KEGG   DRUG: Benazepril hydrochloride
Entry
D00620                      Drug                                   

Name
Benazepril hydrochloride (JAN/USP);
Lotensin (TN)
Product
  Generic
BENAZEPRIL (Direct_Rx), BENAZEPRIL HYDROCHLORIDE (A-S Medication Solutions), BENAZEPRIL HYDROCHLORIDE (A-S Medication Solutions), BENAZEPRIL HYDROCHLORIDE (A-S Medication Solutions), BENAZEPRIL HYDROCHLORIDE (A-S Medication Solutions), BENAZEPRIL HYDROCHLORIDE (A-S Medication Solutions), BENAZEPRIL HYDROCHLORIDE (A-S Medication Solutions), BENAZEPRIL HYDROCHLORIDE (Amneal Pharmaceuticals LLC), BENAZEPRIL HYDROCHLORIDE (Aurobindo Pharma Limited), BENAZEPRIL HYDROCHLORIDE (AvKARE), BENAZEPRIL HYDROCHLORIDE (AvPAK), BENAZEPRIL HYDROCHLORIDE (Bryant Ranch Prepack), BENAZEPRIL HYDROCHLORIDE (Bryant Ranch Prepack), BENAZEPRIL HYDROCHLORIDE (Bryant Ranch Prepack), BENAZEPRIL HYDROCHLORIDE (Bryant Ranch Prepack), BENAZEPRIL HYDROCHLORIDE (Bryant Ranch Prepack), BENAZEPRIL HYDROCHLORIDE (Cadila Healthcare Limited), BENAZEPRIL HYDROCHLORIDE (Cardinal Health), BENAZEPRIL HYDROCHLORIDE (DIRECT RX), BENAZEPRIL HYDROCHLORIDE (Denton Pharma), BENAZEPRIL HYDROCHLORIDE (Denton Pharma), BENAZEPRIL HYDROCHLORIDE (Denton Pharma), BENAZEPRIL HYDROCHLORIDE (Denton Pharma), BENAZEPRIL HYDROCHLORIDE (Denton Pharma), BENAZEPRIL HYDROCHLORIDE (Denton Pharma), BENAZEPRIL HYDROCHLORIDE (Eon Labs), BENAZEPRIL HYDROCHLORIDE (Golden State Medical Supply), BENAZEPRIL HYDROCHLORIDE (International Laboratories), BENAZEPRIL HYDROCHLORIDE (Lake Erie Medical DBA Quality Care Products LLC), BENAZEPRIL HYDROCHLORIDE (NuCare Pharmaceuticals), BENAZEPRIL HYDROCHLORIDE (NuCare Pharmaceuticals), BENAZEPRIL HYDROCHLORIDE (NuCare Pharmaceuticals), BENAZEPRIL HYDROCHLORIDE (NuCare Pharmaceuticals), BENAZEPRIL HYDROCHLORIDE (NuCare Pharmaceuticals), BENAZEPRIL HYDROCHLORIDE (NuCare Pharmaceuticals), BENAZEPRIL HYDROCHLORIDE (NuCare Pharmaceuticals), BENAZEPRIL HYDROCHLORIDE (PD-Rx Pharmaceuticals), BENAZEPRIL HYDROCHLORIDE (PD-Rx Pharmaceuticals), BENAZEPRIL HYDROCHLORIDE (PD-Rx Pharmaceuticals), BENAZEPRIL HYDROCHLORIDE (Preferred Pharmaceuticals), BENAZEPRIL HYDROCHLORIDE (Preferred Pharmaceuticals), BENAZEPRIL HYDROCHLORIDE (Preferred Pharmaceuticals), BENAZEPRIL HYDROCHLORIDE (Preferred Pharmaceuticlas), BENAZEPRIL HYDROCHLORIDE (Proficient Rx LP), BENAZEPRIL HYDROCHLORIDE (Proficient Rx LP), BENAZEPRIL HYDROCHLORIDE (Proficient Rx LP), BENAZEPRIL HYDROCHLORIDE (Proficient Rx LP), BENAZEPRIL HYDROCHLORIDE (Proficient Rx LP), BENAZEPRIL HYDROCHLORIDE (REMEDYREPACK), BENAZEPRIL HYDROCHLORIDE (REMEDYREPACK), BENAZEPRIL HYDROCHLORIDE (REMEDYREPACK), BENAZEPRIL HYDROCHLORIDE (RPK Pharmaceuticals), BENAZEPRIL HYDROCHLORIDE (RPK Pharmaceuticals), BENAZEPRIL HYDROCHLORIDE (Solco healthcare U.S.), BENAZEPRIL HYDROCHLORIDE (St. Mary's Medical Park Pharmacy), BENAZEPRIL HYDROCHLORIDE (St. Mary's Medical Park Pharmacy), BENAZEPRIL HYDROCHLORIDE (Zydus Pharmaceuticals (USA))
Formula
C24H28N2O5. HCl
Exact mass
460.1765
Mol weight
460.9505
Structure
Simcomp
Class
Cardiovascular agent
 DG01501  Angiotensin-converting enzyme inhibitor
 DG01925  Renin-angiotensin system inhibitor
  DG01501  Angiotensin-converting enzyme inhibitor
Remark
Same as: C07701
Therapeutic category: 2144
ATC code: C09AA07
Chemical structure group: DG00339
Product (DG00339): D00620<JP/US>
Product (mixture): D10279<US> D11069<US>
Efficacy
Antihypertensive, Angiotensin-converting enzyme inhibitor
  Disease
Hypertension [DS:H01633]
Comment
Active form of prodrug: Benazeprilat [DR:D03077]
Target
ACE (CD143) [HSA:1636] [KO:K01283]
  Pathway
hsa04614  Renin-angiotensin system
Metabolism
Enzyme: UGT [KO:K00699]
Interaction
Structure map
map07217  Renin-angiotensin system inhibitors
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 C CARDIOVASCULAR SYSTEM
  C09 AGENTS ACTING ON THE RENIN-ANGIOTENSIN SYSTEM
   C09A ACE INHIBITORS, PLAIN
    C09AA ACE inhibitors, plain
     C09AA07 Benazepril
      D00620  Benazepril hydrochloride (JAN/USP) <JP/US>
USP drug classification [BR:br08302]
 Cardiovascular Agents
  Angiotensin-converting Enzyme (ACE) Inhibitors
   Benazepril
    D00620  Benazepril hydrochloride (JAN/USP)
Therapeutic category of drugs in Japan [BR:br08301]
 2  Agents affecting individual organs
  21  Cardiovascular agents
   214  Antihypertensives
    2144  Angiotensin converting enzyme inhibitors
     D00620  Benazepril hydrochloride (JAN/USP)
Target-based classification of drugs [BR:br08310]
 Enzymes
  Hydrolases (EC3)
   Peptidyl-dipeptidases
    ACE (CD143)
     D00620  Benazepril hydrochloride (JAN/USP) <JP/US>
Drug metabolizing enzymes and transporters [br08309.html]
 Drug metabolizing enzymes
  D00620
Prodrugs [br08324.html]
 DG00339
Other DBs
CAS: 86541-74-4
PubChem: 7847686
ChEBI: 3012
ChEMBL: CHEMBL1694
DrugBank: DB00542
LigandBox: D00620
NIKKAJI: J550.745F
LinkDB
KCF data

ATOM        32
            1   C1x C    23.3231  -19.6615
            2   C8y C    22.4372  -18.5840
            3   C8y C    22.7197  -17.2133
            4   N1y N    23.9591  -16.5857
            5   C1x C    24.7308  -19.7019
            6   C5x C    25.2377  -17.1596
            7   C1y C    25.5777  -18.5180
            8   C8x C    21.6743  -16.2838
            9   C8x C    20.3466  -16.7242
            10  C8x C    20.0641  -18.0949
            11  C8x C    21.1095  -19.0246
            12  C1b C    23.9262  -15.1817
            13  C6a C    25.1248  -14.4519
            14  O6a O    26.3615  -15.1276
            15  O6a O    25.1625  -13.0836
            16  O5x O    26.3330  -16.2423
            17  N1b N    26.9766  -18.5180
            18  C1c C    27.6929  -19.7595
            19  C1b C    29.1069  -19.7602
            20  C7a C    27.0102  -20.9405
            21  C1b C    29.8213  -18.5252
            22  C8y C    31.2056  -18.5264
            23  O6a O    25.6102  -20.9399
            24  O7a O    27.6989  -22.1343
            25  C1b C    29.1070  -22.1349
            26  C1a C    29.7937  -23.3254
            27  C8x C    31.9096  -19.7481
            28  C8x C    33.3085  -19.7492
            29  C8x C    34.0091  -18.5383
            30  C8x C    33.3051  -17.3167
            31  C8x C    31.9062  -17.3155
            32  X   Cl   34.6331  -22.3162
BOND        33
            1     3   4 1
            2     1   5 1
            3     4   6 1
            4     2   3 1
            5     5   7 1
            6     1   2 1
            7     6   7 1
            8     3   8 2
            9     8   9 1
            10    9  10 2
            11   10  11 1
            12    2  11 2
            13    4  12 1
            14   12  13 1
            15   13  14 1
            16   13  15 2
            17    6  16 2
            18    7  17 1 #Up
            19   17  18 1
            20   18  19 1 #Up
            21   18  20 1
            22   19  21 1
            23   21  22 1
            24   20  23 2
            25   20  24 1
            26   24  25 1
            27   25  26 1
            28   22  27 2
            29   27  28 1
            30   28  29 2
            31   29  30 1
            32   30  31 2
            33   22  31 1

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