KEGG   DRUG: Ropinirole hydrochlorideHelp
Entry
D00784                      Drug                                   

Name
Ropinirole hydrochloride (JAN/USP);
Requip (TN)
Product
  Generic
ROPINIROLE (A-S Medication Solutions), ROPINIROLE (A-S Medication Solutions), ROPINIROLE (A-S Medication Solutions), ROPINIROLE (Accord Healthcare), ROPINIROLE (Actavis Pharma), ROPINIROLE (Alembic Pharmaceuticals Limited), ROPINIROLE HYDROCHLORIDE (Aphena Pharma Solutions - Tennessee), ROPINIROLE (Bryant Ranch Prepack), ROPINIROLE (Bryant Ranch Prepack), ROPINIROLE (Bryant Ranch Prepack), ROPINIROLE (Direct_Rx), ROPINIROLE (Dr. Reddys Laboratories Limited), ROPINIROLE (Glenmark Pharmaceuticals), ROPINIROLE HYDROCHLORIDE (Golden State Medical Supply), ROPINIROLE (Marlex Pharmaceuticals), ROPINIROLE HYDROCHLORIDE (Mylan Pharmaceuticals), ROPINIROLE (REMEDYREPACK), ROPINIROLE (Sandoz), ROPINIROLE (Trigen Laboratories), ROPINIROLE (Unit Dose Services), ROPINIROLE (West-Ward Pharmaceuticals Corp.), ROPINIROLE HYDROCHLORIDE (A-S Medication Solutions), ROPINIROLE HYDROCHLORIDE (A-S Medication Solutions), ROPINIROLE HYDROCHLORIDE (A-S Medication Solutions), ROPINIROLE HYDROCHLORIDE (A-S Medication Solutions), ROPINIROLE HYDROCHLORIDE (Alembic Pharmaceuticals), ROPINIROLE HYDROCHLORIDE (Alembic Pharmaceuticals Limited), ROPINIROLE HYDROCHLORIDE (Bryant Ranch Prepack), ROPINIROLE HYDROCHLORIDE (Bryant Ranch Prepack), ROPINIROLE HYDROCHLORIDE (Cadila Healthcare Limited), ROPINIROLE HYDROCHLORIDE (Cardinal Health), ROPINIROLE HYDROCHLORIDE (Lake Erie Medical DBA Quality Care Products LLC), ROPINIROLE HYDROCHLORIDE (Major Pharmaceuticals), ROPINIROLE HYDROCHLORIDE (NCS HealthCare of KY), ROPINIROLE HYDROCHLORIDE (REMEDYREPACK), ROPINIROLE HYDROCHLORIDE (SOLCO HEALTHCARE US), ROPINIROLE HYDROCHLORIDE (Zydus Pharmaceuticals (USA))
Formula
C16H24N2O. HCl
Exact mass
296.1655
Mol weight
296.8355
Structure
Mol fileKCF fileDB search
Simcomp SIMCOMP
Class
Neuropsychiatric agent
 DG01472  Dopamine agonist
  DG01468  Dopamine D2-receptor agonist
 DG01967  Antiparkinson agent
Metabolizing enzyme substrate
 DG01892  CYP1A2 substrate
Remark
Therapeutic category: 1169
ATC code: N04BC04
Chemical structure group: DG00862
Product (DG00862): D00784<JP/US>
Efficacy
Antiparkinsonian, Dopamine receptor agonist
  Disease
Parkinson disease [DS:H00057]
Restless legs syndrome [DS:H01597]
Target
DRD2 [HSA:1813] [KO:K04145]
DRD3 [HSA:1814] [KO:K04146]
DRD4 [HSA:1815] [KO:K04147]
  Pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04728  Dopaminergic synapse
hsa05012  Parkinson disease
Metabolism
Enzyme: CYP1A2 [HSA:1544]
Interaction
Drug interaction
Structure map
map07057  Antiparkinsonian agents
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 N NERVOUS SYSTEM
  N04 ANTI-PARKINSON DRUGS
   N04B DOPAMINERGIC AGENTS
    N04BC Dopamine agonists
     N04BC04 Ropinirole
      D00784  Ropinirole hydrochloride (JAN/USP) <JP/US>
USP drug classification [BR:br08302]
 Antiparkinson Agents
  Dopamine Agonists
   Ropinirole
    D00784  Ropinirole hydrochloride (JAN/USP)
Therapeutic category of drugs in Japan [BR:br08301]
 1  Agents affecting nervous system and sensory organs
  11  Agents affecting central nervous system
   116  Antiparkinsonian agents
    1169  Others
     D00784  Ropinirole hydrochloride (JAN/USP)
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Dopamine
    DRD2
     D00784  Ropinirole hydrochloride (JAN/USP) <JP/US>
    DRD3
     D00784  Ropinirole hydrochloride (JAN/USP) <JP/US>
    DRD4
     D00784  Ropinirole hydrochloride (JAN/USP) <JP/US>
New drug approvals in Japan [br08318.html]
 Drugs with new active ingredients
  D00784
Drug metabolizing enzymes and transporters [br08309.html]
 Drug metabolizing enzymes
  D00784
BRITE hierarchy
Other DBs
CAS: 91374-20-8
PubChem: 7847849
ChEBI: 8889
ChEMBL: CHEMBL1200411
DrugBank: DB00268
LigandBox: D00784
LinkDB All DBs
KCF data Show

ATOM        20
            1   C8y C    26.1291  -19.3087
            2   C8y C    24.9204  -18.6139
            3   C8y C    26.1291  -20.7101
            4   C1x C    27.4604  -18.8825
            5   C1b C    24.9204  -17.2007
            6   C8x C    23.6999  -19.3087
            7   N1x N    27.4604  -21.1423
            8   C8x C    24.9204  -21.4225
            9   C5x C    28.2721  -20.0152
            10  C1b C    23.7059  -16.5058
            11  C8x C    23.6999  -20.7159
            12  O5x O    29.6735  -20.0152
            13  N1c N    22.4912  -17.2007
            14  C1b C    21.2767  -16.5058
            15  C1b C    22.4912  -18.5963
            16  C1b C    20.0620  -17.2007
            17  C1b C    21.2767  -19.2970
            18  C1a C    18.8533  -16.5058
            19  C1a C    21.2767  -20.6925
            20  X   Cl   32.6749  -19.9798
BOND        20
            1     1   2 1
            2     1   3 2
            3     1   4 1
            4     2   5 1
            5     2   6 2
            6     3   7 1
            7     3   8 1
            8     4   9 1
            9     5  10 1
            10    6  11 1
            11    9  12 2
            12   10  13 1
            13   13  14 1
            14   13  15 1
            15   14  16 1
            16   15  17 1
            17   16  18 1
            18   17  19 1
            19    7   9 1
            20    8  11 2

» Japanese version   » Back

KEGG   DRUG: RopiniroleHelp
Entry
D08489                      Drug                                   

Name
Ropinirole (USAN/INN);
Ropitor (TN)
Formula
C16H24N2O
Exact mass
260.1889
Mol weight
260.3746
Structure
Mol fileKCF fileDB search
Simcomp SIMCOMP
Class
Neuropsychiatric agent
 DG01472  Dopamine agonist
  DG01468  Dopamine D2-receptor agonist
 DG01967  Antiparkinson agent
Metabolizing enzyme substrate
 DG01892  CYP1A2 substrate
Remark
Same as: C07564
ATC code: N04BC04
Chemical structure group: DG00862
Product (DG00862): D00784<JP/US>
Efficacy
Antiparkinsonian, Dopamine receptor agonist
Target
DRD2 [HSA:1813] [KO:K04145]
DRD3 [HSA:1814] [KO:K04146]
DRD4 [HSA:1815] [KO:K04147]
  Pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04728  Dopaminergic synapse
hsa05012  Parkinson disease
Metabolism
Enzyme: CYP1A2 [HSA:1544]
Interaction
Drug interaction
Structure map
map07057  Antiparkinsonian agents
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 N NERVOUS SYSTEM
  N04 ANTI-PARKINSON DRUGS
   N04B DOPAMINERGIC AGENTS
    N04BC Dopamine agonists
     N04BC04 Ropinirole
      D08489  Ropinirole (USAN/INN)
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Dopamine
    DRD2
     D08489  Ropinirole (USAN/INN)
    DRD3
     D08489  Ropinirole (USAN/INN)
    DRD4
     D08489  Ropinirole (USAN/INN)
Drug metabolizing enzymes and transporters [br08309.html]
 Drug metabolizing enzymes
  D08489
BRITE hierarchy
Other DBs
CAS: 91374-21-9
PubChem: 96025175
ChEBI: 8888
ChEMBL: CHEMBL589
DrugBank: DB00268
LigandBox: D08489
NIKKAJI: J264.965I
LinkDB All DBs
KCF data Show

ATOM        19
            1   C8y C    26.0400  -18.2700
            2   C8y C    24.8500  -17.5700
            3   C8y C    26.0400  -19.6700
            4   C1x C    27.3700  -17.8500
            5   C1b C    24.8500  -16.1700
            6   C8x C    23.6600  -18.2700
            7   N1x N    27.3700  -20.0900
            8   C8x C    24.8500  -20.3700
            9   C5x C    28.2100  -18.9700
            10  C1b C    23.6600  -15.4700
            11  C8x C    23.6600  -19.6700
            12  O5x O    29.6100  -18.9700
            13  N1c N    22.4000  -16.1700
            14  C1b C    21.2100  -15.4700
            15  C1b C    22.4000  -17.5700
            16  C1b C    20.0200  -16.1700
            17  C1b C    21.2100  -18.2700
            18  C1a C    18.7600  -15.4700
            19  C1a C    21.2100  -19.6700
BOND        20
            1     1   2 1
            2     1   3 2
            3     1   4 1
            4     2   5 1
            5     2   6 2
            6     3   7 1
            7     3   8 1
            8     4   9 1
            9     5  10 1
            10    6  11 1
            11    9  12 2
            12   10  13 1
            13   13  14 1
            14   13  15 1
            15   14  16 1
            16   15  17 1
            17   16  18 1
            18   17  19 1
            19    7   9 1
            20    8  11 2

» Japanese version   » Back

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