KEGG   DRUG: Verapamil hydrochlorideHelp
Entry
D00619                      Drug                                   

Name
Verapamil hydrochloride (JP17/USP);
Calan (TN);
Covera-hs (TN);
Vasolan (TN);
Verelan (TN)
Product
  Generic
VERAPAMIL HCI (HF Acquisition Co LLC), VERAPAMIL HCL (Direct_Rx), VERAPAMIL HYDROCHLORIDE (A-S Medication Solutions), VERAPAMIL HYDROCHLORIDE (A-S Medication Solutions), VERAPAMIL HYDROCHLORIDE (A-S Medication Solutions), VERAPAMIL HYDROCHLORIDE (A-S Medication Solutions), VERAPAMIL HYDROCHLORIDE (Actavis Pharma), VERAPAMIL HYDROCHLORIDE (Amneal Biosciences LLC), VERAPAMIL HYDROCHLORIDE (Aphena Pharma Solutions - Tennessee), VERAPAMIL HYDROCHLORIDE (Aphena Pharma Solutions - Tennessee), VERAPAMIL HYDROCHLORIDE (Aphena Pharma Solutions - Tennessee), VERAPAMIL HYDROCHLORIDE (Aphena Pharma Solutions - Tennessee), VERAPAMIL HYDROCHLORIDE (Aphena Pharma Solutions - Tennessee), VERAPAMIL HYDROCHLORIDE (Blenheim Pharmacal), VERAPAMIL HYDROCHLORIDE (Blenheim Pharmacal), VERAPAMIL HYDROCHLORIDE (Blenheim Pharmacal), VERAPAMIL HYDROCHLORIDE (Bryant Ranch Prepack), VERAPAMIL HYDROCHLORIDE (Bryant Ranch Prepack), VERAPAMIL HYDROCHLORIDE (Bryant Ranch Prepack), VERAPAMIL HYDROCHLORIDE (Bryant Ranch Prepack), VERAPAMIL HYDROCHLORIDE (Bryant Ranch Prepack), VERAPAMIL HYDROCHLORIDE (Bryant Ranch Prepack), VERAPAMIL HYDROCHLORIDE (Bryant Ranch Prepack), VERAPAMIL HYDROCHLORIDE (Bryant Ranch Prepack), VERAPAMIL HYDROCHLORIDE (Cadila Pharmaceuticals Limited), VERAPAMIL HYDROCHLORIDE (Carilion Materials Management), VERAPAMIL HYDROCHLORIDE (Carilion Materials Management), VERAPAMIL HYDROCHLORIDE (DIRECT RX), VERAPAMIL HYDROCHLORIDE (Denton Pharma), VERAPAMIL HYDROCHLORIDE (General Injectables & Vaccines), VERAPAMIL HYDROCHLORIDE (General Injectables and Vaccines), VERAPAMIL HYDROCHLORIDE (Glenmark Pharmaceuticals), VERAPAMIL HYDROCHLORIDE (Golden State Medical Supply), VERAPAMIL HYDROCHLORIDE (HF Acquisition Co. LLC), VERAPAMIL HYDROCHLORIDE (Heritage Pharmaceuticals), VERAPAMIL HYDROCHLORIDE (Hospira), VERAPAMIL HYDROCHLORIDE (Hospira), VERAPAMIL HYDROCHLORIDE (Lake Erie Medical DBA Quality Care Products LLC), VERAPAMIL HYDROCHLORIDE (Lake Erie Medical DBA Quality Care Products LLC), VERAPAMIL HYDROCHLORIDE (Lake Erie Medical DBA Quality Care Products LLC), VERAPAMIL HYDROCHLORIDE (Major Pharmaceuticals), VERAPAMIL HYDROCHLORIDE (Micro Labs Limited), VERAPAMIL HYDROCHLORIDE (Mylan Institutional), VERAPAMIL HYDROCHLORIDE (Mylan Institutional), VERAPAMIL HYDROCHLORIDE (Mylan Pharmaceuticals), VERAPAMIL HYDROCHLORIDE (Mylan Pharmaceuticals), VERAPAMIL HYDROCHLORIDE (Mylan Pharmaceuticals), VERAPAMIL HYDROCHLORIDE (Mylan Pharmaceuticals), VERAPAMIL HYDROCHLORIDE (NCS HealthCare of KY), VERAPAMIL HYDROCHLORIDE (NCS HealthCare of KY), VERAPAMIL HYDROCHLORIDE (Nivagen Pharmaceuticals), VERAPAMIL HYDROCHLORIDE (Northwind Pharmaceuticals), VERAPAMIL HYDROCHLORIDE (NuCare Pharmaceuticals), VERAPAMIL HYDROCHLORIDE (NuCare Pharmaceuticals), VERAPAMIL HYDROCHLORIDE (NuCare Pharmaceuticals), VERAPAMIL HYDROCHLORIDE (NuCare Pharmaceuticals), VERAPAMIL HYDROCHLORIDE (NuCare Pharmaceuticals), VERAPAMIL HYDROCHLORIDE (NuCare Pharmaceuticals), VERAPAMIL HYDROCHLORIDE (PD-Rx Pharmaceuticals), VERAPAMIL HYDROCHLORIDE (PD-Rx Pharmaceuticals), VERAPAMIL HYDROCHLORIDE (PD-Rx Pharmaceuticals), VERAPAMIL HYDROCHLORIDE (Preferred Pharmaceuticals), VERAPAMIL HYDROCHLORIDE (Preferred Pharmaceuticals), VERAPAMIL HYDROCHLORIDE (Proficient Rx LP), VERAPAMIL HYDROCHLORIDE (Proficient Rx LP), VERAPAMIL HYDROCHLORIDE (Proficient Rx LP), VERAPAMIL HYDROCHLORIDE (REMEDYREPACK), VERAPAMIL HYDROCHLORIDE (REMEDYREPACK), VERAPAMIL HYDROCHLORIDE (REMEDYREPACK), VERAPAMIL HYDROCHLORIDE (REMEDYREPACK), VERAPAMIL HYDROCHLORIDE (REMEDYREPACK), VERAPAMIL HYDROCHLORIDE (REMEDYREPACK), VERAPAMIL HYDROCHLORIDE (REMEDYREPACK), VERAPAMIL HYDROCHLORIDE (REMEDYREPACK), VERAPAMIL HYDROCHLORIDE (RPK Pharmaceuticals), VERAPAMIL HYDROCHLORIDE (RPK Pharmaceuticals), VERAPAMIL HYDROCHLORIDE (Rebel Distributors Corp), VERAPAMIL HYDROCHLORIDE (Rebel Distributors Corp), VERAPAMIL HYDROCHLORIDE (RedPharm Drug), VERAPAMIL HYDROCHLORIDE (RedPharm Drug), VERAPAMIL HYDROCHLORIDE (Somerset Therapeutics), VERAPAMIL HYDROCHLORIDE (State of Florida DOH Central Pharmacy), VERAPAMIL HYDROCHLORIDE (State of Florida DOH Central Pharmacy), VERAPAMIL HYDROCHLORIDE (State of Florida DOH Central Pharmacy), VERAPAMIL HYDROCHLORIDE (Sun Pharmaceutical Industries), VERAPAMIL HYDROCHLORIDE (Teva Pharmaceuticals USA), VERAPAMIL HYDROCHLORIDE (Unit Dose Services)
Formula
C27H38N2O4. HCl
Exact mass
490.2598
Mol weight
491.0626
Structure
Mol fileKCF fileDB search
Simcomp SIMCOMP
Class
Cardiovascular agent
 DG01653  Antiarrhythmics
  DG01807  Phenylalkylamine derivative
Other
 DG01575  Calcium channel blocker
  DG01496  Calcium channel L type blocker
Metabolizing enzyme substrate
 DG02913  CYP3A4 substrate
Transporter substrate
 DG01665  ABCB1 (P-GP) substrate
Transporter inhibitor
 DG01622  ABCB1 (P-GP) inhibitor
Remark
Therapeutic category: 2129 2171
ATC code: C08DA01
Chemical structure group: DG00329
Product (DG00329): D00619<JP/US>
Product (mixture): D10282<US>
Efficacy
Antiarrhythmic, Vasodilator, Calcium channel blocker
  Disease
Hypertension [DS:H01633]
Angina [DS:H01632]
Atrial flutter [DS:H00731]
Comment
Phenylalkylamine derivative
Target
CACNA1-L [HSA:775 776 778 779] [KO:K04850 K04851 K04853 K04857]
  Pathway
hsa04010  MAPK signaling pathway
hsa04020  Calcium signaling pathway
hsa04260  Cardiac muscle contraction
hsa04270  Vascular smooth muscle contraction
Metabolism
Enzyme: CYP3A4 [HSA:1576]
Transporter: ABCB1 [HSA:5243]
Interaction
Transporter inhibition: ABCB1 [HSA:5243]
Drug interaction
Structure map
map07036  Calcium channel blocking drugs
map07037  Antiarrhythmic drugs
map07048  Antimigraines
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 C CARDIOVASCULAR SYSTEM
  C08 CALCIUM CHANNEL BLOCKERS
   C08D SELECTIVE CALCIUM CHANNEL BLOCKERS WITH DIRECT CARDIAC EFFECTS
    C08DA Phenylalkylamine derivatives
     C08DA01 Verapamil
      D00619  Verapamil hydrochloride (JP17/USP) <JP/US>
USP drug classification [BR:br08302]
 Cardiovascular Agents
  Calcium Channel Blocking Agents
   Verapamil
    D00619  Verapamil hydrochloride (JP17/USP)
Therapeutic category of drugs in Japan [BR:br08301]
 2  Agents affecting individual organs
  21  Cardiovascular agents
   212  Antiarrhythmic agents
    2129  Others
     D00619  Verapamil hydrochloride (JP17/USP)
   217  Vasodilators
    2171  Coronary dilators
     D00619  Verapamil hydrochloride (JP17/USP)
Target-based classification of drugs [BR:br08310]
 Ion channels
  Voltage-gated ion channels
   Calcium channels
    CACNA1-L
     D00619  Verapamil hydrochloride (JP17/USP) <JP/US>
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D00619  Verapamil hydrochloride
  D00619  Verapamil hydrochloride tablets
BRITE hierarchy
Other DBs
CAS: 152-11-4
PubChem: 7847685
ChEBI: 53188
ChEMBL: CHEMBL1280
DrugBank: DB00661
LigandBox: D00619
NIKKAJI: J345.194A
LinkDB All DBs
KCF data Show

ATOM        34
            1   C1d C    21.2610  -18.3478
            2   C8y C    20.0604  -19.0472
            3   C1b C    22.4731  -19.0413
            4   C1c C    21.3019  -16.9957
            5   C8x C    18.8483  -18.3478
            6   C8x C    20.0604  -20.4457
            7   C1b C    23.6853  -18.3419
            8   C1a C    22.5142  -16.2848
            9   C1a C    20.0955  -16.2964
            10  C8y C    17.6362  -19.0472
            11  C8x C    18.8483  -21.1509
            12  C1b C    24.8917  -19.0296
            13  C8y C    17.6362  -20.4457
            14  O2a O    16.4183  -18.3478
            15  N1c N    26.1038  -18.3361
            16  O2a O    16.4183  -21.1509
            17  C1a C    15.2061  -19.0472
            18  C1b C    27.3159  -19.0239
            19  C1a C    26.1038  -16.8851
            20  C1a C    15.2061  -20.4515
            21  C1b C    28.5280  -18.3302
            22  C8y C    29.7284  -19.0180
            23  C8x C    30.9407  -18.3185
            24  C8x C    29.7345  -20.4107
            25  C8y C    32.1471  -19.0122
            26  C8x C    30.9464  -21.1101
            27  C8y C    32.1529  -20.4049
            28  O2a O    33.3592  -18.3070
            29  O2a O    33.3708  -21.1042
            30  C1a C    34.5772  -19.0005
            31  C1a C    34.5828  -20.3991
            32  C3b C    21.2610  -19.7452
            33  N3a N    21.2610  -21.1427
            34  X   Cl   31.2200  -23.3100
BOND        34
            1     1   2 1
            2     1   3 1
            3     1   4 1
            4     2   5 2
            5     2   6 1
            6     3   7 1
            7     4   8 1
            8     4   9 1
            9     5  10 1
            10    6  11 2
            11    7  12 1
            12   10  13 2
            13   10  14 1
            14   12  15 1
            15   13  16 1
            16   14  17 1
            17   15  18 1
            18   15  19 1
            19   16  20 1
            20   18  21 1
            21   21  22 1
            22   22  23 1
            23   22  24 2
            24   23  25 2
            25   24  26 1
            26   25  27 1
            27   25  28 1
            28   27  29 1
            29   28  30 1
            30   29  31 1
            31   11  13 1
            32   26  27 2
            33    1  32 1
            34   32  33 3

» Japanese version   » Back

DBGET integrated database retrieval system