| Entry |
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| Name |
Repaglinide (JAN/USP/INN);
Prandin (TN);
Surepost (TN)
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| Product |
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| Generic |
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| Formula |
C27H36N2O4
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| Exact mass |
452.2675
|
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| Mol weight |
452.5857
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| Structure |
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| Simcomp |
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| Class |
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| Remark |
| Therapeutic category: | 3969 |
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| Efficacy |
Antidiabetic, Hypoglycemic, Sulfonylurea receptor agonist |
|---|
| Disease |
Type 2 diabetes mellitus [DS: H00409] |
|---|
| Comment |
Glinide derivative
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| Target |
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| Pathway |
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| Metabolism |
Enzyme: CYP2C8 [HSA: 1558]; CYP3A4 [HSA: 1576]
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| Interaction |
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| Structure map |
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| Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
A ALIMENTARY TRACT AND METABOLISM
A10 DRUGS USED IN DIABETES
A10B BLOOD GLUCOSE LOWERING DRUGS, EXCL. INSULINS
A10BX Other blood glucose lowering drugs, excl. insulins
A10BX02 Repaglinide
D00594 Repaglinide (JAN/USP/INN) <JP/US>
USP drug classification [BR:br08302]
Blood Glucose Regulators
Antidiabetic Agents
Glucose Control Agents, Other
Repaglinide
D00594 Repaglinide (JAN/USP/INN)
Therapeutic category of drugs in Japan [BR:br08301]
3 Agents affecting metabolism
39 Other agents affecting metabolism
396 Antidiabetic agents
3969 Others
D00594 Repaglinide (JAN/USP/INN)
Target-based classification of drugs [BR:br08310]
Transporters
ABC transporters
ABCC subfamily
ABCC8(SUR1)/KCNJ11(KIR6.2)
D00594 Repaglinide (JAN/USP/INN) <JP/US>
New drug approvals in Europe [br08329.html]
European public assessment reports (EPAR) authorised medicine
D00594
New drug approvals in Japan [br08318.html]
Drugs with new active ingredients
D00594
New drug approvals in the USA, Europe and Japan [br08328.html]
Approval dates by FDA, EMA and PMDA
D00594
Drug metabolizing enzymes and transporters [br08309.html]
Drug metabolizing enzymes
D00594
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| Other DBs |
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| LinkDB |
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| KCF data |
ATOM 33
1 C8y C 29.5484 -19.4440
2 C8y C 29.5543 -20.8486
3 N1y N 28.3361 -18.7446
4 C8x C 30.7608 -18.7446
5 C1c C 28.3478 -21.5481
6 C8x C 30.7608 -21.5423
7 C1x C 28.3361 -17.3457
8 C1x C 27.1296 -19.4497
9 C8x C 31.9790 -19.4440
10 N1b N 27.1296 -20.8486
11 C1b C 28.3478 -22.9469
12 C8x C 31.9790 -20.8486
13 C1x C 27.1238 -16.6520
14 C1x C 25.9114 -18.7503
15 C5a C 25.9173 -21.5481
16 C1c C 29.5543 -23.6521
17 C1x C 25.9114 -17.3514
18 C1b C 24.7049 -20.8486
19 O5a O 25.9173 -22.9469
20 C1a C 29.5543 -25.0569
21 C1a C 30.7666 -22.9469
22 C8y C 23.4867 -21.5481
23 C8x C 22.2744 -20.8486
24 C8x C 23.4867 -22.9469
25 C8y C 21.0679 -21.5538
26 C8x C 22.2744 -23.6521
27 C8y C 21.0562 -22.9469
28 O2a O 19.8556 -20.8603
29 C6a C 19.8497 -23.6521
30 C1b C 18.6432 -21.5538
31 O6a O 18.6375 -22.9410
32 O6a O 19.9140 -25.0510
33 C1a C 17.4309 -20.8603
BOND 35
1 1 2 1
2 1 3 1
3 1 4 2
4 2 5 1
5 2 6 2
6 3 7 1
7 3 8 1
8 4 9 1
9 5 10 1
10 5 11 1 #Down
11 6 12 1
12 7 13 1
13 8 14 1
14 10 15 1
15 11 16 1
16 13 17 1
17 15 18 1
18 15 19 2
19 16 20 1
20 16 21 1
21 18 22 1
22 22 23 2
23 22 24 1
24 23 25 1
25 24 26 2
26 25 27 2
27 25 28 1
28 27 29 1
29 28 30 1
30 29 31 1
31 29 32 2
32 30 33 1
33 9 12 2
34 14 17 1
35 26 27 1
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