KEGG   DRUG: Hydroxyzine hydrochloride
Entry
D00672                      Drug                                   

Name
Hydroxyzine hydrochloride (JP17/USP);
Atarax (TN);
Vistaril (TN)
Product
  Generic
HYDROXYZINE HYDROCHLORIDE (Bryant Ranch Prepack), HYDROXYZINE (General Injectables & Vaccines), HYDROXYZINE (General Injectables & Vaccines), HYDROXYZINE (General Injectables & Vaccines), HYDROXYZINE HYDROCHLORIDE (Golden State Medical Supply), HYDROXYZINE HYDROCHLORIDE (HARRIS Pharmaceutical), HYDROXYZINE HYDROCHLORIDE (PD-Rx Pharmaceuticals), HYDROXYZINE HYDROCHLORIDE (PD-Rx Pharmaceuticals), HYDROXYZINE HYDROCHLORIDE (Proficient Rx LP), HYDROXYZINE HCL (DIRECT RX), HYDROXYZINE HCL (STI Pharma LLC), HYDROXYZINE HYDROCHLORIDE (1 Veterans Health), HYDROXYZINE HYDROCHLORIDE (A-S Medication Solutions), HYDROXYZINE HYDROCHLORIDE (A-S Medication Solutions), HYDROXYZINE HYDROCHLORIDE (A-S Medication Solutions), HYDROXYZINE HYDROCHLORIDE (A-S Medication Solutions), HYDROXYZINE HYDROCHLORIDE (A-S Medication Solutions), HYDROXYZINE HYDROCHLORIDE (A-S Medication Solutions), HYDROXYZINE HYDROCHLORIDE (American Health Packaging), HYDROXYZINE HYDROCHLORIDE (American Regent), HYDROXYZINE HYDROCHLORIDE (Atlantic Biologicals Corps), HYDROXYZINE HYDROCHLORIDE (Bryant Ranch Prepack), HYDROXYZINE HYDROCHLORIDE (Bryant Ranch Prepack), HYDROXYZINE HYDROCHLORIDE (Bryant Ranch Prepack), HYDROXYZINE HYDROCHLORIDE (Bryant Ranch Prepack), HYDROXYZINE HYDROCHLORIDE (Bryant Ranch Prepack), HYDROXYZINE HYDROCHLORIDE (Bryant Ranch Prepack), HYDROXYZINE HYDROCHLORIDE (Bryant Ranch Prepack), HYDROXYZINE HYDROCHLORIDE (Camber Pharmaceuticals), HYDROXYZINE HYDROCHLORIDE (Cardinal Health), HYDROXYZINE HYDROCHLORIDE (Cardinal Health), HYDROXYZINE HYDROCHLORIDE (Denton Pharma), HYDROXYZINE HYDROCHLORIDE (Denton Pharma), HYDROXYZINE HYDROCHLORIDE (Denton Pharma), HYDROXYZINE HYDROCHLORIDE (Denton Pharma), HYDROXYZINE HYDROCHLORIDE (Denton Pharma), HYDROXYZINE HYDROCHLORIDE (Denton Pharma), HYDROXYZINE HYDROCHLORIDE (Denton Pharma), HYDROXYZINE HYDROCHLORIDE (Epic Pharma), HYDROXYZINE HYDROCHLORIDE (Heritage Pharmaceuticals Inc. d/b/a Avet Pharmaceuticals), HYDROXYZINE HYDROCHLORIDE (Hi-Tech Pharmacal), HYDROXYZINE HYDROCHLORIDE (KVK-Tech), HYDROXYZINE HYDROCHLORIDE (Lannett Company), HYDROXYZINE (Major Pharmaceuticals), HYDROXYZINE HYDROCHLORIDE (Major Pharmaceuticals), HYDROXYZINE HYDROCHLORIDE (McKesson Corporation dba SKY Packaging), HYDROXYZINE HYDROCHLORIDE (Morton Grove Pharmaceuticals), HYDROXYZINE HYDROCHLORIDE (NCS HealthCare of KY), HYDROXYZINE HYDROCHLORIDE (Northstar RxLLC), HYDROXYZINE HYDROCHLORIDE (NuCare Pharmaceuticals), HYDROXYZINE HYDROCHLORIDE (NuCare Pharmaceuticals), HYDROXYZINE HYDROCHLORIDE (NuCare Pharmaceuticals), HYDROXYZINE HYDROCHLORIDE (NuCare Pharmaceuticals), HYDROXYZINE HYDROCHLORIDE (NuCare Pharmaceuticals), HYDROXYZINE HYDROCHLORIDE (NuCare Pharmaceuticals), HYDROXYZINE HYDROCHLORIDE (NuCare Pharmaceuticals), HYDROXYZINE HYDROCHLORIDE (NuCare Pharmaceuticals), HYDROXYZINE HYDROCHLORIDE (NuCare Pharmceuticals), HYDROXYZINE HYDROCHLORIDE (PD-Rx Pharmaceuticals), HYDROXYZINE HYDROCHLORIDE (PD-Rx Pharmaceuticals), HYDROXYZINE HYDROCHLORIDE (PD-Rx Pharmaceuticals), HYDROXYZINE HYDROCHLORIDE (PD-Rx Pharmaceuticals), HYDROXYZINE HYDROCHLORIDE (PD-Rx Pharmaceuticals), HYDROXYZINE HYDROCHLORIDE (Preferred Pharmaceuticals), HYDROXYZINE (Preferred Pharmaceuticals), HYDROXYZINE HYDROCHLORIDE (Preferred Pharmaceuticals), HYDROXYZINE HYDROCHLORIDE (Preferred Pharmaceuticals), HYDROXYZINE HYDROCHLORIDE (Preferred Pharmaceuticals), HYDROXYZINE HYDROCHLORIDE (Proficient Rx LP), HYDROXYZINE HYDROCHLORIDE (Proficient Rx LP), HYDROXYZINE HYDROCHLORIDE (Proficient Rx LP), HYDROXYZINE HYDROCHLORIDE (Proficient Rx LP), HYDROXYZINE HYDROCHLORIDE (Proficient Rx LP), HYDROXYZINE HYDROCHLORIDE (Proficient Rx LP), HYDROXYZINE HYDROCHLORIDE (Proficient Rx LP), HYDROXYZINE HYDROCHLORIDE (Proficient Rx LP), HYDROXYZINE HYDROCHLORIDE (Proficient Rx LP), HYDROXYZINE HYDROCHLORIDE (Proficient Rx LP), HYDROXYZINE HYDROCHLORIDE (Quality Care Products), HYDROXYZINE HYDROCHLORIDE (Quality Care Products), HYDROXYZINE HYDROCHLORIDE (REMEDYREPACK), HYDROXYZINE HYDROCHLORIDE (REMEDYREPACK), HYDROXYZINE HYDROCHLORIDE (REMEDYREPACK), HYDROXYZINE HYDROCHLORIDE (REMEDYREPACK), HYDROXYZINE HYDROCHLORIDE (REMEDYREPACK), HYDROXYZINE HYDROCHLORIDE (REMEDYREPACK), HYDROXYZINE HYDROCHLORIDE (REMEDYREPACK), HYDROXYZINE HYDROCHLORIDE (REMEDYREPACK), HYDROXYZINE HYDROCHLORIDE (REMEDYREPACK), HYDROXYZINE HYDROCHLORIDE (REMEDYREPACK), HYDROXYZINE HYDROCHLORIDE (REMEDYREPACK), HYDROXYZINE HYDROCHLORIDE (REMEDYREPACK), HYDROXYZINE HYDROCHLORIDE (RedPharm Drug), HYDROXYZINE HYDROCHLORIDE (RedPharm Drug), HYDROXYZINE HYDROCHLORIDE (RedPharm Drug), HYDROXYZINE HYDROCHLORIDE (RedPharm Drug), HYDROXYZINE HYDROCHLORIDE (RedPharm Drug), HYDROXYZINE HYDROCHLORIDE (St Mary's Medical Park Pharmacy), HYDROXYZINE HYDROCHLORIDE (St. Mary's Medical Park Pharmacy), HYDROXYZINE HYDROCHLORIDE (St. Mary's Medical Park Pharmacy), HYDROXYZINE HYDROCHLORIDE (Teva Pharmaceuticals USA), HYDROXYZINE HYDROCHLORIDE (Torrent Pharmaceuticals Limited), HYDROXYZINE HYDROCHLORIDE (Unit Dose Services)
Formula
C21H27ClN2O2. 2HCl
Exact mass
446.1295
Mol weight
447.8262
Structure
Simcomp
Class
Anti-allergic agent
 DG01557  Histamine receptor antagonist
  DG01482  Histamine receptor H1 antagonist
Remark
Therapeutic category: 1179
ATC code: N05BB01
Chemical structure group: DG00912
Product (DG00912): D00672<JP/US> D01096<JP/US>
Efficacy
Antianxiety, Minor tranquilizer, H1 receptor antagonist
Comment
In vitro studies suggested a role for CYP3A4 and CYP3A5 in the metabolism of Hydroxyzine.
Target
HRH1 [HSA:3269] [KO:K04149]
  Pathway
hsa04020  Calcium signaling pathway
hsa04080  Neuroactive ligand-receptor interaction
Interaction
Structure map
map07030  Anxiolytics
map07032  Hypnotics
map07212  Histamine H1 receptor antagonists
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 N NERVOUS SYSTEM
  N05 PSYCHOLEPTICS
   N05B ANXIOLYTICS
    N05BB Diphenylmethane derivatives
     N05BB01 Hydroxyzine
      D00672  Hydroxyzine hydrochloride (JP17/USP) <JP/US>
USP drug classification [BR:br08302]
 Antiemetics
  Antiemetics, Other
   Hydroxyzine
    D00672  Hydroxyzine hydrochloride (JP17/USP)
 Anxiolytics
  Anxiolytics, Other
   Hydroxyzine
    D00672  Hydroxyzine hydrochloride (JP17/USP)
 Respiratory Tract/Pulmonary Agents
  Antihistamines
   Histamine (H1) Receptor Antagonists, Sedating
    Hydroxyzine
     D00672  Hydroxyzine hydrochloride (JP17/USP)
Therapeutic category of drugs in Japan [BR:br08301]
 1  Agents affecting nervous system and sensory organs
  11  Agents affecting central nervous system
   117  Psychotropics
    1179  Others
     D00672  Hydroxyzine hydrochloride (JP17/USP)
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Histamine
    HRH1
     D00672  Hydroxyzine hydrochloride (JP17/USP) <JP/US>
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D00672  Hydroxyzine hydrochloride
Other DBs
CAS: 2192-20-3
PubChem: 7847738
ChEBI: 5819
ChEMBL: CHEMBL3186993
DrugBank: DB00557
LigandBox: D00672
NIKKAJI: J300.838J
LinkDB
KCF data

ATOM        28
            1   C8x C     8.6800  -18.1300
            2   C8y C     8.6800  -19.5300
            3   C8x C     9.8924  -20.2300
            4   C8x C    11.1049  -19.5300
            5   C8y C    11.1049  -18.1300
            6   C8x C     9.8924  -17.4300
            7   C8x C    13.5297  -19.5300
            8   C8y C    13.5297  -18.1300
            9   C1c C    12.3173  -17.4300
            10  N1y N    12.3173  -16.0300
            11  C1x C    13.5318  -15.3288
            12  C1x C    13.5318  -13.9288
            13  N1y N    12.3193  -13.2288
            14  C1x C    11.1049  -13.9300
            15  C1x C    11.1049  -15.3300
            16  C8x C    14.7422  -20.2300
            17  C8x C    15.9546  -19.5300
            18  C8x C    15.9546  -18.1300
            19  C8x C    14.7422  -17.4300
            20  X   Cl    7.4676  -20.2300
            21  C1b C    12.3193  -11.8300
            22  C1b C    13.5323  -11.1297
            23  O2a O    14.7280  -11.8202
            24  C1b C    15.9152  -11.1349
            25  C1b C    17.1065  -11.8229
            26  O1a O    18.2960  -11.1362
            27  X   Cl   17.8500  -15.4000
            28  X   Cl   17.8500  -15.4000
BOND        28
            1     1   2 2
            2     2   3 1
            3     3   4 2
            4     4   5 1
            5     5   6 2
            6     1   6 1
            7     7   8 1
            8     8   9 1
            9     5   9 1
            10    9  10 1
            11   10  11 1
            12   11  12 1
            13   12  13 1
            14   13  14 1
            15   14  15 1
            16   10  15 1
            17    7  16 2
            18   16  17 1
            19   17  18 2
            20   18  19 1
            21    8  19 2
            22    2  20 1
            23   13  21 1
            24   21  22 1
            25   22  23 1
            26   23  24 1
            27   24  25 1
            28   25  26 1
BRACKET     1    16.2400  -16.2400   16.2400  -14.6300
            1    18.6900  -14.6300   18.6900  -16.2400
            1  2
 ORIGINAL  1   27
 REPEAT    1   28

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