DRUG: Ropinirole hydrochloride
Help
Entry
D00784 Drug
Name
Ropinirole hydrochloride (JAN/USP);
Requip (TN)
Product
Generic
ROPINIROLE (A-S Medication Solutions)
,
ROPINIROLE (A-S Medication Solutions)
,
ROPINIROLE (A-S Medication Solutions)
,
ROPINIROLE (A-S Medication Solutions)
,
ROPINIROLE (Accord Healthcare)
,
ROPINIROLE (Actavis Pharma)
,
ROPINIROLE (Alembic Pharmaceuticals)
,
ROPINIROLE (Alembic Pharmaceuticals Limited)
,
ROPINIROLE HYDROCHLORIDE (Aphena Pharma Solutions - Tennessee)
,
ROPINIROLE (Bryant Ranch Prepack)
,
ROPINIROLE (Bryant Ranch Prepack)
,
ROPINIROLE (Bryant Ranch Prepack)
,
ROPINIROLE (Bryant Ranch Prepack)
,
ROPINIROLE (Direct_Rx)
,
ROPINIROLE (Dr. Reddys Laboratories Limited)
,
ROPINIROLE (Glenmark Pharmaceuticals)
,
ROPINIROLE HYDROCHLORIDE (Golden State Medical Supply)
,
ROPINIROLE (Marlex Pharmaceuticals)
,
ROPINIROLE (Mylan Pharmaceuticals)
,
ROPINIROLE (REMEDYREPACK)
,
ROPINIROLE (REMEDYREPACK)
,
ROPINIROLE (Sandoz)
,
ROPINIROLE (Trigen Laboratories)
,
ROPINIROLE (West-Ward Pharmaceuticals Corp.)
,
ROPINIROLE HYDROCHLORIDE (A-S Medication Solutions)
,
ROPINIROLE HYDROCHLORIDE (A-S Medication Solutions)
,
ROPINIROLE HYDROCHLORIDE (A-S Medication Solutions)
,
ROPINIROLE HYDROCHLORIDE (A-S Medication Solutions)
,
ROPINIROLE HYDROCHLORIDE (Alembic Pharmaceuticals)
,
ROPINIROLE HYDROCHLORIDE (Alembic Pharmaceuticals Limited)
,
ROPINIROLE HYDROCHLORIDE (Bryant Ranch Prepack)
,
ROPINIROLE HYDROCHLORIDE (Bryant Ranch Prepack)
,
ROPINIROLE HYDROCHLORIDE (Bryant Ranch Prepack)
,
ROPINIROLE HYDROCHLORIDE (Bryant Ranch Prepack)
,
ROPINIROLE HYDROCHLORIDE (Cadila Healthcare Limited)
,
ROPINIROLE HYDROCHLORIDE (Cardinal Health)
,
ROPINIROLE HYDROCHLORIDE (Major Pharmaceuticals)
,
ROPINIROLE HYDROCHLORIDE (NCS HealthCare of KY)
,
ROPINIROLE HYDROCHLORIDE (Northwind Pharmaceuticals)
,
ROPINIROLE HYDROCHLORIDE (REMEDYREPACK)
,
ROPINIROLE HYDROCHLORIDE (SOLCO HEALTHCARE US)
,
ROPINIROLE HYDROCHLORIDE (Zydus Pharmaceuticals (USA))
Formula
C16H24N2O. HCl
Exact mass
296.1655
Mol weight
296.8355
Structure
Mol file
KCF file
DB search
Simcomp
Neighbor
Class
Neuropsychiatric agent
DG01472
Dopamine agonist
DG01468
Dopamine D2-receptor agonist
DG01967
Antiparkinson agent
Metabolizing enzyme substrate
DG01892
CYP1A2 substrate
Remark
Therapeutic category:
1169
ATC code:
N04BC04
Chemical structure group:
DG00862
Product (DG00862):
D00784<
JP
/US>
Efficacy
Antiparkinsonian, Dopamine receptor agonist
Disease
Parkinson disease [DS:
H00057
]
Restless legs syndrome [DS:
H01597
]
Target
DRD2 [HSA:
1813
] [KO:
K04145
]
DRD3 [HSA:
1814
] [KO:
K04146
]
DRD4 [HSA:
1815
] [KO:
K04147
]
Pathway
hsa04080
Neuroactive ligand-receptor interaction
hsa04728
Dopaminergic synapse
hsa05012
Parkinson disease
Metabolism
Enzyme: CYP1A2 [HSA:
1544
]
Interaction
DDI search
Structure map
map07057
Antiparkinsonian agents
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:
br08303
]
N NERVOUS SYSTEM
N04 ANTI-PARKINSON DRUGS
N04B DOPAMINERGIC AGENTS
N04BC Dopamine agonists
N04BC04 Ropinirole
D00784 Ropinirole hydrochloride (JAN/USP) <JP/US>
USP drug classification [BR:
br08302
]
Antiparkinson Agents
Dopamine Agonists
Ropinirole
D00784 Ropinirole hydrochloride (JAN/USP)
Therapeutic category of drugs in Japan [BR:
br08301
]
1 Agents affecting nervous system and sensory organs
11 Agents affecting central nervous system
116 Antiparkinsonian agents
1169 Others
D00784 Ropinirole hydrochloride (JAN/USP)
Target-based classification of drugs [BR:
br08310
]
G Protein-coupled receptors
Rhodopsin family
Dopamine
DRD2
D00784 Ropinirole hydrochloride (JAN/USP) <JP/US>
DRD3
D00784 Ropinirole hydrochloride (JAN/USP) <JP/US>
DRD4
D00784 Ropinirole hydrochloride (JAN/USP) <JP/US>
New drug approvals in Japan [
br08318.html
]
Drugs with new active ingredients
D00784
Drug metabolizing enzymes and transporters [
br08309.html
]
Drug metabolizing enzymes
D00784
BRITE hierarchy
Other DBs
CAS:
91374-20-8
PubChem:
7847849
ChEBI:
8889
ChEMBL:
CHEMBL1200411
DrugBank:
DB00268
LigandBox:
D00784
LinkDB
All DBs
KCF data
Show
ATOM 20
1 C8y C 26.1291 -19.3087
2 C8y C 24.9204 -18.6139
3 C8y C 26.1291 -20.7101
4 C1x C 27.4604 -18.8825
5 C1b C 24.9204 -17.2007
6 C8x C 23.6999 -19.3087
7 N1x N 27.4604 -21.1423
8 C8x C 24.9204 -21.4225
9 C5x C 28.2721 -20.0152
10 C1b C 23.7059 -16.5058
11 C8x C 23.6999 -20.7159
12 O5x O 29.6735 -20.0152
13 N1c N 22.4912 -17.2007
14 C1b C 21.2767 -16.5058
15 C1b C 22.4912 -18.5963
16 C1b C 20.0620 -17.2007
17 C1b C 21.2767 -19.2970
18 C1a C 18.8533 -16.5058
19 C1a C 21.2767 -20.6925
20 X Cl 32.6749 -19.9798
BOND 20
1 1 2 1
2 1 3 2
3 1 4 1
4 2 5 1
5 2 6 2
6 3 7 1
7 3 8 1
8 4 9 1
9 5 10 1
10 6 11 1
11 9 12 2
12 10 13 1
13 13 14 1
14 13 15 1
15 14 16 1
16 15 17 1
17 16 18 1
18 17 19 1
19 7 9 1
20 8 11 2
» Japanese version
» Back
DBGET
integrated database retrieval system