KEGG   DRUG: LorazepamHelp
Entry
D00365                      Drug                                   

Name
Lorazepam (JP17/USP/INN);
Ativan (TN)
Product
  Generic
LORAZEPAM (A-S Medication Solutions), LORAZEPAM (A-S Medication Solutions), LORAZEPAM (A-S Medication Solutions), LORAZEPAM (A-S Medication Solutions), LORAZEPAM (A-S Medication Solutions), LORAZEPAM (A-S Medication Solutions), LORAZEPAM (A-S Medication Solutions), LORAZEPAM (A-S Medication Solutions), LORAZEPAM (A-S Medication Solutions), LORAZEPAM (ATLANTIC BIOLOGICALS CORP.), LORAZEPAM (ATLANTIC BIOLOGICALS CORP.), LORAZEPAM (Actavis Pharma), LORAZEPAM (Akorn), LORAZEPAM (American Health Packaging), LORAZEPAM (Amneal Pharmaceuticals LLC), LORAZEPAM (Aphena Pharma Solutions - Tennessee), LORAZEPAM (Aphena Pharma Solutions - Tennessee), LORAZEPAM (Aphena Pharma Solutions - Tennessee), LORAZEPAM (Aphena Pharma Solutions - Tennessee), LORAZEPAM (Aphena Pharma Solutions - Tennessee), LORAZEPAM (Aphena Pharma Solutions - Tennessee), LORAZEPAM (Aphena Pharma Solutions - Tennessee), LORAZEPAM (Aphena Pharma Solutions - Tennessee), LORAZEPAM (Aphena Pharma Solutions - Tennessee), LORAZEPAM (Aphena Pharma Solutions - Tennessee), LORAZEPAM (Aurolife Pharma), LORAZEPAM (Bryant Ranch Prepack), LORAZEPAM (Bryant Ranch Prepack), LORAZEPAM (Bryant Ranch Prepack), LORAZEPAM (Bryant Ranch Prepack), LORAZEPAM (Bryant Ranch Prepack), LORAZEPAM (Bryant Ranch Prepack), LORAZEPAM (Cardinal Health), LORAZEPAM (Cardinal Health), LORAZEPAM (Clinical Solutions Wholesale), LORAZEPAM (Contract Pharmacy Services-PA), LORAZEPAM (DirectRX), LORAZEPAM (Direct_Rx), LORAZEPAM (Direct_Rx), LORAZEPAM (H.J. Harkins Company), LORAZEPAM (Hi-Tech Pharmacal), LORAZEPAM (Hospira), LORAZEPAM (Hospira), LORAZEPAM (Hospira), LORAZEPAM (International Medication Systems), LORAZEPAM (Lake Erie Medical DBA Quality Care Products LLC), LORAZEPAM (Lake Erie Medical DBA Quality Care Products LLC), LORAZEPAM (Lake Erie Medical DBA Quality Care Products LLC), LORAZEPAM (Leading Pharma), LORAZEPAM (Major Pharmaceuticals), LORAZEPAM (McKesson Corporation dba RX Pak), LORAZEPAM (McKesson Corporation dba SKY Packaging), LORAZEPAM (McKesson Corporation dba SKY Packaging), LORAZEPAM (Medsource Pharmaceuticals), LORAZEPAM (Medsource Pharmaceuticals), LORAZEPAM (Medsource Pharmaceuticals), LORAZEPAM (Mylan Institutional), LORAZEPAM (Mylan Pharmaceuticals), LORAZEPAM (NCS HealthCare of KY), LORAZEPAM (NuCare Pharmaceuticals), LORAZEPAM (NuCare Pharmaceuticals), LORAZEPAM (NuCare Pharmaceuticals), LORAZEPAM (NuCare Pharmaceuticals), LORAZEPAM (NuCare Pharmaceuticals), LORAZEPAM (NuCare Pharmaceuticals), LORAZEPAM (NuCare Pharmaceuticals), LORAZEPAM (NuCare Pharmaceuticals), LORAZEPAM (NuCare Pharmaceuticals), LORAZEPAM (NuCare Pharmaceuticals), LORAZEPAM (NuCare Pharmaceuticals), LORAZEPAM (NuCare Pharmaceuticals), LORAZEPAM (NuCare Pharmaceuticals), LORAZEPAM (NuCare Pharmaceuticals), LORAZEPAM (PD-Rx Pharmaceuticals), LORAZEPAM (PD-Rx Pharmaceuticals), LORAZEPAM (PD-Rx Pharmaceuticals), LORAZEPAM (PD-Rx Pharmaceuticals), LORAZEPAM (PD-Rx Pharmaceuticals), LORAZEPAM (PharmPak), LORAZEPAM (PharmPak), LORAZEPAM (Pharmaceutical Associates), LORAZEPAM (Preferred Pharmaceuticals), LORAZEPAM (Preferred Pharmaceuticals), LORAZEPAM (Preferred Pharmaceuticals), LORAZEPAM (Preferred Pharmaceuticals), LORAZEPAM (Preferred Pharmaceuticals), LORAZEPAM (Preferred Pharmaceuticals), LORAZEPAM (Preferred Pharmaceuticals), LORAZEPAM (Proficient Rx LP), LORAZEPAM (Proficient Rx LP), LORAZEPAM (Proficient Rx LP), LORAZEPAM (Proficient Rx LP), LORAZEPAM (Proficient Rx LP), LORAZEPAM (Proficient Rx LP), LORAZEPAM (Proficient Rx LP), LORAZEPAM (Proficient Rx LP), LORAZEPAM (Qualitest Pharmaceuticals), LORAZEPAM (Quality Care Products), LORAZEPAM (Quality Care Products), LORAZEPAM (REMEDYREPACK), LORAZEPAM (REMEDYREPACK), LORAZEPAM (REMEDYREPACK), LORAZEPAM (REMEDYREPACK), LORAZEPAM (REMEDYREPACK), LORAZEPAM (REMEDYREPACK), LORAZEPAM (REMEDYREPACK), LORAZEPAM (REMEDYREPACK), LORAZEPAM (REMEDYREPACK), LORAZEPAM (REMEDYREPACK), LORAZEPAM (REMEDYREPACK), LORAZEPAM (REMEDYREPACK), LORAZEPAM (REMEDYREPACK), LORAZEPAM (REMEDYREPACK), LORAZEPAM (REMEDYREPACK), LORAZEPAM (RPK Pharmaceuticals), LORAZEPAM (RPK Pharmaceuticals), LORAZEPAM (RPK Pharmaceuticals), LORAZEPAM (RedPharm Drug), LORAZEPAM (RedPharm Drug), LORAZEPAM (RedPharm Drug), LORAZEPAM (Sandoz), LORAZEPAM (St. Mary's Medical Park Pharmacy), LORAZEPAM (St. Mary's Medical Park Pharmacy), LORAZEPAM (West-Ward Pharmaceuticals Corp.)
Formula
C15H10Cl2N2O2
Exact mass
320.0119
Mol weight
321.1581
Structure
Mol fileKCF fileDB search
Simcomp SIMCOMP
Class
Neuropsychiatric agent
 DG01567  GABA-A receptor agonist
 DG01914  Anxiolytics, benzodiazepine derivatives
Remark
Therapeutic category: 1124 1139
ATC code: N05BA06
Product: D00365<JP/US>
Efficacy
Antianxiety, Anticonvulsant, Minor tranquilizer
Comment
Benzodiazepine derivative
Target
  Pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04727  GABAergic synapse
Metabolism
Enzyme: UGT2B7 [HSA:7364], UGT2B15 [HSA:7366]
Interaction
Drug interaction
Structure map
map07030  Anxiolytics
map07230  GABA-A receptor agonists/antagonists
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 N NERVOUS SYSTEM
  N05 PSYCHOLEPTICS
   N05B ANXIOLYTICS
    N05BA Benzodiazepine derivatives
     N05BA06 Lorazepam
      D00365  Lorazepam (JP17/USP/INN) <JP/US>
USP drug classification [BR:br08302]
 Anticonvulsants
  Gamma-aminobutyric Acid (GABA) Augmenting Agents
   Lorazepam
    D00365  Lorazepam (JP17/USP/INN)
 Anxiolytics
  Benzodiazepines
   Lorazepam
    D00365  Lorazepam (JP17/USP/INN)
Therapeutic category of drugs in Japan [BR:br08301]
 1  Agents affecting nervous system and sensory organs
  11  Agents affecting central nervous system
   112  Hypnotics and sedatives, anxiolytics
    1124  Benzodiazepins
     D00365  Lorazepam (JP17/USP/INN)
   113  Antiepileptics
    1139  Others
     D00365  Lorazepam (JP17/USP/INN)
Target-based classification of drugs [BR:br08310]
 Ion channels
  Ligand-gated ion channels
   GABA (ionotropic)
    GABR
     D00365  Lorazepam (JP17/USP/INN) <JP/US>
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D00365  Lorazepam
BRITE hierarchy
Other DBs
CAS: 846-49-1
PubChem: 7847431
ChEBI: 6539
ChEMBL: CHEMBL580
DrugBank: DB00186
LigandBox: D00365
NIKKAJI: J3.337E
LinkDB All DBs
KCF data Show

ATOM        21
            1   C2y C    19.5808  -11.8131
            2   C8y C    18.7361  -10.7001
            3   C8y C    19.0723   -9.3392
            4   N1x N    20.3372   -8.7593
            5   N2x N    20.9909  -11.8384
            6   C5x C    21.5946   -9.3835
            7   C1y C    21.8820  -10.7564
            8   C8x C    18.0621   -8.3678
            9   C8x C    16.7160   -8.7571
            10  C8y C    16.3798  -10.1180
            11  C8x C    17.3900  -11.0891
            12  O1a O    23.2172  -11.1948
            13  O5x O    22.6419   -8.4462
            14  X   Cl   15.0268  -10.5091
            15  C8y C    18.8591  -13.0128
            16  C8x C    17.4591  -13.0128
            17  C8x C    16.7591  -14.2252
            18  C8x C    17.4591  -15.4377
            19  C8x C    18.8591  -15.4377
            20  C8y C    19.5591  -14.2252
            21  X   Cl   20.9299  -14.2249
BOND        23
            1     3   4 1
            2     1   5 2
            3     4   6 1
            4     2   3 1
            5     5   7 1
            6     1   2 1
            7     6   7 1
            8     3   8 2
            9     8   9 1
            10    9  10 2
            11   10  11 1
            12    2  11 2
            13    7  12 1
            14    6  13 2
            15   10  14 1
            16    1  15 1
            17   15  16 1
            18   16  17 2
            19   17  18 1
            20   18  19 2
            21   19  20 1
            22   15  20 2
            23   20  21 1

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