KEGG   DRUG: Ondansetron
Entry
D00456                      Drug                                   

Name
Ondansetron (JAN/USP/INN);
Zofran ODT (TN)
Product
  Generic
ONDANSETRON (A-S Medication Solutions), ONDANSETRON (A-S Medication Solutions), ONDANSETRON (A-S Medication Solutions), ONDANSETRON (Asclemed USA), ONDANSETRON (Aurobindo Pharma Limited), ONDANSETRON (BluePoint Laboratories), ONDANSETRON (Bryant Ranch Prepack), ONDANSETRON (Bryant Ranch Prepack), ONDANSETRON (Bryant Ranch Prepack), ONDANSETRON (Bryant Ranch Prepack), ONDANSETRON (Bryant Ranch Prepack), ONDANSETRON (Bryant Ranch Prepack), ONDANSETRON (Cardinal Health), ONDANSETRON (DIRECT RX), ONDANSETRON (Denton Pharma), ONDANSETRON (Denton Pharma), ONDANSETRON (Direct Rx), ONDANSETRON (HF Acquisition Co LLC), ONDANSETRON (HF Acquisition Co LLC), ONDANSETRON (Lake Erie Medical DBA Quality Care Products LLC), ONDANSETRON (Lake Erie Medical DBA Quality Care Products LLC), ONDANSETRON (Medsource Pharmaceuticals), ONDANSETRON (Mylan Pharmaceuticals), ONDANSETRON (NuCare Pharmaceuticals), ONDANSETRON (NuCare Pharmaceuticals), ONDANSETRON (NuCare Pharmaceuticals), ONDANSETRON (NuCare Pharmaceuticals), ONDANSETRON (NuCare Pharmaceuticals), ONDANSETRON (NuCare Pharmaceuticals), ONDANSETRON (NuCare Pharmaceuticals), ONDANSETRON (NuCare Pharmaceuticals), ONDANSETRON (NuCare Pharmaceuticals), ONDANSETRON (NuCare Pharmaceuticals), ONDANSETRON (NuCare Pharmaceuticals), ONDANSETRON (NuCare Pharmaceuticals), ONDANSETRON (NuCare Pharmaceuticals), ONDANSETRON (NuCare Pharmaceuticals), ONDANSETRON (NuCare Pharmaceuticals), ONDANSETRON (NuCare Pharmaceuticals), ONDANSETRON (PD-Rx Pharmaceuticals), ONDANSETRON (PD-Rx Pharmaceuticals), ONDANSETRON (PD-Rx Pharmaceuticals), ONDANSETRON (PD-Rx Pharmaceuticals), ONDANSETRON (Preferred Pharmaceuticals), ONDANSETRON (Preferred Pharmaceuticals), ONDANSETRON (Preferred Pharmaceuticals), ONDANSETRON (Preferred Pharmaceuticals), ONDANSETRON (Proficient Rx LP), ONDANSETRON (Proficient Rx LP), ONDANSETRON (Proficient Rx LP), ONDANSETRON (Proficient Rx LP), ONDANSETRON (Proficient Rx LP), ONDANSETRON (Proficient Rx LP), ONDANSETRON (REMEDYREPACK), ONDANSETRON (Rising Health), ONDANSETRON (Sandoz), ONDANSETRON (St Marys Medical Park Pharmacy), ONDANSETRON (St Marys Medical Park Pharmacy), ONDANSETRON (St. Mary's Medical Park Pharmacy), ONDANSETRON (United States Department of Health & Human Services)
Formula
C18H19N3O
Exact mass
293.1528
Mol weight
293.363
Structure
Simcomp
Class
Gastrointestinal agent
 DG01762  Antiemetic
Other
 DG01489  5-HT3-receptor antagonist
Metabolizing enzyme substrate
 DG01892  CYP1A2 substrate
 DG01644  CYP2D6 substrate
 DG02913  CYP3A4 substrate
Remark
Same as: C07325
ATC code: A04AA01
Chemical structure group: DG00060
Product (DG00060): D00456<US> D00678<JP/US>
Efficacy
Anti-emetic, Serotonin 5-HT3 receptor antagonist
Target
  Pathway
hsa04726  Serotonergic synapse
Metabolism
Enzyme: CYP1A2 [HSA:1544], CYP3A4 [HSA:1576], CYP2D6 [HSA:1565]
Interaction
Structure map
map07211  Serotonin receptor agonists/antagonists
Other map
map04976  Bile secretion
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 A ALIMENTARY TRACT AND METABOLISM
  A04 ANTIEMETICS AND ANTINAUSEANTS
   A04A ANTIEMETICS AND ANTINAUSEANTS
    A04AA Serotonin (5HT3) antagonists
     A04AA01 Ondansetron
      D00456  Ondansetron (JAN/USP/INN) <US>
USP drug classification [BR:br08302]
 Antiemetics
  Emetogenic Therapy Adjuncts
   Ondansetron
    D00456  Ondansetron (JAN/USP/INN)
Target-based classification of drugs [BR:br08310]
 Ion channels
  Ligand-gated ion channels
   Serotonin
    HTR3
     D00456  Ondansetron (JAN/USP/INN) <US>
Drug metabolizing enzymes and transporters [br08309.html]
 Drug metabolizing enzymes
  D00456
Other DBs
CAS: 99614-02-5
PubChem: 7847522
ChEBI: 7773
ChEMBL: CHEMBL46
DrugBank: DB00904
LigandBox: D00456
NIKKAJI: J245.610I
LinkDB
KCF data

ATOM        22
            1   C8y C    33.5159  -17.7325
            2   C8y C    34.8490  -18.1807
            3   C8y C    33.5217  -16.3295
            4   C5x C    32.3109  -18.4368
            5   C8y C    35.6698  -17.0396
            6   C8x C    35.4254  -19.4557
            7   N4y N    34.8607  -15.9044
            8   C1x C    32.3109  -15.6367
            9   C1y C    31.0941  -17.7325
            10  O5x O    32.3166  -19.8341
            11  C8x C    37.0613  -17.1794
            12  C8x C    36.8167  -19.5896
            13  C1a C    35.2972  -14.5771
            14  C1x C    31.0941  -16.3295
            15  C1b C    29.8831  -18.4368
            16  C8x C    37.6318  -18.4544
            17  N4y N    28.6780  -17.7325
            18  C8y C    28.7203  -16.3253
            19  C8x C    27.3348  -18.1219
            20  N5x N    27.3985  -15.8508
            21  C1a C    29.8791  -15.5437
            22  C8x C    26.5473  -16.9625
BOND        25
            1     1   2 1
            2     1   3 2
            3     1   4 1
            4     2   5 1
            5     2   6 2
            6     3   7 1
            7     3   8 1
            8     4   9 1
            9     4  10 2
            10    5  11 2
            11    6  12 1
            12    7  13 1
            13    8  14 1
            14    9  15 1
            15   11  16 1
            16   15  17 1
            17   17  18 1
            18   17  19 1
            19   18  20 2
            20   18  21 1
            21   19  22 2
            22    5   7 1
            23    9  14 1
            24   12  16 2
            25   20  22 1

» Japanese version   » Back

KEGG   DRUG: Ondansetron hydrochloride hydrate
Entry
D00678                      Drug                                   

Name
Ondansetron hydrochloride hydrate (JAN/USP);
Ondansetron hydrochloride;
Zofran (TN)
Product
  Generic
ONDANSETRON (A-S Medication Solutions), ONDANSETRON (A-S Medication Solutions), ONDANSETRON (ACTAVIS PHARMA), ONDANSETRON (Accord Healthcare), ONDANSETRON (Accord Healthcare), ONDANSETRON (American Health Packaging), ONDANSETRON (Amneal Pharmaceuticals LLC), ONDANSETRON (Apotex Corp.), ONDANSETRON (Atlantic Biologicals Corps), ONDANSETRON (Bryant Ranch Prepack), ONDANSETRON (Cardinal Health), ONDANSETRON (Cardinal Health), ONDANSETRON (Cardinal Health), ONDANSETRON (Cardinal Health), ONDANSETRON (Civica), ONDANSETRON (Direct_Rx), ONDANSETRON (Direct_Rx), ONDANSETRON (Direct_Rx), ONDANSETRON (Direct_Rx), ONDANSETRON (Direct_Rx), ONDANSETRON (Eywa Pharma), ONDANSETRON (Fosun Pharma USA), ONDANSETRON (General Injectables and Vaccines), ONDANSETRON (Gland Pharma Limited), ONDANSETRON (Gland Pharma Limited), ONDANSETRON (Glenmark Pharmaceuticals), ONDANSETRON (HF Acquisition Co LLC), ONDANSETRON (HF Acquisition Co LLC), ONDANSETRON (HF Acquisition Co LLC), ONDANSETRON (HF Acquisition Co LLC), ONDANSETRON (Heritage Pharmaceuticals), ONDANSETRON (Heritage Pharmaceuticals), ONDANSETRON (Lohxa), ONDANSETRON (McKesson Corporation dba RX Pak), ONDANSETRON (McKesson Corporation dba SKY Packaging), ONDANSETRON (Medical Purchasing Solutions), ONDANSETRON (Medical Purchasing Solutions), ONDANSETRON (Medical Purchasing Solutions), ONDANSETRON HYDROCHLORIDE (Medical Purchasing Solutions), ONDANSETRON (Medical Purchasing Solutions), ONDANSETRON (Medsource Pharmaceuticals), ONDANSETRON HYDROCHLORIDE (Mylan Institutional LLC), ONDANSETRON (NuCare Pharmaceuticals), ONDANSETRON (NuCare Pharmaceuticals), ONDANSETRON (NuCare Pharmaceuticals), ONDANSETRON (PD-Rx Pharmaceuticals), ONDANSETRON (PD-Rx Pharmaceuticals), ONDANSETRON (PharmPak), ONDANSETRON (Preferred Pharmaceuticals), ONDANSETRON (Proficient Rx LP), ONDANSETRON (Proficient Rx LP), ONDANSETRON (Qilu Pharmaceutical), ONDANSETRON (REMEDYREPACK), ONDANSETRON (RedPharm Drug), ONDANSETRON (Sun Pharmaceutical Industries), ONDANSETRON (Unit Dose Services), ONDANSETRON (Unit Dose Services), ONDANSETRON (West-Ward Pharmaceuticals Corp), ONDANSETRON (West-Ward Pharmaceuticals Corp.), ONDANSETRON (West-Ward Pharmaceuticals Corp.), ONDANSETRON (A-S Medication Solutions), ONDANSETRON HYDROCHLORIDE (A-S Medication Solutions), ONDANSETRON HYDROCHLORIDE (A-S Medication Solutions), ONDANSETRON HYDROCHLORIDE (American Health Packaging), ONDANSETRON HYDROCHLORIDE (Aphena Pharma Solutions - Tennessee), ONDANSETRON (Ascend Laboratories), ONDANSETRON (Athenex Pharmaceutical Division), ONDANSETRON (AuroMedics Pharma LLC), ONDANSETRON (AuroMedics Pharma LLC), ONDANSETRON HYDROCHLORIDE (Aurobindo Pharma Limited), ONDANSETRON (Aurobindo Pharma Limited), ONDANSETRON HYDROCHLORIDE (AvPAK), ONDANSETRON HYDROCHLORIDE (Baxter Healthcare Corporation), ONDANSETRON HYDROCHLORIDE (Bryant Ranch Prepack), ONDANSETRON (Bryant Ranch Prepack), ONDANSETRON HYDROCHLORIDE (Bryant Ranch Prepack), ONDANSETRON HYDROCHLORIDE (Bryant Ranch Prepack), ONDANSETRON HYDROCHLORIDE (Bryant Ranch Prepack), ONDANSETRON HYDROCHLORIDE (Bryant Ranch Prepack), ONDANSETRON HYDROCHLORIDE (Bryant Ranch Prepack), ONDANSETRON HYDROCHLORIDE (Cardinal Health), ONDANSETRON HYDROCHLORIDE (Cardinal Health), ONDANSETRON (Cardinal Health), ONDANSETRON HYDROCHLORIDE (Cardinal Health), ONDANSETRON HYDROCHLORIDE (Cardinal Health), ONDANSETRON HYDROCHLORIDE (Clinical Solutions Wholesale), ONDANSETRON HYDROCHLORIDE (DOH CENTRAL PHARMACY), ONDANSETRON HYDROCHLORIDE (Denton Pharma), ONDANSETRON HYDROCHLORIDE (Denton Pharma), ONDANSETRON HYDROCHLORIDE (Denton Pharma), ONDANSETRON HYDROCHLORIDE (Dr. Reddy's Laboratories Limited), ONDANSETRON HYDROCHLORIDE (Dr. Reddy's Laboratories Limited), ONDANSETRON (Fresenius Kabi USA), ONDANSETRON (Fresenius Kabi USA), ONDANSETRON HYDROCHLORIDE (Heritage Pharmaceuticals), ONDANSETRON HYDROCHLORIDE (Heritage Pharmaceuticals), ONDANSETRON HYDROCHLORIDE (KAISER FOUNDATION HOSPITALS), ONDANSETRON HYDROCHLORIDE (Lake Erie Medical DBA Quality Care Products LLC), ONDANSETRON HYDROCHLORIDE (Lake Erie Medical DBA Quality Care Products LLC), ONDANSETRON HYDROCHLORIDE (Lannett Company), ONDANSETRON (Lannett Company), ONDANSETRON HYDROCHLORIDE (Major Pharmaceuticals), ONDANSETRON (Medical Purchasing Solutions), ONDANSETRON HYDROCHLORIDE (NCS HealthCare of KY), ONDANSETRON HYDROCHLORIDE (NUCARE PHARMACEUTICALS), ONDANSETRON (NorthStar Rx LLC), ONDANSETRON HYDROCHLORIDE (Northwind Pharmaceuticals), ONDANSETRON HYDROCHLORIDE (NuCare Pharmaceuticals), ONDANSETRON HYDROCHLORIDE (NuCare Pharmaceuticals), ONDANSETRON HYDROCHLORIDE (NuCare Pharmaceuticals), ONDANSETRON HYDROCHLORIDE (NuCare Pharmaceuticals), ONDANSETRON (NuCare Pharmaceuticals), ONDANSETRON HYDROCHLORIDE (NuCare Pharmaceuticals), ONDANSETRON (NuCare Pharmaceuticals), ONDANSETRON HYDROCHLORIDE (NuCare Pharmaceuticals), ONDANSETRON HYDROCHLORIDE (NuCare Pharmceuticals), ONDANSETRON HYDROCHLORIDE (PD-Rx Pharmaceuticals), ONDANSETRON HYDROCHLORIDE (PD-Rx Pharmaceuticals), ONDANSETRON (PD-Rx Pharmaceuticals), ONDANSETRON HYDROCHLORIDE (Pharmpak), ONDANSETRON HYDROCHLORIDE (Precision Dose), ONDANSETRON HYDROCHLORIDE (Preferred Pharmaceuticals), ONDANSETRON HYDROCHLORIDE (Proficient Rx LP), ONDANSETRON HYDROCHLORIDE (Proficient Rx LP), ONDANSETRON (Proficient Rx LP), ONDANSETRON (Proficient Rx LP), ONDANSETRON HYDROCHLORIDE (QPharma), ONDANSETRON HYDROCHLORIDE (QPharma), ONDANSETRON HYDROCHLORIDE (REMEDYREPACK), ONDANSETRON HYDROCHLORIDE (REMEDYREPACK), ONDANSETRON HYDROCHLORIDE (RedPharm Drug), ONDANSETRON HYDROCHLORIDE (RedPharm Drug), ONDANSETRON HYDROCHLORIDE (Rising Health), ONDANSETRON (Sagent Pharmaceuticals), ONDANSETRON HYDROCHLORIDE (St. Mary's Medical Park Pharmacy), ONDANSETRON HYDROCHLORIDE (St. Mary's Medical Park Pharmacy), ONDANSETRON HYDROCHLORIDE (Sun Pharmaceutical Industries), ONDANSETRON HYDROCHLORIDE (Taro Pharmaceuticals U.S.A.), ONDANSETRON (Taro Pharmaceuticals U.S.A.), ONDANSETRON HYDROCHLORIDE (Unit Dose Services), ONDANSETRON (Unit Dose Services), ONDANSETRON (Unit Dose Services), ONDANSETRON HYDROCHLORIDE (Unit Dose Services), ONDANSETRON HYDROCHLORIDE (West-Ward Pharmaceuticals Corp.), ONDANSETRON HYDROCHLORIDE (Wockhardt USA LLC.), ONDANSETRON HYDROCHLORIDE (medsource pharmaceuticals), ONDANSETRON (Natco Pharma Limited)
Formula
C18H19N3O. 2H2O. HCl
Exact mass
365.1506
Mol weight
365.8545
Structure
Simcomp
Class
Gastrointestinal agent
 DG01762  Antiemetic
Other
 DG01489  5-HT3-receptor antagonist
Metabolizing enzyme substrate
 DG01892  CYP1A2 substrate
 DG01644  CYP2D6 substrate
 DG02913  CYP3A4 substrate
Remark
Therapeutic category: 2391
ATC code: A04AA01
Chemical structure group: DG00060
Product (DG00060): D00456<US> D00678<JP/US>
Efficacy
Anti-emetic, Serotonin 5-HT3 receptor antagonist
Target
  Pathway
hsa04726  Serotonergic synapse
Metabolism
Enzyme: CYP1A2 [HSA:1544], CYP2D6 [HSA:1565], CYP3A4 [HSA:1576]
Interaction
Structure map
map07211  Serotonin receptor agonists/antagonists
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 A ALIMENTARY TRACT AND METABOLISM
  A04 ANTIEMETICS AND ANTINAUSEANTS
   A04A ANTIEMETICS AND ANTINAUSEANTS
    A04AA Serotonin (5HT3) antagonists
     A04AA01 Ondansetron
      D00678  Ondansetron hydrochloride hydrate (JAN/USP) <JP/US>
USP drug classification [BR:br08302]
 Antiemetics
  Emetogenic Therapy Adjuncts
   Ondansetron
    D00678  Ondansetron hydrochloride hydrate (JAN/USP)
Therapeutic category of drugs in Japan [BR:br08301]
 2  Agents affecting individual organs
  23  Digestive organ agents
   239  Miscellaneous
    2391  Antiemetics
     D00678  Ondansetron hydrochloride hydrate (JAN/USP)
Target-based classification of drugs [BR:br08310]
 Ion channels
  Ligand-gated ion channels
   Serotonin
    HTR3
     D00678  Ondansetron hydrochloride hydrate (JAN/USP) <JP/US>
Drug metabolizing enzymes and transporters [br08309.html]
 Drug metabolizing enzymes
  D00678
Other DBs
CAS: 103639-04-9
PubChem: 7847744
ChEBI: 7774
ChEMBL: CHEMBL3186492
DrugBank: DB00904
LigandBox: D00678
NIKKAJI: J1.630.992C
LinkDB
KCF data

ATOM        25
            1   C8y C    27.9300   -8.4700
            2   C8y C    29.2600   -8.9600
            3   C8y C    27.9300   -7.0700
            4   C5x C    26.7400   -9.1700
            5   C8y C    30.0300   -7.7700
            6   C8x C    29.8200  -10.2200
            7   N4y N    29.2600   -6.6500
            8   C1x C    26.7400   -6.3700
            9   C1y C    25.4800   -8.4700
            10  O5x O    26.7400  -10.5700
            11  C8x C    31.4300   -7.9100
            12  C8x C    31.2200  -10.3600
            13  C1a C    29.6800   -5.3200
            14  C1x C    25.4800   -7.0700
            15  C1b C    24.2900   -9.1700
            16  C8x C    32.0600   -9.2400
            17  N4y N    23.1000   -8.4700
            18  C8y C    23.1000   -7.0700
            19  C8x C    21.7000   -8.8900
            20  N5x N    21.7700   -6.5800
            21  C1a C    24.2900   -6.3000
            22  C8x C    20.9300   -7.7000
            23  X   Cl   34.7900   -6.5800
            24  O0  O    35.4900   -8.5400
            25  O0  O    35.4900   -8.5400
BOND        25
            1     1   2 1
            2     1   3 2
            3     1   4 1
            4     2   5 1
            5     2   6 2
            6     3   7 1
            7     3   8 1
            8     4   9 1
            9     4  10 2
            10    5  11 2
            11    6  12 1
            12    7  13 1
            13    8  14 1
            14    9  15 1
            15   11  16 1
            16   15  17 1
            17   17  18 1
            18   17  19 1
            19   18  20 2
            20   18  21 1
            21   19  22 2
            22    5   7 1
            23    9  14 1
            24   12  16 2
            25   20  22 1
BRACKET     1    33.3200   -9.3800   33.3200   -7.7700
            1    35.9800   -7.7700   35.9800   -9.3800
            1  2
 ORIGINAL  1   24
 REPEAT    1   25

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