KEGG   DRUG: Phenylephrine hydrochloride
Entry
D00511                      Drug                                   

Name
Phenylephrine hydrochloride (JP17/USP);
Neo-synephrine (TN)
Product
  Generic
Formula
C9H13NO2. HCl
Exact mass
203.0713
Mol weight
203.666
Structure
Simcomp
Class
Cardiovascular agent
 DG01703  Cardiotonic
  DG01702  Phenethylamine cardiotonic
 DG01456  Adrenergic receptor agonist
  DG01450  alpha-Adrenergic receptor agonist
   DG01448  alpha1-Adrenergic receptor agonist
    DG01654  alpha1-Adrenergic receptor specific agonist
Remark
Therapeutic category: 1311 2160
ATC code: C01CA06 R01AA04 R01AB01 R01BA03 S01FB01 S01GA05
Chemical structure group: DG00215
Product (DG00215): D00511<JP/US>
Product (mixture): D04081<JP> D10837<US> D11698<US>
Efficacy
Antihypotensive, Midriatic, Vasoconstrictor, alpha1-Adrenergic receptor agonist
Comment
Phenethylamine derivative
Target
ADRA1 [HSA:148 147 146] [KO:K04135 K04136 K04137]
  Pathway
hsa04020  Calcium signaling pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04261  Adrenergic signaling in cardiomyocytes
hsa04270  Vascular smooth muscle contraction
Interaction
Structure map
map07215  alpha-Adrenergic receptor agonists/antagonists
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 C CARDIOVASCULAR SYSTEM
  C01 CARDIAC THERAPY
   C01C CARDIAC STIMULANTS EXCL. CARDIAC GLYCOSIDES
    C01CA Adrenergic and dopaminergic agents
     C01CA06 Phenylephrine
      D00511  Phenylephrine hydrochloride (JP17/USP) <JP/US>
 R RESPIRATORY SYSTEM
  R01 NASAL PREPARATIONS
   R01A DECONGESTANTS AND OTHER NASAL PREPARATIONS FOR TOPICAL USE
    R01AA Sympathomimetics, plain
     R01AA04 Phenylephrine
      D00511  Phenylephrine hydrochloride (JP17/USP) <JP/US>
    R01AB Sympathomimetics, combinations excl. corticosteroids
     R01AB01 Phenylephrine
      D00511  Phenylephrine hydrochloride (JP17/USP) <JP/US>
   R01B NASAL DECONGESTANTS FOR SYSTEMIC USE
    R01BA Sympathomimetics
     R01BA03 Phenylephrine
      D00511  Phenylephrine hydrochloride (JP17/USP) <JP/US>
 S SENSORY ORGANS
  S01 OPHTHALMOLOGICALS
   S01F MYDRIATICS AND CYCLOPLEGICS
    S01FB Sympathomimetics excl. antiglaucoma preparations
     S01FB01 Phenylephrine
      D00511  Phenylephrine hydrochloride (JP17/USP) <JP/US>
   S01G DECONGESTANTS AND ANTIALLERGICS
    S01GA Sympathomimetics used as decongestants
     S01GA05 Phenylephrine
      D00511  Phenylephrine hydrochloride (JP17/USP) <JP/US>
Therapeutic category of drugs in Japan [BR:br08301]
 1  Agents affecting nervous system and sensory organs
  13  Agents affecting sensory organs
   131  Ophthalmic agents
    1311  Mydriatic agents
     D00511  Phenylephrine hydrochloride (JP17/USP)
 2  Agents affecting individual organs
  21  Cardiovascular agents
   216  Vasoconstrictors
    2160  Vasoconstrictors
     D00511  Phenylephrine hydrochloride (JP17/USP)
Risk category of Japanese OTC drugs [BR:br08312]
 Second-class OTC drugs
  Inorganic and organic chemicals
   Phenylephrine
    D00511  Phenylephrine hydrochloride (JP17/USP)
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Adrenaline
    ADRA1
     D00511  Phenylephrine hydrochloride (JP17/USP) <JP/US>
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D00511  Phenylephrine hydrochloride
Rx-to-OTC switch list in the USA [br08315.html]
 D00511
Other DBs
CAS: 61-76-7
PubChem: 7847577
ChEBI: 8094
ChEMBL: CHEMBL1200339
DrugBank: DB00388
LigandBox: D00511
NIKKAJI: J98.894D
LinkDB
KCF data

ATOM        13
            1   X   Cl   25.9001  -19.1101
            2   C8y C    18.0600  -16.7300
            3   C8x C    18.0600  -18.1300
            4   C8x C    19.2500  -18.8300
            5   C8x C    20.4400  -18.1300
            6   C8y C    20.4400  -16.7300
            7   C8x C    19.2500  -16.0300
            8   O1a O    16.8000  -16.0300
            9   C1c C    21.7000  -16.0300
            10  C1b C    22.8900  -16.7300
            11  O1a O    21.7000  -14.6300
            12  N1b N    24.0800  -16.0300
            13  C1a C    25.2700  -16.7300
BOND        12
            1     2   3 2
            2     3   4 1
            3     4   5 2
            4     5   6 1
            5     6   7 2
            6     2   7 1
            7     2   8 1
            8     6   9 1
            9     9  10 1
            10    9  11 1 #Up
            11   10  12 1
            12   12  13 1

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