KEGG   DRUG: MethylprednisoloneHelp
Entry
D00407                      Drug                                   

Name
Methylprednisolone (JP17/USP/INN);
Medrol (TN)
Product
  Generic
METHYLPRED DP (Direct_Rx), METHYLPREDNISOLONE (A-S Medication Solutions), METHYLPREDNISOLONE (Actavis Pharma), METHYLPREDNISOLONE (American Health Packaging), METHYLPREDNISOLONE (Asclemed USA), METHYLPREDNISOLONE (BluePoint Laboratories), METHYLPREDNISOLONE (Cadila Healthcare Limited), METHYLPREDNISOLONE (DIRECT RX), METHYLPREDNISOLONE (Doc Rx), METHYLPREDNISOLONE (Epic Pharma), METHYLPREDNISOLONE (Greenstone LLC), METHYLPREDNISOLONE (Ingenus Pharmaceuticals), METHYLPREDNISOLONE (JUBILANT CADISTA PHARMACEUTICALS), METHYLPREDNISOLONE (Lupin Pharmaceuticals), METHYLPREDNISOLONE (Major Pharmaceuticals), METHYLPREDNISOLONE (McKesson Corporation dba SKY Packaging), METHYLPREDNISOLONE (Medsource Pharmaceuticals), METHYLPREDNISOLONE (NuCare Pharmaceuticals), METHYLPREDNISOLONE (NuCare Pharmaceuticals), METHYLPREDNISOLONE (NuCare Pharmaceuticals), METHYLPREDNISOLONE (OAKRUM PHARMA), METHYLPREDNISOLONE (PD-Rx Pharmaceuticals), METHYLPREDNISOLONE (Par Pharmaceutical), METHYLPREDNISOLONE (Preferred Pharmaceuticals), METHYLPREDNISOLONE (Preferred Pharmaceuticals), METHYLPREDNISOLONE (Proficient Rx LP), METHYLPREDNISOLONE (Proficient Rx LP), METHYLPREDNISOLONE (Proficient Rx LP), METHYLPREDNISOLONE (REMEDYREPACK), METHYLPREDNISOLONE (Sandoz), METHYLPREDNISOLONE (St. Mary's Medical Park Pharmacy), METHYLPREDNISOLONE (SunGen Pharma LLC), METHYLPREDNISOLONE (Tianjin Tianyao Pharmaceuticals), METHYLPREDNISOLONE (Unit Dose Services), METHYLPREDNISOLONE (Zydus Pharmaceuticals (USA))
Formula
C22H30O5
Exact mass
374.2093
Mol weight
374.4706
Structure
Mol fileKCF fileDB search
Simcomp SIMCOMP
Class
Anti-inflammatory
 DG01955  Corticosteroid
  DG02068  Glucocorticoid
Metabolizing enzyme substrate
 DG02913  CYP3A4 substrate
Remark
Therapeutic category: 2456
ATC code: D07AA01 D10AA02 H02AB04
Chemical structure group: DG00410
Product (DG00410): D00407<JP/US> D00751<JP/US> D00979<JP/US>
Product (mixture): D04250<JP>
Efficacy
Antiallergic, Anti-inflammatory, Glucocorticoid receptor agonist
  Disease
Congenital adrenal hyperplasia [DS:H00216]
Rheumatoid arthritis [DS:H00630]
Juvenile rheumatoid arthritis [DS:H01672]
Ankylosing spondylitis [DS:H01674]
Psoriatic arthritis [DS:H01507]
Systemic lupus erythematosus [DS:H00080]
Systemic dermatomyositis and polymyositis [DS:H01604]
Bullous dermatitis herpetiformis [DS:H01362]
Erythema multiforme [DS:H01695]
Stevens-Johnson syndrome [DS:H01694]
Seborrheic dermatitis [DS:H01652]
Mycosis fungoides [DS:H01463]
Pemphigus [DS:H01648]
Severe psoriasis [DS:H01656]
Seasonal or perennial allergic rhinitis [DS:H01360]
Contact dermatitis [DS:H01357]
Bronchial asthma [DS:H00079]
Atopic dermatitis [DS:H01358]
Optic neuritis [DS:H01717]
Pulmonary tuberculosis [DS:H00342]
Acquired (autoimmune) hemolytic anemia [DS:H01585]
Nephrotic syndrome [DS:H01657]
Ulcerative colitis [DS:H01466]
Multiple sclerosis [DS:H01490]
Target
NR3C1 (GR) [HSA:2908] [KO:K05771]
  Pathway
hsa04080  Neuroactive ligand-receptor interaction
Metabolism
Enzyme: CYP3A4 [HSA:1576]
Interaction
Drug interaction
Structure map
map07225  Glucocorticoid and mineralocorticoid receptor agonists/antagonists
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 D DERMATOLOGICALS
  D07 CORTICOSTEROIDS, DERMATOLOGICAL PREPARATIONS
   D07A CORTICOSTEROIDS, PLAIN
    D07AA Corticosteroids, weak (group I)
     D07AA01 Methylprednisolone
      D00407  Methylprednisolone (JP17/USP/INN) <JP/US>
  D10 ANTI-ACNE PREPARATIONS
   D10A ANTI-ACNE PREPARATIONS FOR TOPICAL USE
    D10AA Corticosteroids, combinations for treatment of acne
     D10AA02 Methylprednisolone
      D00407  Methylprednisolone (JP17/USP/INN) <JP/US>
 H SYSTEMIC HORMONAL PREPARATIONS, EXCL. SEX HORMONES AND INSULINS
  H02 CORTICOSTEROIDS FOR SYSTEMIC USE
   H02A CORTICOSTEROIDS FOR SYSTEMIC USE, PLAIN
    H02AB Glucocorticoids
     H02AB04 Methylprednisolone
      D00407  Methylprednisolone (JP17/USP/INN) <JP/US>
USP drug classification [BR:br08302]
 Hormonal Agents, Stimulant/Replacement/Modifying (Adrenal)
  Methylprednisolone
   D00407  Methylprednisolone (JP17/USP/INN)
 Inflammatory Bowel Disease Agents
  Glucocorticoids
   Methylprednisolone
    D00407  Methylprednisolone (JP17/USP/INN)
Therapeutic category of drugs in Japan [BR:br08301]
 2  Agents affecting individual organs
  24  Hormones
   245  Adrenal hormone preparations
    2456  Prednisolones
     D00407  Methylprednisolone (JP17/USP/INN)
Target-based classification of drugs [BR:br08310]
 Nuclear receptors
  Estrogen like receptors
   3-Ketosteroid receptor
    NR3C1 (GR)
     D00407  Methylprednisolone (JP17/USP/INN) <JP/US>
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D00407  Methylprednisolone
Drug metabolizing enzymes and transporters [br08309.html]
 Drug metabolizing enzymes
  D00407
BRITE hierarchy
Other DBs
CAS: 83-43-2
PubChem: 7847473
ChEBI: 6888
ChEMBL: CHEMBL650
DrugBank: DB00959
LigandBox: D00407
NIKKAJI: J3.872E
LinkDB All DBs
KCF data Show

ATOM        27
            1   C2x C    26.6700  -18.6900
            2   C5x C    26.6700  -20.0900
            3   C2x C    27.8600  -20.7900
            4   C2y C    29.1200  -20.0900
            5   C1z C    29.1200  -18.6900
            6   C2x C    27.8600  -17.9900
            7   C1y C    30.3100  -20.7900
            8   C1x C    31.5000  -20.0900
            9   C1y C    31.5000  -18.6900
            10  C1y C    30.3100  -17.9900
            11  C1y C    32.7600  -17.9900
            12  C1z C    32.7600  -16.5900
            13  C1x C    31.5000  -15.8900
            14  C1y C    30.3100  -16.5900
            15  C1x C    35.1400  -17.9900
            16  C1x C    35.1400  -16.5900
            17  C1z C    33.9500  -15.8900
            18  O5x O    25.4800  -20.7900
            19  C1a C    29.1200  -17.2900
            20  O1a O    29.1200  -15.8900
            21  C1a C    32.7600  -15.1900
            22  C5a C    33.9500  -14.2100
            23  C1a C    30.3100  -22.1900
            24  O1a O    35.1400  -15.1900
            25  C1b C    35.1400  -13.5100
            26  O5a O    32.7600  -13.5100
            27  O1a O    36.3300  -14.2100
BOND        30
            1     1   2 1
            2     2   3 1
            3     3   4 2
            4     4   5 1
            5     5   6 1
            6     1   6 2
            7     4   7 1
            8     7   8 1
            9     8   9 1
            10    9  10 1
            11    5  10 1
            12    9  11 1
            13   11  12 1
            14   12  13 1
            15   13  14 1
            16   10  14 1
            17   11  15 1
            18   15  16 1
            19   16  17 1
            20   12  17 1
            21    2  18 2
            22    5  19 1 #Up
            23   14  20 1 #Up
            24   12  21 1 #Up
            25   17  22 1 #Up
            26    7  23 1 #Down
            27   17  24 1 #Down
            28   22  25 1
            29   22  26 2
            30   25  27 1

» Japanese version   » Back

KEGG   DRUG: Methylprednisolone sodium succinateHelp
Entry
D00751                      Drug                                   

Name
Methylprednisolone sodium succinate (JAN/USP);
A-methapred (TN);
Solu-medrol (TN)
Product
  Generic
Formula
C26H33O8. Na
Exact mass
496.2073
Mol weight
496.5252
Structure
Mol fileKCF fileDB search
Simcomp SIMCOMP
Class
Anti-inflammatory
 DG01955  Corticosteroid
  DG02068  Glucocorticoid
Metabolizing enzyme substrate
 DG02913  CYP3A4 substrate
Remark
Therapeutic category: 2456
ATC code: D07AA01 D10AA02 H02AB04
Chemical structure group: DG00410
Product (DG00410): D00407<JP/US> D00751<JP/US> D00979<JP/US>
Efficacy
Anti-inflammatory, Immunosuppressant, Glucocorticoid receptor agonist
  Disease
Asthma [DS:H00079]
Atopic dermatitis [DS:H01358]
Contact dermatitis [DS:H01357]
Allergic rhinitis [DS:H01360]
Dermatitis herpetiformis [DS:H01362]
Mycosis fungoides [DS:H01463]
Pemphigus [DS:H01648]
Erythema multiforme [DS:H01695]
Stevens-Johnson syndrome [DS:H01694]
Congenital adrenal hyperplasia [DS:H00216]
Ulcerative colitis [DS:H01466]
Acquired (autoimmune) hemolytic anemia [DS:H01585]
Congenital (erythroid) hypoplastic anemia; Diamond-Blackfan anemia [DS:H00237]
Idiopathic thrombocytopenic purpura [DS:H01240]
Pure red cell aplasia [DS:H01586]
Multiple sclerosis [DS:H01490]
Ankylosing spondylitis [DS:H01674]
Psoriatic arthritis [DS:H01507]
Rheumatoid arthritis [DS:H00630]
Juvenile idiopathic arthritis [DS:H01672]
Dermatomyositis [DS:H01604]
Temporal arteritis [DS:H01698]
Polymyositis [DS:H01604]
Systemic lupus erythematosus [DS:H00080]
Target
NR3C1 (GR) [HSA:2908] [KO:K05771]
  Pathway
hsa04080  Neuroactive ligand-receptor interaction
Metabolism
Enzyme: CYP3A4 [HSA:1576]
Interaction
Drug interaction
Structure map
map07225  Glucocorticoid and mineralocorticoid receptor agonists/antagonists
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 D DERMATOLOGICALS
  D07 CORTICOSTEROIDS, DERMATOLOGICAL PREPARATIONS
   D07A CORTICOSTEROIDS, PLAIN
    D07AA Corticosteroids, weak (group I)
     D07AA01 Methylprednisolone
      D00751  Methylprednisolone sodium succinate (JAN/USP) <JP/US>
  D10 ANTI-ACNE PREPARATIONS
   D10A ANTI-ACNE PREPARATIONS FOR TOPICAL USE
    D10AA Corticosteroids, combinations for treatment of acne
     D10AA02 Methylprednisolone
      D00751  Methylprednisolone sodium succinate (JAN/USP) <JP/US>
 H SYSTEMIC HORMONAL PREPARATIONS, EXCL. SEX HORMONES AND INSULINS
  H02 CORTICOSTEROIDS FOR SYSTEMIC USE
   H02A CORTICOSTEROIDS FOR SYSTEMIC USE, PLAIN
    H02AB Glucocorticoids
     H02AB04 Methylprednisolone
      D00751  Methylprednisolone sodium succinate (JAN/USP) <JP/US>
USP drug classification [BR:br08302]
 Hormonal Agents, Stimulant/Replacement/Modifying (Adrenal)
  Methylprednisolone
   D00751  Methylprednisolone sodium succinate (JAN/USP)
 Inflammatory Bowel Disease Agents
  Glucocorticoids
   Methylprednisolone
    D00751  Methylprednisolone sodium succinate (JAN/USP)
Therapeutic category of drugs in Japan [BR:br08301]
 2  Agents affecting individual organs
  24  Hormones
   245  Adrenal hormone preparations
    2456  Prednisolones
     D00751  Methylprednisolone sodium succinate (JAN/USP)
Target-based classification of drugs [BR:br08310]
 Nuclear receptors
  Estrogen like receptors
   3-Ketosteroid receptor
    NR3C1 (GR)
     D00751  Methylprednisolone sodium succinate (JAN/USP) <JP/US>
Drug metabolizing enzymes and transporters [br08309.html]
 Drug metabolizing enzymes
  D00751
BRITE hierarchy
Other DBs
CAS: 2375-03-3
PubChem: 7847816
ChEBI: 6890
ChEMBL: CHEMBL1201081 CHEMBL346476
DrugBank: DB00959
LigandBox: D00751
NIKKAJI: J7.880H
LinkDB All DBs
KCF data Show

ATOM        35
            1   C2x C    26.6700  -18.6900
            2   C5x C    26.6700  -20.0900
            3   C2x C    27.8600  -20.7900
            4   C2y C    29.1200  -20.0900
            5   C1z C    29.1200  -18.6900
            6   C2x C    27.8600  -17.9900
            7   C1y C    30.3100  -20.7900
            8   C1x C    31.5000  -20.0900
            9   C1y C    31.5000  -18.6900
            10  C1y C    30.3100  -17.9900
            11  C1y C    32.7600  -17.9900
            12  C1z C    32.7600  -16.5900
            13  C1x C    31.5000  -15.8900
            14  C1y C    30.3100  -16.5900
            15  C1x C    35.1400  -17.9900
            16  C1x C    35.1400  -16.5900
            17  C1z C    33.9500  -15.8900
            18  O5x O    25.4800  -20.7900
            19  C1a C    29.1200  -17.2900
            20  O1a O    29.1200  -15.8900
            21  C1a C    32.7600  -15.1900
            22  C5a C    33.9500  -14.2100
            23  C1a C    30.3100  -22.1900
            24  O1a O    35.1400  -15.1900
            25  C1b C    35.1400  -13.5100
            26  O5a O    32.7600  -13.5100
            27  O7a O    36.3300  -14.2100
            28  C7a C    37.5200  -13.5100
            29  C1b C    38.7100  -14.2100
            30  O6a O    37.5200  -12.1100
            31  C1b C    39.9281  -13.5199
            32  C6a C    41.1095  -14.2150
            33  O6a O    42.3149  -13.5320 #-
            34  O6a O    41.0981  -15.6100
            35  Z   Na   43.7500  -13.5100 #+
BOND        37
            1     1   2 1
            2     2   3 1
            3     3   4 2
            4     4   5 1
            5     5   6 1
            6     1   6 2
            7     4   7 1
            8     7   8 1
            9     8   9 1
            10    9  10 1
            11    5  10 1
            12    9  11 1
            13   11  12 1
            14   12  13 1
            15   13  14 1
            16   10  14 1
            17   11  15 1
            18   15  16 1
            19   16  17 1
            20   12  17 1
            21    2  18 2
            22    5  19 1 #Up
            23   14  20 1 #Up
            24   12  21 1 #Up
            25   17  22 1 #Up
            26    7  23 1 #Down
            27   17  24 1 #Down
            28   22  25 1
            29   22  26 2
            30   25  27 1
            31   27  28 1
            32   28  29 1
            33   28  30 2
            34   29  31 1
            35   31  32 1
            36   32  33 1
            37   32  34 2

» Japanese version   » Back

KEGG   DRUG: Methylprednisolone acetateHelp
Entry
D00979                      Drug                                   

Name
Methylprednisolone acetate (JAN/USP);
Depo-medrol (TN)
Product
  Generic
Formula
C24H32O6
Exact mass
416.2199
Mol weight
416.5073
Structure
Mol fileKCF fileDB search
Simcomp SIMCOMP
Class
Anti-inflammatory
 DG01955  Corticosteroid
  DG02068  Glucocorticoid
Metabolizing enzyme substrate
 DG02913  CYP3A4 substrate
Remark
Same as: C08179
Therapeutic category: 2456
ATC code: D07AA01 D10AA02 H02AB04
Chemical structure group: DG00410
Product (DG00410): D00407<JP/US> D00751<JP/US> D00979<JP/US>
Efficacy
Anti-inflammatory, Glucocorticoid receptor agonist
  Disease
Asthma [DS:H00079]
Atopic dermatitis [DS:H01358]
Contact dermatitis [DS:H01357]
Seasonal or perennial allergic rhinitis [DS:H01360]
Bullous dermatitis herpetiformis [DS:H01362]
Mcosis fungoides [DS:H01463]
Pemphigus [DS:H01648]
Stevens-Johnson syndrome [DS:H01694]
Congenital adrenal hyperplasia [DS:H00216]
Ulcerative colitis [DS:H01466]
Acquired (autoimmune) hemolytic anemia [DS:H01585]
Diamond blackfan anemia [DS:H00237]
Multiple sclerosis [DS:H01490]
Temporal arteritis [DS:H01698]
Pulmonary tuberculosis [DS:H00342]
Ankylosing spondylitis [DS:H01674]
Psoriatic arthritis [DS:H01507]
Rheumatoid arthritis [DS:H00630]
Juvenile rheumatoid arthritis [DS:H01672]
Dermatomyositis and polymyositis [DS:H01604]
Systemic lupus erythematosus [DS:H00080]
Discoid lupus erythematosus [DS:H01595]
Lichen planus [DS:H01654]
Target
NR3C1 (GR) [HSA:2908] [KO:K05771]
  Pathway
hsa04080  Neuroactive ligand-receptor interaction
Metabolism
Enzyme: CYP3A4 [HSA:1576]
Interaction
Drug interaction
Structure map
map07225  Glucocorticoid and mineralocorticoid receptor agonists/antagonists
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 D DERMATOLOGICALS
  D07 CORTICOSTEROIDS, DERMATOLOGICAL PREPARATIONS
   D07A CORTICOSTEROIDS, PLAIN
    D07AA Corticosteroids, weak (group I)
     D07AA01 Methylprednisolone
      D00979  Methylprednisolone acetate (JAN/USP) <JP/US>
  D10 ANTI-ACNE PREPARATIONS
   D10A ANTI-ACNE PREPARATIONS FOR TOPICAL USE
    D10AA Corticosteroids, combinations for treatment of acne
     D10AA02 Methylprednisolone
      D00979  Methylprednisolone acetate (JAN/USP) <JP/US>
 H SYSTEMIC HORMONAL PREPARATIONS, EXCL. SEX HORMONES AND INSULINS
  H02 CORTICOSTEROIDS FOR SYSTEMIC USE
   H02A CORTICOSTEROIDS FOR SYSTEMIC USE, PLAIN
    H02AB Glucocorticoids
     H02AB04 Methylprednisolone
      D00979  Methylprednisolone acetate (JAN/USP) <JP/US>
USP drug classification [BR:br08302]
 Hormonal Agents, Stimulant/Replacement/Modifying (Adrenal)
  Methylprednisolone
   D00979  Methylprednisolone acetate (JAN/USP)
 Inflammatory Bowel Disease Agents
  Glucocorticoids
   Methylprednisolone
    D00979  Methylprednisolone acetate (JAN/USP)
Therapeutic category of drugs in Japan [BR:br08301]
 2  Agents affecting individual organs
  24  Hormones
   245  Adrenal hormone preparations
    2456  Prednisolones
     D00979  Methylprednisolone acetate (JAN/USP)
Target-based classification of drugs [BR:br08310]
 Nuclear receptors
  Estrogen like receptors
   3-Ketosteroid receptor
    NR3C1 (GR)
     D00979  Methylprednisolone acetate (JAN/USP) <JP/US>
Drug metabolizing enzymes and transporters [br08309.html]
 Drug metabolizing enzymes
  D00979
BRITE hierarchy
Other DBs
CAS: 53-36-1
PubChem: 7848042
ChEBI: 6889
ChEMBL: CHEMBL1364144 CHEMBL1474440 CHEMBL66870
DrugBank: DB00959
LigandBox: D00979
NIKKAJI: J4.144K
LinkDB All DBs
KCF data Show

ATOM        30
            1   C2x C     6.3700  -24.5700
            2   C5x C     6.3700  -25.9700
            3   C2x C     7.5824  -26.6700
            4   C2y C     8.7949  -25.9700
            5   C1z C     8.7949  -24.5700
            6   C2x C     7.5824  -23.8700
            7   C1y C    10.0073  -26.6700
            8   C1x C    11.2197  -25.9700
            9   C1y C    11.2197  -24.5700
            10  C1y C    10.0073  -23.8700
            11  C1y C    12.4322  -23.8700
            12  C1z C    12.4322  -22.4700
            13  C1x C    11.2197  -21.7700
            14  C1y C    10.0073  -22.4700
            15  C1x C    14.8570  -23.8700
            16  C1x C    14.8570  -22.4700
            17  C1z C    13.6446  -21.7700
            18  O5x O     5.1576  -26.6700
            19  C1a C     8.7949  -23.1700
            20  O1a O     8.7969  -21.7712
            21  C1a C    12.4322  -21.0700
            22  C5a C    13.6446  -20.0900
            23  C1a C    10.0073  -28.0700
            24  O1a O    14.8570  -21.0700
            25  C1b C    14.8611  -19.3877
            26  O5a O    12.4362  -19.3923
            27  O7a O    16.0586  -20.0792
            28  C7a C    17.2449  -19.3943
            29  C1a C    18.4367  -20.0826
            30  O6a O    17.2451  -17.9902
BOND        33
            1     1   2 1
            2     2   3 1
            3     3   4 2
            4     4   5 1
            5     5   6 1
            6     1   6 2
            7     4   7 1
            8     7   8 1
            9     8   9 1
            10    9  10 1
            11    5  10 1
            12    9  11 1
            13   11  12 1
            14   12  13 1
            15   13  14 1
            16   10  14 1
            17   11  15 1
            18   15  16 1
            19   16  17 1
            20   12  17 1
            21    2  18 2
            22    5  19 1 #Up
            23   14  20 1 #Up
            24   12  21 1 #Up
            25   17  22 1 #Up
            26    7  23 1 #Down
            27   17  24 1 #Down
            28   22  25 1
            29   22  26 2
            30   25  27 1
            31   27  28 1
            32   28  29 1
            33   28  30 2

» Japanese version   » Back

KEGG   DRUG: Methylprednisolone hemisuccinateHelp
Entry
D05000                      Drug                                   

Name
Methylprednisolone hemisuccinate (USP);
Methylprednisolone succinate (JP17)
Formula
C26H34O8
Exact mass
474.2254
Mol weight
474.5434
Structure
Mol fileKCF fileDB search
Simcomp SIMCOMP
Class
Anti-inflammatory
 DG01955  Corticosteroid
  DG02068  Glucocorticoid
Metabolizing enzyme substrate
 DG02913  CYP3A4 substrate
Remark
ATC code: D07AA01 D10AA02 H02AB04
Chemical structure group: DG00410
Product (DG00410): D00407<JP/US> D00751<JP/US> D00979<JP/US>
Efficacy
Anti-inflammatory, Glucocorticoid receptor agonist
Target
NR3C1 (GR) [HSA:2908] [KO:K05771]
  Pathway
hsa04080  Neuroactive ligand-receptor interaction
Metabolism
Enzyme: CYP3A4 [HSA:1576]
Interaction
Drug interaction
Structure map
map07225  Glucocorticoid and mineralocorticoid receptor agonists/antagonists
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 D DERMATOLOGICALS
  D07 CORTICOSTEROIDS, DERMATOLOGICAL PREPARATIONS
   D07A CORTICOSTEROIDS, PLAIN
    D07AA Corticosteroids, weak (group I)
     D07AA01 Methylprednisolone
      D05000  Methylprednisolone hemisuccinate (USP)
  D10 ANTI-ACNE PREPARATIONS
   D10A ANTI-ACNE PREPARATIONS FOR TOPICAL USE
    D10AA Corticosteroids, combinations for treatment of acne
     D10AA02 Methylprednisolone
      D05000  Methylprednisolone hemisuccinate (USP)
 H SYSTEMIC HORMONAL PREPARATIONS, EXCL. SEX HORMONES AND INSULINS
  H02 CORTICOSTEROIDS FOR SYSTEMIC USE
   H02A CORTICOSTEROIDS FOR SYSTEMIC USE, PLAIN
    H02AB Glucocorticoids
     H02AB04 Methylprednisolone
      D05000  Methylprednisolone hemisuccinate (USP)
Target-based classification of drugs [BR:br08310]
 Nuclear receptors
  Estrogen like receptors
   3-Ketosteroid receptor
    NR3C1 (GR)
     D05000  Methylprednisolone hemisuccinate (USP)
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D05000  Methylprednisolone succinate
Drug metabolizing enzymes and transporters [br08309.html]
 Drug metabolizing enzymes
  D05000
BRITE hierarchy
Other DBs
CAS: 2921-57-5
PubChem: 47206728
ChEMBL: CHEMBL1201265 CHEMBL1207082
DrugBank: DB00959
LigandBox: D05000
NIKKAJI: J7.938C
LinkDB All DBs
KCF data Show

ATOM        34
            1   C2x C    26.6700  -18.6900
            2   C5x C    26.6700  -20.0900
            3   C2x C    27.8600  -20.7900
            4   C2y C    29.1200  -20.0900
            5   C1z C    29.1200  -18.6900
            6   C2x C    27.8600  -17.9900
            7   C1y C    30.3100  -20.7900
            8   C1x C    31.5000  -20.0900
            9   C1y C    31.5000  -18.6900
            10  C1y C    30.3100  -17.9900
            11  C1y C    32.7600  -17.9900
            12  C1z C    32.7600  -16.5900
            13  C1x C    31.5000  -15.8900
            14  C1y C    30.3100  -16.5900
            15  C1x C    35.1400  -17.9900
            16  C1x C    35.1400  -16.5900
            17  C1z C    33.9500  -15.8900
            18  O5x O    25.4800  -20.7900
            19  C1a C    29.1200  -17.2900
            20  O1a O    29.1200  -15.8900
            21  C1a C    32.7600  -15.1900
            22  C5a C    33.9500  -14.2100
            23  C1a C    30.3100  -22.1900
            24  O1a O    35.1400  -15.1900
            25  C1b C    35.1400  -13.5100
            26  O5a O    32.7600  -13.5100
            27  O7a O    36.3300  -14.2100
            28  C7a C    37.5200  -13.5100
            29  C1b C    38.7100  -14.2100
            30  O6a O    37.5200  -12.1100
            31  C1b C    39.9281  -13.5199
            32  C6a C    41.1095  -14.2150
            33  O6a O    42.3149  -13.5320
            34  O6a O    41.0981  -15.6100
BOND        37
            1     1   2 1
            2     2   3 1
            3     3   4 2
            4     4   5 1
            5     5   6 1
            6     1   6 2
            7     4   7 1
            8     7   8 1
            9     8   9 1
            10    9  10 1
            11    5  10 1
            12    9  11 1
            13   11  12 1
            14   12  13 1
            15   13  14 1
            16   10  14 1
            17   11  15 1
            18   15  16 1
            19   16  17 1
            20   12  17 1
            21    2  18 2
            22    5  19 1 #Up
            23   14  20 1 #Up
            24   12  21 1 #Up
            25   17  22 1 #Up
            26    7  23 1 #Down
            27   17  24 1 #Down
            28   22  25 1
            29   22  26 2
            30   25  27 1
            31   27  28 1
            32   28  29 1
            33   28  30 2
            34   29  31 1
            35   31  32 1
            36   32  33 1
            37   32  34 2

» Japanese version   » Back

KEGG   DRUG: Methylprednisolone sodium phosphateHelp
Entry
D05001                      Drug                                   

Name
Methylprednisolone sodium phosphate (USAN)
Formula
C22H29O8P. 2Na
Exact mass
498.1395
Mol weight
498.4142
Structure
Mol fileKCF fileDB search
Simcomp SIMCOMP
Class
Anti-inflammatory
 DG01955  Corticosteroid
  DG02068  Glucocorticoid
Metabolizing enzyme substrate
 DG02913  CYP3A4 substrate
Remark
ATC code: D07AA01 D10AA02 H02AB04
Chemical structure group: DG00410
Product (DG00410): D00407<JP/US> D00751<JP/US> D00979<JP/US>
Efficacy
Anti-inflammatory, Glucocorticoid receptor agonist
Target
NR3C1 (GR) [HSA:2908] [KO:K05771]
  Pathway
hsa04080  Neuroactive ligand-receptor interaction
Metabolism
Enzyme: CYP3A4 [HSA:1576]
Interaction
Drug interaction
Structure map
map07225  Glucocorticoid and mineralocorticoid receptor agonists/antagonists
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 D DERMATOLOGICALS
  D07 CORTICOSTEROIDS, DERMATOLOGICAL PREPARATIONS
   D07A CORTICOSTEROIDS, PLAIN
    D07AA Corticosteroids, weak (group I)
     D07AA01 Methylprednisolone
      D05001  Methylprednisolone sodium phosphate (USAN)
  D10 ANTI-ACNE PREPARATIONS
   D10A ANTI-ACNE PREPARATIONS FOR TOPICAL USE
    D10AA Corticosteroids, combinations for treatment of acne
     D10AA02 Methylprednisolone
      D05001  Methylprednisolone sodium phosphate (USAN)
 H SYSTEMIC HORMONAL PREPARATIONS, EXCL. SEX HORMONES AND INSULINS
  H02 CORTICOSTEROIDS FOR SYSTEMIC USE
   H02A CORTICOSTEROIDS FOR SYSTEMIC USE, PLAIN
    H02AB Glucocorticoids
     H02AB04 Methylprednisolone
      D05001  Methylprednisolone sodium phosphate (USAN)
Target-based classification of drugs [BR:br08310]
 Nuclear receptors
  Estrogen like receptors
   3-Ketosteroid receptor
    NR3C1 (GR)
     D05001  Methylprednisolone sodium phosphate (USAN)
Drug metabolizing enzymes and transporters [br08309.html]
 Drug metabolizing enzymes
  D05001
BRITE hierarchy
Other DBs
CAS: 5015-36-1
PubChem: 47206729
ChEMBL: CHEMBL3989785
DrugBank: DB00959
LigandBox: D05001
NIKKAJI: J12.822H
LinkDB All DBs
KCF data Show

ATOM        33
            1   C2x C    26.6700  -18.6900
            2   C5x C    26.6700  -20.0900
            3   C2x C    27.8600  -20.7900
            4   C2y C    29.1200  -20.0900
            5   C1z C    29.1200  -18.6900
            6   C2x C    27.8600  -17.9900
            7   C1y C    30.3100  -20.7900
            8   C1x C    31.5000  -20.0900
            9   C1y C    31.5000  -18.6900
            10  C1y C    30.3100  -17.9900
            11  C1y C    32.7600  -17.9900
            12  C1z C    32.7600  -16.5900
            13  C1x C    31.5000  -15.8900
            14  C1y C    30.3100  -16.5900
            15  C1x C    35.1400  -17.9900
            16  C1x C    35.1400  -16.5900
            17  C1z C    33.9500  -15.8900
            18  O5x O    25.4800  -20.7900
            19  C1a C    29.1200  -17.2900
            20  O1a O    29.1200  -15.8900
            21  C1a C    32.7600  -15.1900
            22  C5a C    33.9500  -14.2100
            23  C1a C    30.3100  -22.1900
            24  O1a O    35.1400  -15.1900
            25  C1b C    35.1400  -13.5100
            26  O5a O    32.7600  -13.5100
            27  O2b O    36.3300  -14.2100
            28  P1b P    37.5200  -13.5100
            29  O1c O    38.7324  -12.8100 #-
            30  O1c O    36.8151  -12.3004
            31  O1c O    38.2249  -14.7196 #-
            32  Z   Na   40.1800  -12.8800 #+
            33  Z   Na   39.7600  -14.7700 #+
BOND        34
            1     1   2 1
            2     2   3 1
            3     3   4 2
            4     4   5 1
            5     5   6 1
            6     1   6 2
            7     4   7 1
            8     7   8 1
            9     8   9 1
            10    9  10 1
            11    5  10 1
            12    9  11 1
            13   11  12 1
            14   12  13 1
            15   13  14 1
            16   10  14 1
            17   11  15 1
            18   15  16 1
            19   16  17 1
            20   12  17 1
            21    2  18 2
            22    5  19 1 #Up
            23   14  20 1 #Up
            24   12  21 1 #Up
            25   17  22 1 #Up
            26    7  23 1 #Down
            27   17  24 1 #Down
            28   22  25 1
            29   22  26 2
            30   25  27 1
            31   27  28 1
            32   28  29 1
            33   28  30 2
            34   28  31 1

» Japanese version   » Back

KEGG   DRUG: Methylprednisolone suleptanateHelp
Entry
D05002                      Drug                                   

Name
Methylprednisolone suleptanate (USAN/INN)
Formula
C33H48NO10S. Na
Exact mass
673.2897
Mol weight
673.7897
Structure
Mol fileKCF fileDB search
Class
Anti-inflammatory
 DG01955  Corticosteroid
  DG02068  Glucocorticoid
Metabolizing enzyme substrate
 DG02913  CYP3A4 substrate
Remark
ATC code: D07AA01 D10AA02 H02AB04
Chemical structure group: DG00410
Product (DG00410): D00407<JP/US> D00751<JP/US> D00979<JP/US>
Efficacy
Anti-inflammatory, Glucocorticoid receptor agonist
Target
NR3C1 (GR) [HSA:2908] [KO:K05771]
  Pathway
hsa04080  Neuroactive ligand-receptor interaction
Metabolism
Enzyme: CYP3A4 [HSA:1576]
Interaction
Drug interaction
Structure map
map07225  Glucocorticoid and mineralocorticoid receptor agonists/antagonists
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 D DERMATOLOGICALS
  D07 CORTICOSTEROIDS, DERMATOLOGICAL PREPARATIONS
   D07A CORTICOSTEROIDS, PLAIN
    D07AA Corticosteroids, weak (group I)
     D07AA01 Methylprednisolone
      D05002  Methylprednisolone suleptanate (USAN/INN)
  D10 ANTI-ACNE PREPARATIONS
   D10A ANTI-ACNE PREPARATIONS FOR TOPICAL USE
    D10AA Corticosteroids, combinations for treatment of acne
     D10AA02 Methylprednisolone
      D05002  Methylprednisolone suleptanate (USAN/INN)
 H SYSTEMIC HORMONAL PREPARATIONS, EXCL. SEX HORMONES AND INSULINS
  H02 CORTICOSTEROIDS FOR SYSTEMIC USE
   H02A CORTICOSTEROIDS FOR SYSTEMIC USE, PLAIN
    H02AB Glucocorticoids
     H02AB04 Methylprednisolone
      D05002  Methylprednisolone suleptanate (USAN/INN)
Target-based classification of drugs [BR:br08310]
 Nuclear receptors
  Estrogen like receptors
   3-Ketosteroid receptor
    NR3C1 (GR)
     D05002  Methylprednisolone suleptanate (USAN/INN)
Drug metabolizing enzymes and transporters [br08309.html]
 Drug metabolizing enzymes
  D05002
BRITE hierarchy
Other DBs
CAS: 90350-40-6
PubChem: 47206730
ChEMBL: CHEMBL2106453
DrugBank: DB00959
LigandBox: D05002
LinkDB All DBs
KCF data Show

ATOM        46
            1   C2x C    23.5900  -36.8900
            2   C5x C    23.5900  -38.2200
            3   C2x C    24.7800  -38.9200
            4   C2y C    25.9700  -38.2200
            5   C1z C    25.9700  -36.8900
            6   C2x C    24.7800  -36.1900
            7   C1y C    27.0900  -38.9200
            8   C1x C    28.2800  -38.2200
            9   C1y C    28.2800  -36.8900
            10  C1y C    27.0900  -36.1900
            11  C1y C    29.4700  -36.1900
            12  C1z C    29.4700  -34.8600
            13  C1x C    28.2800  -34.1600
            14  C1y C    27.0900  -34.8600
            15  C1x C    31.8500  -36.1900
            16  C1x C    31.8500  -34.8600
            17  C1z C    30.6600  -34.1600
            18  O5x O    22.4000  -38.9200
            19  C1a C    25.9700  -35.4900
            20  O1a O    25.9700  -34.1600
            21  C1a C    29.4700  -33.4600
            22  C5a C    30.6600  -32.4800
            23  C1a C    27.0900  -40.2500
            24  O1a O    31.8500  -33.4600
            25  C1b C    31.8500  -31.7800
            26  O5a O    29.4700  -31.7800
            27  O7a O    32.9700  -32.4800
            28  C7a C    34.0900  -31.7800
            29  C1b C    35.2800  -32.4800
            30  O6a O    34.0900  -30.4500
            31  C1b C    36.4700  -31.7800
            32  C1b C    37.7300  -32.4800
            33  C1b C    38.9200  -31.7800
            34  C1b C    40.1100  -32.4800
            35  C1b C    41.3700  -31.7800
            36  C5a C    42.5600  -32.4800
            37  O5a O    42.5600  -33.8800
            38  N1c N    43.7500  -31.8500
            39  C1b C    44.9400  -32.6200
            40  C1a C    43.7500  -30.4500
            41  C1b C    46.1300  -31.9900
            42  S4a S    47.3200  -32.6900
            43  O1d O    48.5100  -33.3900 #-
            44  O1d O    46.6200  -33.8800
            45  O1d O    48.0200  -31.5000
            46  Z   Na   48.1600  -34.9300 #+
BOND        48
            1     1   2 1
            2     2   3 1
            3     3   4 2
            4     4   5 1
            5     5   6 1
            6     1   6 2
            7     4   7 1
            8     7   8 1
            9     8   9 1
            10    9  10 1
            11    5  10 1
            12    9  11 1
            13   11  12 1
            14   12  13 1
            15   13  14 1
            16   10  14 1
            17   11  15 1
            18   15  16 1
            19   16  17 1
            20   12  17 1
            21    2  18 2
            22    5  19 1 #Up
            23   14  20 1 #Up
            24   12  21 1 #Up
            25   17  22 1 #Up
            26    7  23 1 #Down
            27   17  24 1 #Down
            28   22  25 1
            29   22  26 2
            30   25  27 1
            31   27  28 1
            32   28  30 2
            33   28  29 1
            34   29  31 1
            35   31  32 1
            36   32  33 1
            37   33  34 1
            38   34  35 1
            39   35  36 1
            40   36  37 2
            41   36  38 1
            42   38  39 1
            43   38  40 1
            44   39  41 1
            45   41  42 1
            46   42  43 1
            47   42  44 2
            48   42  45 2

» Japanese version   » Back

KEGG   DRUG: Methylprednisolone aceponateHelp
Entry
D07203                      Drug                                   

Name
Methylprednisolone aceponate (INN);
Advantan (TN)
Formula
C27H36O7
Exact mass
472.2461
Mol weight
472.5705
Structure
Mol fileKCF fileDB search
Simcomp SIMCOMP
Class
Anti-inflammatory
 DG01955  Corticosteroid
  DG02068  Glucocorticoid
Metabolizing enzyme substrate
 DG02913  CYP3A4 substrate
Remark
ATC code: D07AA01 D07AC14 D10AA02 H02AB04
Chemical structure group: DG00410
Product (DG00410): D00407<JP/US> D00751<JP/US> D00979<JP/US>
Efficacy
Anti-inflammatory, Glucocorticoid receptor agonist
Target
NR3C1 (GR) [HSA:2908] [KO:K05771]
  Pathway
hsa04080  Neuroactive ligand-receptor interaction
Metabolism
Enzyme: CYP3A4 [HSA:1576]
Interaction
Drug interaction
Structure map
map07225  Glucocorticoid and mineralocorticoid receptor agonists/antagonists
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 D DERMATOLOGICALS
  D07 CORTICOSTEROIDS, DERMATOLOGICAL PREPARATIONS
   D07A CORTICOSTEROIDS, PLAIN
    D07AA Corticosteroids, weak (group I)
     D07AA01 Methylprednisolone
      D07203  Methylprednisolone aceponate (INN)
    D07AC Corticosteroids, potent (group III)
     D07AC14 Methylprednisolone aceponate
      D07203  Methylprednisolone aceponate (INN)
  D10 ANTI-ACNE PREPARATIONS
   D10A ANTI-ACNE PREPARATIONS FOR TOPICAL USE
    D10AA Corticosteroids, combinations for treatment of acne
     D10AA02 Methylprednisolone
      D07203  Methylprednisolone aceponate (INN)
 H SYSTEMIC HORMONAL PREPARATIONS, EXCL. SEX HORMONES AND INSULINS
  H02 CORTICOSTEROIDS FOR SYSTEMIC USE
   H02A CORTICOSTEROIDS FOR SYSTEMIC USE, PLAIN
    H02AB Glucocorticoids
     H02AB04 Methylprednisolone
      D07203  Methylprednisolone aceponate (INN)
Target-based classification of drugs [BR:br08310]
 Nuclear receptors
  Estrogen like receptors
   3-Ketosteroid receptor
    NR3C1 (GR)
     D07203  Methylprednisolone aceponate (INN)
Drug metabolizing enzymes and transporters [br08309.html]
 Drug metabolizing enzymes
  D07203
BRITE hierarchy
Other DBs
CAS: 86401-95-8
PubChem: 51091541
ChEMBL: CHEMBL1697782
LigandBox: D07203
NIKKAJI: J25.810E
LinkDB All DBs
KCF data Show

ATOM        34
            1   C1z C    27.4416  -18.9534
            2   C1y C    27.4416  -20.3466
            3   C1x C    29.8101  -20.3466
            4   C1x C    29.8101  -18.9534
            5   C1z C    28.6259  -18.2568
            6   C1x C    26.2574  -18.2568
            7   C1y C    25.0731  -18.9534
            8   C1y C    25.0731  -20.3466
            9   C1y C    26.2574  -21.0433
            10  C1z C    23.8889  -21.0433
            11  C2y C    23.8889  -22.3668
            12  C1y C    25.0731  -22.9938
            13  C1x C    26.2574  -22.3668
            14  C2x C    22.7046  -20.3466
            15  C2x C    21.5204  -21.0433
            16  C5x C    21.5204  -22.3668
            17  C2x C    22.7046  -22.9938
            18  C1a C    27.4416  -17.6298
            19  O1a O    23.8889  -18.2568
            20  C1a C    23.8889  -19.6500
            21  O5x O    20.4058  -22.9938
            22  C5a C    28.6259  -16.8635
            23  O7a O    29.8353  -17.5650
            24  C1b C    29.8324  -16.1669
            25  O7a O    29.8324  -14.7737
            26  C7a C    31.0222  -14.0866
            27  C1a C    31.0222  -12.6934
            28  C7a C    31.0181  -18.2545
            29  C1b C    32.2086  -17.5735
            30  C1a C    33.3841  -18.2587
            31  O6a O    31.0124  -19.6499
            32  O5a O    27.4194  -16.1669
            33  O6a O    32.2037  -14.7688
            34  C1a C    25.0728  -24.3599
BOND        37
            1     1   2 1
            2     2   3 1
            3     3   4 1
            4     4   5 1
            5     1   5 1
            6     1   6 1
            7     6   7 1
            8     7   8 1
            9     8   9 1
            10    9   2 1
            11    8  10 1
            12   10  11 1
            13   11  12 1
            14   12  13 1
            15   13   9 1
            16   10  14 1
            17   14  15 2
            18   15  16 1
            19   16  17 1
            20   17  11 2
            21    1  18 1 #Up
            22    7  19 1 #Up
            23   10  20 1 #Up
            24   16  21 2
            25    5  22 1 #Up
            26    5  23 1 #Down
            27   22  24 1
            28   24  25 1
            29   25  26 1
            30   26  27 1
            31   23  28 1
            32   28  29 1
            33   29  30 1
            34   28  31 2
            35   22  32 2
            36   26  33 2
            37   12  34 1 #Down

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