DRUG: Lorazepam
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Entry
D00365 Drug
Name
Lorazepam (JP17/USP/INN);
Ativan (TN)
Product
ATIVAN (Bausch Health US LLC)
,
LORAZEPAM (Civica)
,
ATIVAN (Hikma Pharmaceuticals USA)
,
LORAZEPAM (West-Ward Pharmaceuticals Corp.)
,
LORAZEPAM (West-Ward Pharmaceuticals Corp.)
,
LORAZEPAM (West-Ward Pharmaceuticals Corp.)
Generic
LORAZEPAM (A-S Medication Solutions)
,
LORAZEPAM (A-S Medication Solutions)
,
LORAZEPAM (A-S Medication Solutions)
,
LORAZEPAM (A-S Medication Solutions)
,
LORAZEPAM (A-S Medication Solutions)
,
LORAZEPAM (A-S Medication Solutions)
,
LORAZEPAM (A-S Medication Solutions)
,
LORAZEPAM (A-S Medication Solutions)
,
LORAZEPAM (ATLANTIC BIOLOGICALS CORP.)
,
LORAZEPAM (ATLANTIC BIOLOGICALS CORP.)
,
LORAZEPAM (Actavis Pharma)
,
LORAZEPAM (Akorn)
,
LORAZEPAM (American Health Packaging)
,
LORAZEPAM (Amneal Pharmaceuticals LLC)
,
LORAZEPAM (Amneal Pharmaceuticals LLC)
,
LORAZEPAM (Aphena Pharma Solutions - Tennessee)
,
LORAZEPAM (Aphena Pharma Solutions - Tennessee)
,
LORAZEPAM (Aphena Pharma Solutions - Tennessee)
,
LORAZEPAM (Aphena Pharma Solutions - Tennessee)
,
LORAZEPAM (Aphena Pharma Solutions - Tennessee)
,
LORAZEPAM (Aphena Pharma Solutions - Tennessee)
,
LORAZEPAM (Aphena Pharma Solutions - Tennessee)
,
LORAZEPAM (Aphena Pharma Solutions - Tennessee)
,
LORAZEPAM (Aphena Pharma Solutions - Tennessee)
,
LORAZEPAM (Aphena Pharma Solutions - Tennessee)
,
LORAZEPAM (Aurolife Pharma)
,
LORAZEPAM (Bryant Ranch Prepack)
,
LORAZEPAM (Bryant Ranch Prepack)
,
LORAZEPAM (Bryant Ranch Prepack)
,
LORAZEPAM (Bryant Ranch Prepack)
,
LORAZEPAM (Bryant Ranch Prepack)
,
LORAZEPAM (Cardinal Health)
,
LORAZEPAM (Clinical Solutions Wholesale)
,
LORAZEPAM (Contract Pharmacy Services-PA)
,
LORAZEPAM (Contract Pharmacy Services-PA)
,
LORAZEPAM (DIRECT RX)
,
LORAZEPAM (Denton Pharma)
,
LORAZEPAM (DirectRX)
,
LORAZEPAM (Direct_Rx)
,
LORAZEPAM (Hospira)
,
LORAZEPAM (Hospira)
,
LORAZEPAM (Hospira)
,
LORAZEPAM (International Medication Systems)
,
LORAZEPAM (Leading Pharma)
,
LORAZEPAM (Major Pharmaceuticals)
,
LORAZEPAM (Medsource Pharmaceuticals)
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LORAZEPAM (NCS HealthCare of KY)
,
LORAZEPAM (NuCare Pharmaceuticals)
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LORAZEPAM (NuCare Pharmaceuticals)
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LORAZEPAM (NuCare Pharmaceuticals)
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LORAZEPAM (NuCare Pharmaceuticals)
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LORAZEPAM (NuCare Pharmaceuticals)
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LORAZEPAM (NuCare Pharmaceuticals)
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LORAZEPAM (NuCare Pharmaceuticals)
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LORAZEPAM (NuCare Pharmaceuticals)
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LORAZEPAM (NuCare Pharmaceuticals)
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LORAZEPAM (NuCare Pharmaceuticals)
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LORAZEPAM (NuCare Pharmaceuticals)
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LORAZEPAM (NuCare Pharmaceuticals)
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LORAZEPAM (NuCare Pharmaceuticals)
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LORAZEPAM (NuCare Pharmaceuticals)
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LORAZEPAM (PD-Rx Pharmaceuticals)
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LORAZEPAM (PD-Rx Pharmaceuticals)
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LORAZEPAM (PD-Rx Pharmaceuticals)
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LORAZEPAM (PD-Rx Pharmaceuticals)
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LORAZEPAM (PD-Rx Pharmaceuticals)
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LORAZEPAM (PharmPak)
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LORAZEPAM (PharmPak)
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LORAZEPAM (Pharmaceutical Associates)
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LORAZEPAM (Preferred Pharmaceuticals)
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LORAZEPAM (Preferred Pharmaceuticals)
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LORAZEPAM (Preferred Pharmaceuticals)
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LORAZEPAM (Preferred Pharmaceuticals)
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LORAZEPAM (Proficient Rx LP)
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LORAZEPAM (Proficient Rx LP)
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LORAZEPAM (Proficient Rx LP)
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LORAZEPAM (Proficient Rx LP)
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LORAZEPAM (Proficient Rx LP)
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LORAZEPAM (Proficient Rx LP)
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LORAZEPAM (Quality Care Products)
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LORAZEPAM (Quality Care Products)
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LORAZEPAM (REMEDYREPACK)
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LORAZEPAM (REMEDYREPACK)
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LORAZEPAM (REMEDYREPACK)
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LORAZEPAM (REMEDYREPACK)
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LORAZEPAM (REMEDYREPACK)
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LORAZEPAM (REMEDYREPACK)
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LORAZEPAM (REMEDYREPACK)
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LORAZEPAM (REMEDYREPACK)
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LORAZEPAM (RPK Pharmaceuticals)
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LORAZEPAM (RPK Pharmaceuticals)
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LORAZEPAM (RPK Pharmaceuticals)
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LORAZEPAM (RPK Pharmaceuticals)
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LORAZEPAM (RedPharm Drug)
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LORAZEPAM (RedPharm Drug)
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LORAZEPAM (RedPharm Drug)
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LORAZEPAM (RedPharm Drug)
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LORAZEPAM (RedPharm Drug)
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LORAZEPAM (RedPharm Drug)
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LORAZEPAM (RedPharm Drug)
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LORAZEPAM (RedPharm Drug)
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LORAZEPAM (Sandoz)
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LORAZEPAM (St. Mary's Medical Park Pharmacy)
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LORAZEPAM (St. Mary's Medical Park Pharmacy)
,
LORAZEPAM (West-Ward Pharmaceuticals Corp.)
Formula
C15H10Cl2N2O2
Exact mass
320.0119
Mol weight
321.1581
Structure
Mol file
KCF file
DB search
Simcomp
Neighbor
Class
Neuropsychiatric agent
DG01567
GABA-A receptor agonist
DG01914
Anxiolytics, benzodiazepine derivatives
Remark
Therapeutic category:
1124 1139
ATC code:
N05BA06
Product:
D00365<
JP
/US>
Efficacy
Antianxiety, Anticonvulsant, Minor tranquilizer
Comment
Benzodiazepine derivative
Target
GABR [HSA:
2554
2555
2556
2557
2558
2559
2560
2561
2562
2563
2564
2565
2566
2567
2568
55879
] [KO:
K05175
K05181
K05184
K05185
K05186
K05189
K05192
]
Pathway
hsa04080
Neuroactive ligand-receptor interaction
hsa04727
GABAergic synapse
Metabolism
Enzyme: UGT2B7 [HSA:
7364
], UGT2B15 [HSA:
7366
]
Interaction
DDI search
Structure map
map07030
Anxiolytics
map07230
GABA-A receptor agonists/antagonists
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:
br08303
]
N NERVOUS SYSTEM
N05 PSYCHOLEPTICS
N05B ANXIOLYTICS
N05BA Benzodiazepine derivatives
N05BA06 Lorazepam
D00365 Lorazepam (JP17/USP/INN) <JP/US>
USP drug classification [BR:
br08302
]
Anticonvulsants
Gamma-aminobutyric Acid (GABA) Augmenting Agents
Benzodiazepines
Lorazepam
D00365 Lorazepam (JP17/USP/INN)
Anxiolytics
Benzodiazepines
Lorazepam
D00365 Lorazepam (JP17/USP/INN)
Therapeutic category of drugs in Japan [BR:
br08301
]
1 Agents affecting nervous system and sensory organs
11 Agents affecting central nervous system
112 Hypnotics and sedatives, anxiolytics
1124 Benzodiazepins
D00365 Lorazepam (JP17/USP/INN)
113 Antiepileptics
1139 Others
D00365 Lorazepam (JP17/USP/INN)
Target-based classification of drugs [BR:
br08310
]
Ion channels
Ligand-gated ion channels
GABA (ionotropic)
GABR
D00365 Lorazepam (JP17/USP/INN) <JP/US>
Drugs listed in the Japanese Pharmacopoeia [BR:
br08311
]
Chemicals
D00365 Lorazepam
Drug metabolizing enzymes and transporters [
br08309.html
]
Drug metabolizing enzymes
D00365
BRITE hierarchy
Other DBs
CAS:
846-49-1
PubChem:
7847431
ChEBI:
6539
ChEMBL:
CHEMBL580
DrugBank:
DB00186
LigandBox:
D00365
NIKKAJI:
J3.337E
LinkDB
All DBs
KCF data
Show
ATOM 21
1 C2y C 19.5808 -11.8131
2 C8y C 18.7361 -10.7001
3 C8y C 19.0723 -9.3392
4 N1x N 20.3372 -8.7593
5 N2x N 20.9909 -11.8384
6 C5x C 21.5946 -9.3835
7 C1y C 21.8820 -10.7564
8 C8x C 18.0621 -8.3678
9 C8x C 16.7160 -8.7571
10 C8y C 16.3798 -10.1180
11 C8x C 17.3900 -11.0891
12 O1a O 23.2172 -11.1948
13 O5x O 22.6419 -8.4462
14 X Cl 15.0268 -10.5091
15 C8y C 18.8591 -13.0128
16 C8x C 17.4591 -13.0128
17 C8x C 16.7591 -14.2252
18 C8x C 17.4591 -15.4377
19 C8x C 18.8591 -15.4377
20 C8y C 19.5591 -14.2252
21 X Cl 20.9299 -14.2249
BOND 23
1 3 4 1
2 1 5 2
3 4 6 1
4 2 3 1
5 5 7 1
6 1 2 1
7 6 7 1
8 3 8 2
9 8 9 1
10 9 10 2
11 10 11 1
12 2 11 2
13 7 12 1
14 6 13 2
15 10 14 1
16 1 15 1
17 15 16 1
18 16 17 2
19 17 18 1
20 18 19 2
21 19 20 1
22 15 20 2
23 20 21 1
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