KEGG   DRUG: Dopamine hydrochlorideHelp
Entry
D00633                      Drug                                   

Name
Dopamine hydrochloride (JP17/USP);
Actopamin (TN);
Intropin (TN)
Product
  Generic
Formula
C8H11NO2. HCl
Exact mass
189.0557
Mol weight
189.6394
Structure
Mol fileKCF fileDB search
Simcomp SIMCOMP
Class
Cardiovascular agent
 DG01703  Cardiotonic
  DG01699  Catecholamine cardiotonic
 DG01592  COMT substrate
Neuropsychiatric agent
 DG01472  Dopamine agonist
  DG01467  Dopamine D1-receptor agonist
  DG01468  Dopamine D2-receptor agonist
  DG01469  Dopamine D3-receptor agonist
  DG01470  Dopamine D4-receptor agonist
  DG01471  Dopamine D5-receptor agonist
Metabolizing enzyme substrate
 DG02917  MAO substrate
Transporter substrate
 DG02854  SLC22A2 (OCT2) substrate
Remark
Therapeutic category: 2119
ATC code: C01CA04
Chemical structure group: DG00213
Product (DG00213): D00633<JP/US>
Efficacy
Cardiotonic, Dopamine receptor agonist
  Disease
Myocardial infarction [DS:H01730]
Comment
Catecholamine derivative
Target
  Pathway
hsa04020  Calcium signaling pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04728  Dopaminergic synapse
Metabolism
Enzyme: MAOB [HSA:4129], COMT [HSA:1312]
Transporter: SLC22A2 [HSA:6582]
Interaction
Drug interaction
Structure map
map07213  Dopamine receptor agonists/antagonists
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 C CARDIOVASCULAR SYSTEM
  C01 CARDIAC THERAPY
   C01C CARDIAC STIMULANTS EXCL. CARDIAC GLYCOSIDES
    C01CA Adrenergic and dopaminergic agents
     C01CA04 Dopamine
      D00633  Dopamine hydrochloride (JP17/USP) <JP/US>
Therapeutic category of drugs in Japan [BR:br08301]
 2  Agents affecting individual organs
  21  Cardiovascular agents
   211  Cardiotonics
    2119  Others
     D00633  Dopamine hydrochloride (JP17/USP)
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Dopamine
    DRD
     D00633  Dopamine hydrochloride (JP17/USP) <JP/US>
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D00633  Dopamine hydrochloride
  D00633  Dopamine hydrochloride injection
BRITE hierarchy
Other DBs
CAS: 62-31-7
PubChem: 7847699
ChEBI: 4698
ChEMBL: CHEMBL1557
DrugBank: DB00988
LigandBox: D00633
NIKKAJI: J237.158H
LinkDB All DBs
KCF data Show

ATOM        12
            1   C8y C    28.7000  -14.7000
            2   C8x C    27.5100  -14.0000
            3   C8x C    28.7000  -16.1000
            4   C1b C    29.8900  -14.0000
            5   C8y C    26.3200  -14.7000
            6   C8x C    27.5100  -16.8000
            7   C1b C    31.1500  -14.7000
            8   C8y C    26.3200  -16.1000
            9   O1a O    25.0600  -14.0000
            10  N1a N    32.3400  -14.0000
            11  O1a O    25.0600  -16.8000
            12  X   Cl   32.5500  -16.8000
BOND        11
            1     1   2 1
            2     1   3 2
            3     1   4 1
            4     2   5 2
            5     3   6 1
            6     4   7 1
            7     5   8 1
            8     5   9 1
            9     7  10 1
            10    8  11 1
            11    6   8 2

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