DRUG: Promethazine hydrochloride
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Entry
D00480 Drug
Name
Promethazine hydrochloride (JP17/USP);
Phenergan (TN);
Promethegan (TN)
Product
Generic
PROMETHAZINE HYDROCHLORIDE (Amneal Pharmaceuticals LLC)
,
PROMETHAZINE (PharmPak)
,
PROMETHAZINE HCI (HF Acquisition Co. LLC)
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PROMETHAZINE HCI (HF Acquisition Co. LLC)
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PROMETHAZINE HYDROCHLORIDE (A-S Medication Solutions)
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PROMETHAZINE HYDROCHLORIDE (A-S Medication Solutions)
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PROMETHAZINE HYDROCHLORIDE (A-S Medication Solutions)
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PHENADOZ (A-S Medication Solutions)
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PROMETHAZINE HYDROCHLORIDE (A-S Medication Solutions)
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PROMETHAZINE HYDROCHLORIDE (A-S Medication Solutions)
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PROMETHAZINE HYDROCHLORIDE (A-S Medication Solutions)
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PHENADOZ (A-S Medication Solutions)
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PROMETHAZINE HYDROCHLORIDE (Actavis Pharma)
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PHENADOZ (Actavis Pharma)
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PROMETHAZINE HYDROCHLORIDE (American Health Packaging)
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PROMETHAZINE HYDROCHLORIDE (Amneal Pharmaceuticals LLC)
,
PROMETHAZINE HYDROCHLORIDE (BluePoint Laboratories)
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PROMETHAZINE HYDROCHLORIDE (Bryant Ranch Prepack)
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PROMETHAZINE HYDROCHLORIDE (Bryant Ranch Prepack)
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PROMETHAZINE HYDROCHLORIDE (Bryant Ranch Prepack)
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PROMETHAZINE HYDROCHLORIDE (Bryant Ranch Prepack)
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PROMETHAZINE HYDROCHLORIDE (Bryant Ranch Prepack)
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PROMETHAZINE HYDROCHLORIDE (Bryant Ranch Prepack)
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PROMETHAZINE HYDROCHLORIDE (Bryant Ranch Prepack)
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PROMETHAZINE HYDROCHLORIDE (Bryant Ranch Prepack)
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PROMETHAZINE HYDROCHLORIDE (Cadila Healthcare Limited)
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PROMETHAZINE HYDROCHLORIDE (Cardinal Health)
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PROMETHAZINE HYDROCHLORIDE (Cardinal Health)
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PROMETHAZINE HYDROCHLORIDE (Clinical Solutions Wholesale)
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PROMETHAZINE HYDROCHLORIDE (Contract Pharmacy Services-PA)
,
PROMETHEGAN (Cosette Pharmaceuticals)
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PROMETHEGAN (Cosette Pharmaceuticals)
,
PROMETHAZINE HYDROCHLORIDE (DIERCT RX)
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PROMETHAZINE HYDROCHLORIDE (DIRECT RX)
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PROMETHAZINE HYDROCHLORIDE (DIRECT RX)
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PROMETHAZINE HYDROCHLORIDE (DIRECT RX)
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PROMETHAZINE HYDROCHLORIDE (DIRECT RX)
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PROMETHAZINE HYDROCHLORIDE (Denton Pharma)
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PROMETHAZINE HYDROCHLORIDE (Denton Pharma)
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PROMETHAZINE HYDROCHLORIDE (Denton Pharma)
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PROMETHAZINE HYDROCHLORIDE (Denton Pharma)
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PROMETHAZINE HYDROCHLORIDE (Direct Rx)
,
PROMETHAZINE HYDROCHLORIDE (Direct_Rx)
,
PROMETHAZINE HYDROCHLORIDE (Direct_Rx)
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PROMETHAZINE HYDROCHLORIDE (General Injectables & Vaccines)
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PROMETHAZINE HYDROCHLORIDE (General Injectables & Vaccines)
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PROMETHAZINE HYDROCHLORIDE (General Injectables and Vaccines)
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PROMETHAZINE HYDROCHLORIDE (Golden State Medical Supply)
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PROMETHAZINE HYDROCHLORIDE (Hi-Tech Pharmacal)
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PROMETHAZINE HYDROCHLORIDE (KVK-Tech)
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PROMETHAZINE HYDROCHLORIDE (Lake Erie Medical DBA Quality Care Products LLC)
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PROMETHAZINE HYDROCHLORIDE (Lake Erie Medical DBA Quality Care Products LLC)
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PROMETHAZINE HYDROCHLORIDE (Major Pharmaceuticals)
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PROMETHAZINE HYDROCHLORIDE (Marlex Pharmaceuticals)
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PROMETHAZINE HYDROCHLORIDE (McKesson Corporation dba SKY Packaging)
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PROMETHAZINE HYDROCHLORIDE (Medical Purchasing Solutions)
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PROMETHAZINE HYDROCHLORIDE (Morton Grove Pharmaceuticals)
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PROMETHAZINE HYDROCHLORIDE (NCS HealthCare of KY)
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PROMETHAZINE HYDROCHLORIDE (Nostrum Laboratories)
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PROMETHAZINE HYDROCHLORIDE (PD-Rx Pharmaceuticals)
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PROMETHAZINE HYDROCHLORIDE (PD-Rx Pharmaceuticals)
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PROMETHEGAN (PD-Rx Pharmaceuticals)
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PROMETHAZINE HYDROCHLORIDE (PD-Rx Pharmaceuticals)
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PROMETHAZINE HYDROCHLORIDE (PD-Rx Pharmaceuticals)
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PROMETHAZINE HYDROCHLORIDE (PD-Rx Pharmaceuticals)
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PROMETHAZINE HYDROCHLORIDE (PD-Rx Pharmaceuticals)
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PROMETHAZINE (PD-Rx Pharmaceuticals)
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PROMETHAZINE HYDROCHLORIDE (PD-Rx Pharmaceuticals)
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PROMETHAZINE HYDROCHLORIDE (Par Pharmaceutical)
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PROMETHAZINE HYDROCHLORIDE (Perrigo New York)
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PROMETHAZINE HYDROCHLORIDE (Pharmaceutical Associates)
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PROMETHAZINE HYDROCHLORIDE (Preferred Pharmaceutical)
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PROMETHAZINE HYDROCHLORIDE (Preferred Pharmaceuticals)
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PROMETHAZINE HYDROCHLORIDE (Proficient Rx LP)
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PROMETHAZINE HYDROCHLORIDE (Proficient Rx LP)
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PROMETHAZINE HYDROCHLORIDE (Proficient Rx LP)
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PROMETHAZINE HYDROCHLORIDE (Proficient Rx LP)
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PHENERGAN (REMEDYREPACK)
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PROMETHAZINE HYDROCHLORIDE (REMEDYREPACK)
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PROMETHAZINE HYDROCHLORIDE (REMEDYREPACK)
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PROMETHAZINE HYDROCHLORIDE (REMEDYREPACK)
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PROMETHAZINE HYDROCHLORIDE (REMEDYREPACK)
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PROMETHAZINE HYDROCHLORIDE (REMEDYREPACK)
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PROMETHAZINE HYDROCHLORIDE (REMEDYREPACK)
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PROMETHAZINE HYDROCHLORIDE (REMEDYREPACK)
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PROMETHAZINE HYDROCHLORIDE (REMEDYREPACK)
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PROMETHAZINE HYDROCHLORIDE (RPK Pharmaceuticals)
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PROMETHAZINE HYDROCHLORIDE (RedPharm Drug)
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PROMETHAZINE HYDROCHLORIDE (RedPharm Drug)
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PROMETHAZINE HYDROCHLORIDE (RedPharm Drug)
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PROMETHAZINE HYDROCHLORIDE (RedPharm Drug)
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PROMETHAZINE HYDROCHLORIDE (Sandoz)
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PROMETHAZINE HYDROCHLORIDE (St. Mary's Medical Park Pharmacy)
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PROMETHAZINE HYDROCHLORIDE (St. Mary's Medical Park Pharmacy)
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PROMETHAZINE HYDROCHLORIDE (Strides Pharma Science Limited)
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PROMETHAZINE HYDROCHLORIDE (Taro Pharmaceuticals U.S.A.)
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PROMETHAZINE HYDROCHLORIDE (West-Ward Pharmaceuticals Corp.)
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PROMETHAZINE HYDROCHLORIDE (West-Ward Pharmaceuticals Corp.)
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PHENERGAN (West-Ward Pharmaceuticals Corp.)
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PROMETHAZINE HYDROCHLORIDE (West-Ward Pharmaceuticals Corp.)
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PHENERGAN (West-Ward Pharmaceuticals Corp.)
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PROMETHAZINE HYDROCHLORIDE (West-Ward Pharmaceuticals Corp.)
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PROMETHAZINE HYDROCHLORIDE (West-Ward Pharmaceuticals Corp.)
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PROMETHAZINE HCL (Wockhardt USA LLC.)
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PROMETHAZINE HYDROCHLORIDE (X-GEN Pharmaceuticals)
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PROMETHAZINE HYDROCHLORIDE (X-GEN Pharmaceuticals)
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PROMETHAZINE HYDROCHLORIDE (Zydus Pharmaceuticals (USA))
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PROMETHAZINE HYDROCHLORIDE (medsource pharmaceuticals)
Formula
C17H20N2S. HCl
Exact mass
320.1114
Mol weight
320.88
Structure
Mol file
KCF file
DB search
Simcomp
Neighbor
Class
Anti-allergic agent
DG01557
Histamine receptor antagonist
DG01482
Histamine receptor H1 antagonist
Metabolizing enzyme substrate
DG01644
CYP2D6 substrate
Remark
Therapeutic category:
4413
ATC code:
D04AA10 R06AD02
Chemical structure group:
DG00385
Product (DG00385):
D00480<
JP
/US> D03290<
JP
> D08768<
JP
>
Product (mixture):
D11852<
US
> D11853<
US
> D11854<
US
>
Efficacy
Antiallergic, Anti-emetic, Antiparkinsonian, H1 receptor antagonist
Disease
Perennial and seasonal allergic rhinitis [DS:
H01360
]
Comment
Phenothiazine derivative
Target
HRH1 [HSA:
3269
] [KO:
K04149
]
Pathway
hsa04020
Calcium signaling pathway
hsa04080
Neuroactive ligand-receptor interaction
hsa04750
Inflammatory mediator regulation of TRP channels
Metabolism
Enzyme: CYP2D6 [HSA:
1565
]
Interaction
DDI search
Structure map
map07028
Antipsychotics
map07029
Antipsychotics - phenothiazines
map07032
Hypnotics
map07212
Histamine H1 receptor antagonists
map07213
Dopamine receptor agonists/antagonists
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:
br08303
]
D DERMATOLOGICALS
D04 ANTIPRURITICS, INCL. ANTIHISTAMINES, ANESTHETICS, ETC.
D04A ANTIPRURITICS, INCL. ANTIHISTAMINES, ANESTHETICS, ETC.
D04AA Antihistamines for topical use
D04AA10 Promethazine
D00480 Promethazine hydrochloride (JP17/USP) <JP/US>
R RESPIRATORY SYSTEM
R06 ANTIHISTAMINES FOR SYSTEMIC USE
R06A ANTIHISTAMINES FOR SYSTEMIC USE
R06AD Phenothiazine derivatives
R06AD02 Promethazine
D00480 Promethazine hydrochloride (JP17/USP) <JP/US>
USP drug classification [BR:
br08302
]
Antiemetics
Antiemetics, Other
Promethazine
D00480 Promethazine hydrochloride (JP17/USP)
Respiratory Tract/Pulmonary Agents
Antihistamines
Histamine (H1) Receptor Antagonists, Sedating
Promethazine
D00480 Promethazine hydrochloride (JP17/USP)
Therapeutic category of drugs in Japan [BR:
br08301
]
4 Agents affecting cellular function
44 Allergic agents
441 Antihistamines
4413 Phenothiazines
D00480 Promethazine hydrochloride (JP17/USP)
Risk category of Japanese OTC drugs [BR:
br08312
]
Designated second-class OTC drugs
Inorganic and organic chemicals
Promethazine
D00480 Promethazine hydrochloride (JP17/USP)
Second-class OTC drugs
Inorganic and organic chemicals
Promethazine
D00480 Promethazine hydrochloride (JP17/USP)
Target-based classification of drugs [BR:
br08310
]
G Protein-coupled receptors
Rhodopsin family
Histamine
HRH1
D00480 Promethazine hydrochloride (JP17/USP) <JP/US>
Drugs listed in the Japanese Pharmacopoeia [BR:
br08311
]
Chemicals
D00480 Promethazine hydrochloride
Drug metabolizing enzymes and transporters [
br08309.html
]
Drug metabolizing enzymes
D00480
BRITE hierarchy
Other DBs
CAS:
58-33-3
PubChem:
7847546
ChEBI:
8462
ChEMBL:
CHEMBL1200750
DrugBank:
DB01069
LigandBox:
D00480
NIKKAJI:
J371.970G
LinkDB
All DBs
KCF data
Show
ATOM 21
1 N1y N 24.1512 -19.0928
2 C8y C 25.3914 -19.7915
3 C8y C 22.9575 -19.7915
4 C1b C 24.1512 -17.6779
5 C8y C 25.3914 -21.1947
6 C8x C 26.5851 -19.0928
7 C8y C 22.9575 -21.1947
8 C8x C 21.7580 -19.0928
9 C1c C 25.3565 -16.9850
10 S2x S 24.1512 -21.8934
11 C8x C 26.5851 -21.8934
12 C8x C 27.7904 -19.7915
13 C8x C 21.7580 -21.8934
14 C8x C 20.5179 -19.7915
15 N1c N 25.3565 -15.6691
16 C1a C 26.5442 -17.6779
17 C8x C 27.7904 -21.1947
18 C8x C 20.5179 -21.1947
19 C1a C 24.0173 -14.8947
20 C1a C 26.4919 -14.9296
21 X Cl 30.1777 -19.5178
BOND 22
1 1 2 1
2 1 3 1
3 1 4 1
4 2 5 2
5 2 6 1
6 3 7 2
7 3 8 1
8 4 9 1
9 5 10 1
10 5 11 1
11 6 12 2
12 7 13 1
13 8 14 2
14 9 15 1
15 9 16 1
16 11 17 2
17 13 18 2
18 15 19 1
19 15 20 1
20 7 10 1
21 12 17 1
22 14 18 1
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