KEGG   DRUG: FurosemideHelp
Entry
D00331                      Drug                                   

Name
Furosemide (JP17/USP/INN);
Frusemide;
Lasix (TN)
Product
FUROSEMIDE (A-S Medication Solutions), FUROSEMIDE (A-S Medication Solutions), FUROSEMIDE (A-S Medication Solutions), FUROSEMIDE (A-S Medication Solutions), FUROSEMIDE (Aphena Pharma Solutions - Tennessee), FUROSEMIDE (Aphena Pharma Solutions - Tennessee), FUROSEMIDE (Aphena Pharma Solutions - Tennessee), FUROSEMIDE (Aphena Pharma Solutions - Tennessee), FUROSEMIDE (Bryant Ranch Prepack), FUROSEMIDE (Bryant Ranch Prepack), FUROSEMIDE (Cardinal Health), FUROSEMIDE (Cardinal Health), FUROSEMIDE (Cardinal Health), FUROSEMIDE (Cardinal Health), FUROSEMIDE (Cardinal Health), FUROSEMIDE (Contract Pharmacy Services-PA), FUROSEMIDE (Denton Pharma), FUROSEMIDE (Fresenius Kabi USA), FUROSEMIDE (Fresenius Kabi USA), FUROSEMIDE (General Injectables & Vaccines), FUROSEMIDE (Golden State Medical Supply), FUROSEMIDE (HF Acquisition Co LLC), FUROSEMIDE (HF Acquisition Co LLC), FUROSEMIDE (HF Acquisition Co LLC), FUROSEMIDE (Hospira), FUROSEMIDE (Hospira), FUROSEMIDE (Mylan Institutional), FUROSEMIDE (Mylan Pharmaceuticals), FUROSEMIDE (NCS HealthCare of KY), FUROSEMIDE (NCS HealthCare of KY), FUROSEMIDE (NuCare Pharmaceuticals), FUROSEMIDE (NuCare Pharmaceuticals), FUROSEMIDE (PD-Rx Pharmaceuticals), LASIX (REMEDYREPACK), FUROSEMIDE (REMEDYREPACK), FUROSEMIDE (RedPharm Drug), FUROSEMIDE (Sandoz), LASIX (Validus Pharmaceuticals LLC), FUROSEMIDE (West-Ward Pharmaceuticals Corp.)
  Generic
FUROSEMIDE (A-S Medication Solutions), FUROSEMIDE (A-S Medication Solutions), FUROSEMIDE (A-S Medication Solutions), FUROSEMIDE (Amneal Pharmaceuticals LLC), FUROSEMIDE (Aphena Pharma Solutions - Tennessee), FUROSEMIDE (Aphena Pharma Solutions - Tennessee), FUROSEMIDE (Aphena Pharma Solutions - Tennessee), FUROSEMIDE (Aphena Pharma Solutions - Tennessee), FUROSEMIDE (Apotheca), FUROSEMIDE (Apotheca), FUROSEMIDE (AuroMedics Pharma LLC), FUROSEMIDE (Baxter Healthcare Corporation), FUROSEMIDE (Bryant Ranch Prepack), FUROSEMIDE (Bryant Ranch Prepack), FUROSEMIDE (Bryant Ranch Prepack), FUROSEMIDE (Cardinal Health), FUROSEMIDE (Cardinal Health), FUROSEMIDE (Clinical Solutions Wholesale), FUROSEMIDE (DIRECT RX), FUROSEMIDE (DOH CENTRAL PHARMACY), FUROSEMIDE (Denton Pharma), FUROSEMIDE (Denton Pharma), FUROSEMIDE (General Injectables & Vaccines), FUROSEMIDE (General Injectables & Vaccines), FUROSEMIDE (General Injectables & Vaccines), FUROSEMIDE (General Injectables and Vaccines), FUROSEMIDE (General Injectables and Vaccines), FUROSEMIDE (Heritage Pharmaceuticals Inc. d/b/a Avet Pharmaceuticals), DIASCREEN 12-PANEL MEDICATED COLLECTION SYSTEM (IT3 Medical LLC), FUROSEMIDE (IT3 Medical LLC), FUROSEMIDE (IT3 Medical LLC), TOXYCOLOGY MEDICATED COLLECTION SYSTEM (IT3 Medical LLC), FUROSEMIDE (Lake Erie Medical DBA Quality Care Products LLC), FUROSEMIDE (Lake Erie Medical DBA Quality Care Products LLC), FUROSEMIDE (Leading Pharma), FUROSEMIDE (McKesson Corporation dba SKY Packaging), FUROSEMIDE (Medical Purchasing Solutions), FUROSEMIDE (Medical Purchasing Solutions), FUROSEMIDE (Morton Grove Pharmaceuticals), FUROSEMIDE (NuCare Pharmaceuticals), FUROSEMIDE (NuCare Pharmaceuticals), FUROSEMIDE (NuCare Pharmaceuticals), FUROSEMIDE (NuCare Pharmaceuticals), FUROSEMIDE (NuCare Pharmaceuticals), FUROSEMIDE (NuCare Pharmaceuticals), FUROSEMIDE (NuCare Pharmaceuticals), FUROSEMIDE (NuCare Pharmaceuticals), FUROSEMIDE (NuCare Pharmaceuticals), FUROSEMIDE (PD-Rx Pharmaceuticals), FUROSEMIDE (PD-Rx Pharmaceuticals), FUROSEMIDE (PD-Rx Pharmaceuticals), FUROSEMIDE (PD-Rx Pharmaceuticals), FUROSEMIDE (PD-Rx Pharmaceuticals), FUROSEMIDE (PD-Rx Pharmaceuticals), FUROSEMIDE (Precision Dose), FUROSEMIDE (Precision Dose), FUROSEMIDE (Preferred Pharmaceuticals), FUROSEMIDE (Preferred Pharmaceuticals), FUROSEMIDE (Preferred Pharmaceuticals), FUROSEMIDE (Preferred Pharmaceuticals), FUROSEMIDE (Proficient Rx LP), FUROSEMIDE (Proficient Rx LP), FUROSEMIDE (Proficient Rx LP), FUROSEMIDE (Proficient Rx LP), FUROSEMIDE (QPharma), FUROSEMIDE (QPharma), FUROSEMIDE (REMEDYREPACK), FUROSEMIDE (REMEDYREPACK), FUROSEMIDE (REMEDYREPACK), FUROSEMIDE (RedPharm Drug), FUROSEMIDE (RedPharm Drug), FUROSEMIDE (RedPharm Drug), FUROSEMIDE (Solco Healthcare LLC), FUROSEMIDE (St Mary's Medical Park Pharmacy), FUROSEMIDE (St Marys Medical Park Pharmacy), FUROSEMIDE (St. Mary's Medical Park Pharmacy), FUROSEMIDE (St. Mary's Medical Park Pharmacy), FUROSEMIDE (Wockhardt USA LLC.)
Formula
C12H11ClN2O5S
Exact mass
330.0077
Mol weight
330.7441
Structure
Mol fileKCF fileDB search
Simcomp SIMCOMP
Class
Cardiovascular agent
 DG01690  Sulfonamide diuretic
  DG01747  Furosemide type diuretic
 DG01748  Loop diuretic
  DG01747  Furosemide type diuretic
Transporter substrate
 DG02920  ABCC4 substrate
 DG02859  SLC22A6 (OAT1) substrate
 DG02860  SLC22A8 (OAT3) substrate
Remark
Same as: C07017
Therapeutic category: 2139 2149
ATC code: C03CA01
Chemical structure group: DG00272
Product (DG00272): D00331<JP/US>
Efficacy
Diuretic, Na-K-Cl cotransporter inhibitor
  Disease
Hypertension [DS:H01633]
Comment
Loop diuretic
Sulfonamide derivative
Target
SLC12A1 (NKCC2) [HSA:6557] [KO:K14425]
SLC12A2 (NKCC1) [HSA:6558] [KO:K10951]
Metabolism
Transporter: SLC22A6 [HSA:9356], SLC22A8 [HSA:9376], ABCC4 [HSA:10257]
Interaction
Drug interaction
Structure map
map07017  Sulfonamide derivatives - diuretics
map07055  Sulfonamide derivatives - overview
map07233  Ion transporter inhibitors
Other map
map04976  Bile secretion
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 C CARDIOVASCULAR SYSTEM
  C03 DIURETICS
   C03C HIGH-CEILING DIURETICS
    C03CA Sulfonamides, plain
     C03CA01 Furosemide
      D00331  Furosemide (JP17/USP/INN) <JP/US>
USP drug classification [BR:br08302]
 Cardiovascular Agents
  Diuretics, Loop
   Furosemide
    D00331  Furosemide (JP17/USP/INN)
Therapeutic category of drugs in Japan [BR:br08301]
 2  Agents affecting individual organs
  21  Cardiovascular agents
   213  Diuretics
    2139  Others
     D00331  Furosemide (JP17/USP/INN)
   214  Antihypertensives
    2149  Others
     D00331  Furosemide (JP17/USP/INN)
Target-based classification of drugs [BR:br08310]
 Transporters
  Solute carrier family
   SLC12
    SLC12A1 (NKCC2)
     D00331  Furosemide (JP17/USP/INN) <JP/US>
    SLC12A2 (NKCC1)
     D00331  Furosemide (JP17/USP/INN) <JP/US>
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D00331  Furosemide
  D00331  Furosemide tablets
  D00331  Furosemide injection
Drug metabolizing enzymes and transporters [br08309.html]
 Drug transporters
  D00331
BRITE hierarchy
Other DBs
CAS: 54-31-9
PubChem: 7847397
ChEBI: 47426
ChEMBL: CHEMBL35
DrugBank: DB00695
PDB-CCD: FUN[PDBj]
LigandBox: D00331
NIKKAJI: J1.913E
LinkDB All DBs
KCF data Show

ATOM        21
            1   C8y C    33.0198  -14.5445
            2   C8y C    31.8035  -15.2369
            3   C8x C    34.2301  -15.2545
            4   C6a C    33.0314  -13.1420
            5   C8x C    31.7978  -16.6395
            6   N1b N    30.5932  -14.5270
            7   C8y C    34.2185  -16.6511
            8   O6a O    31.8211  -12.4379
            9   O6a O    34.2477  -12.4553
            10  C8y C    33.0024  -17.3436
            11  C1b C    29.3827  -15.2253
            12  S4a S    35.4290  -17.3552
            13  X   Cl   32.9965  -18.7402
            14  C8y C    28.1781  -14.5153
            15  N1a N    36.6336  -18.0652
            16  O3c O    34.7364  -18.5772
            17  O3c O    36.1506  -16.1623
            18  O2x O    28.1781  -13.1153
            19  C8x C    26.8466  -12.6826
            20  C8x C    26.0237  -13.8153
            21  C8x C    26.8466  -14.9479
BOND        22
            1     1   2 2
            2     1   3 1
            3     1   4 1
            4     2   5 1
            5     2   6 1
            6     3   7 2
            7     4   8 2
            8     4   9 1
            9     5  10 2
            10    6  11 1
            11    7  12 1
            12   10  13 1
            13   11  14 1
            14   12  15 1
            15   12  16 2
            16   12  17 2
            17    7  10 1
            18   14  18 1
            19   18  19 1
            20   19  20 2
            21   20  21 1
            22   14  21 2

» Japanese version   » Back

KEGG   DRUG: Sodium furosemideHelp
Entry
D07999                      Drug                                   

Name
Sodium furosemide;
Frosemide sodium;
Lasix (TN)
Formula
C12H10ClN2O5S. Na
Exact mass
351.9897
Mol weight
352.726
Structure
Mol fileKCF fileDB search
Simcomp SIMCOMP
Class
Cardiovascular agent
 DG01690  Sulfonamide diuretic
  DG01747  Furosemide type diuretic
 DG01748  Loop diuretic
  DG01747  Furosemide type diuretic
Transporter substrate
 DG02920  ABCC4 substrate
 DG02859  SLC22A6 (OAT1) substrate
 DG02860  SLC22A8 (OAT3) substrate
Remark
ATC code: C03CA01
Chemical structure group: DG00272
Product (DG00272): D00331<JP/US>
Efficacy
Diuretic, Na-K-Cl cotransporter inhibitor
Comment
loop diuretic
Sulufonamide derivative
Target
SLC12A1 (NKCC2) [HSA:6557] [KO:K14425]
SLC12A2 (NKCC1) [HSA:6558] [KO:K10951]
Metabolism
Transporter: SLC22A6 [HSA:9356], SLC22A8 [HSA:9376], ABCC4 [HSA:10257]
Interaction
Drug interaction
Structure map
map07017  Sulfonamide derivatives - diuretics
map07055  Sulfonamide derivatives - overview
map07233  Ion transporter inhibitors
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 C CARDIOVASCULAR SYSTEM
  C03 DIURETICS
   C03C HIGH-CEILING DIURETICS
    C03CA Sulfonamides, plain
     C03CA01 Furosemide
      D07999  Sodium furosemide
Target-based classification of drugs [BR:br08310]
 Transporters
  Solute carrier family
   SLC12
    SLC12A1 (NKCC2)
     D07999  Sodium furosemide
    SLC12A2 (NKCC1)
     D07999  Sodium furosemide
Drug metabolizing enzymes and transporters [br08309.html]
 Drug transporters
  D07999
BRITE hierarchy
Other DBs
CAS: 41733-55-5
PubChem: 96024692
LigandBox: D07999
NIKKAJI: J278.262F
LinkDB All DBs
KCF data Show

ATOM        22
            1   C8y C    25.8300  -16.8700
            2   C8y C    24.5700  -17.5700
            3   C8x C    27.0200  -17.5700
            4   C6a C    25.8300  -15.4700
            5   C8x C    24.5700  -18.9700
            6   N1b N    23.3800  -16.8700
            7   C8y C    27.0200  -18.9700
            8   O6a O    24.6400  -14.7700
            9   O6a O    27.0200  -14.7700 #-
            10  C8y C    25.8300  -19.6700
            11  C1b C    22.1900  -17.5700
            12  S4a S    28.2100  -19.6700
            13  X   Cl   25.8300  -21.0700
            14  C8y C    21.0000  -16.8000
            15  N1a N    29.4700  -20.3700
            16  O3c O    27.5100  -20.8600
            17  O3c O    28.9800  -18.4800
            18  O2x O    21.0000  -15.4000
            19  C8x C    19.6700  -14.9800
            20  C8x C    18.8300  -16.1000
            21  C8x C    19.6700  -17.2900
            22  Z   Na   30.0300  -14.5600 #+
BOND        22
            1     1   2 2
            2     1   3 1
            3     1   4 1
            4     2   5 1
            5     2   6 1
            6     3   7 2
            7     4   8 2
            8     4   9 1
            9     5  10 2
            10    6  11 1
            11    7  12 1
            12   10  13 1
            13   11  14 1
            14   12  15 1
            15   12  16 2
            16   12  17 2
            17    7  10 1
            18   14  18 1
            19   18  19 1
            20   19  20 2
            21   20  21 1
            22   14  21 2

» Japanese version   » Back

KEGG   DRUG: Furosemide diolamineHelp
Entry
D08001                      Drug                                   

Name
Furosemide diolamine;
Furosemide diethanolamine salt;
Nuriban (TN)
Formula
C12H11ClN2O5S. C4H11NO2
Exact mass
435.0867
Mol weight
435.8798
Structure
Mol fileKCF fileDB search
Class
Cardiovascular agent
 DG01690  Sulfonamide diuretic
  DG01747  Furosemide type diuretic
 DG01748  Loop diuretic
  DG01747  Furosemide type diuretic
Transporter substrate
 DG02920  ABCC4 substrate
 DG02859  SLC22A6 (OAT1) substrate
 DG02860  SLC22A8 (OAT3) substrate
Remark
ATC code: C03CA01
Chemical structure group: DG00272
Product (DG00272): D00331<JP/US>
Efficacy
Diuretic, Na-K-Cl cotransporter inhibitor
Comment
loop diuretic
Sulufonamide derivative
Target
SLC12A1 (NKCC2) [HSA:6557] [KO:K14425]
SLC12A2 (NKCC1) [HSA:6558] [KO:K10951]
Metabolism
Transporter: SLC22A6 [HSA:9356], SLC22A8 [HSA:9376], ABCC4 [HSA:10257]
Interaction
Drug interaction
Structure map
map07017  Sulfonamide derivatives - diuretics
map07055  Sulfonamide derivatives - overview
map07233  Ion transporter inhibitors
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 C CARDIOVASCULAR SYSTEM
  C03 DIURETICS
   C03C HIGH-CEILING DIURETICS
    C03CA Sulfonamides, plain
     C03CA01 Furosemide
      D08001  Furosemide diolamine
Target-based classification of drugs [BR:br08310]
 Transporters
  Solute carrier family
   SLC12
    SLC12A1 (NKCC2)
     D08001  Furosemide diolamine
    SLC12A2 (NKCC1)
     D08001  Furosemide diolamine
Drug metabolizing enzymes and transporters [br08309.html]
 Drug transporters
  D08001
BRITE hierarchy
Other DBs
PubChem: 96024694
LigandBox: D08001
LinkDB All DBs
KCF data Show

ATOM        28
            1   C8y C    20.2300  -16.8700
            2   C8y C    18.9700  -17.5700
            3   C8x C    21.4200  -17.5700
            4   C6a C    20.2300  -15.4700
            5   C8x C    18.9700  -18.9700
            6   N1b N    17.7800  -16.8700
            7   C8y C    21.4200  -18.9700
            8   O6a O    19.0400  -14.7700
            9   O6a O    21.4200  -14.7700
            10  C8y C    20.2300  -19.6700
            11  C1b C    16.5900  -17.5700
            12  S4a S    22.6100  -19.6700
            13  X   Cl   20.2300  -21.0700
            14  C8y C    15.4000  -16.8000
            15  N1a N    23.8700  -20.3700
            16  O3c O    21.9100  -20.8600
            17  O3c O    23.3800  -18.4800
            18  O2x O    15.4000  -15.4000
            19  C8x C    14.0700  -14.9800
            20  C8x C    13.2300  -16.1000
            21  C8x C    14.0700  -17.2900
            22  O1a O    28.1400  -18.6200
            23  C1b C    29.3524  -17.9200
            24  C1b C    30.5649  -18.6200
            25  N1b N    31.7773  -17.9200
            26  C1b C    32.9897  -18.6200
            27  C1b C    34.2022  -17.9200
            28  O1a O    35.4146  -18.6200
BOND        28
            1     1   2 2
            2     1   3 1
            3     1   4 1
            4     2   5 1
            5     2   6 1
            6     3   7 2
            7     4   8 2
            8     4   9 1
            9     5  10 2
            10    6  11 1
            11    7  12 1
            12   10  13 1
            13   11  14 1
            14   12  15 1
            15   12  16 2
            16   12  17 2
            17    7  10 1
            18   14  18 1
            19   18  19 1
            20   19  20 2
            21   20  21 1
            22   14  21 2
            23   22  23 1
            24   23  24 1
            25   24  25 1
            26   25  26 1
            27   26  27 1
            28   27  28 1

» Japanese version   » Back

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