DRUG: Benazepril hydrochloride
Entry
D00620 Drug
Name
Benazepril hydrochloride (JAN/USAN);
Lotensin (TN)
Product
LOTENSIN (Validus Pharmaceuticals LLC)
Generic
BENAZEPRIL (Direct_Rx)
,
BENAZEPRIL HCL (Northwind Pharmaceuticals)
,
BENAZEPRIL HYDROCHLORIDE (A-S Medication Solutions)
,
BENAZEPRIL HYDROCHLORIDE (A-S Medication Solutions)
,
BENAZEPRIL HYDROCHLORIDE (A-S Medication Solutions)
,
BENAZEPRIL HYDROCHLORIDE (A-S Medication Solutions)
,
BENAZEPRIL HYDROCHLORIDE (A-S Medication Solutions)
,
BENAZEPRIL HYDROCHLORIDE (A-S Medication Solutions)
,
BENAZEPRIL HYDROCHLORIDE (Aidarex Pharmaceuticals LLC)
,
BENAZEPRIL HYDROCHLORIDE (Aidarex Pharmaceuticals LLC)
,
BENAZEPRIL HYDROCHLORIDE (Amneal Pharmaceuticals LLC)
,
BENAZEPRIL HYDROCHLORIDE (Aurobindo Pharma Limited)
,
BENAZEPRIL HYDROCHLORIDE (AvKARE)
,
BENAZEPRIL HYDROCHLORIDE (AvPAK)
,
BENAZEPRIL HYDROCHLORIDE (Bryant Ranch Prepack)
,
BENAZEPRIL HYDROCHLORIDE (Bryant Ranch Prepack)
,
BENAZEPRIL HYDROCHLORIDE (Bryant Ranch Prepack)
,
BENAZEPRIL HYDROCHLORIDE (Bryant Ranch Prepack)
,
BENAZEPRIL HYDROCHLORIDE (Bryant Ranch Prepack)
,
BENAZEPRIL HYDROCHLORIDE (Cadila Healthcare Limited)
,
BENAZEPRIL HYDROCHLORIDE (Cardinal Health)
,
BENAZEPRIL HYDROCHLORIDE (Denton Pharma)
,
BENAZEPRIL HYDROCHLORIDE (Eon Labs)
,
BENAZEPRIL HYDROCHLORIDE (Golden State Medical Supply)
,
BENAZEPRIL HYDROCHLORIDE (International Laboratories)
,
BENAZEPRIL HYDROCHLORIDE (Lake Erie Medical DBA Quality Care Products LLC)
,
BENAZEPRIL HYDROCHLORIDE (Mylan Institutional)
,
BENAZEPRIL HYDROCHLORIDE (Mylan Pharmaceuticals)
,
BENAZEPRIL HYDROCHLORIDE (Northwind Pharmaceuticals)
,
BENAZEPRIL HYDROCHLORIDE (NuCare Pharmaceuticals)
,
BENAZEPRIL HYDROCHLORIDE (NuCare Pharmaceuticals)
,
BENAZEPRIL HYDROCHLORIDE (NuCare Pharmaceuticals)
,
BENAZEPRIL HYDROCHLORIDE (NuCare Pharmaceuticals)
,
BENAZEPRIL HYDROCHLORIDE (NuCare Pharmaceuticals)
,
BENAZEPRIL HYDROCHLORIDE (NuCare Pharmaceuticals)
,
BENAZEPRIL HYDROCHLORIDE (NuCare Pharmaceuticals)
,
BENAZEPRIL HYDROCHLORIDE (NuCare Pharmaceuticals)
,
BENAZEPRIL HYDROCHLORIDE (NuCare Pharmaceuticals)
,
BENAZEPRIL HYDROCHLORIDE (NuCare Pharmaceuticals)
,
BENAZEPRIL HYDROCHLORIDE (NuCare Pharmaceuticals)
,
BENAZEPRIL HYDROCHLORIDE (NuCare Pharmaceuticals)
,
BENAZEPRIL HYDROCHLORIDE (NuCare Pharmaceuticals)
,
BENAZEPRIL HYDROCHLORIDE (NuCare Pharmaceuticals)
,
BENAZEPRIL HYDROCHLORIDE (NuCare Pharmaceuticals)
,
BENAZEPRIL HYDROCHLORIDE (PD-Rx Pharmaceuticals)
,
BENAZEPRIL HYDROCHLORIDE (PD-Rx Pharmaceuticals)
,
BENAZEPRIL HYDROCHLORIDE (PD-Rx Pharmaceuticals)
,
BENAZEPRIL HYDROCHLORIDE (Preferred Pharmaceuticals)
,
BENAZEPRIL HYDROCHLORIDE (Preferred Pharmaceuticals)
,
BENAZEPRIL HYDROCHLORIDE (Preferred Pharmaceuticals)
,
BENAZEPRIL HYDROCHLORIDE (Preferred Pharmaceuticals)
,
BENAZEPRIL HYDROCHLORIDE (Proficient Rx LP)
,
BENAZEPRIL HYDROCHLORIDE (Proficient Rx LP)
,
BENAZEPRIL HYDROCHLORIDE (Proficient Rx LP)
,
BENAZEPRIL HYDROCHLORIDE (Proficient Rx LP)
,
BENAZEPRIL HYDROCHLORIDE (Proficient Rx LP)
,
BENAZEPRIL HYDROCHLORIDE (REMEDYREPACK)
,
BENAZEPRIL HYDROCHLORIDE (REMEDYREPACK)
,
BENAZEPRIL HYDROCHLORIDE (REMEDYREPACK)
,
BENAZEPRIL HYDROCHLORIDE (REMEDYREPACK)
,
BENAZEPRIL HYDROCHLORIDE (REMEDYREPACK)
,
BENAZEPRIL HYDROCHLORIDE (Solco healthcare U.S.)
,
BENAZEPRIL HYDROCHLORIDE (St. Mary's Medical Park Pharmacy)
,
BENAZEPRIL HYDROCHLORIDE (St. Mary's Medical Park Pharmacy)
,
BENAZEPRIL HYDROCHLORIDE (St. Mary's Medical Park Pharmacy)
,
BENAZEPRIL HYDROCHLORIDE (Unit Dose Services)
,
BENAZEPRIL HYDROCHLORIDE (Zydus Pharmaceuticals (USA))
Formula
C24H28N2O5. HCl
Exact mass
460.1765
Mol weight
460.9505
Structure
Simcomp
Class
Cardiovascular agent
DG01501
Angiotensin-converting enzyme inhibitor
DG01925
Renin-angiotensin system inhibitor
DG01501
Angiotensin-converting enzyme inhibitor
Remark
Same as:
C07701
Therapeutic category:
2144
ATC code:
C09AA07
Chemical structure group:
DG00339
Product (DG00339):
D00620<
JP
/US>
Product (mixture):
D10279<
US
> D11069<
US
>
Efficacy
Antihypertensive, Angiotensin-converting enzyme inhibitor
Disease
Hypertension [DS:
H01633
]
Comment
Active form of prodrug: Benazeprilat [DR:
D03077
]
Target
ACE (CD143) [HSA:
1636
] [KO:
K01283
]
Pathway
hsa04614
Renin-angiotensin system
Interaction
Structure map
map07217
Renin-angiotensin system inhibitors
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:
br08303
]
C CARDIOVASCULAR SYSTEM
C09 AGENTS ACTING ON THE RENIN-ANGIOTENSIN SYSTEM
C09A ACE INHIBITORS, PLAIN
C09AA ACE inhibitors, plain
C09AA07 Benazepril
D00620 Benazepril hydrochloride (JAN/USAN) <JP/US>
USP drug classification [BR:
br08302
]
Cardiovascular Agents
Angiotensin-converting Enzyme (ACE) Inhibitors
Benazepril
D00620 Benazepril hydrochloride (JAN/USAN)
Therapeutic category of drugs in Japan [BR:
br08301
]
2 Agents affecting individual organs
21 Cardiovascular agents
214 Antihypertensives
2144 Angiotensin converting enzyme inhibitors
D00620 Benazepril hydrochloride (JAN/USAN)
Target-based classification of drugs [BR:
br08310
]
Enzymes
Hydrolases (EC3)
Peptidyl-dipeptidases
ACE (CD143)
D00620 Benazepril hydrochloride (JAN/USAN) <JP/US>
Prodrugs [
br08324.html
]
DG00339
Other DBs
CAS:
86541-74-4
PubChem:
7847686
ChEBI:
3012
ChEMBL:
CHEMBL1694
DrugBank:
DB00542
LigandBox:
D00620
NIKKAJI:
J550.745F
LinkDB
KCF data
ATOM 32
1 C1x C 23.3231 -19.6615
2 C8y C 22.4372 -18.5840
3 C8y C 22.7197 -17.2133
4 N1y N 23.9591 -16.5857
5 C1x C 24.7308 -19.7019
6 C5x C 25.2377 -17.1596
7 C1y C 25.5777 -18.5180
8 C8x C 21.6743 -16.2838
9 C8x C 20.3466 -16.7242
10 C8x C 20.0641 -18.0949
11 C8x C 21.1095 -19.0246
12 C1b C 23.9262 -15.1817
13 C6a C 25.1248 -14.4519
14 O6a O 26.3615 -15.1276
15 O6a O 25.1625 -13.0836
16 O5x O 26.3330 -16.2423
17 N1b N 26.9766 -18.5180
18 C1c C 27.6929 -19.7595
19 C1b C 29.1069 -19.7602
20 C7a C 27.0102 -20.9405
21 C1b C 29.8213 -18.5252
22 C8y C 31.2056 -18.5264
23 O6a O 25.6102 -20.9399
24 O7a O 27.6989 -22.1343
25 C1b C 29.1070 -22.1349
26 C1a C 29.7937 -23.3254
27 C8x C 31.9096 -19.7481
28 C8x C 33.3085 -19.7492
29 C8x C 34.0091 -18.5383
30 C8x C 33.3051 -17.3167
31 C8x C 31.9062 -17.3155
32 X Cl 34.6331 -22.3162
BOND 33
1 3 4 1
2 1 5 1
3 4 6 1
4 2 3 1
5 5 7 1
6 1 2 1
7 6 7 1
8 3 8 2
9 8 9 1
10 9 10 2
11 10 11 1
12 2 11 2
13 4 12 1
14 12 13 1
15 13 14 1
16 13 15 2
17 6 16 2
18 7 17 1 #Up
19 17 18 1
20 18 19 1 #Up
21 18 20 1
22 19 21 1
23 21 22 1
24 20 23 2
25 20 24 1
26 24 25 1
27 25 26 1
28 22 27 2
29 27 28 1
30 28 29 2
31 29 30 1
32 30 31 2
33 22 31 1
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