KEGG   DRUG: Buspirone hydrochlorideHelp
Entry
D00702                      Drug                                   

Name
Buspirone hydrochloride (USP);
Buspar (TN)
Product
  Generic
BUSPIRONE HYDROCHLORIDE (Physicians Total Care), BUSPIRONE HCL (RedPharm Drug), BUSPIRONE HYDROCHLORIDE (A-S Medication Solutions), BUSPIRONE HCL (A-S Medication Solutions), BUSPIRONE HYDROCHLORIDE (A-S Medication Solutions), BUSPIRONE HYDROCHLORIDE (A-S Medication Solutions), BUSPIRONE HYDROCHLORIDE (Accord Healthcare), BUSPIRONE HCL (Actavis Pharma), BUSPIRONE HYDROCHLORIDE (Aidarex Pharmaceuticals LLC), BUSPIRONE HYDROCHLORIDE (Aidarex Pharmaceuticals LLC), BUSPIRONE HCL (American Health Packaging), BUSPIRONE HCL (Amneal Pharmaceuticals LLC), BUSPIRONE HCL (Aphena Pharma Solutions - Tennessee), BUSPIRONE HYDROCHLORIDE (Aphena Pharma Solutions - Tennessee), BUSPIRONE HYDROCHLORIDE (Aphena Pharma Solutions - Tennessee), BUSPIRONE HYDROCHLORIDE (AvKARE), BUSPIRONE HYDROCHLORIDE (AvKARE), BUSPIRONE HCL (Blenheim Pharmacal), BUSPIRONE HCL (Bryant Ranch Prepack), BUSPIRONE HYDROCHLORIDE (Bryant Ranch Prepack), BUSPIRONE HCL (Bryant Ranch Prepack), BUSPIRONE HYDROCHLORIDE (Bryant Ranch Prepack), BUSPIRONE HYDROCHLORIDE (Bryant Ranch Prepack), BUSPIRONE HCL (Bryant Ranch Prepack), BUSPIRONE HYDROCHLORIDE (Bryant Ranch Prepack), BUSPIRONE HYDROCHLORIDE (Bryant Ranch Prepack), BUSPIRONE HYDROCHLORIDE (Bryant Ranch Prepack), BUSPIRONE HYDROCHLORIDE (Bryant Ranch Prepack), BUSPIRONE HYDROCHLORIDE (Bryant Ranch Prepack), BUSPIRONE HYDROCHLORIDE (Bryant Ranch Prepack), BUSPIRONE HYDROCHLORIDE (Cadila Healthcare Limited), BUSPIRONE HYDROCHLORIDE (Cardinal Health), BUSPIRONE HYDROCHLORIDE (Carilion Materials Management), BUSPIRONE HYDROCHLORIDE (Carilion Materials Management), BUSPIRONE HYDROCHLORIDE (Clinical Solutions Wholesale), BUSPIRONE HYDROCHLORIDE (Contract Pharmacy Services-PA), BUSPIRONE HYDROCHLORIDE (DIRECT RX), BUSPIRONE HYDROCHLORIDE (Direct Rx), BUSPIRONE HYDROCHLORIDE (DirectRX), BUSPIRONE HCL (Dispensing Solutions), BUSPIRONE HCL (Dispensing Solutions), BUSPIRONE HYDROCHLORIDE (Dr. Reddy's Laboratories Limited), BUSPIRONE HYDROCHLORIDE (Golden State Medical Supply), BUSPIRONE HYDROCHLORIDE (H.J. Harkins Company), BUSPIRONE HYDROCHLORIDE (Heritage Pharmaceuticals), BUSPIRONE HCL (Impax Generics), BUSPIRONE HYDROCHLORIDE (Inventia Healthcare Private Limited), BUSPIRONE HYDROCHLORIDE (Lake Erie Medical DBA Quality Care Products LLC), BUSPIRONE HYDROCHLORIDE (Lake Erie Medical DBA Quality Care Products LLC), BUSPIRONE HYDROCHLORIDE (Lake Erie Medical DBA Quality Care Products LLC), BUSPIRONE HYDROCHLORIDE (Lake Erie Medical DBA Quality Care Products LLC), BUSPIRONE HCL (Lake Erie Medical DBA Quality Care Products LLC), BUSPIRONE HYDROCHLORIDE (Lake Erie Medical DBA Quality Care Products LLC), BUSPIRONE HCL (Medsource Pharmaceuticals), BUSPIRONE HYDROCHLORIDE (Mylan Institutional), BUSPIRONE HYDROCHLORIDE (Mylan Pharmaceuticals), BUSPIRONE HYDROCHLORIDE (NCS HealthCare of KY), BUSPIRONE HYDROCHLORIDE (NCS HealthCare of KY), BUSPIRONE HYDROCHLORIDE (NCS HealthCare of KY), BUSPIRONE HYDROCHLORIDE (NCS HealthCare of KY), BUSPIRONE HYDROCHLORIDE (New Horizon Rx Group), BUSPIRONE HYDROCHLORIDE (Northwind Pharmaceuticals), BUSPIRONE HYDROCHLORIDE (NuCare Pharmaceuticals), BUSPIRONE HYDROCHLORIDE (NuCare Pharmaceuticals), BUSPIRONE HYDROCHLORIDE (NuCare Pharmaceuticals), BUSPIRONE HYDROCHLORIDE (NuCare Pharmaceuticals), BUSPIRONE HYDROCHLORIDE (NuCare Pharmaceuticals), BUSPIRONE HYDROCHLORIDE (NuCare Pharmaceuticals), BUSPIRONE HYDROCHLORIDE (PD-Rx Pharmaceuticals), BUSPIRONE HYDROCHLORIDE (Par Pharmaceutical), BUSPIRONE HYDROCHLORIDE (Physicians Total Care), BUSPIRONE HYDROCHLORIDE (Preferred Pharmaceuticals), BUSPIRONE HYDROCHLORIDE (Preferred Pharmaceuticals), BUSPIRONE HYDROCHLORIDE (Preferred Pharmaceuticals), BUSPIRONE HYDROCHLORIDE (Preferred Pharmaceuticals), BUSPIRONE HYDROCHLORIDE (Preferred Pharmaceuticals), BUSPIRONE HCL (Preferred Pharmaceuticals), BUSPIRONE HYDROCHLORIDE (PreferredPharmaceuticals), BUSPIRONE HCL (Proficient Rx LP), BUSPIRONE HCL (Proficient Rx LP), BUSPIRONE HYDROCHLORIDE (Proficient Rx LP), BUSPIRONE HYDROCHLORIDE (Proficient Rx LP), BUSPIRONE HYDROCHLORIDE (REMEDYREPACK), BUSPIRONE HYDROCHLORIDE (REMEDYREPACK), BUSPIRONE HYDROCHLORIDE (REMEDYREPACK), BUSPIRONE HYDROCHLORIDE (REMEDYREPACK), BUSPIRONE HYDROCHLORIDE (REMEDYREPACK), BUSPIRONE HYDROCHLORIDE (REMEDYREPACK), BUSPIRONE HYDROCHLORIDE (REMEDYREPACK), BUSPIRONE HYDROCHLORIDE (REMEDYREPACK), BUSPIRONE HYDROCHLORIDE (REMEDYREPACK), BUSPIRONE HYDROCHLORIDE (REMEDYREPACK), BUSPIRONE HYDROCHLORIDE (REMEDYREPACK), BUSPIRONE HYDROCHLORIDE (REMEDYREPACK), BUSPIRONE HYDROCHLORIDE (REMEDYREPACK), BUSPIRONE HYDROCHLORIDE (REMEDYREPACK), BUSPIRONE HYDROCHLORIDE (REMEDYREPACK), BUSPIRONE HYDROCHLORIDE (REMEDYREPACK), BUSPIRONE HYDROCHLORIDE (REMEDYREPACK), BUSPIRONE HYDROCHLORIDE (RPK Pharmaceuticals), BUSPIRONE HYDROCHLORIDE (Rebel Distributors Corp), BUSPIRONE HYDROCHLORIDE (Rebel Distributors Corp), BUSPIRONE HCL (Rebel Distributors Corp.), BUSPIRONE HYDROCHLORIDE (RedPharm Drug), BUSPIRONE HCL (State of Florida DOH Central Pharmacy), BUSPIRONE HYDROCHLORIDE (Strides Shasun Limited), BUSPIRONE HCL (TYA Pharmaceuticals), BUSPIRONE HYDROCHLORIDE (Teva Pharmaceuticals USA), BUSPIRONE HCL (Unit Dose Services), BUSPIRONE HYDROCHLORIDE (Zydus Pharmaceuticals (USA))
Formula
C21H31N5O2. HCl
Exact mass
421.2245
Mol weight
421.9641
Structure
Mol fileKCF fileDB search
Simcomp SIMCOMP
Class
Neuropsychiatric agent
 DG01483  5-HT1A-receptor agonist
Remark
ATC code: N05BE01
Chemical structure group: DG00913
Product (DG00913): D00702<US>
Efficacy
Antianxiety, Minor tranquilizer, Serotonin 5-HT1A receptor agonist
Comment
Buspirone derivative
Target
HTR1A [HSA:3350] [KO:K04153]
DRD2 [HSA:1813] [KO:K04145]
  Pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04726  Serotonergic synapse
hsa04728  Dopaminergic synapse
Interaction
Drug interaction
Structure map
map07030  Anxiolytics
map07211  Serotonin receptor agonists/antagonists
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 N NERVOUS SYSTEM
  N05 PSYCHOLEPTICS
   N05B ANXIOLYTICS
    N05BE Azaspirodecanedione derivatives
     N05BE01 Buspirone
      D00702  Buspirone hydrochloride (USP) <US>
USP drug classification [BR:br08302]
 Anxiolytics
  Anxiolytics, Other
   Buspirone
    D00702  Buspirone hydrochloride (USP)
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Dopamine
    DRD2
     D00702  Buspirone hydrochloride (USP) <US>
   Serotonin
    HTR1A
     D00702  Buspirone hydrochloride (USP) <US>
Drug classes of therapeutic agents [br08360.html]
 Psychiatric agents
  D00702
BRITE hierarchy
Other DBs
CAS: 33386-08-2
PubChem: 7847767
ChEBI: 3224
ChEMBL: CHEMBL1200399
DrugBank: DB00490
LigandBox: D00702
NIKKAJI: J240.216E
LinkDB All DBs
KCF data Show

ATOM        29
            1   C1z C    30.6703  -12.8797
            2   C1x C    29.4326  -12.1783
            3   C1x C    30.6740  -14.2783
            4   C5x C    28.2471  -12.9204
            5   C5x C    29.4419  -15.0222
            6   N1y N    28.2509  -14.3190
            7   O5x O    27.0095  -12.2190
            8   O5x O    29.4440  -16.3742
            9   C1b C    27.0637  -15.0147
            10  C1b C    25.8261  -14.3132
            11  C1b C    24.6389  -15.0088
            12  C1b C    23.4014  -14.3074
            13  N1y N    22.2159  -15.0496
            14  C1x C    20.9783  -14.3482
            15  C1x C    22.2197  -16.4482
            16  C1x C    19.7911  -15.0437
            17  C1x C    20.9859  -17.1454
            18  N1y N    19.7949  -16.4424
            19  C8y C    18.5612  -17.1396
            20  N5x N    17.3702  -16.4366
            21  N5x N    18.5183  -18.5383
            22  C8x C    16.0664  -17.1338
            23  C8x C    17.3311  -19.2338
            24  C8x C    16.0935  -18.5308
            25  C1x C    32.0020  -13.3124
            26  C1x C    32.8245  -12.1795
            27  C1x C    32.0012  -11.0471
            28  C1x C    30.6698  -11.4802
            29  X   Cl   32.5491  -16.1055
BOND        31
            1     1   2 1
            2     1   3 1
            3     2   4 1
            4     3   5 1
            5     4   6 1
            6     4   7 2
            7     5   8 2
            8     6   9 1
            9     9  10 1
            10   10  11 1
            11   11  12 1
            12   12  13 1
            13   13  14 1
            14   13  15 1
            15   14  16 1
            16   15  17 1
            17   16  18 1
            18   18  19 1
            19   19  20 1
            20   19  21 2
            21   20  22 2
            22   21  23 1
            23   22  24 1
            24    5   6 1
            25   17  18 1
            26   23  24 2
            27    1  25 1
            28   25  26 1
            29   26  27 1
            30   27  28 1
            31    1  28 1

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