KEGG   DRUG: PhenobarbitalHelp
Entry
D00506                      Drug                                   

Name
Phenobarbital (JP17/USP/INN);
Luminal (TN)
Product
  Other
PHENOBARBITAL (ATLANTIC BIOLOGICALS CORP), PHENOBARBITAL (Aphena Pharma Solutions - Tennessee), PHENOBARBITAL (Atlantic Biologicals Corps), DONNATAL (Atlantic Biologicals Corps), PHENOBARBITAL (AvPAK), PHENOBARBITAL (BioRamo), PHENOBARBITAL (Bryant Ranch Prepack), PHENOBARBITAL (Bryant Ranch Prepack), PHENOBARBITAL (C.O. Truxton), PHENOBARBITAL (Contract Pharmacy Services-PA), PHENOBARBITAL (DIRECT RX), PHENOBARBITAL (ECI Pharmaceuticals), PHENOBARBITAL (Lohxa), PHENOBARBITAL (Major Pharmaceuticals), PHENOBARBITAL (McKesson Corporation), PHENOBARBITAL (PD-Rx Pharmaceuticals), PHENOBARBITAL (PD-Rx Pharmaceuticals), PHENOBARBITAL (Par Pharmaceutical), PHENOBARBITAL (Proficient Rx LP), PHENOBARBITAL (Qualitest Pharmaceuticals), PHENOBARBITAL (REMEDYREPACK), PHENOBARBITAL (REMEDYREPACK), PHENOBARBITAL (REMEDYREPACK), PHENOBARBITAL (REMEDYREPACK), PHENOBARBITAL (REMEDYREPACK), PHENOBARBITAL (REMEDYREPACK), PHENOBARBITAL (REMEDYREPACK), PHENOBARBITAL (REMEDYREPACK), PHENOBARBITAL (Rising Pharmaceuticals), PHENOBARBITAL (Sterling-Knight Pharmaceuticals), DONNATAL (Unit Dose Services), PHENOBARBITAL (West-Ward Pharmaceuticals Corp), PHENOBARBITAL (e5 Pharma), PHENOBARBITAL (e5 Pharma), DONNATAL (AvKARE), DONNATAL (PBM Pharmaceuticals), DONNATAL (PBM Pharmaceuticals), DONNATAL (PBM Pharmaceuticals)
Formula
C12H12N2O3
Exact mass
232.0848
Mol weight
232.2353
Structure
Mol fileKCF fileDB search
Simcomp SIMCOMP
Class
Neuropsychiatric agent
 DG01567  GABA-A receptor agonist
 DG01904  Barbiturate antiepileptics
Cyp substrate
 DG01639  CYP2C19 substrate
Cyp inducer
 DG01637  CYP1A2 inducer
Transporter inducer
 DG01893  P-glycoprotein inducer
Unclassified
 DG02853  CYP3A inducer
Remark
Same as: C07434
Therapeutic category: 1125 1134
ATC code: N03AA02
Chemical structure group: DG00845
Product (DG00845): D00506<JP/US> D00701<JP/US>
Product (mixture): D04307<JP> D04059<JP> D07583<JP>
Efficacy
Antianxiety, Anticonvulsant, Sedative-hypnotic
Comment
Barbiturates
Target
  Pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04727  GABAergic synapse
Interaction
CYP induction: CYP3A [HSA:1576 1577 1551]; CYP1A2 [HSA:1544], CYP2B6 [HSA:1555], CYP2C9 [HSA:1559]
Transporter induction: ABCB1 [HSA:5243]
Drug interaction
Structure map
map07032  Hypnotics
map07033  Anticonvulsants
map07230  GABA-A receptor agonists/antagonists
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 N NERVOUS SYSTEM
  N03 ANTIEPILEPTICS
   N03A ANTIEPILEPTICS
    N03AA Barbiturates and derivatives
     N03AA02 Phenobarbital
      D00506  Phenobarbital (JP17/USP/INN) <JP/US>
Therapeutic category of drugs in Japan [BR:br08301]
 1  Agents affecting nervous system and sensory organs
  11  Agents affecting central nervous system
   112  Hypnotics and sedatives, anxiolytics
    1125  Barbiturates and thiobarbiturates
     D00506  Phenobarbital (JP17/USP/INN)
   113  Antiepileptics
    1134  Barbiturates
     D00506  Phenobarbital (JP17/USP/INN)
Target-based classification of drugs [BR:br08310]
 Ion channels
  Ligand-gated ion channels
   GABA (ionotropic)
    GABR
     D00506  Phenobarbital (JP17/USP/INN) <JP/US>
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D00506  Phenobarbital
  D00506  10% Phenobarbital powder
Drug classes of therapeutic agents [br08360.html]
 Neurological agents
  D00506
Prodrugs [br08324.html]
 D00506
BRITE hierarchy
Other DBs
CAS: 50-06-6
PubChem: 7847572
ChEBI: 8069
ChEMBL: CHEMBL40
DrugBank: DB01174
LigandBox: D00506
NIKKAJI: J4.499G
LinkDB All DBs
KCF data Show

ATOM        17
            1   C1z C    24.5688  -19.5768
            2   C8y C    25.7739  -18.8690
            3   C5x C    23.3288  -18.8924
            4   C5x C    24.5688  -20.9807
            5   C1b C    25.7679  -20.2728
            6   C8x C    26.9847  -19.5534
            7   C8x C    25.7562  -17.4653
            8   N1x N    22.1238  -19.5768
            9   O5x O    23.3288  -17.4770
            10  N1x N    23.3288  -21.6826
            11  O5x O    25.7621  -21.6826
            12  C1a C    27.1718  -20.2728
            13  C8x C    28.1895  -18.8457
            14  C8x C    26.9612  -16.7574
            15  C5x C    22.1238  -20.9807
            16  C8x C    28.1778  -17.4476
            17  O5x O    20.9130  -21.6766
BOND        18
            1     1   2 1
            2     1   3 1
            3     1   4 1
            4     1   5 1
            5     2   6 2
            6     2   7 1
            7     3   8 1
            8     3   9 2
            9     4  10 1
            10    4  11 2
            11    5  12 1
            12    6  13 1
            13    7  14 2
            14    8  15 1
            15   13  16 2
            16   15  17 2
            17   10  15 1
            18   14  16 1

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