KEGG   DRUG: Ondansetron hydrochloride hydrateHelp
Entry
D00678                      Drug                                   

Name
Ondansetron hydrochloride hydrate (JAN/USP);
Ondansetron hydrochloride;
Zofran (TN)
Product
  Generic
ONDANSETRON (ACTAVIS PHARMA), ONDANSETRON (Amneal Pharmaceuticals of New York), ONDANSETRON (Aphena Pharma Solutions - Tennessee), ONDANSETRON (Apotex Corp.), ONDANSETRON (Atlantic Biologicals Corps), ONDANSETRON (Atlantic Biologicals Corps), ONDANSETRON (Bryant Ranch Prepack), ONDANSETRON (Bryant Ranch Prepack), ONDANSETRON (Bryant Ranch Prepack), ONDANSETRON (Bryant Ranch Prepack), ONDANSETRON (Cardinal Health), ONDANSETRON (Cardinal Health), ONDANSETRON (Cardinal Health), ONDANSETRON (Clinical Solutions Wholesale), ONDANSETRON (DIRECT RX), ONDANSETRON (DIRECT RX), ONDANSETRON (DIRECT RX), ONDANSETRON (Gland Pharma Limited), ONDANSETRON (Gland Pharma Limited), ONDANSETRON (Heritage Pharmaceuticals), ONDANSETRON (Hospira), ONDANSETRON (Hospira), ONDANSETRON (Lake Erie Medical DBA Quality Care Products LLC), ONDANSETRON (Lake Erie Medical DBA Quality Care Products LLC), ONDANSETRON (Lake Erie Medical DBA Quality Care Products LLC), ONDANSETRON (Life Line Home Care Services), ONDANSETRON (Medical Purchasing Solutions), ONDANSETRON (Mylan Institutional), ONDANSETRON HYDROCHLORIDE (Mylan Institutional LLC), ONDANSETRON (Mylan Pharmaceuticals), ONDANSETRON (NuCare Pharmaceuticals), ONDANSETRON (PD-Rx Pharmaceuticals), ONDANSETRON (PD-Rx Pharmaceuticals), ONDANSETRON (Preferred Pharmaceuticals), ONDANSETRON (Proficient Rx LP), ONDANSETRON (Qilu Pharmaceutical), ONDANSETRON (REMEDYREPACK), ONDANSETRON (REMEDYREPACK), ONDANSETRON (REMEDYREPACK), ONDANSETRON (RPK Pharmaceuticals), ONDANSETRON (Ranbaxy Pharmaceuticals), ONDANSETRON (RedPharm Drug), ONDANSETRON (Sandoz), ONDANSETRON (Teva Parenteral Medicines), ONDANSETRON (Teva Parenteral Medicines), ONDANSETRON (Unit Dose Services), ONDANSETRON (West-Ward Pharmaceuticals Corp), ONDANSETRON (West-Ward Pharmaceuticals Corp.), ONDANSETRON (West-Ward Pharmaceuticals Corp.), ONDANSETRON HCL (Northwind Pharmaceuticals), ONDANSETRON (A-S Medication Solutions), ONDANSETRON (Aidarex Pharmaceuticals LLC), ONDANSETRON HYDROCHLORIDE (Aidarex Pharmaceuticals LLC), ONDANSETRON HYDROCHLORIDE (American Health Packaging), ONDANSETRON (Ascend Laboratories), ONDANSETRON (Athenex Pharmaceutical Division), ONDANSETRON (AuroMedics Pharma LLC), ONDANSETRON (AuroMedics Pharma LLC), ONDANSETRON HYDROCHLORIDE (Aurobindo Pharma Limited), ONDANSETRON (Aurobindo Pharma Limited), ONDANSETRON HYDROCHLORIDE (AvPAK), ONDANSETRON HYDROCHLORIDE (Baxter Healthcare Corporation), ONDANSETRON HYDROCHLORIDE (Blenheim Pharmacal), ONDANSETRON HYDROCHLORIDE (Bryant Ranch Prepack), ONDANSETRON HYDROCHLORIDE (Bryant Ranch Prepack), ONDANSETRON HYDROCHLORIDE (Bryant Ranch Prepack), ONDANSETRON HYDROCHLORIDE (Cardinal Health), ONDANSETRON (Cardinal Health), ONDANSETRON HYDROCHLORIDE (Cardinal Health), ONDANSETRON HYDROCHLORIDE (Carilion Materials Management), ONDANSETRON HYDROCHLORIDE (DIRECT RX), ONDANSETRON HYDROCHLORIDE (Dispensing Solutions), ONDANSETRON HYDROCHLORIDE (Dispensing Solutions), ONDANSETRON HYDROCHLORIDE (Dr.Reddy's Laboratories Limited), ONDANSETRON (Fresenius Kabi USA), ONDANSETRON (Fresenius Kabi USA), ONDANSETRON HYDROCHLORIDE (H.J. Harkins Company), ONDANSETRON HYDROCHLORIDE (Heritage Pharmaceuticals), ONDANSETRON HYDROCHLORIDE (Heritage Pharmaceuticals), ONDANSETRON HYDROCHLORIDE (Heritage Pharmaceuticals), ONDANSETRON HYDROCHLORIDE (Heritage Pharmaceuticals), ONDANSETRON HYDROCHLORIDE (KAISER FOUNDATION HOSPITALS), ONDANSETRON HYDROCHLORIDE (Lake Erie Medical DBA Quality Care Products LLC), ONDANSETRON HYDROCHLORIDE (Lake Erie Medical DBA Quality Care Products LLC), ONDANSETRON HYDROCHLORIDE (Lake Erie Medical DBA Quality Care Products LLC), ONDANSETRON HYDROCHLORIDE (Lannett Company), ONDANSETRON (Lannett Company), ONDANSETRON HYDROCHLORIDE (Major Pharmaceuticals), ONDANSETRON HYDROCHLORIDE (MedVantx), ONDANSETRON (Medical Purchasing Solutions), ONDANSETRON (NorthStar Rx LLC), ONDANSETRON HYDROCHLORIDE (Northwind Pharmaceuticals), ONDANSETRON (Northwind Pharmaceuticals), ONDANSETRON HYDROCHLORIDE (NuCare Pharmaceuticals), ONDANSETRON (NuCare Pharmaceuticals), ONDANSETRON HYDROCHLORIDE (NuCare Pharmaceuticals), ONDANSETRON HYDROCHLORIDE (NuCare Pharmaceuticals), ONDANSETRON HYDROCHLORIDE (NuCare Pharmceuticals), ONDANSETRON HYDROCHLORIDE (PD-Rx Pharmaceuticals), ONDANSETRON (PD-Rx Pharmaceuticals), ONDANSETRON HYDROCHLORIDE (Physicians Total Care), ONDANSETRON (Physicians Total Care), ONDANSETRON HYDROCHLORIDE (Precision Dose), ONDANSETRON HYDROCHLORIDE (Preferred Pharmaceuticals), ONDANSETRON HYDROCHLORIDE (Preferred Pharmaceuticals), ONDANSETRON HYDROCHLORIDE (Proficient Rx LP), ONDANSETRON HYDROCHLORIDE (Proficient Rx LP), ONDANSETRON (Proficient Rx LP), ONDANSETRON HYDROCHLORIDE (QPharma), ONDANSETRON HYDROCHLORIDE (QPharma), ONDANSETRON HYDROCHLORIDE (REMEDYREPACK), ONDANSETRON HYDROCHLORIDE (REMEDYREPACK), ONDANSETRON HYDROCHLORIDE (REMEDYREPACK), ONDANSETRON (RPK Pharmaceuticals), ONDANSETRON HYDROCHLORIDE (Rebel Distributors Corp), ONDANSETRON HYDROCHLORIDE (RedPharm Drug), ONDANSETRON HYDROCHLORIDE (RedPharm Drug), ONDANSETRON HYDROCHLORIDE (Rising Health), ONDANSETRON (Sagent Pharmaceuticals), ONDANSETRON HYDROCHLORIDE (St. Mary's Medical Park Pharmacy), ONDANSETRON HYDROCHLORIDE (St. Mary's Medical Park Pharmacy), ONDANSETRON HYDROCHLORIDE (Sun Pharmaceutical Industries Limited), ONDANSETRON HYDROCHLORIDE (Taro Pharmaceuticals U.S.A.), ONDANSETRON (Taro Pharmaceuticals U.S.A.), ONDANSETRON (The Medicines Company), ONDANSETRON HYDROCHLORIDE (Unit Dose Services), ONDANSETRON (Unit Dose Services), ONDANSETRON (Unit Dose Services), ONDANSETRON HYDROCHLORIDE (Unit Dose Services), ONDANSETRON HYDROCHLORIDE (WOCKHARDT LIMITED), ONDANSETRON HYDROCHLORIDE (West-Ward Pharmaceuticals Corp.), ONDANSETRON (West-ward Pharmaceutical Corp), ONDANSETRON HYDROCHLORIDE (Wockhardt USA LLC.), ONDANSETRON HYDROCHLORIDE AND DEXTROSE (Pfizer Labs), ONDANSETRON HYDROCHLORIDE AND DEXTROSE (West-ward Pharmaceutical Corp)
Formula
C18H19N3O. 2H2O. HCl
Exact mass
365.1506
Mol weight
365.8545
Structure
Mol fileKCF fileDB search
Simcomp SIMCOMP
Class
Gastrointestinal agent
 DG01762  Antiemetic
Other
 DG01489  5-HT3-receptor antagonist
Cyp substrate
 DG01892  CYP1A2 substrate
 DG01644  CYP2D6 substrate
 DG01633  CYP3A substrate
Remark
Therapeutic category: 2391
ATC code: A04AA01
Chemical structure group: DG00060
Product (DG00060): D00456<JP/US> D00678<JP/US>
Efficacy
Antianxiety, Anti-emetic, Antipsychotic, Serotonin 5-HT3 receptor antagonist
Target
  Pathway
hsa04726  Serotonergic synapse
Metabolism
Enzyme: CYP1A2 [HSA:1544], CYP2D6 [HSA:1565], CYP3A4 [HSA:1576]
Interaction
Drug interaction
Structure map
map07211  Serotonin receptor agonists/antagonists
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 A ALIMENTARY TRACT AND METABOLISM
  A04 ANTIEMETICS AND ANTINAUSEANTS
   A04A ANTIEMETICS AND ANTINAUSEANTS
    A04AA Serotonin (5HT3) antagonists
     A04AA01 Ondansetron
      D00678  Ondansetron hydrochloride hydrate (JAN/USP) <JP/US>
USP drug classification [BR:br08302]
 Antiemetics
  Emetogenic Therapy Adjuncts
   Ondansetron
    D00678  Ondansetron hydrochloride hydrate (JAN/USP)
Therapeutic category of drugs in Japan [BR:br08301]
 2  Agents affecting individual organs
  23  Digestive organ agents
   239  Miscellaneous
    2391  Antiemetics
     D00678  Ondansetron hydrochloride hydrate (JAN/USP)
Target-based classification of drugs [BR:br08310]
 Ion channels
  Ligand-gated ion channels
   Serotonin
    HTR3
     D00678  Ondansetron hydrochloride hydrate (JAN/USP) <JP/US>
Drug classes of therapeutic agents [br08360.html]
 Gastrointestinal agents
  D00678
BRITE hierarchy
Other DBs
CAS: 103639-04-9
PubChem: 7847744
ChEBI: 7774
ChEMBL: CHEMBL3186492
DrugBank: DB00904
LigandBox: D00678
NIKKAJI: J1.630.992C
LinkDB All DBs
KCF data Show

ATOM        25
            1   C8y C    27.9300   -8.4700
            2   C8y C    29.2600   -8.9600
            3   C8y C    27.9300   -7.0700
            4   C5x C    26.7400   -9.1700
            5   C8y C    30.0300   -7.7700
            6   C8x C    29.8200  -10.2200
            7   N4y N    29.2600   -6.6500
            8   C1x C    26.7400   -6.3700
            9   C1y C    25.4800   -8.4700
            10  O5x O    26.7400  -10.5700
            11  C8x C    31.4300   -7.9100
            12  C8x C    31.2200  -10.3600
            13  C1a C    29.6800   -5.3200
            14  C1x C    25.4800   -7.0700
            15  C1b C    24.2900   -9.1700
            16  C8x C    32.0600   -9.2400
            17  N4y N    23.1000   -8.4700
            18  C8y C    23.1000   -7.0700
            19  C8x C    21.7000   -8.8900
            20  N5x N    21.7700   -6.5800
            21  C1a C    24.2900   -6.3000
            22  C8x C    20.9300   -7.7000
            23  X   Cl   34.7900   -6.5800
            24  O0  O    35.4900   -8.5400
            25  O0  O    35.4900   -8.5400
BOND        25
            1     1   2 1
            2     1   3 2
            3     1   4 1
            4     2   5 1
            5     2   6 2
            6     3   7 1
            7     3   8 1
            8     4   9 1
            9     4  10 2
            10    5  11 2
            11    6  12 1
            12    7  13 1
            13    8  14 1
            14    9  15 1
            15   11  16 1
            16   15  17 1
            17   17  18 1
            18   17  19 1
            19   18  20 2
            20   18  21 1
            21   19  22 2
            22    5   7 1
            23    9  14 1
            24   12  16 2
            25   20  22 1
BRACKET     1    33.3200   -9.3800   33.3200   -7.7700
            1    35.9800   -7.7700   35.9800   -9.3800
            1  2
 ORIGINAL  1   24
 REPEAT    1   25

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