
            12    9  11 1
            13   11  12 1
            14   12  13 1
            15   13  14 1
            16   10  14 1
            17   15  16 1
            18   16  17 1
            19   12  17 1
            20   17  18 1 #Down
            21   10  19 1 #Down
            22    2  20 2
            23   11  15 1
            24   12  21 1 #Up
            25    5  22 1 #Up
            26   14  23 1 #Up
            27   16  24 1 #Down
            28   25  26 2
            29   17  25 1 #Up
            30   25  27 1
            31   27  28 1
            32   28  29 1
            33   29  30 1
            34   29  31 2
            35   30  32 1
            36   32  33 1
            37   33  34 2
            38   34  35 1
            39   35  36 2
            40   36  37 1
            41   37  38 2
            42   33  38 1

» Japanese version   » Back

KEGG   DRUG: Dexamethasone phosphateHelp
Entry
D07802                      Drug                                   

Name
Dexamethasone phosphate;
Decadron-phosphate (TN)
Formula
C22H30FO8P
Exact mass
472.1662
Mol weight
472.441
Structure
Mol fileKCF fileDB search
Simcomp SIMCOMP
Class
Anti-inflammatory
 DG01955  Corticosteroid
  DG02068  Glucocorticoid
Metabolizing enzyme substrate
 DG02913  CYP3A4 substrate
Metabolizing enzyme inducer
 DG01635  CYP3A4 inducer
Remark
ATC code: A01AC02 C05AA09 D07AB19 D07XB05 D10AA03 H02AB02 R01AD03 S01BA01 S01CB01 S02BA06 S03BA01
Chemical structure group: DG00011
Product (DG00011): D00292<JP/US> D00975<JP/US> D01510<JP> D01615<JP> D01632<JP> D01948<JP> D07073<JP>
Efficacy
Anti-inflammatory, Glucocorticoid receptor agonist
Target
NR3C1 (GR) [HSA:2908] [KO:K05771]
  Pathway
hsa04080  Neuroactive ligand-receptor interaction
Metabolism
Enzyme: CYP3A4 [HSA:1576]
Interaction
CYP induction: CYP3A4 [HSA:1576]
Drug interaction
Structure map
map07225  Glucocorticoid and mineralocorticoid receptor agonists/antagonists
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 A ALIMENTARY TRACT AND METABOLISM
  A01 STOMATOLOGICAL PREPARATIONS
   A01A STOMATOLOGICAL PREPARATIONS
    A01AC Corticosteroids for local oral treatment
     A01AC02 Dexamethasone
      D07802  Dexamethasone phosphate
 C CARDIOVASCULAR SYSTEM
  C05 VASOPROTECTIVES
   C05A AGENTS FOR TREATMENT OF HEMORRHOIDS AND ANAL FISSURES FOR TOPICAL USE
    C05AA Corticosteroids
     C05AA09 Dexamethasone
      D07802  Dexamethasone phosphate
 D DERMATOLOGICALS
  D07 CORTICOSTEROIDS, DERMATOLOGICAL PREPARATIONS
   D07A CORTICOSTEROIDS, PLAIN
    D07AB Corticosteroids, moderately potent (group II)
     D07AB19 Dexamethasone
      D07802  Dexamethasone phosphate
   D07X CORTICOSTEROIDS, OTHER COMBINATIONS
    D07XB Corticosteroids, moderately potent, other combinations
     D07XB05 Dexamethasone
      D07802  Dexamethasone phosphate
  D10 ANTI-ACNE PREPARATIONS
   D10A ANTI-ACNE PREPARATIONS FOR TOPICAL USE
    D10AA Corticosteroids, combinations for treatment of acne
     D10AA03 Dexamethasone
      D07802  Dexamethasone phosphate
 H SYSTEMIC HORMONAL PREPARATIONS, EXCL. SEX HORMONES AND INSULINS
  H02 CORTICOSTEROIDS FOR SYSTEMIC USE
   H02A CORTICOSTEROIDS FOR SYSTEMIC USE, PLAIN
    H02AB Glucocorticoids
     H02AB02 Dexamethasone
      D07802  Dexamethasone phosphate
 R RESPIRATORY SYSTEM
  R01 NASAL PREPARATIONS
   R01A DECONGESTANTS AND OTHER NASAL PREPARATIONS FOR TOPICAL USE
    R01AD Corticosteroids
     R01AD03 Dexamethasone
      D07802  Dexamethasone phosphate
 S SENSORY ORGANS
  S01 OPHTHALMOLOGICALS
   S01B ANTIINFLAMMATORY AGENTS
    S01BA Corticosteroids, plain
     S01BA01 Dexamethasone
      D07802  Dexamethasone phosphate
   S01C ANTIINFLAMMATORY AGENTS AND ANTIINFECTIVES IN COMBINATION
    S01CB Corticosteroids/antiinfectives/mydriatics in combination
     S01CB01 Dexamethasone
      D07802  Dexamethasone phosphate
  S02 OTOLOGICALS
   S02B CORTICOSTEROIDS
    S02BA Corticosteroids
     S02BA06 Dexamethasone
      D07802  Dexamethasone phosphate
  S03 OPHTHALMOLOGICAL AND OTOLOGICAL PREPARATIONS
   S03B CORTICOSTEROIDS
    S03BA Corticosteroids
     S03BA01 Dexamethasone
      D07802  Dexamethasone phosphate
Target-based classification of drugs [BR:br08310]
 Nuclear receptors
  Estrogen like receptors
   3-Ketosteroid receptor
    NR3C1 (GR)
     D07802  Dexamethasone phosphate
Drug metabolizing enzymes and transporters [br08309.html]
 Drug metabolizing enzymes
  D07802
BRITE hierarchy
Other DBs
CAS: 312-93-6
PubChem: 96024499
ChEMBL: CHEMBL1201302 CHEMBL63694
PDB-CCD: 3T5[PDBj]
LigandBox: D07802
NIKKAJI: J5.658H
LinkDB All DBs
KCF data Show

ATOM        32
            1   C1y C    23.5200  -19.2500
            2   C1y C    22.3300  -19.9500
            3   C1z C    23.5200  -17.8500
            4   C1x C    25.9000  -19.2500
            5   C1z C    21.1400  -19.2500
            6   C1x C    22.3300  -21.2800
            7   C1z C    24.7100  -17.2200
            8   C1x C    22.3300  -17.2200
            9   C1a C    23.5200  -16.5200
            10  C1y C    25.9000  -17.9200
            11  C1z C    19.9500  -19.9500
            12  C1y C    21.1400  -17.8500
            13  X   F    21.1400  -20.5800
            14  C1x C    21.1400  -21.9800
            15  C5a C    24.7100  -15.8200
            16  O1a O    26.0400  -16.8000
            17  C1a C    27.2300  -17.7100
            18  C2y C    19.9500  -21.2800
            19  C2x C    18.7600  -19.2500
            20  C1a C    19.9500  -18.5500
            21  O1a O    19.9500  -17.1500
            22  C1b C    25.9000  -15.1200
            23  O5a O    23.5200  -15.1200
            24  C2x C    18.7600  -21.9800
            25  C2x C    17.5700  -19.9500
            26  O2b O    27.0900  -15.8200
            27  C5x C    17.5700  -21.2800
            28  P1b P    28.2100  -15.0500
            29  O5x O    16.3800  -21.9800
            30  O1c O    29.4000  -14.2800
            31  O1c O    27.4400  -13.8600
            32  O1c O    28.9100  -16.2624
BOND        35
            1     1   2 1
            2     1   3 1
            3     1   4 1
            4     2   5 1
            5     2   6 1
            6     3   7 1
            7     3   8 1
            8     3   9 1 #Up
            9     4  10 1
            10    5  11 1
            11    5  12 1
            12    5  13 1 #Down
            13    6  14 1
            14    7  15 1 #Up
            15    7  16 1 #Down
            16   10  17 1 #Down
            17   11  18 1
            18   11  19 1
            19   11  20 1 #Up
            20   12  21 1 #Up
            21   15  22 1
            22   15  23 2
            23   18  24 2
            24   19  25 2
            25   22  26 1
            26   24  27 1
            27   26  28 1
            28   27  29 2
            29   28  30 1
            30   28  31 1
            31    7  10 1
            32    8  12 1
            33   14  18 1
            34   25  27 1
            35   28  32 2

» Japanese version   » Back

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