KEGG   DRUG: OlanzapineHelp
Entry
D00454                      Drug                                   

Name
Olanzapine (JAN/USP/INN);
Zyprexa (TN)
Product
  Generic
OLANZAPINE (A-S Medication Solutions), OLANZAPINE (A-S Medication Solutions), OLANZAPINE (A-S Medication Solutions), OLANZAPINE (ACETRIS HEALTH), OLANZAPINE (American Health Packaging), OLANZAPINE (American Health Packaging), OLANZAPINE (American Regent), OLANZAPINE (Aphena Pharma Solutions - Tennessee), OLANZAPINE (Apotex Corp.), OLANZAPINE (Apotex Corp.), OLANZAPINE (Aurobindo Pharma Limited), OLANZAPINE (Aurobindo Pharma Limited), OLANZAPINE (AvPAK), OLANZAPINE (Bryant Ranch Prepack), OLANZAPINE (Bryant Ranch Prepack), OLANZAPINE (Bryant Ranch Prepack), OLANZAPINE (Bryant Ranch Prepack), OLANZAPINE (Bryant Ranch Prepack), OLANZAPINE (Cadila Healthcare Limited), OLANZAPINE (Cardinal Health), OLANZAPINE (Clinical Solutions Wholesale), OLANZAPINE (Clinical Solutions Wholesale), OLANZAPINE (Dr. Reddy's Laboratories), OLANZAPINE (Dr. Reddy's Laboratories), OLANZAPINE (Dr. Reddy's Laboratories), OLANZAPINE (Dr.Reddy's Laboratories Limited), OLANZAPINE (Golden State Medical Supply), OLANZAPINE (Golden State Medical Supply), OLANZAPINE (Jiangsu Hansoh Pharmaceutical Group), OLANZAPINE (Jubilant Cadista Pharmaceuticals), OLANZAPINE (Macleods Pharmaceuticals Limited), OLANZAPINE (Macleods Pharmaceuticals Limited), OLANZAPINE (Major Pharmaceuticals), OLANZAPINE (Major Pharmaceuticals), OLANZAPINE (Major Pharmaceuticals), OLANZAPINE (Mylan Pharmaceuticals), OLANZAPINE (NCS HealthCare of KY), OLANZAPINE (Par Pharmaceutical), OLANZAPINE (Prasco Laboratories), OLANZAPINE (Proficient Rx LP), OLANZAPINE (Proficient Rx LP), OLANZAPINE (Proficient Rx LP), OLANZAPINE (Proficient Rx LP), OLANZAPINE (Qilu Pharmaceutical), OLANZAPINE (Quality Care Products), OLANZAPINE (Quality Care Products), OLANZAPINE (REMEDYREPACK), OLANZAPINE (REMEDYREPACK), OLANZAPINE (REMEDYREPACK), OLANZAPINE (REMEDYREPACK), OLANZAPINE (REMEDYREPACK), OLANZAPINE (REMEDYREPACK), OLANZAPINE (REMEDYREPACK), OLANZAPINE (REMEDYREPACK), OLANZAPINE (REMEDYREPACK), OLANZAPINE (REMEDYREPACK), OLANZAPINE (REMEDYREPACK), OLANZAPINE (REMEDYREPACK), OLANZAPINE (REMEDYREPACK), OLANZAPINE (REMEDYREPACK), OLANZAPINE (REMEDYREPACK), OLANZAPINE (REMEDYREPACK), OLANZAPINE (RedPharm Drug), OLANZAPINE (Sandoz), OLANZAPINE (Sandoz), OLANZAPINE (Sunshine Lake Pharma), OLANZAPINE (Sunshine Lake Pharma), OLANZAPINE (Teva Pharmaceuticals USA), OLANZAPINE (Torrent Pharmaceuticals Limited), OLANZAPINE (Virtus Pharmaceuticals), OLANZAPINE (Zydus Pharmaceuticals (USA))
Formula
C17H20N4S
Exact mass
312.1409
Mol weight
312.4325
Structure
Mol fileKCF fileDB search
Simcomp SIMCOMP
Class
Cardiovascular agent
 DG01466  Adrenergic receptor antagonist
  DG01465  alpha-Adrenergic receptor antagonist
   DG01457  alpha1-Adrenergic receptor antagonist
Neuropsychiatric agent
 DG01478  Dopamine antagonist
  DG01474  Dopamine D2-receptor antagonist
  DG01475  Dopamine D3-receptor antagonist
  DG01476  Dopamine D4-receptor antagonist
Anti-allergic agent
 DG01557  Histamine receptor antagonist
  DG01482  Histamine receptor H1 antagonist
Metabolizing enzyme substrate
 DG01892  CYP1A2 substrate
 DG01644  CYP2D6 substrate
Remark
Same as: C07322
Therapeutic category: 1179 2391
ATC code: N05AH03
Chemical structure group: DG00898
Product (DG00898): D00454<JP/US> D06623<US>
Product (mixture): D10206<US>
Efficacy
Antipsychotic
  Disease
Schizophrenia [DS:H01649]
Bipolar I disorder, manic or mixed episodes [DS:H01653]
Comment
Multi-acting-receptor-targeting-antipsychotics (MARTA)
Target
HTR2 [HSA:3356 3357 3358] [KO:K04157]
HTR6 [HSA:3362] [KO:K04162]
HRH1 [HSA:3269] [KO:K04149]
ADRA1 [HSA:148 147 146] [KO:K04135 K04136 K04137]
DRD2 [HSA:1813] [KO:K04145]
DRD3 [HSA:1814] [KO:K04146]
DRD4 [HSA:1815] [KO:K04147]
  Pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04726  Serotonergic synapse
hsa04728  Dopaminergic synapse
Metabolism
Enzyme: CYP1A2 [HSA:1544]; CYP2D6 [HSA:1565]
Interaction
Drug interaction
Structure map
map07117  Benzodiazepine family
map07211  Serotonin receptor agonists/antagonists
map07213  Dopamine receptor agonists/antagonists
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 N NERVOUS SYSTEM
  N05 PSYCHOLEPTICS
   N05A ANTIPSYCHOTICS
    N05AH Diazepines, oxazepines and thiazepines
     N05AH03 Olanzapine
      D00454  Olanzapine (JAN/USP/INN) <JP/US>
USP drug classification [BR:br08302]
 Antipsychotics
  2nd Generation/Atypical
   Olanzapine
    D00454  Olanzapine (JAN/USP/INN)
 Bipolar Agents
  Bipolar Agents, Other
   Olanzapine
    D00454  Olanzapine (JAN/USP/INN)
Therapeutic category of drugs in Japan [BR:br08301]
 1  Agents affecting nervous system and sensory organs
  11  Agents affecting central nervous system
   117  Psychotropics
    1179  Others
     D00454  Olanzapine (JAN/USP/INN)
 2  Agents affecting individual organs
  23  Digestive organ agents
   239  Miscellaneous
    2391  Antiemetics
     D00454  Olanzapine (JAN/USP/INN)
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Adrenaline
    ADRA1
     D00454  Olanzapine (JAN/USP/INN) <JP/US>
   Dopamine
    DRD2
     D00454  Olanzapine (JAN/USP/INN) <JP/US>
    DRD3
     D00454  Olanzapine (JAN/USP/INN) <JP/US>
    DRD4
     D00454  Olanzapine (JAN/USP/INN) <JP/US>
   Histamine
    HRH1
     D00454  Olanzapine (JAN/USP/INN) <JP/US>
   Serotonin
    HTR2
     D00454  Olanzapine (JAN/USP/INN) <JP/US>
    HTR6
     D00454  Olanzapine (JAN/USP/INN) <JP/US>
New drug approvals in Europe [br08329.html]
 European public assessment reports (EPAR) authorised medicine
  D00454
New drug approvals in Japan [br08318.html]
 Drugs with new active ingredients
  D00454
Drug metabolizing enzymes and transporters [br08309.html]
 Drug metabolizing enzymes
  D00454
BRITE hierarchy
Other DBs
CAS: 132539-06-1
PubChem: 7847520
ChEBI: 7735
ChEMBL: CHEMBL715
DrugBank: DB00334
LigandBox: D00454
NIKKAJI: J489.991A
LinkDB All DBs
KCF data Show

ATOM        22
            1   C8y C    18.4919  -10.5513
            2   C8y C    17.6483   -9.4316
            3   C8y C    17.9905   -8.0673
            4   N4x N    19.2617   -7.4901
            5   N5x N    19.9065  -10.5817
            6   C8y C    20.5211   -8.1208
            7   C8y C    20.8046   -9.4994
            8   S2x S    16.7987   -7.3203
            9   C8y C    15.7200   -8.2230
            10  C8x C    16.2450   -9.4575
            11  C1a C    14.3803   -7.9003
            12  N1y N    17.7660  -11.7484
            13  C8x C    22.1331   -9.9409
            14  C8x C    23.1798   -9.0111
            15  C8x C    22.8963   -7.6326
            16  C8x C    21.5678   -7.1910
            17  C1x C    16.3806  -11.7887
            18  C1x C    15.7162  -13.0210
            19  N1y N    16.4511  -14.2126
            20  C1x C    17.8365  -14.2422
            21  C1x C    18.5010  -12.9400
            22  C1a C    15.7566  -15.4262
BOND        25
            1     3   4 1
            2     1   5 2
            3     4   6 1
            4     2   3 2
            5     5   7 1
            6     1   2 1
            7     6   7 1
            8     3   8 1
            9     8   9 1
            10    9  10 2
            11    2  10 1
            12    9  11 1
            13    1  12 1
            14    7  13 2
            15   13  14 1
            16   14  15 2
            17   15  16 1
            18    6  16 2
            19   12  17 1
            20   17  18 1
            21   18  19 1
            22   19  20 1
            23   20  21 1
            24   12  21 1
            25   19  22 1

» Japanese version   » Back

KEGG   DRUG: Olanzapine pamoateHelp
Entry
D06623                      Drug                                   

Name
Olanzapine pamoate (USAN);
Olanzapine pamoate monohydrate;
Zyprexa (TN)
Product
Formula
C23H16O6. C17H20N4S. H2O
Exact mass
718.2461
Mol weight
718.8173
Structure
Mol fileKCF fileDB search
Class
Cardiovascular agent
 DG01466  Adrenergic receptor antagonist
  DG01465  alpha-Adrenergic receptor antagonist
   DG01457  alpha1-Adrenergic receptor antagonist
Neuropsychiatric agent
 DG01478  Dopamine antagonist
  DG01474  Dopamine D2-receptor antagonist
  DG01475  Dopamine D3-receptor antagonist
  DG01476  Dopamine D4-receptor antagonist
Anti-allergic agent
 DG01557  Histamine receptor antagonist
  DG01482  Histamine receptor H1 antagonist
Metabolizing enzyme substrate
 DG01892  CYP1A2 substrate
 DG01644  CYP2D6 substrate
Remark
ATC code: N05AH03
Chemical structure group: DG00898
Product (DG00898): D00454<JP/US> D06623<US>
Efficacy
Antipsychotic
  Disease
Schizophrenia [DS:H01649]
Comment
Multi-acting-receptor-targeting-antipsychotics (MARTA)
Target
HTR2 [HSA:3356 3357 3358] [KO:K04157]
HTR6 [HSA:3362] [KO:K04162]
HRH1 [HSA:3269] [KO:K04149]
ADRA1 [HSA:148 147 146] [KO:K04135 K04136 K04137]
DRD2 [HSA:1813] [KO:K04145]
DRD3 [HSA:1814] [KO:K04146]
DRD4 [HSA:1815] [KO:K04147]
  Pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04726  Serotonergic synapse
hsa04728  Dopaminergic synapse
Metabolism
Enzyme: CYP1A2 [HSA:1544]; CYP2D6 [HSA:1565]
Interaction
Drug interaction
Structure map
map07211  Serotonin receptor agonists/antagonists
map07213  Dopamine receptor agonists/antagonists
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 N NERVOUS SYSTEM
  N05 PSYCHOLEPTICS
   N05A ANTIPSYCHOTICS
    N05AH Diazepines, oxazepines and thiazepines
     N05AH03 Olanzapine
      D06623  Olanzapine pamoate (USAN) <US>
USP drug classification [BR:br08302]
 Antipsychotics
  2nd Generation/Atypical
   Olanzapine
    D06623  Olanzapine pamoate (USAN)
 Bipolar Agents
  Bipolar Agents, Other
   Olanzapine
    D06623  Olanzapine pamoate (USAN)
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Adrenaline
    ADRA1
     D06623  Olanzapine pamoate (USAN) <US>
   Dopamine
    DRD2
     D06623  Olanzapine pamoate (USAN) <US>
    DRD3
     D06623  Olanzapine pamoate (USAN) <US>
    DRD4
     D06623  Olanzapine pamoate (USAN) <US>
   Histamine
    HRH1
     D06623  Olanzapine pamoate (USAN) <US>
   Serotonin
    HTR2
     D06623  Olanzapine pamoate (USAN) <US>
    HTR6
     D06623  Olanzapine pamoate (USAN) <US>
New drug approvals in Europe [br08329.html]
 European public assessment reports (EPAR) authorised medicine
  D06623
Drug metabolizing enzymes and transporters [br08309.html]
 Drug metabolizing enzymes
  D06623
BRITE hierarchy
Other DBs
CAS: 221373-18-8
PubChem: 47208274
ChEMBL: CHEMBL3989694
DrugBank: DB00334
LigandBox: D06623
LinkDB All DBs
KCF data Show

ATOM        52
            1   C8y C    11.3427  -11.7361
            2   C8y C    10.4996  -10.6169
            3   C8y C    10.8416   -9.2533
            4   N4x N    12.1122   -8.6764
            5   N5x N    12.7566  -11.7665
            6   C8y C    13.3709   -9.3068
            7   C8y C    13.6543  -10.6847
            8   S2x S     9.6504   -8.5067
            9   C8y C     8.5722   -9.4089
            10  C8x C     9.0970  -10.6428
            11  C1a C     7.2332   -9.0864
            12  N1y N    10.6172  -12.9326
            13  C8x C    14.9821  -11.1260
            14  C8x C    16.0283  -10.1966
            15  C8x C    15.7450   -8.8188
            16  C8x C    14.4171   -8.3774
            17  C1x C     9.2325  -12.9729
            18  C1x C     8.5684  -14.2046
            19  N1y N     9.3030  -15.3956
            20  C1x C    10.6877  -15.4251
            21  C1x C    11.3518  -14.1236
            22  C1a C     8.6088  -16.6086
            23  C8x C    16.8979  -13.3774
            24  C8x C    16.8979  -14.7572
            25  C8x C    18.0927  -15.4470
            26  C8x C    19.2877  -14.7572
            27  C8y C    19.2877  -13.3774
            28  C8y C    18.0927  -12.6876
            29  C8y C    20.4825  -12.6876
            30  C8y C    20.4825  -11.3078
            31  C8y C    19.2877  -10.6180
            32  C8x C    18.0927  -11.3078
            33  C1b C    22.3693  -13.5166
            34  C8y C    23.9624  -12.6976
            35  C8y C    25.1320  -13.3729
            36  C8y C    26.3269  -12.6829
            37  C8x C    26.3269  -11.3032
            38  C8y C    25.1572  -10.6280
            39  C8y C    23.9623  -11.3179
            40  C8x C    25.1320  -14.7526
            41  C8x C    26.3270  -15.4424
            42  C8x C    27.5218  -14.7525
            43  C8x C    27.5218  -13.3728
            44  C6a C    19.2877   -9.2384
            45  O6a O    20.5011   -8.5377
            46  O6a O    18.1114   -8.5592
            47  C6a C    25.1570   -9.2383
            48  O6a O    23.9765   -8.5569
            49  O6a O    26.3662   -8.5399
            50  O1a O    21.6794  -10.6168
            51  O1a O    22.7422  -10.6134
            52  O0  O    22.8900  -16.5200
BOND        57
            1     3   4 1
            2     1   5 2
            3     4   6 1
            4     2   3 2
            5     5   7 1
            6     1   2 1
            7     6   7 1
            8     3   8 1
            9     8   9 1
            10    9  10 2
            11    2  10 1
            12    9  11 1
            13    1  12 1
            14    7  13 2
            15   13  14 1
            16   14  15 2
            17   15  16 1
            18    6  16 2
            19   12  17 1
            20   17  18 1
            21   18  19 1
            22   19  20 1
            23   20  21 1
            24   12  21 1
            25   19  22 1
            26   23  24 2
            27   24  25 1
            28   25  26 2
            29   26  27 1
            30   27  28 2
            31   23  28 1
            32   27  29 1
            33   29  30 2
            34   30  31 1
            35   31  32 2
            36   28  32 1
            37   29  33 1
            38   33  34 1
            39   34  35 1
            40   35  36 2
            41   36  37 1
            42   37  38 2
            43   38  39 1
            44   34  39 2
            45   35  40 1
            46   40  41 2
            47   41  42 1
            48   42  43 2
            49   36  43 1
            50   31  44 1
            51   44  45 2
            52   44  46 1
            53   38  47 1
            54   47  48 2
            55   47  49 1
            56   30  50 1
            57   39  51 1

» Japanese version   » Back

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