KEGG   DRUG: FamotidineHelp
Entry
D00318                      Drug                                   

Name
Famotidine (JP17/USP/INN);
Fluxid (TN);
Pepcid (TN)
Product
  Generic
FAMOTIDINE (A-S Medication Solutions), FAMOTIDINE (Aidarex Pharmaceuticals LLC), FAMOTIDINE (Aidarex Pharmaceuticals LLC), FAMOTIDINE (Alembic Pharmaceuticals), FAMOTIDINE (Alembic Pharmaceuticals Limited), FAMOTIDINE (Apotheca), FAMOTIDINE (Aurobindo Pharma Limited), FAMOTIDINE (AvKARE), FAMOTIDINE (AvPAK), FAMOTIDINE (Baxter Healthcare Corporation), FAMOTIDINE (Blenheim Pharmacal), FAMOTIDINE (BluePoint Laboratories), FAMOTIDINE (Bryant Ranch Prepack), FAMOTIDINE (Bryant Ranch Prepack), FAMOTIDINE (Bryant Ranch Prepack), FAMOTIDINE (Bryant Ranch Prepack), FAMOTIDINE (Bryant Ranch Prepack), FAMOTIDINE (Bryant Ranch Prepack), FAMOTIDINE (Cardinal Health), FAMOTIDINE (Cardinal Health), FAMOTIDINE (Cardinal Health), FAMOTIDINE (Carilion Materials Management), FAMOTIDINE (Carilion Materials Management), FAMOTIDINE (Carlsbad Technology), FAMOTIDINE (Clinical Solutions Wholesale), FAMOTIDINE (Contract Pharmacy Services-PA), FAMOTIDINE (DIRECT RX), FAMOTIDINE (Direct Rx), FAMOTIDINE (Dispensing Solutions), FAMOTIDINE (Dr.Reddy's Laboratories Limited), FAMOTIDINE (Fresenius Kabi USA), FAMOTIDINE (Fresenius Kabi USA), FAMOTIDINE (Fresenius Kabi USA), FAMOTIDINE (Golden State Medical Supply), FAMOTIDINE (Hi-Tech Pharmacal), FAMOTIDINE (Lake Erie Medical DBA Quality Care Products LLC), FAMOTIDINE (Legacy Pharmaceutical Packaging), FAMOTIDINE (Lupin Pharmaceuticals), FAMOTIDINE (Lupin Pharmaceuticals), PEPCID (Marathon Pharmaceuticals), FAMOTIDINE (McKesson Corporation), FAMOTIDINE (McKesson Corporation), FAMOTIDINE (Mylan Institutional), FAMOTIDINE (Mylan Institutional LLC), FAMOTIDINE (Mylan Pharmaceuticals), FAMOTIDINE (NCS HealthCare of KY), FAMOTIDINE (NCS HealthCare of KY), FAMOTIDINE (Northwind Pharmaceuticals), FAMOTIDINE (Northwind Pharmaceuticals), FAMOTIDINE (Novel Laboratories), FAMOTIDINE (NuCare Pharmaceutical), FAMOTIDINE (NuCare Pharmaceuticals), FAMOTIDINE (NuCare Pharmaceuticals), FAMOTIDINE (NuCare Pharmaceuticals), FAMOTIDINE (NuCare Pharmaceuticals), FAMOTIDINE (NuCare Pharmaceuticals), FAMOTIDINE (NuCare Pharmaceuticals), FAMOTIDINE (NuCare Pharmaceuticals), FAMOTIDINE (PD-Rx Pharmaceuticals), FAMOTIDINE (PD-Rx Pharmaceuticals), FAMOTIDINE (PD-Rx Pharmaceuticals), FAMOTIDINE (PD-Rx Pharmaceuticals), FAMOTIDINE (PD-Rx Pharmaceuticals), FAMOTIDINE (Preferred Pharmaceuticals), FAMOTIDINE (Preferred Pharmaceuticals), FAMOTIDINE (Preferred Pharmaceuticals), FAMOTIDINE (Preferred Pharmaceuticals), FAMOTIDINE (Preferred Pharmaceuticals), FAMOTIDINE (Preferred Pharmaceuticals), FAMOTIDINE (Proficient Rx LP), FAMOTIDINE (Proficient Rx LP), FAMOTIDINE (Proficient Rx LP), FAMOTIDINE (REMEDYREPACK), FAMOTIDINE (REMEDYREPACK), FAMOTIDINE (REMEDYREPACK), FAMOTIDINE (REMEDYREPACK), FAMOTIDINE (REMEDYREPACK), FAMOTIDINE (REMEDYREPACK), FAMOTIDINE (REMEDYREPACK), FAMOTIDINE (RPK Pharmaceuticals), FAMOTIDINE (RPK Pharmaceuticals), FAMOTIDINE (RedPharm Drug), FAMOTIDINE (RedPharm Drug), FAMOTIDINE (Teva Pharmaceuticals USA), FAMOTIDINE (Unit Dose Services), FAMOTIDINE (Unit Dose Services), FAMOTIDINE (Unit Dose Services), PEPCID (Valeant Pharmaceuticals North America LLC), FAMOTIDINE (West-Ward Pharmaceuticals Corp.), FAMOTIDINE (Wockhardt Limited), FAMOTIDINE (Wockhardt USA LLC.), FAMOTIDINE (Zydus Pharmaceuticals USA)
Formula
C8H15N7O2S3
Exact mass
337.0449
Mol weight
337.4454
Structure
Mol fileKCF fileDB search
Class
Gastrointestinal agent
 DG01481  Histamine receptor H2 antagonist
 DG01975  Agents for peptic ulcer
  DG01481  Histamine receptor H2 antagonist
Enzyme inhibitor
 DG01634  CYP1A2 inhibitor
Transporter substrate
 DG02854  SLC22A2 (OCT2) substrate
 DG02860  SLC22A8 (OAT3) substrate
Transporter inhibitor
 DG02863  SLC22A2 (OCT2) inhibitor
 DG02881  SLC22A3 (OCT3) inhibitor
Remark
Therapeutic category: 2325
ATC code: A02BA03
Product: D00318<JP/US>
Efficacy
Anti-ulcerative, H2 receptor antagonist
  Disease
Duodenal ulcer [DS:H01634]
Gastric ulcer [DS:H01634]
Gastroesophageal reflux disease [DS:H01602]
Zollinger-Ellison syndrome [DS:H01522]
Target
HRH2 [HSA:3274] [KO:K04150]
  Pathway
hsa04020  Calcium signaling pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04971  Gastric acid secretion
Metabolism
Transporter: SLC22A2 [HSA:6582], SLC22A8 [HSA:9376]
Interaction
CYP inhibition: CYP1A2 [HSA:1544]
Transporter inhibition: SLC22A2 [HSA:6582], SLC22A3 [HSA:6581]
Drug interaction
Structure map
map07038  Antiulcer drugs
map07227  Histamine H2/H3 receptor agonists/antagonists
Other map
map04976  Bile secretion
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 A ALIMENTARY TRACT AND METABOLISM
  A02 DRUGS FOR ACID RELATED DISORDERS
   A02B DRUGS FOR PEPTIC ULCER AND GASTRO-OESOPHAGEAL REFLUX DISEASE (GORD)
    A02BA H2-receptor antagonists
     A02BA03 Famotidine
      D00318  Famotidine (JP17/USP/INN) <JP/US>
USP drug classification [BR:br08302]
 Gastrointestinal Agents
  Histamine2 (H2) receptor Antagonists
   Famotidine
    D00318  Famotidine (JP17/USP/INN)
Therapeutic category of drugs in Japan [BR:br08301]
 2  Agents affecting individual organs
  23  Digestive organ agents
   232  Peptic ulcer agents
    2325  H2 blockers
     D00318  Famotidine (JP17/USP/INN)
Classification of Japanese OTC drugs [BR:br08313]
 Agents for digestive organs
  09 Histamine H2 receptor blocker containing drugs
   D00318  Famotidine (JP17/USP/INN)
Risk category of Japanese OTC drugs [BR:br08312]
 First-class OTC drugs
  Inorganic and organic chemicals
   Famotidine
    D00318  Famotidine (JP17/USP/INN)
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Histamine
    HRH2
     D00318  Famotidine (JP17/USP/INN) <JP/US>
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D00318  Famotidine
  D00318  Famotidine tablets
  D00318  Famotidine powder
  D00318  Famotidine injection
  D00318  Famotidine for injection
Drug classes of therapeutic agents [br08360.html]
 Gastrointestinal agents
  D00318
Rx-to-OTC switch list in the USA [br08315.html]
 D00318
Rx-to-OTC switch list in Japan [br08314.html]
 D00318
BRITE hierarchy
Other DBs
CAS: 76824-35-6
PubChem: 7847384
ChEBI: 4975
ChEMBL: CHEMBL902
DrugBank: DB00927
LigandBox: D00318
NIKKAJI: J22.992J
LinkDB All DBs
KCF data Show

ATOM        20
            1   C1b C    21.2100  -23.8000
            2   S2a S    22.4700  -23.1000
            3   C1b C    23.6600  -23.8000
            4   C1b C    24.8500  -23.1000
            5   C2c C    26.1100  -23.8000
            6   N2b N    27.3000  -23.1000
            7   C8y C    20.0200  -23.1000
            8   N5x N    20.0200  -21.7000
            9   C8y C    18.6900  -21.2800
            10  S2x S    17.8500  -22.4000
            11  C8x C    18.6900  -23.5200
            12  N2b N    18.2620  -19.9470
            13  C2c C    16.9019  -19.6530
            14  N1a N    15.9389  -20.7155
            15  N1a N    16.4756  -18.3267
            16  N1a N    26.1272  -25.1999
            17  S4a S    28.5181  -23.7901
            18  O3c O    29.6995  -23.0950
            19  O3c O    28.4598  -25.1994
            20  N1a N    29.7021  -24.5005
BOND        20
            1     1   2 1
            2     2   3 1
            3     3   4 1
            4     4   5 1
            5     5   6 2
            6     1   7 1
            7     7   8 1
            8     8   9 2
            9     9  10 1
            10   10  11 1
            11    7  11 2
            12    9  12 1
            13   12  13 2
            14   13  14 1
            15   13  15 1
            16    5  16 1
            17    6  17 1
            18   17  18 2
            19   17  19 2
            20   17  20 1

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