KEGG   DRUG: IndapamideHelp
Entry
D00345                      Drug                                   

Name
Indapamide (JP17/USP);
Lozol (TN);
Natrix (TN)
Product
  Generic
Formula
C16H16ClN3O3S
Exact mass
365.0601
Mol weight
365.8345
Structure
Mol fileKCF fileDB search
Simcomp SIMCOMP
Class
Cardiovascular agent
 DG01690  Sulfonamide diuretic
 DG02992  Thiazide related diuretic
Remark
Therapeutic category: 2149
ATC code: C03BA11
Chemical structure group: DG00269
Product (DG00269): D00345<JP/US>
Efficacy
Antihypertensive, Diuretic, Na+-Cl- symport inhibitor
  Disease
Hypertension [DS:H01633]
Comment
Sulfonamide derivative
Target
SLC12A3 (TSC) [HSA:6559] [KO:K14426]
Interaction
Drug interaction
Structure map
map07017  Sulfonamide derivatives - diuretics
map07055  Sulfonamide derivatives - overview
map07233  Ion transporter inhibitors
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 C CARDIOVASCULAR SYSTEM
  C03 DIURETICS
   C03B LOW-CEILING DIURETICS, EXCL. THIAZIDES
    C03BA Sulfonamides, plain
     C03BA11 Indapamide
      D00345  Indapamide (JP17/USP) <JP/US>
USP drug classification [BR:br08302]
 Cardiovascular Agents
  Diuretics, Thiazide
   Indapamide
    D00345  Indapamide (JP17/USP)
Therapeutic category of drugs in Japan [BR:br08301]
 2  Agents affecting individual organs
  21  Cardiovascular agents
   214  Antihypertensives
    2149  Others
     D00345  Indapamide (JP17/USP)
Target-based classification of drugs [BR:br08310]
 Transporters
  Solute carrier family
   SLC12
    SLC12A3 (TSC)
     D00345  Indapamide (JP17/USP) <JP/US>
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D00345  Indapamide
  D00345  Indapamide tablets
BRITE hierarchy
Other DBs
CAS: 26807-65-8
PubChem: 7847411
ChEBI: 5893
ChEMBL: CHEMBL406
DrugBank: DB00808
LigandBox: D00345
NIKKAJI: J10.425F
LinkDB All DBs
KCF data Show

ATOM        24
            1   C8x C    16.4080  -16.4924
            2   C8x C    16.4080  -17.8843
            3   C8x C    17.6134  -18.5803
            4   C8x C    18.8190  -17.8843
            5   C8y C    18.8190  -16.4924
            6   C8y C    17.6134  -15.7964
            7   N1y N    20.0245  -15.7964
            8   C1y C    19.5262  -14.4348
            9   C1x C    18.0723  -14.4284
            10  N1b N    21.2300  -16.4924
            11  C5a C    22.4355  -15.7964
            12  C1a C    20.3390  -13.2774
            13  C8y C    23.6841  -16.5171
            14  O5a O    22.4361  -14.4204
            15  C8x C    23.6842  -17.9198
            16  C8x C    24.8967  -18.6197
            17  C8y C    26.1091  -17.9196
            18  C8y C    26.1090  -16.5169
            19  C8x C    24.8965  -15.8170
            20  S4a S    27.3208  -15.8172
            21  X   Cl   27.3224  -18.6200
            22  N1a N    28.5332  -15.1172
            23  O3c O    26.6169  -14.5979
            24  O3c O    28.0167  -17.0226
BOND        26
            1     1   2 2
            2     2   3 1
            3     3   4 2
            4     4   5 1
            5     5   6 2
            6     1   6 1
            7     5   7 1
            8     7   8 1
            9     8   9 1
            10    9   6 1
            11   10  11 1
            12    7  10 1
            13    8  12 1
            14   11  13 1
            15   11  14 2
            16   13  15 2
            17   15  16 1
            18   16  17 2
            19   17  18 1
            20   18  19 2
            21   13  19 1
            22   18  20 1
            23   17  21 1
            24   20  22 1
            25   20  23 2
            26   20  24 2

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KEGG   DRUG: Indapamide hydrateHelp
Entry
D06401                      Drug                                   

Name
Indapamide hydrate;
Tenaxil (TN)
Formula
(C16H16ClN3O3S)2. H2O
Exact mass
748.1307
Mol weight
749.6844
Structure
Mol fileKCF fileDB search
Class
Cardiovascular agent
 DG01690  Sulfonamide diuretic
 DG02992  Thiazide related diuretic
Remark
ATC code: C03BA11
Chemical structure group: DG00269
Product (DG00269): D00345<JP/US>
Efficacy
Antihypertensive, Diuretic, Na+-Cl- symport inhibitor
Target
SLC12A3 (TSC) [HSA:6559] [KO:K14426]
Interaction
Drug interaction
Structure map
map07017  Sulfonamide derivatives - diuretics
map07055  Sulfonamide derivatives - overview
map07233  Ion transporter inhibitors
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 C CARDIOVASCULAR SYSTEM
  C03 DIURETICS
   C03B LOW-CEILING DIURETICS, EXCL. THIAZIDES
    C03BA Sulfonamides, plain
     C03BA11 Indapamide
      D06401  Indapamide hydrate
Target-based classification of drugs [BR:br08310]
 Transporters
  Solute carrier family
   SLC12
    SLC12A3 (TSC)
     D06401  Indapamide hydrate
BRITE hierarchy
Other DBs
PubChem: 47208058
DrugBank: DB00808
LigandBox: D06401
LinkDB All DBs
KCF data Show

ATOM        49
            1   C8x C    24.5477  -14.8319
            2   C8x C    24.5477  -16.2195
            3   C8x C    25.7494  -16.9134
            4   C8x C    26.9513  -16.2195
            5   C8y C    26.9513  -14.8319
            6   C8y C    25.7494  -14.1380
            7   N1y N    28.1531  -14.1380
            8   C1y C    27.6564  -12.7106
            9   C1x C    26.2069  -12.7742
            10  N1b N    29.3549  -14.8319
            11  C5a C    30.5568  -14.1380
            12  C1a C    28.4667  -11.6267
            13  C8y C    31.8015  -14.8565
            14  O5a O    30.5573  -12.7662
            15  C8x C    31.8016  -16.2549
            16  C8x C    33.0104  -16.9526
            17  C8y C    34.2191  -16.2547
            18  C8y C    34.2190  -14.8563
            19  C8x C    33.0102  -14.1585
            20  S4a S    35.4271  -14.1587
            21  X   Cl   35.4287  -16.9529
            22  N1a N    36.6358  -13.4609
            23  O3c O    34.7253  -12.9432
            24  O3c O    36.1208  -15.3604
            25  O0  O    40.9500  -14.7000
            26  C8x C    24.5477  -14.8319
            27  C8x C    24.5477  -16.2195
            28  C8x C    25.7494  -16.9134
            29  C8x C    26.9513  -16.2195
            30  C8y C    26.9513  -14.8319
            31  C8y C    25.7494  -14.1380
            32  C1x C    26.2069  -12.7742
            33  C1y C    27.6564  -12.7106
            34  N1y N    28.1531  -14.1380
            35  N1b N    29.3549  -14.8319
            36  C5a C    30.5568  -14.1380
            37  C8y C    31.8015  -14.8565
            38  C8x C    31.8016  -16.2549
            39  C8x C    33.0104  -16.9526
            40  C8y C    34.2191  -16.2547
            41  C8y C    34.2190  -14.8563
            42  C8x C    33.0102  -14.1585
            43  S4a S    35.4271  -14.1587
            44  N1a N    36.6358  -13.4609
            45  O3c O    34.7253  -12.9432
            46  O3c O    36.1208  -15.3604
            47  X   Cl   35.4287  -16.9529
            48  O5a O    30.5573  -12.7662
            49  C1a C    28.4667  -11.6267
BOND        52
            1     1   2 2
            2     2   3 1
            3     3   4 2
            4     4   5 1
            5     5   6 2
            6     1   6 1
            7     5   7 1
            8     7   8 1
            9     8   9 1
            10    9   6 1
            11   10  11 1
            12    7  10 1
            13    8  12 1
            14   11  13 1
            15   11  14 2
            16   13  15 2
            17   15  16 1
            18   16  17 2
            19   17  18 1
            20   18  19 2
            21   13  19 1
            22   18  20 1
            23   17  21 1
            24   20  22 1
            25   20  23 2
            26   20  24 2
            27   26  27 2
            28   27  28 1
            29   28  29 2
            30   29  30 1
            31   30  31 2
            32   26  31 1
            33   30  34 1
            34   34  33 1
            35   33  32 1
            36   32  31 1
            37   35  36 1
            38   34  35 1
            39   33  49 1
            40   36  37 1
            41   36  48 2
            42   37  38 2
            43   38  39 1
            44   39  40 2
            45   40  41 1
            46   41  42 2
            47   37  42 1
            48   41  43 1
            49   40  47 1
            50   43  44 1
            51   43  45 2
            52   43  46 2
BRACKET     1    24.1500  -17.7100   24.1500  -10.9200
            1    38.0800  -10.9200   38.0800  -17.7100
            1  2
 ORIGINAL  1    1   2   3   4   5   6   9   8   7  10  11  13  15  16  17  18
            1   19  20  22  23  24  21  14  12
 REPEAT    1   26  27  28  29  30  31  32  33  34  35  36  37  38  39  40  41
            1   42  43  44  45  46  47  48  49

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