KEGG   DRUG: Sumatriptan
Entry
D00451                      Drug                                   

Name
Sumatriptan (JAN/USP/INN);
Imigran (TN);
Imitrex (TN)
Product
  Generic
Formula
C14H21N3O2S
Exact mass
295.1354
Mol weight
295.4004
Structure
Simcomp
Class
Analgesic
 DG01484  5-HT1B-receptor agonist
 DG01485  5-HT1D-receptor agonist
 DG01518  5-HT1B/1D-receptor agonist
 DG01943  Triptan
Metabolizing enzyme substrate
 DG02917  MAO substrate
Remark
Same as: C07319
Therapeutic category: 2160
ATC code: N02CC01
Chemical structure group: DG00836
Product (DG00836): D00451<JP/US> D00676<JP/US>
Product (mixture): D11577<US>
Efficacy
Antimigraine, Vasoconstrictor, Serotonin receptor agonist
Comment
Triptans
Target
HTR1B [HSA:3351] [KO:K04153]
HTR1D [HSA:3352] [KO:K04153]
  Pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04726  Serotonergic synapse
Metabolism
Enzyme: MAOA [HSA:4128]
Interaction
Structure map
map07048  Antimigraines
map07211  Serotonin receptor agonists/antagonists
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 N NERVOUS SYSTEM
  N02 ANALGESICS
   N02C ANTIMIGRAINE PREPARATIONS
    N02CC Selective serotonin (5HT1) agonists
     N02CC01 Sumatriptan
      D00451  Sumatriptan (JAN/USP/INN) <JP/US>
USP drug classification [BR:br08302]
 Antimigraine Agents
  Serotonin (5-HT) Receptor Agonists
   Sumatriptan
    D00451  Sumatriptan (JAN/USP/INN)
Therapeutic category of drugs in Japan [BR:br08301]
 2  Agents affecting individual organs
  21  Cardiovascular agents
   216  Vasoconstrictors
    2160  Vasoconstrictors
     D00451  Sumatriptan (JAN/USP/INN)
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Serotonin
    HTR1B
     D00451  Sumatriptan (JAN/USP/INN) <JP/US>
    HTR1D
     D00451  Sumatriptan (JAN/USP/INN) <JP/US>
Drug metabolizing enzymes and transporters [br08309.html]
 Drug metabolizing enzymes
  D00451
Other DBs
CAS: 103628-46-2
PubChem: 7847517
ChEBI: 10650
ChEMBL: CHEMBL128
DrugBank: DB00669
LigandBox: D00451
NIKKAJI: J128.634J
LinkDB
KCF data

ATOM        20
            1   C8y C    27.5550  -17.9600
            2   C8y C    27.5609  -19.3636
            3   C8y C    28.8886  -17.5290
            4   C8x C    26.3496  -17.2496
            5   N4x N    28.8944  -19.7886
            6   C8x C    26.3438  -20.0565
            7   C8x C    29.7097  -18.6531
            8   C1b C    29.2031  -16.1606
            9   C8y C    25.1325  -17.9543
            10  C8x C    25.1384  -19.3576
            11  C1b C    30.5365  -15.7472
            12  C1b C    23.9154  -17.2612
            13  N1c N    30.8452  -14.3846
            14  S4a S    22.7101  -17.9659
            15  C1a C    32.1787  -13.9710
            16  C1a C    29.8203  -13.4353
            17  N1b N    21.5047  -17.2671
            18  O3c O    23.7001  -18.9675
            19  O3c O    21.7142  -18.9675
            20  C1a C    20.2933  -17.9717
BOND        21
            1     1   2 1
            2     1   3 1
            3     1   4 2
            4     2   5 1
            5     2   6 2
            6     3   7 2
            7     3   8 1
            8     4   9 1
            9     6  10 1
            10    8  11 1
            11    9  12 1
            12   11  13 1
            13   12  14 1
            14   13  15 1
            15   13  16 1
            16   14  17 1
            17   14  18 2
            18   14  19 2
            19   17  20 1
            20    5   7 1
            21    9  10 2

» Japanese version   » Back

KEGG   DRUG: Sumatriptan succinate
Entry
D00676                      Drug                                   

Name
Sumatriptan succinate (JAN/USP);
Alsuma (TN);
Imitrex (TN);
Sumave dosepro (TN);
Zecutity (TN)
Product
  Generic
SUMATRIPTAN (A-S Medication Solutions), SUMATRIPTAN (AuroMedics Pharma LLC), SUMATRIPTAN (AuroMedics Pharma LLC), SUMATRIPTAN (Golden State Medical Supply), SUMATRIPTAN (Mylan Institutional LLC), SUMATRIPTAN (Mylan Institutional LLC), SUMATRIPTAN (Northstar Rx LLC), SUMATRIPTAN (OrchidPharma), SUMATRIPTAN (Proficient Rx LP), SUMATRIPTAN (Proficient Rx LP), SUMATRIPTAN (Unit Dose Services), SUMATRIPTAN (Unit Dose Services), SUMATRIPTAN (West-Ward Pharmaceuticals Corp), SUMATRIPTAN (A-S Medication Solutions), SUMATRIPTAN (Aurobindo Pharma Limited), SUMATRIPTAN (Bryant Ranch Prepack), SUMATRIPTAN SUCCINATE (Dr. Reddy's Laboratories Limited), SUMATRIPTAN SUCCINATE (Dr. Reddy's Laboratories Limited), SUMATRIPTAN SUCCINATE (Fresenius Kabi USA), SUMATRIPTAN SUCCINATE (GSMS), SUMATRIPTAN (Golden State Medical Supply), SUMATRIPTAN SUCCINATE (Lake Erie Medical DBA Quality Care Products LLC), SUMATRIPTAN SUCCINATE (Lake Erie Medical DBA Quality Care Products LLC), SUMATRIPTAN SUCCINATE (Medsource Pharmaceuticals), SUMATRIPTAN SUCCINATE (Mylan Pharmaceuticals), SUMATRIPTAN (NorthStar Rx LLC), SUMATRIPTAN (NuCare Pharmaceuticals), SUMATRIPTAN SUCCINATE (NuCare Pharmaceuticals), SUMATRIPTAN SUCCINATE (NuCare Pharmaceuticals), SUMATRIPTAN (NuCare Pharmaceuticals), SUMATRIPTAN (NuCare Pharmaceuticals), SUMATRIPTAN SUCCINATE (Prasco Laboratories), SUMATRIPTAN SUCCINATE (Preferred Pharmaceuticals), SUMATRIPTAN (Preferred Pharmaceuticals), SUMATRIPTAN (Preferred Pharmaceuticals), SUMATRIPTAN (Preferred Pharmaceuticals), SUMATRIPTAN (Proficient Rx LP), SUMATRIPTAN SUCCINATE (Proficient Rx LP), SUMATRIPTAN SUCCINATE (Proficient Rx LP), SUMATRIPTAN SUCCINATE (Proficient Rx LP), SUMATRIPTAN SUCCINATE (Proficient Rx LP), SUMATRIPTAN (Proficient Rx LP), SUMATRIPTAN SUCCINATE (Proficient Rx LP), SUMATRIPTAN SUCCINATE (Proficient Rx LP), SUMATRIPTAN (Proficient Rx LP), SUMATRIPTAN (Quality Care Products), SUMATRIPTAN SUCCINATE (Quality Care Products), SUMATRIPTAN SUCCINATE (REMEDYREPACK), SUMATRIPTAN (REMEDYREPACK), SUMATRIPTAN SUCCINATE (Sandoz), SUMATRIPTAN SUCCINATE (Sun Pharmaceutical Industries), SUMATRIPTAN SUCCINATE (Sun Pharmaceutical Industries), SUMATRIPTAN (Teva Pharmaceuticals USA), SUMATRIPTAN (Unit Dose Services), SUMATRIPTAN SUCCINATE (Wockhardt USA LLC.), SUMATRIPTAN (NuCare Pharmaceuticals)
Formula
C14H21N3O2S. C4H6O4
Exact mass
413.1621
Mol weight
413.4885
Structure
Simcomp
Class
Analgesic
 DG01484  5-HT1B-receptor agonist
 DG01485  5-HT1D-receptor agonist
 DG01518  5-HT1B/1D-receptor agonist
 DG01943  Triptan
Metabolizing enzyme substrate
 DG02917  MAO substrate
Remark
Therapeutic category: 2160
ATC code: N02CC01
Chemical structure group: DG00836
Product (DG00836): D00451<JP/US> D00676<JP/US>
Product (mixture): D11577<US>
Efficacy
Antimigraine, Vasoconstrictor, Serotonin receptor agonist
  Disease
Cluster headache [DS:H01588]
Comment
Triptans
Target
HTR1B [HSA:3351] [KO:K04153]
HTR1D [HSA:3352] [KO:K04153]
  Pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04726  Serotonergic synapse
Metabolism
Enzyme: MAOA [HSA:4128]
Interaction
Structure map
map07048  Antimigraines
map07211  Serotonin receptor agonists/antagonists
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 N NERVOUS SYSTEM
  N02 ANALGESICS
   N02C ANTIMIGRAINE PREPARATIONS
    N02CC Selective serotonin (5HT1) agonists
     N02CC01 Sumatriptan
      D00676  Sumatriptan succinate (JAN/USP) <JP/US>
USP drug classification [BR:br08302]
 Antimigraine Agents
  Serotonin (5-HT) Receptor Agonists
   Sumatriptan
    D00676  Sumatriptan succinate (JAN/USP)
Therapeutic category of drugs in Japan [BR:br08301]
 2  Agents affecting individual organs
  21  Cardiovascular agents
   216  Vasoconstrictors
    2160  Vasoconstrictors
     D00676  Sumatriptan succinate (JAN/USP)
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Serotonin
    HTR1B
     D00676  Sumatriptan succinate (JAN/USP) <JP/US>
    HTR1D
     D00676  Sumatriptan succinate (JAN/USP) <JP/US>
New drug approvals in Japan [br08318.html]
 Drugs with new active ingredients
  D00676
Drug metabolizing enzymes and transporters [br08309.html]
 Drug metabolizing enzymes
  D00676
Other DBs
CAS: 103628-48-4
PubChem: 7847742
ChEBI: 64359
ChEMBL: CHEMBL1201150
DrugBank: DB00669
LigandBox: D00676
NIKKAJI: J528.534H
LinkDB
KCF data

ATOM        28
            1   C8y C    23.6794  -17.9951
            2   C8y C    23.6853  -19.3996
            3   C8y C    25.0140  -17.5639
            4   C8x C    22.4731  -17.2843
            5   N4x N    25.0197  -19.8250
            6   C8x C    22.4673  -20.0930
            7   C8x C    25.8357  -18.6886
            8   C1b C    25.3287  -16.1944
            9   C8y C    21.2553  -17.9893
            10  C8x C    21.2610  -19.3937
            11  C1b C    26.6633  -15.7807
            12  C1b C    20.0373  -17.2957
            13  N1c N    26.9720  -14.4170
            14  S4a S    18.8310  -18.0010
            15  C1a C    28.3066  -14.0033
            16  C1a C    25.9464  -13.4671
            17  N1b N    17.6247  -17.3017
            18  O3c O    19.8217  -19.0033
            19  O3c O    17.8344  -19.0033
            20  C1a C    16.4124  -18.0067
            21  C1b C    30.7583  -18.8477
            22  C1b C    31.9646  -18.1484
            23  C6a C    29.5461  -18.1543
            24  C6a C    33.1767  -18.8420
            25  O6a O    28.3397  -18.8536
            26  O6a O    29.5461  -16.7557
            27  O6a O    34.3889  -18.1426
            28  O6a O    33.1767  -20.2406
BOND        28
            1     1   2 1
            2     1   3 1
            3     1   4 2
            4     2   5 1
            5     2   6 2
            6     3   7 2
            7     3   8 1
            8     4   9 1
            9     6  10 1
            10    8  11 1
            11    9  12 1
            12   11  13 1
            13   12  14 1
            14   13  15 1
            15   13  16 1
            16   14  17 1
            17   14  18 2
            18   14  19 2
            19   17  20 1
            20    5   7 1
            21    9  10 2
            22   21  22 1
            23   21  23 1
            24   22  24 1
            25   23  25 1
            26   23  26 2
            27   24  27 1
            28   24  28 2

» Japanese version   » Back

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