KEGG   DRUG: Tizanidine hydrochloride
Entry
D00776                      Drug                                   

Name
Tizanidine hydrochloride (JP17/USP);
Zanaflex (TN)
Product
  Generic
TIZANDINE (DIRECT RX), TIZANDINE (DirectRX), TIZANDINE (Direct_Rx), TIZANDINE (Direct_Rx), TIZANDINE (Direct_Rx), TIZANIDINE (A-S Medication Solutions), TIZANIDINE (American Health Packaging), TIZANIDINE (Aphena Pharma Solutions - Tennessee), TIZANIDINE (Aphena Pharma Solutions - Tennessee), TIZANIDINE (Aphena Pharma Solutions - Tennessee), TIZANIDINE (Aphena Pharma Solutions - Tennessee), TIZANIDINE (Aphena Pharma Solutions - Tennessee), TIZANIDINE (Aphena Pharma Solutions - Tennessee), TIZANIDINE (Aphena Pharma Solutions - Tennessee), TIZANIDINE (Aphena Pharma Solutions - Tennessee), TIZANIDINE (Aphena Pharma Solutions - Tennessee), TIZANIDINE (Apotex Corp.), TIZANIDINE (Ascend Laboratories), TIZANIDINE (AvKARE), TIZANIDINE (AvPAK), TIZANIDINE (Bryant Ranch Prepack), TIZANIDINE (Bryant Ranch Prepack), TIZANIDINE (Bryant Ranch Prepack), TIZANIDINE (Cadila Healthcare Limited), TIZANIDINE (Cardinal Health), TIZANIDINE (Cardinal Health), TIZANIDINE (Denton Pharma), TIZANIDINE (Denton Pharma), TIZANIDINE (Direct_Rx), TIZANIDINE (Direct_Rx), TIZANIDINE (Dr. Reddy's Laboratories Limited), TIZANIDINE (Golden State Medical Supply), TIZANIDINE (Lake Erie Medical DBA Quality Care Products LLC), TIZANIDINE (Lake Erie Medical DBA Quality Care Products LLC), TIZANIDINE (Major Pharmaceuticals), TIZANIDINE (Major Pharmaceuticals), TIZANIDINE (Mylan Pharmaceuticals), TIZANIDINE (NCS HealthCare of KY), TIZANIDINE (NCS HealthCare of KY), TIZANIDINE (NuCare Pharmaceuticals), TIZANIDINE (NuCare Pharmaceuticals), TIZANIDINE (NuCare Pharmaceuticals), TIZANIDINE (NuCare Pharmaceuticals), TIZANIDINE (NuCare Pharmaceuticals), TIZANIDINE (PD-Rx Pharmaceuticals), TIZANIDINE (PD-Rx Pharmaceuticals), TIZANIDINE (Par Pharmaceutical), TIZANIDINE (Preferred Pharmaceuticals), TIZANIDINE (Preferred Pharmaceuticals), TIZANIDINE (Preferred Pharmaceuticals), TIZANIDINE (Preferred Pharmaceuticals), TIZANIDINE (Proficient Rx LP), TIZANIDINE (Proficient Rx LP), TIZANIDINE (Proficient Rx LP), TIZANIDINE (Proficient Rx LP), TIZANIDINE (Proficient Rx LP), TIZANIDINE (Proficient Rx LP), TIZANIDINE (Quality Care Products), TIZANIDINE (REMEDYREPACK), TIZANIDINE (REMEDYREPACK), TIZANIDINE (REMEDYREPACK), TIZANIDINE (REMEDYREPACK), TIZANIDINE (RedPharm Drug), TIZANIDINE (RedPharm Drug), TIZANIDINE (RedPharm Drug), TIZANIDINE (St. Mary's Medical Park Pharmacy), TIZANIDINE (St. Mary's Medical Park Pharmacy), TIZANIDINE (St. Mary's Medical Park Pharmacy), TIZANIDINE (St. Mary's Medical Park Pharmacy), TIZANIDINE (Sun Pharmaceutical Industries), TIZANIDINE (Unichem Pharmaceuticals (USA)), TIZANIDINE (Unit Dose Services), TIZANIDINE (Zydus Pharmaceuticals (USA)), TIZANIDINE HYDROCHLORIDE (Advagen Pharma Limited), TIZANIDINE HYDROCHLORIDE (Alembic Pharmaceuticals), TIZANIDINE HYDROCHLORIDE (Alembic Pharmaceuticals Limited), TIZANIDINE HYDROCHLORIDE (Aphena Pharma Solutions - Tennessee), TIZANIDINE HYDROCHLORIDE (Apotex Corp.), TIZANIDINE HYDROCHLORIDE (Aurobindo Pharma Limited), TIZANIDINE HYDROCHLORIDE (AvKARE), TIZANIDINE HYDROCHLORIDE (Bryant Ranch Prepack), TIZANIDINE HYDROCHLORIDE (Cadila Healthcare Limited), TIZANIDINE HYDROCHLORIDE (Cadila Pharmaceuticals Limited), TIZANIDINE HYDROCHLORIDE (Eon Labs), TIZANIDINE HYDROCHLORIDE (Ingenus Pharmaceuticals), TIZANIDINE HYDROCHLORIDE (Jubilant Cadista Pharmaceuticals), TIZANIDINE HYDROCHLORIDE (Lake Erie Medical DBA Quality Care Products LLC), TIZANIDINE HYDROCHLORIDE (Nivagen Pharmaceuticals), TIZANIDINE HYDROCHLORIDE (PD-Rx Pharmaceuticals), TIZANIDINE HYDROCHLORIDE (Par Pharmaceutical), TIZANIDINE HYDROCHLORIDE (Quality Care Products), TIZANIDINE HYDROCHLORIDE (Quality Care Products), TIZANIDINE (SA3), TIZANIDINE HYDROCHLORIDE (TIZANIDINE HYDROCHLORIDE), TIZANIDINE HYDROCHLORIDE (Zydus Pharmaceuticals (USA)), TIZANIDINE HYDROCHLORIDE (medsource pharmaceuticals), TIZANIDNE HYDROCHLORIDE (Ascend Laboratories)
Formula
C9H8ClN5S. HCl
Exact mass
288.9956
Mol weight
290.1723
Structure
Simcomp
Class
Cardiovascular agent
 DG01456  Adrenergic receptor agonist
  DG01450  alpha-Adrenergic receptor agonist
   DG01449  alpha2-Adrenergic receptor agonist
    DG01655  alpha2-adrenergic receptor specific agonist
Other
 DG02029  Muscle relaxant
  DG01974  Centrally acting muscle relaxant
 DG01974  Centrally acting muscle relaxant
Metabolizing enzyme substrate
 DG01892  CYP1A2 substrate
Remark
Therapeutic category: 1249
ATC code: M03BX02
Chemical structure group: DG00773
Product (DG00773): D00776<JP/US>
Efficacy
Antispasmodic, Muscle relaxant, alpha2-Adrenergic receptor agonist
Comment
Imidazoline derivative
Target
ADRA2 [HSA:150 151 152] [KO:K04138 K04139 K04140]
  Pathway
hsa04080  Neuroactive ligand-receptor interaction
Metabolism
Enzyme: CYP1A2 [HSA:1544]
Interaction
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 M MUSCULO-SKELETAL SYSTEM
  M03 MUSCLE RELAXANTS
   M03B MUSCLE RELAXANTS, CENTRALLY ACTING AGENTS
    M03BX Other centrally acting agents
     M03BX02 Tizanidine
      D00776  Tizanidine hydrochloride (JP17/USP) <JP/US>
USP drug classification [BR:br08302]
 Antispasticity Agents
  Tizanidine
   D00776  Tizanidine hydrochloride (JP17/USP)
Therapeutic category of drugs in Japan [BR:br08301]
 1  Agents affecting nervous system and sensory organs
  12  Agents affecting peripheral nervous system
   124  Antispasmodics
    1249  Others
     D00776  Tizanidine hydrochloride (JP17/USP)
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Adrenaline
    ADRA2
     D00776  Tizanidine hydrochloride (JP17/USP) <JP/US>
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D00776  Tizanidine hydrochloride
Drug metabolizing enzymes and transporters [br08309.html]
 Drug metabolizing enzymes
  D00776
Other DBs
CAS: 64461-82-1
PubChem: 7847841
ChEBI: 9609
ChEMBL: CHEMBL1200329
DrugBank: DB00697
LigandBox: D00776
NIKKAJI: J276.249H
LinkDB
KCF data

ATOM        17
            1   C8y C    29.0260  -18.0837
            2   C8y C    29.0260  -16.6827
            3   C8y C    27.8120  -18.7958
            4   N5x N    30.0708  -19.0235
            5   N1b N    30.2343  -15.9882
            6   C8y C    27.8120  -15.9823
            7   C8x C    26.5921  -18.0837
            8   N5x N    28.1155  -20.1617
            9   S2x S    29.5105  -20.3018
            10  C2y C    31.4426  -16.6944
            11  C8x C    26.5921  -16.6827
            12  X   Cl   27.8003  -14.5816
            13  N1x N    32.7500  -16.2424
            14  N2x N    31.4535  -18.0910
            15  C1x C    33.5919  -17.3543
            16  C1x C    32.7903  -18.4961
            17  X   Cl   36.7067  -17.3950
BOND        18
            1     1   2 1
            2     1   3 1
            3     1   4 2
            4     2   5 1
            5     2   6 2
            6     3   7 1
            7     3   8 2
            8     4   9 1
            9     5  10 1
            10    6  11 1
            11    6  12 1
            12   10  13 1
            13   10  14 2
            14   13  15 1
            15   14  16 1
            16    7  11 2
            17    8   9 1
            18   15  16 1

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