KEGG   DRUG: PrednisoneHelp
Entry
D00473                      Drug                                   

Name
Prednisone (USP);
Prednisone monohydrate;
Deltasone (TN);
Meticorten (TN);
Rayos (TN)
Product
  Generic
PREDNISONE (A-S Medication Solutions), PREDNISONE (A-S Medication Solutions), PREDNISONE (A-S Medication Solutions), PREDNISONE (A-S Medication Solutions), PREDNISONE (A-S Medication Solutions), PREDNISONE (A-S Medication Solutions), PREDNISONE (A-S Medication Solutions), PREDNISONE (A-S Medication Solutions), PREDNISONE (A-S Medication Solutions), PREDNISONE (A-S Medication Solutions), PREDNISONE (A-S Medication Solutions), PREDNISONE (A-S Medication Solutions), PREDNISONE (Actavis Pharma), PREDNISONE (Aidarex Pharmaceuticals LLC), PREDNISONE (Aidarex Pharmaceuticals LLC), PREDNISONE (Aidarex Pharmaceuticals LLC), PREDNISONE (Aidarex Pharmaceuticals LLC), PREDNISONE (Aidarex Pharmaceuticals LLC), PREDNISONE (Aidarex Pharmaceuticals LLC), PREDNISONE (American Health Packaging), PREDNISONE (Aphena Pharma Solutions - Tennessee), PREDNISONE (Aphena Pharma Solutions - Tennessee), PREDNISONE (Aphena Pharma Solutions - Tennessee), PREDNISONE (Apotheca), PREDNISONE (Apotheca), PREDNISONE (Bryant Ranch Prepack), PREDNISONE (Bryant Ranch Prepack), PREDNISONE (Bryant Ranch Prepack), PREDNISONE (Bryant Ranch Prepack), PREDNISONE (Bryant Ranch Prepack), PREDNISONE (Bryant Ranch Prepack), PREDNISONE (Bryant Ranch Prepack), PREDNISONE (Bryant Ranch Prepack), PREDNISONE (Bryant Ranch Prepack), PREDNISONE (Bryant Ranch Prepack), PREDNISONE (Bryant Ranch Prepack), PREDNISONE (Bryant Ranch Prepack), PREDNISONE (Bryant Ranch Prepack), PREDNISONE (Bryant Ranch Prepack), PREDNISONE (Cambridge Therapeutics Technologies), PREDNISONE (Cardinal Health), PREDNISONE (Cardinal Health), PREDNISONE (Clinical Solutions Wholesale), PREDNISONE (DIRECT RX), PREDNISONE (Denton Pharma), PREDNISONE (Denton Pharma), PREDNISONE (Denton Pharma), PREDNISONE (Denton Pharma), PREDNISONE (Denton Pharma), PREDNISONE (Diect_Rx), PREDNISONE (DirectRX), PREDNISONE (Direct_Rx), PREDNISONE (Direct_Rx), PREDNISONE (Direct_Rx), PREDNISONE (Direct_Rx), PREDNISONE (Direct_Rx), PREDNISONE (Direct_Rx), PREDNISONE (Direct_Rx), PREDNISONE (Direct_Rx), PREDNISONE (Direct_Rx), PREDNISONE (GeneYork Pharmaceuticals Group LLC), PREDNISONE (GeneYork Pharmaceuticals Group LLC), PREDNISONE (GeneYork Pharmaceuticals Group LLC), PREDNISONE (H. J. Harkins Company), PREDNISONE (H. J. Harkins Company), PREDNISONE (H.J. Harkins Company), PREDNISONE (JUBILANT CADISTA PHARMACEUTICALS), PREDNISONE (JUBILANT CADISTA PHARMACEUTICALS), PREDNISONE (Lake Erie Medical DBA Quality Care Products LLC), PREDNISONE (Lake Erie medical DBA Quality Care Products LLC), PREDNISONE (Lannett Company), PREDNISONE (Lannett Company), PREDNISONE (Lannett Company), PREDNISONE (McKesson Corporation dba SKY Packaging), PREDNISONE (McKesson Corporation dba SKY Packaging), PREDNISONE (Mylan Pharmaceuticals), PREDNISONE (NCS HealthCare of KY), PREDNISONE (NCS HealthCare of KY), PREDNISONE (Novitium Pharma LLC), PREDNISONE (NuCare Pharmaceuticals), PREDNISONE (NuCare Pharmaceuticals), PREDNISONE (NuCare Pharmaceuticals), PREDNISONE (NuCare Pharmaceuticals), PREDNISONE (NuCare Pharmaceuticals), PREDNISONE (NuCare Pharmaceuticals), PREDNISONE (NuCare Pharmaceuticals), PREDNISONE (NuCare Pharmaceuticals), PREDNISONE (NuCare Pharmaceuticals), PREDNISONE (NuCare Pharmaceuticals), PREDNISONE (NuCare Pharmaceuticals), PREDNISONE (NuCare Pharmaceuticals), PREDNISONE (NuCare Pharmaceuticals), PREDNISONE (NuCare Pharmaceuticals), PREDNISONE (NuCare Pharmaceuticals), PREDNISONE (NuCare Pharmaceuticals), PREDNISONE (NuCare Pharmaceuticals), PREDNISONE (NuCare Pharmaceuticals), PREDNISONE (NuCare Pharmaceuticls), DELTASONE (Oculus Innovative Sciences), PREDNISONE (PD-Rx Pharmaceuticals), PREDNISONE (PD-Rx Pharmaceuticals), PREDNISONE (PD-Rx Pharmaceuticals), PREDNISONE (PD-Rx Pharmaceuticals), PREDNISONE (PD-Rx Pharmaceuticals), PREDNISONE (Par Pharmaceutical), PREDNISONE (PharmPak), PREDNISONE (Preferred Pharmaceuticals), PREDNISONE (Preferred Pharmaceuticals), PREDNISONE (Proficient Rx LP), PREDNISONE (Proficient Rx LP), PREDNISONE (Proficient Rx LP), PREDNISONE (Proficient Rx LP), PREDNISONE (Proficient Rx LP), PREDNISONE (Proficient Rx LP), PREDNISONE (Proficient Rx LP), PREDNISONE (Proficient Rx LP), PREDNISONE (Proficient Rx LP), PREDNISONE (QPharma), PREDNISONE (QPharma), PREDNISONE (QPharma), PREDNISONE (QPharma), PREDNISONE (QPharma), PREDNISONE (QPharma), PREDNISONE (Quality Care Products), PREDNISONE (Quality Care Products), PREDNISONE (REMEDYREPACK), PREDNISONE (REMEDYREPACK), PREDNISONE (REMEDYREPACK), PREDNISONE (REMEDYREPACK), PREDNISONE (REMEDYREPACK), PREDNISONE (REMEDYREPACK), PREDNISONE (REMEDYREPACK), PREDNISONE (REMEDYREPACK), PREDNISONE (REMEDYREPACK), PREDNISONE (REMEDYREPACK), PREDNISONE (REMEDYREPACK), PREDNISONE (REMEDYREPACK), PREDNISONE (REMEDYREPACK), PREDNISONE (REMEDYREPACK), PREDNISONE (REMEDYREPACK), PREDNISONE (REMEDYREPACK), PREDNISONE (REMEDYREPACK), PREDNISONE (REMEDYREPACK), PREDNISONE (REMEDYREPACK), PREDNISONE (REMEDYREPACK), PREDNISONE (REMEDYREPACK), PREDNISONE (REMEDYREPACK), PREDNISONE (REMEDYREPACK), PREDNISONE (REMEDYREPACK), PREDNISONE (REMEDYREPACK), PREDNISONE (RPK Pharmaceuticals), PREDNISONE (RPK Pharmaceuticals), PREDNISONE (RPK Pharmaceuticals), PREDNISONE (RPK Pharmaceuticals), PREDNISONE (RedPharm Drug), PREDNISONE (RedPharm Drug), PREDNISONE (RedPharm Drug), PREDNISONE (RedPharm Drug), PREDNISONE (RedPharm Drug), PREDNISONE (Safecor Health), DELTASONE (Sonoma Pharmaceuticals), PREDNISONE (St. Mary's Medical Park Pharmacy), PREDNISONE (St. Mary's Medical Park Pharmacy), PREDNISONE (St. Mary's Medical Park Pharmacy), PREDNISONE (St. Mary's Medical Park Pharmacy), PREDNISONE (Unit Dose Services), PREDNISONE (Unit Dose Services), PREDNISONE (Unit Dose Services), PREDNISONE (West-Ward Pharmaceuticals Corp.), PREDNISONE (West-ward Pharmaceuticals Corp)
Formula
C21H26O5. H2O
Exact mass
376.1886
Mol weight
376.4434
Structure
Mol fileKCF fileDB search
Simcomp SIMCOMP
Class
Anti-inflammatory
 DG01955  Corticosteroid
  DG02068  Glucocorticoid
Remark
ATC code: A07EA03 H02AB07
Chemical structure group: DG00094
Product (DG00094): D00473<US>
Efficacy
Anti-inflammatory, Glucocorticoid receptor agonist
  Disease
Atopic dermatitis [DS:H01358]
Allergic rhinitis [DS:H01360]
Bullous dermatitis herpetiformis [DS:H01362]
Contact dermatitis [DS:H01357]
Mycosis fungoides [DS:H01463]
Pemphigus [DS:H01648]
Severe erythema multiforme (Stevens-Johnson syndrome) [DS:H01694]
Congenital adrenal hyperplasia [DS:H00216]
Primary or secondary adrenocortical insufficiency [DS:H01598]
Crohn's disease [DS:H00286]
Ulcerative colitis [DS:H01466]
Acquired (autoimmune) hemolytic anemia [DS:H01585]
Diamond-Blackfan anemia [DS:H00237]
Idiopathic thrombocytopenic purpura [DS:H01240]
Pure red cell aplasia [DS:H01586]
Multiple sclerosis [DS:H01490]
Chronic obstructive pulmonary disease [DS:H01714]
Allergic bronchopulmonary aspergillosis [DS:H01328]
Asthma [DS:H00079]
Pulmonary tuberculosis [DS:H00342]
Hypersensitivity pneumonitis [DS:H00346]
Idiopathic pulmonary fibrosis [DS:H01299]
Pneumocystis carinii pneumonia [DS:H01521]
Ankylosing spondylitis [DS:H01674]
Dermatomyositis and polymyositis [DS:H01604]
Polymyalgia rheumatica [DS:H01606]
Psoriatic arthritis [DS:H01507]
Relapsing polychondritis [DS:H01758]
Rheumatoid arthritis [DS:H00630]
Juvenile rheumatoid arthritis [DS:H01672]
Sjogren's syndrome [DS:H01502]
Systemic lupus erythematosus [DS:H00080]
Target
NR3C1 (GR) [HSA:2908] [KO:K05771]
  Pathway
hsa04080  Neuroactive ligand-receptor interaction
Interaction
Drug interaction
Structure map
map07043  Antineoplastics - hormones
map07046  Immunosuppressive agents
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 A ALIMENTARY TRACT AND METABOLISM
  A07 ANTIDIARRHEALS, INTESTINAL ANTIINFLAMMATORY/ANTIINFECTIVE AGENTS
   A07E INTESTINAL ANTIINFLAMMATORY AGENTS
    A07EA Corticosteroids acting locally
     A07EA03 Prednisone
      D00473  Prednisone (USP) <US>
 H SYSTEMIC HORMONAL PREPARATIONS, EXCL. SEX HORMONES AND INSULINS
  H02 CORTICOSTEROIDS FOR SYSTEMIC USE
   H02A CORTICOSTEROIDS FOR SYSTEMIC USE, PLAIN
    H02AB Glucocorticoids
     H02AB07 Prednisone
      D00473  Prednisone (USP) <US>
USP drug classification [BR:br08302]
 Hormonal Agents, Stimulant/Replacement/Modifying (Adrenal)
  Prednisone
   D00473  Prednisone (USP)
 Inflammatory Bowel Disease Agents
  Glucocorticoids
   Prednisone
    D00473  Prednisone (USP)
Target-based classification of drugs [BR:br08310]
 Nuclear receptors
  Estrogen like receptors
   3-Ketosteroid receptor
    NR3C1 (GR)
     D00473  Prednisone (USP) <US>
Antineoplastics [br08340.html]
 D00473
BRITE hierarchy
Other DBs
PubChem: 7847539
DrugBank: DB00635
LigandBox: D00473
LinkDB All DBs
KCF data Show

ATOM        27
            1   C2x C     4.2529  -10.3884
            2   C5x C     4.2529  -11.7514
            3   C2x C     5.4333  -12.4329
            4   C2y C     6.6137  -11.7514
            5   C1z C     6.6137  -10.3884
            6   C2x C     5.4333   -9.7068
            7   C1x C     7.7941  -12.4329
            8   C1x C     8.9745  -11.7514
            9   C1y C     8.9745  -10.3884
            10  C1y C     7.7941   -9.7068
            11  C1y C    10.1550   -9.7068
            12  C1z C    10.1550   -8.3438
            13  C1x C     8.9745   -7.6623
            14  C5x C     7.7941   -8.3438
            15  C1x C    12.5157   -9.7068
            16  C1x C    12.5157   -8.3438
            17  C1z C    11.3354   -7.6623
            18  O5x O     3.0725  -12.4329
            19  C1a C     6.6137   -9.0253
            20  O5x O     6.6157   -7.6635
            21  C1a C    10.1550   -6.9808
            22  C5a C    11.3354   -6.0948
            23  O1a O    12.5157   -6.9808
            24  C1b C    12.5197   -5.4111
            25  O5a O    10.1589   -5.4155
            26  O1a O    13.6856   -6.0843
            27  O0  O    15.8200   -9.8700
BOND        29
            1     1   2 1
            2     2   3 1
            3     3   4 2
            4     4   5 1
            5     5   6 1
            6     1   6 2
            7     4   7 1
            8     7   8 1
            9     8   9 1
            10    9  10 1
            11    5  10 1
            12    9  11 1
            13   11  12 1
            14   12  13 1
            15   13  14 1
            16   10  14 1
            17   11  15 1
            18   15  16 1
            19   16  17 1
            20   12  17 1
            21    2  18 2
            22    5  19 1 #Up
            23   14  20 2
            24   12  21 1 #Up
            25   17  22 1 #Up
            26   17  23 1 #Down
            27   22  24 1
            28   22  25 2
            29   24  26 1

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