KEGG   DRUG: Quetiapine fumarateHelp
Entry
D00458                      Drug                                   

Name
Quetiapine fumarate (JP17/USAN);
Seroquel (TN)
Product
  Generic
QUETIAPINE FUMARATE (A-S Medication Solutions), QUETIAPINE (A-S Medication Solutions), QUETIAPINE (ACI Healthcare USA), QUETIAPINE (Accord Healthcare), QUETIAPINE FUMARATE (American Health Packaging), QUETIAPINE FUMARATE (Aurobindo Pharma Limited), QUETIAPINE FUMARATE (BluePoint Laboratories), QUETIAPINE FUMARATE (Bryant Ranch Prepack), QUETIAPINE (Bryant Ranch Prepack), QUETIAPINE FUMARATE (Contract Pharmacy Services-PA), QUETIAPINE (Contract Pharmacy Services-PA), QUETIAPINE (Macleods Pharmaceuticals Limited), QUETIAPINE (Marlex Pharmaceuticals), QUETIAPINE (NCS HealthCare of KY), QUETIAPINE (Northstar RxLLC), QUETIAPINE (NuCare Pharmaceuticals), QUETIAPINE (NuCare Pharmaceuticals), QUETIAPINE (Preferred Pharmaceuticals), QUETIAPINE (Preferred Pharmaceuticals), QUETIAPINE (Preferred Pharmaceuticals), QUETIAPINE (Preferred Pharmaceuticals), QUETIAPINE (Proficient Rx LP), QUETIAPINE (REMEDYREPACK), QUETIAPINE (REMEDYREPACK), QUETIAPINE (REMEDYREPACK), QUETIAPINE (REMEDYREPACK), QUETIAPINE (REMEDYREPACK), QUETIAPINE (REMEDYREPACK), QUETIAPINE (REMEDYREPACK), QUETIAPINE (REMEDYREPACK), QUETIAPINE (REMEDYREPACK), QUETIAPINE (REMEDYREPACK), QUETIAPINE (REMEDYREPACK), QUETIAPINE (REMEDYREPACK), QUETIAPINE (REMEDYREPACK), QUETIAPINE (REMEDYREPACK), QUETIAPINE (REMEDYREPACK), QUETIAPINE (REMEDYREPACK), QUETIAPINE (RPK Pharmaceuticals), QUETIAPINE (ScieGen Pharmaceuticals), QUETIAPINE (Teva Pharmaceuticals USA), QUETIAPINE FUMARATE (Unit Dose Services), QUETIAPINE (Amneal Pharmaceuticals LLC), QUETIAPINE FUMARATE (A-S Medication Solutions), QUETIAPINE FUMARATE (A-S Medication Solutions), QUETIAPINE FUMARATE (A-S Medication Solutions), QUETIAPINE FUMARATE (A-S Medication Solutions), QUETIAPINE FUMARATE (Accord Healthcare), QUETIAPINE FUMARATE (Accord Healthcare), QUETIAPINE FUMARATE (Akron Pharma), QUETIAPINE FUMARATE (Alembic Pharmaceuticals Limited), QUETIAPINE FUMARATE (American Health Packaging), QUETIAPINE FUMARATE (American Health Packaging), QUETIAPINE FUMARATE (Aphena Pharma Solutions - Tennessee), QUETIAPINE FUMARATE (Aphena Pharma Solutions - Tennessee), QUETIAPINE FUMARATE (Aphena Pharma Solutions - Tennessee), QUETIAPINE FUMARATE (Aphena Pharma Solutions - Tennessee), QUETIAPINE FUMARATE (Aphena Pharma Solutions - Tennessee), QUETIAPINE FUMARATE (Aphena Pharma Solutions - Tennessee), QUETIAPINE FUMARATE (Apotex Corp.), QUETIAPINE FUMARATE (Ascend Laboratories), QUETIAPINE FUMARATE (AstraZeneca Pharmaceuticals LP), QUETIAPINE FUMARATE (Aurobindo Pharma Limited), QUETIAPINE FUMARATE (AvPAK), QUETIAPINE FUMARATE (Avera McKennan Hospital), QUETIAPINE FUMARATE (Avera McKennan Hospital), QUETIAPINE FUMARATE (Bryant Ranch Prepack), QUETIAPINE FUMARATE (Bryant Ranch Prepack), QUETIAPINE FUMARATE (Bryant Ranch Prepack), QUETIAPINE FUMARATE (Bryant Ranch Prepack), QUETIAPINE FUMARATE (Bryant Ranch Prepack), QUETIAPINE FUMARATE (Bryant Ranch Prepack), QUETIAPINE FUMARATE (Cardinal Health), QUETIAPINE FUMARATE (Cardinal Health), QUETIAPINE FUMARATE (Cardinal Health), QUETIAPINE FUMARATE (Carilion Materials Management), QUETIAPINE FUMARATE (Citron Pharma LLC), QUETIAPINE FUMARATE (Contract Pharmacy Services-PA), QUETIAPINE FUMARATE (DIRECT RX), QUETIAPINE FUMARATE (Direct RX), QUETIAPINE FUMARATE (Dr.Reddy's Laboratories Limited), QUETIAPINE FUMARATE (Golden State Medical Supply), QUETIAPINE FUMARATE (Golden State Medical Supply), QUETIAPINE FUMARATE (Ingenus Pharmaceuticals), QUETIAPINE FUMARATE (Jubilant Cadista Pharmaceuticals), QUETIAPINE FUMARATE (LUPIN LIMITED), QUETIAPINE FUMARATE (Lake Erie Medical DBA Quality Care Products LLC), QUETIAPINE FUMARATE (Lake Erie Medical DBA Quality Care Products LLC), QUETIAPINE FUMARATE (Lake Erie Medical DBA Quality Care Products LLC), QUETIAPINE FUMARATE (Lake Erie Medical DBA Quality Care Products LLC), QUETIAPINE FUMARATE (Lupin Pharmaceuticals), QUETIAPINE FUMARATE (Lupin Pharmaceuticals), QUETIAPINE FUMARATE (Macleods Pharmaceuticals Limited), QUETIAPINE FUMARATE (Major Pharmaceuticals), QUETIAPINE FUMARATE (Major Pharmaceuticals), QUETIAPINE FUMARATE (Major Pharmaceuticals), QUETIAPINE FUMARATE (McKesson Corporation), QUETIAPINE FUMARATE (NCS HealthCare of KY), QUETIAPINE FUMARATE (NCS HealthCare of KY), QUETIAPINE FUMARATE (NuCare Pharmaceuticals), QUETIAPINE FUMARATE (Par Pharmaceutical), QUETIAPINE FUMARATE (Preferred Pharmaceuticals), QUETIAPINE FUMARATE (Preferred Pharmaceuticals), QUETIAPINE FUMARATE (Preferred Pharmaceuticals), QUETIAPINE FUMARATE (Proficient Rx LP), QUETIAPINE FUMARATE (Proficient Rx LP), QUETIAPINE FUMARATE (Proficient Rx LP), QUETIAPINE FUMARATE (REMEDYREPACK), QUETIAPINE FUMARATE (REMEDYREPACK), QUETIAPINE FUMARATE (REMEDYREPACK), QUETIAPINE FUMARATE (REMEDYREPACK), QUETIAPINE FUMARATE (REMEDYREPACK), QUETIAPINE FUMARATE (REMEDYREPACK), QUETIAPINE FUMARATE (REMEDYREPACK), QUETIAPINE FUMARATE (REMEDYREPACK), QUETIAPINE FUMARATE (REMEDYREPACK), QUETIAPINE FUMARATE (REMEDYREPACK), QUETIAPINE FUMARATE (REMEDYREPACK), QUETIAPINE FUMARATE (REMEDYREPACK), QUETIAPINE FUMARATE (REMEDYREPACK), QUETIAPINE FUMARATE (REMEDYREPACK), QUETIAPINE FUMARATE (REMEDYREPACK), QUETIAPINE FUMARATE (REMEDYREPACK), QUETIAPINE FUMARATE (REMEDYREPACK), QUETIAPINE FUMARATE (REMEDYREPACK), QUETIAPINE FUMARATE (REMEDYREPACK), QUETIAPINE FUMARATE (REMEDYREPACK), QUETIAPINE FUMARATE (REMEDYREPACK), QUETIAPINE FUMARATE (RedPharm Drug), QUETIAPINE FUMARATE (RedPharm Drug), QUETIAPINE FUMARATE (RedPharm Drug), QUETIAPINE FUMARATE (RedPharm Drug), QUETIAPINE FUMARATE (Safecor Health), QUETIAPINE FUMARATE (Sandoz), QUETIAPINE FUMARATE (SpecGx LLC), QUETIAPINE FUMARATE (Sun Pharmaceutical Industries), QUETIAPINE FUMARATE (TORRENT PHARMACEUTICALS LIMITED), QUETIAPINE FUMARATE (TYA Pharmaceuticals), QUETIAPINE FUMARATE (TYA Pharmaceuticals), QUETIAPINE FUMARATE (TYA Pharmaceuticals), QUETIAPINE FUMARATE (TYA Pharmaceuticals), QUETIAPINE FUMARATE (TruPharma), QUETIAPINE FUMARATE (Unichem Pharmaceuticals (USA)), QUETIAPINE FUMARATE (West-Ward Pharmaceuticals Corp)
Formula
(C21H25N3O2S)2. C4H4O4
Exact mass
882.3445
Mol weight
883.0864
Structure
Mol fileKCF fileDB search
Class
Cardiovascular agent
 DG01466  Adrenergic receptor antagonist
  DG01465  alpha-Adrenergic receptor antagonist
   DG01457  alpha1-Adrenergic receptor antagonist
Neuropsychiatric agent
 DG01478  Dopamine antagonist
  DG01474  Dopamine D2-receptor antagonist
  DG01475  Dopamine D3-receptor antagonist
  DG01476  Dopamine D4-receptor antagonist
Anti-allergic agent
 DG01557  Histamine receptor antagonist
  DG01482  Histamine receptor H1 antagonist
Enzyme substrate
 DG01633  CYP3A substrate
Remark
Therapeutic category: 1179
ATC code: N05AH04
Chemical structure group: DG00899
Product (DG00899): D00458<JP/US>
Efficacy
Antipsychotic
  Disease
Schizophrenia [DS:H01649]
Bipolar disorder [DS:H01653]
Comment
Multi-acting-receptor-targeting-antipsychotics (MARTA)
Target
HTR2A [HSA:3356] [KO:K04157]
DRD2 [HSA:1813] [KO:K04145]
  Pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04726  Serotonergic synapse
hsa04728  Dopaminergic synapse
Metabolism
Enzyme: CYP3A4 [HSA:1576]
Interaction
Drug interaction
Structure map
map07213  Dopamine receptor agonists/antagonists
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 N NERVOUS SYSTEM
  N05 PSYCHOLEPTICS
   N05A ANTIPSYCHOTICS
    N05AH Diazepines, oxazepines and thiazepines
     N05AH04 Quetiapine
      D00458  Quetiapine fumarate (JP17/USAN) <JP/US>
USP drug classification [BR:br08302]
 Antidepressants
  Antidepressants, Other
   Quetiapine
    D00458  Quetiapine fumarate (JP17/USAN)
 Antipsychotics
  2nd Generation/Atypical
   Quetiapine
    D00458  Quetiapine fumarate (JP17/USAN)
 Bipolar Agents
  Bipolar Agents, Other
   Quetiapine
    D00458  Quetiapine fumarate (JP17/USAN)
Therapeutic category of drugs in Japan [BR:br08301]
 1  Agents affecting nervous system and sensory organs
  11  Agents affecting central nervous system
   117  Psychotropics
    1179  Others
     D00458  Quetiapine fumarate (JP17/USAN)
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Dopamine
    DRD2
     D00458  Quetiapine fumarate (JP17/USAN) <JP/US>
   Serotonin
    HTR2A
     D00458  Quetiapine fumarate (JP17/USAN) <JP/US>
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D00458  Quetiapine fumarate
  D00458  Quetiapine fumarate tablets
  D00458  Quetiapine fumarate fine granules
Drug classes of therapeutic agents [br08360.html]
 Psychiatric agents
  D00458
New drug approvals in Japan [br08318.html]
 Drugs with new active ingredients
  D00458
BRITE hierarchy
Other DBs
CAS: 111974-72-2
PubChem: 7847524
ChEBI: 8708
ChEMBL: CHEMBL3188993
DrugBank: DB01224
LigandBox: D00458
NIKKAJI: J388.154G
LinkDB All DBs
KCF data Show

ATOM        62
            1   C6a C    22.4475  -22.4692
            2   C2b C    23.6586  -23.1712
            3   O6a O    21.2365  -23.1712
            4   O6a O    22.4475  -21.0711
            5   C2b C    24.8753  -22.4692
            6   C6a C    26.0863  -23.1712
            7   O6a O    27.2973  -22.4692
            8   O6a O    26.0863  -24.5693
            9   C8y C    16.3800  -19.7400
            10  N2x N    15.5400  -20.8600
            11  C2y C    14.1400  -20.8600
            12  C8y C    13.2300  -19.8100
            13  C8y C    16.1000  -18.4100
            14  C8y C    13.5100  -18.4100
            15  S2x S    14.7700  -17.7800
            16  C8x C    12.4600  -17.5000
            17  C8x C    11.1300  -17.9200
            18  C8x C    10.8500  -19.3200
            19  C8x C    11.9000  -20.2300
            20  C8x C    17.7800  -20.1600
            21  C8x C    18.7600  -19.1800
            22  C8x C    18.4100  -17.7800
            23  C8x C    17.0800  -17.4300
            24  N1y N    13.5100  -22.1200
            25  C1x C    12.1800  -22.2600
            26  C1x C    11.5500  -23.5200
            27  N1y N    12.3900  -24.7100
            28  C1x C    13.7200  -24.5700
            29  C1x C    14.3500  -23.3100
            30  C1b C    11.8300  -25.9700
            31  C1b C    10.4300  -25.9700
            32  O2a O     9.7300  -24.7800
            33  C1b C     8.3300  -24.7800
            34  C1b C     7.6300  -23.5900
            35  O1a O     6.2300  -23.5900
            36  C8y C    16.3800  -19.7400
            37  C8y C    16.1000  -18.4100
            38  S2x S    14.7700  -17.7800
            39  C8y C    13.5100  -18.4100
            40  C8y C    13.2300  -19.8100
            41  C2y C    14.1400  -20.8600
            42  N2x N    15.5400  -20.8600
            43  N1y N    13.5100  -22.1200
            44  C1x C    12.1800  -22.2600
            45  C1x C    11.5500  -23.5200
            46  N1y N    12.3900  -24.7100
            47  C1x C    13.7200  -24.5700
            48  C1x C    14.3500  -23.3100
            49  C1b C    11.8300  -25.9700
            50  C1b C    10.4300  -25.9700
            51  O2a O     9.7300  -24.7800
            52  C1b C     8.3300  -24.7800
            53  C1b C     7.6300  -23.5900
            54  O1a O     6.2300  -23.5900
            55  C8x C    11.9000  -20.2300
            56  C8x C    10.8500  -19.3200
            57  C8x C    11.1300  -17.9200
            58  C8x C    12.4600  -17.5000
            59  C8x C    17.0800  -17.4300
            60  C8x C    18.4100  -17.7800
            61  C8x C    18.7600  -19.1800
            62  C8x C    17.7800  -20.1600
BOND        67
            1     1   2 1
            2     1   3 1
            3     1   4 2
            4     2   5 2
            5     5   6 1
            6     6   7 1
            7     6   8 2
            8    11  12 1
            9     9  13 1
            10   12  14 1
            11   10  11 2
            12   13  15 1
            13    9  10 1
            14   14  15 1
            15   14  16 2
            16   16  17 1
            17   17  18 2
            18   18  19 1
            19   12  19 2
            20    9  20 2
            21   20  21 1
            22   21  22 2
            23   22  23 1
            24   13  23 2
            25   11  24 1
            26   24  25 1
            27   25  26 1
            28   26  27 1
            29   27  28 1
            30   28  29 1
            31   24  29 1
            32   27  30 1
            33   30  31 1
            34   31  32 1
            35   32  33 1
            36   33  34 1
            37   34  35 1
            38   41  40 1
            39   36  37 1
            40   40  39 1
            41   42  41 2
            42   37  38 1
            43   36  42 1
            44   39  38 1
            45   39  58 2
            46   58  57 1
            47   57  56 2
            48   56  55 1
            49   40  55 2
            50   36  62 2
            51   62  61 1
            52   61  60 2
            53   60  59 1
            54   37  59 2
            55   41  43 1
            56   43  44 1
            57   44  45 1
            58   45  46 1
            59   46  47 1
            60   47  48 1
            61   43  48 1
            62   46  49 1
            63   49  50 1
            64   50  51 1
            65   51  52 1
            66   52  53 1
            67   53  54 1
BRACKET     1     4.4800  -26.8800    4.4800  -16.8000
            1    19.1800  -16.8000   19.1800  -26.8800
            1  2
 ORIGINAL  1    9  13  15  14  12  11  10  24  25  26  27  28  29  30  31  32
            1   33  34  35  19  18  17  16  23  22  21  20
 REPEAT    1   36  37  38  39  40  41  42  43  44  45  46  47  48  49  50  51
            1   52  53  54  55  56  57  58  59  60  61  62

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