KEGG   DRUG: Zolpidem tartrateHelp
Entry
D00706                      Drug                                   

Name
Zolpidem tartrate (JP17/USAN);
Ambien (TN);
Intermezzo (TN)
Product
  Generic
ZOLPIDEM TARTRATE (A-S Medication Solutions), ZOLPIDEM TARTRATE (A-S Medication Solutions), ZOLPIDEM TARTRATE (APOTHECA), ZOLPIDEM TARTRATE (Actavis Pharma), ZOLPIDEM TARTRATE (Actavis Pharma), ZOLPIDEM TARTRATE (Aidarex Pharmaceuticals LLC), ZOLPIDEM TARTRATE (American Health Packaging), ZOLPIDEM TARTRATE (American Health Packaging), ZOLPIDEM TARTRATE (Aphena Pharma Solutions - Tennessee), ZOLPIDEM TARTRATE (Aphena Pharma Solutions - Tennessee), ZOLPIDEM TARTRATE (Aphena Pharma Solutions - Tennessee), ZOLPIDEM TARTRATE (Aphena Pharma Solutions - Tennessee), ZOLPIDEM TARTRATE (Aphena Pharma Solutions - Tennessee), ZOLPIDEM TARTRATE (Aphena Pharma Solutions - Tennessee), ZOLPIDEM TARTRATE (Aphena Pharma Solutions - Tennessee), ZOLPIDEM TARTRATE (Aurobindo Pharma Limited), ZOLPIDEM TARTRATE (Blenheim Pharmacal), ZOLPIDEM TARTRATE (Blenheim Pharmacal), ZOLPIDEM TARTRATE (Blenheim Pharmacal), ZOLPIDEM TARTRATE (Bryant Ranch Prepack), ZOLPIDEM TARTRATE (Bryant Ranch Prepack), ZOLPIDEM TARTRATE (Bryant Ranch Prepack), ZOLPIDEM TARTRATE (Bryant Ranch Prepack), ZOLPIDEM TARTRATE (Bryant Ranch Prepack), ZOLPIDEM TARTRATE (Bryant Ranch Prepack), ZOLPIDEM TARTRATE (Bryant Ranch Prepack), ZOLPIDEM TARTRATE (Cardinal Health), ZOLPIDEM TARTRATE (Carlsbad Technology), ZOLPIDEM TARTRATE (DIRECT RX), AMBIEN (DIRECT RX), AMBIEN (DIRECT RX), ZOLPIDEM TARTRATE (DIRECT RX), ZOLPIDEM TARTRATE (DIRECT RX), ZOLPIDEM TARTRATE (DIRECT RX), ZOLPIDEM TARTRATE (DirectRX), ZOLPIDEM TARTRATE (DirectRX), ZOLPIDEM TARTRATE (Dispensing Solutions), ZOLPIDEM TARTRATE (Dispensing Solutions), ZOLPIDEM TARTRATE (Dispensing Solutions), ZOLPIDEM TARTRATE (Dr. Reddy's Laboratories Limited), ZOLPIDEM TARTRATE (H. J. Harkins), ZOLPIDEM TARTRATE (H. J. Harkins), ZOLPIDEM TARTRATE (H.J. Harkins Company), ZOLPIDEM TARTRATE (KAISER FOUNDATION HOSPITALS), ZOLPIDEM TARTRATE (Lake Erie Medical DBA Quality Care Products LLC), ZOLPIDEM TARTRATE (Lake Erie Medical DBA Quality Care Products LLC), ZOLPIDEM TARTRATE (Lake Erie Medical DBA Quality Care Products LLC), ZOLPIDEM TARTRATE (Lake Erie Medical DBA Quality Care Products LLC), ZOLPIDEM TARTRATE (Lake Erie Medical DBA Quality Care Products LLC), ZOLPIDEM TARTRATE (Lake Erie Medical DBA Quality Care Products LLC), ZOLPIDEM TARTRATE (Lake Erie Medical DBA Quality Care Products LLC), ZOLPIDEM TARTRATE (Life Line Home Care Services), ZOLPIDEM TARTRATE (Lupin Pharmaceuticals), ZOLPIDEM TARTRATE (Lupin Pharmaceuticals), ZOLPIDEM TARTRATE (Major Pharmaceuticals), ZOLPIDEM TARTRATE (McKesson Corporation), ZOLPIDEM TARTRATE (Medsource Pharmaceuticals), ZOLPIDEM TARTRATE (Medsource Pharmaceuticals), ZOLPIDEM TARTRATE (Mylan Institutional), ZOLPIDEM TARTRATE (Mylan Pharmaceuticals), ZOLPIDEM TARTRATE (NCS HealthCare of KY), ZOLPIDEM TARTRATE (NCS HealthCare of KY), ZOLPIDEM TARTRATE (NorthStar Rx LLC), ZOLPIDEM TARTRATE (Novel Laboratories), ZOLPIDEM TARTRATE (NuCare Pharmaceuticals), ZOLPIDEM TARTRATE (NuCare Pharmaceuticals), ZOLPIDEM TARTRATE (NuCare Pharmaceuticals), ZOLPIDEM TARTRATE (NuCare Pharmaceuticals), ZOLPIDEM TARTRATE (NuCare Pharmaceuticals), ZOLPIDEM TARTRATE (PD-Rx Pharmaceuticals), ZOLPIDEM TARTRATE (PD-Rx Pharmaceuticals), ZOLPIDEM TARTRATE (Par Pharmaceutical), ZOLPIDEM TARTRATE (Par Pharmaceutical), ZOLPIDEM TARTRATE (Preferred Pharmaceuticals), ZOLPIDEM TARTRATE (Preferred Pharmaceuticals), ZOLPIDEM TARTRATE (Preferred Pharmaceuticals), ZOLPIDEM TARTRATE (Preferred Pharmaceuticals), ZOLPIDEM TARTRATE (Preferred Pharmaceuticals), ZOLPIDEM TARTRATE (Preferred Pharmaceuticals), ZOLPIDEM TARTRATE (Preferred Pharmaceuticals), ZOLPIDEM TARTRATE (Proficient Rx LP), ZOLPIDEM TARTRATE (Proficient Rx LP), ZOLPIDEM TARTRATE (Proficient Rx LP), ZOLPIDEM TARTRATE (Proficient Rx LP), ZOLPIDEM TARTRATE (Proficient Rx LP), ZOLPIDEM TARTRATE (Proficient Rx LP), ZOLPIDEM TARTRATE (Proficient Rx LP), ZOLPIDEM TARTRATE (Proficient Rx LP), ZOLPIDEM TARTRATE (REMEDYREPACK), ZOLPIDEM TARTRATE (REMEDYREPACK), ZOLPIDEM TARTRATE (RPK Pharmaceuticals), ZOLPIDEM TARTRATE (Ranbaxy Pharmaceuticals), ZOLPIDEM TARTRATE (Rebel Distributors Corp.), ZOLPIDEM TARTRATE (RedPharm Drug), ZOLPIDEM TARTRATE (RedPharm Drug), ZOLPIDEM TARTRATE (RedPharm Drug), ZOLPIDEM TARTRATE (RedPharm Drug), ZOLPIDEM TARTRATE (RedPharm Drug), ZOLPIDEM TARTRATE (Roxane Laboratories), ZOLPIDEM TARTRATE (RxChange), ZOLPIDEM TARTRATE (RxChange), ZOLPIDEM TARTRATE (Sandoz), ZOLPIDEM TARTRATE (Sandoz), ZOLPIDEM TARTRATE (St Marys Medical Park Pharmacy), ZOLPIDEM TARTRATE EXTENDED RELEASE (St Marys Medical Park Pharmacy), ZOLPIDEM TARTRATE (St. Mary's Medical Park Pharmacy), ZOLPIDEM TARTRATE (St. Mary's Medical Park Pharmacy), ZOLPIDEM TARTRATE (Sun Pharmaceutical Industries), ZOLPIDEM TARTRATE (TYA Pharmaceuticals), ZOLPIDEM TARTRATE (Teva Pharmaceuticals USA), ZOLPIDEM TARTRATE (Torrent Pharmaceuticals Limited), ZOLPIDEM TARTRATE (Unit Dose Services), ZOLPIDEM TARTRATE (Unit Dose Services), ZOLPIDEM TARTRATE (Unit Dose Services), ZOLPIDEM TARTRATE (Unit Dose Services), ZOLPIDEM TARTRATE (Unit Dose Services), ZOLPIDEM (West-ward Pharmaceutical Corp), ZOLPIDEM TARTRATE (Winthrop U.S), ZOLPIDEM TARTRATE (Wockhardt Limited), ZOLPIDEM TARTRATE (Wockhardt USA LLC.), ZOLPIDEM TARTRATE SUBLINGUAL (Par Pharmaceutical)
Formula
(C19H21N3O)2. C4H6O6
Exact mass
764.3534
Mol weight
764.8659
Structure
Mol fileKCF fileDB search
Class
Neuropsychiatric agent
 DG01836  Non-benzodiazepine sedative-hypnotics
 DG01567  GABA-A receptor agonist
Enzyme substrate
 DG01892  CYP1A2 substrate
 DG01642  CYP2C9 substrate
 DG01633  CYP3A substrate
Remark
Therapeutic category: 1129
ATC code: N05CF02
Chemical structure group: DG00922
Product (DG00922): D00706<JP/US>
Efficacy
Sedative-hypnotic
  Disease
Insomnia [DS:H01609]
Comment
Imidazopyridines
Target
  Pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04727  GABAergic synapse
Metabolism
Enzyme: CYP3A4 [HSA:1576]; CYP2C9 [HSA:1559], CYP1A2 [HSA:1544]
Interaction
Drug interaction
Structure map
map07032  Hypnotics
map07230  GABA-A receptor agonists/antagonists
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 N NERVOUS SYSTEM
  N05 PSYCHOLEPTICS
   N05C HYPNOTICS AND SEDATIVES
    N05CF Benzodiazepine related drugs
     N05CF02 Zolpidem
      D00706  Zolpidem tartrate (JP17/USAN) <JP/US>
USP drug classification [BR:br08302]
 Sleep Disorder Agents
  GABA Receptor Modulators
   Zolpidem
    D00706  Zolpidem tartrate (JP17/USAN)
Therapeutic category of drugs in Japan [BR:br08301]
 1  Agents affecting nervous system and sensory organs
  11  Agents affecting central nervous system
   112  Hypnotics and sedatives, anxiolytics
    1129  Others
     D00706  Zolpidem tartrate (JP17/USAN)
Target-based classification of drugs [BR:br08310]
 Ion channels
  Ligand-gated ion channels
   GABA (ionotropic)
    GABR
     D00706  Zolpidem tartrate (JP17/USAN) <JP/US>
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D00706  Zolpidem tartrate
  D00706  Zolpidem tartrate tablets
Drug classes of therapeutic agents [br08360.html]
 Psychiatric agents
  D00706
New drug approvals in Japan [br08318.html]
 Drugs with new active ingredients
  D00706
BRITE hierarchy
Other DBs
CAS: 99294-93-6
PubChem: 7847771
ChEBI: 10126
DrugBank: DB00425
LigandBox: D00706
NIKKAJI: J375.045K
LinkDB All DBs
KCF data Show

ATOM        56
            1   C8y C    19.9502  -16.5666
            2   C8y C    20.7843  -15.4409
            3   N4y N    18.6204  -16.1292
            4   C1b C    19.9445  -17.9607
            5   C8y C    22.1841  -15.4469
            6   N5x N    19.9562  -14.2979
            7   C8y C    18.6263  -14.7236
            8   C8x C    17.4130  -16.8291
            9   C5a C    21.1576  -18.6547
            10  C8x C    22.8783  -16.6542
            11  C8x C    22.8900  -14.2336
            12  C8x C    17.4130  -14.0237
            13  C8y C    16.1942  -16.1234
            14  N1c N    21.1576  -20.0546
            15  O5a O    22.3709  -17.9490
            16  C8x C    24.2782  -16.6600
            17  C8x C    24.2898  -14.2395
            18  C8x C    16.1942  -14.7236
            19  C1a C    14.9809  -16.8291
            20  C1a C    22.3709  -20.7428
            21  C1a C    19.9445  -20.7487
            22  C8y C    24.9838  -15.4585
            23  C1a C    26.3837  -15.4643
            24  C1c C    32.6423  -17.7973
            25  C1c C    33.8437  -17.0974
            26  C6a C    31.4292  -17.1033
            27  O1a O    32.6423  -19.1972
            28  C6a C    35.0570  -17.7856
            29  O1a O    33.8437  -15.6918
            30  O6a O    30.2159  -17.8032
            31  O6a O    31.4233  -15.7035
            32  O6a O    36.2701  -17.0916
            33  O6a O    35.0511  -19.1914
            34  C8y C    19.9502  -16.5666
            35  C8y C    20.7843  -15.4409
            36  C8y C    22.1841  -15.4469
            37  C8x C    22.8783  -16.6542
            38  C8x C    24.2782  -16.6600
            39  C8y C    24.9838  -15.4585
            40  C1a C    26.3837  -15.4643
            41  C8x C    24.2898  -14.2395
            42  C8x C    22.8900  -14.2336
            43  N5x N    19.9562  -14.2979
            44  C8y C    18.6263  -14.7236
            45  N4y N    18.6204  -16.1292
            46  C8x C    17.4130  -16.8291
            47  C8y C    16.1942  -16.1234
            48  C1a C    14.9809  -16.8291
            49  C8x C    16.1942  -14.7236
            50  C8x C    17.4130  -14.0237
            51  C1b C    19.9445  -17.9607
            52  C5a C    21.1576  -18.6547
            53  N1c N    21.1576  -20.0546
            54  C1a C    22.3709  -20.7428
            55  C1a C    19.9445  -20.7487
            56  O5a O    22.3709  -17.9490
BOND        59
            1    24  25 1
            2    24  26 1
            3    24  27 1 #Up
            4    25  28 1
            5    25  29 1 #Up
            6    26  30 1
            7    26  31 2
            8    28  32 1
            9    28  33 2
            10    1   2 2
            11    1   3 1
            12    1   4 1
            13    2   5 1
            14    2   6 1
            15    3   7 1
            16    3   8 1
            17    4   9 1
            18    5  10 2
            19    5  11 1
            20    7  12 1
            21    8  13 2
            22    9  14 1
            23    9  15 2
            24   10  16 1
            25   11  17 2
            26   12  18 2
            27   13  19 1
            28   14  20 1
            29   14  21 1
            30   16  22 2
            31   22  23 1
            32    6   7 2
            33   13  18 1
            34   17  22 1
            35   34  35 2
            36   34  45 1
            37   34  51 1
            38   35  36 1
            39   35  43 1
            40   45  44 1
            41   45  46 1
            42   51  52 1
            43   36  37 2
            44   36  42 1
            45   44  50 1
            46   46  47 2
            47   52  53 1
            48   52  56 2
            49   37  38 1
            50   42  41 2
            51   50  49 2
            52   47  48 1
            53   53  54 1
            54   53  55 1
            55   38  39 2
            56   39  40 1
            57   43  44 2
            58   47  49 1
            59   41  39 1
BRACKET     1    13.0900  -21.8400   13.0900  -12.8100
            1    28.1400  -12.8100   28.1400  -21.8400
            1  2
 ORIGINAL  1    1   2   5  10  16  22  23  17  11   6   7   3   8  13  19  18
            1   12   4   9  14  20  21  15
 REPEAT    1   34  35  36  37  38  39  40  41  42  43  44  45  46  47  48  49
            1   50  51  52  53  54  55  56

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