KEGG   DRUG: Promazine hydrochlorideHelp
Entry
D00797                      Drug                                   

Name
Promazine hydrochloride (USP);
Sparine (TN)
Formula
C17H20N2S. HCl
Exact mass
320.1114
Mol weight
320.88
Structure
Mol fileKCF fileDB search
Simcomp SIMCOMP
Class
Neuropsychiatric agent
 DG01905  Phenothiazine antipsychotics
 DG01478  Dopamine antagonist
  DG01474  Dopamine D2-receptor antagonist
Remark
ATC code: N05AA03
Chemical structure group: DG00869
Efficacy
Antipsychotic, Dopamine D2 receptor antagonist
Comment
Phenothiazine derivative
Target
DRD2 [HSA:1813] [KO:K04145]
  Pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04728  Dopaminergic synapse
Interaction
Drug interaction
Structure map
map07029  Antipsychotics - phenothiazines
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 N NERVOUS SYSTEM
  N05 PSYCHOLEPTICS
   N05A ANTIPSYCHOTICS
    N05AA Phenothiazines with aliphatic side-chain
     N05AA03 Promazine
      D00797  Promazine hydrochloride (USP)
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Dopamine
    DRD2
     D00797  Promazine hydrochloride (USP)
BRITE hierarchy
Other DBs
CAS: 53-60-1
PubChem: 7847862
ChEBI: 8460
ChEMBL: CHEMBL1200469
DrugBank: DB00420
LigandBox: D00797
NIKKAJI: J231.247F
LinkDB All DBs
KCF data Show

ATOM        21
            1   X   Cl   36.9353  -17.9239
            2   C8x C    26.7400  -17.2200
            3   C8x C    26.7400  -18.6200
            4   C8x C    27.9524  -19.3200
            5   C8y C    29.1649  -18.6200
            6   C8y C    29.1649  -17.2200
            7   C8x C    27.9524  -16.5200
            8   S2x S    30.3773  -19.3200
            9   C8y C    31.5897  -18.6200
            10  C8y C    31.5897  -17.2200
            11  N4y N    30.3773  -16.5200
            12  C8x C    32.8022  -19.3200
            13  C8x C    34.0146  -18.6200
            14  C8x C    34.0146  -17.2200
            15  C8x C    32.8022  -16.5200
            16  C1b C    30.3773  -15.1200
            17  C1b C    31.5918  -14.4188
            18  C1b C    32.7883  -15.1098
            19  N1c N    33.9751  -14.4246
            20  C1a C    35.1666  -15.1128
            21  C1a C    33.9753  -13.0202
BOND        22
            1     2   3 2
            2     3   4 1
            3     4   5 2
            4     5   6 1
            5     6   7 2
            6     2   7 1
            7     5   8 1
            8     8   9 1
            9     9  10 1
            10   10  11 1
            11    6  11 1
            12    9  12 2
            13   12  13 1
            14   13  14 2
            15   14  15 1
            16   10  15 2
            17   11  16 1
            18   16  17 1
            19   17  18 1
            20   18  19 1
            21   19  20 1
            22   19  21 1

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