KEGG   DRUG: Ketorolac tromethamine
Entry
D00813                      Drug                                   

Name
Ketorolac tromethamine (USP);
Acular (TN);
Toradol (TN)
Product
  Generic
KETOROLAC TROMETHAMINE (A-S Medication Solutions), KETOROLAC TROMETHAMINE (A-S Medication Solutions), KETOROLAC TROMETHAMINE (A-S Medication Solutions), KETOROLAC TROMETHAMINE (A-S Medication Solutions), KETOROLAC TROMETHAMINE (A-S Medication Solutions), KETOROLAC TROMETHAMINE (A-S Medication Solutions), KETOROLAC TROMETHAMINE (Akorn), KETOROLAC TROMETHAMINE (Akorn), KETOROLAC TROMETHAMINE (Akorn), KETOROLAC TROMETHAMINE (Almaject), KETOROLAC TROMETHAMINE (Alvogen), KETOROLAC TROMETHAMINE (Amphastar Pharmaceuticals), KETOROLAC TROMETHAMINE (Apotex Corp.), KETOROLAC TROMETHAMINE (Athenex Pharmaceutical Division), KETOROLAC TROMETHAMINE (Aurobindo Pharma Limited), KETOROLAC TROMETHAMINE (AvKARE), KETOROLAC TROMETHAMINE (Baxter Healthcare Corporation), KETOROLAC TROMETHAMINE (Bryant Ranch Prepack), KETOROLAC TROMETHAMINE (Cardinal Health), KETOROLAC TROMETHAMINE (Cardinal Health), KETOROLAC TROMETHAMINE (Cardinal Health), KETOROLAC TROMETHAMINE (Cardinal Health), KETOROLAC TROMETHAMINE (Cardinal Health), KETOROLAC TROMETHAMINE (Cardinal Health), KETOROLAC TROMETHAMINE (DIRECT RX), KETOROLAC TROMETHAMINE (DIRECT RX), KETOROLAC TROMETHAMINE (Denton Pharma), KETOROLAC TROMETHAMINE (Fosun Pharma USA), KETOROLAC TROMETHAMINE (Fresenius Kabi USA), KETOROLAC TROMETHAMINE (Fresenius Kabi USA), KETOROLAC TROMETHAMINE (Fresenius Kabi USA), KETOROLAC TROMETHAMINE (Fresenius Kabi USA), KETOROLAC TROMETHAMINE (General Injectables & Vaccines), KETOROLAC TROMETHAMINE (General Injectables and Vaccines), KETOROLAC TROMETHAMINE (General Injectables and Vaccines), KETOROLAC TROMETHAMINE (General Injectables and Vaccines), KETOROLAC TROMETHAMINE (General Injectables and Vaccines), KETOROLAC TROMETHAMINE (Gland Pharma Limited), KETOROLAC TROMETHAMINE (Gland Pharma Limited), KETOROLAC TROMETHAMINE (HF Acquisition Co LLC), KETOROLAC TROMETHAMINE (Hospira), KETOROLAC TROMETHAMINE (Hospira), ACUNIVIVE 15 (IT3 Medical LLC), ACUNIVIVE 30 (IT3 Medical LLC), ACUNIVIVE 60 (IT3 Medical LLC), ACUNIVIVE 90 (IT3 Medical LLC), KETOROLAC TROMETHAMINE (Lake Erie Medical DBA Quality Care Products LLC), KETOROLAC TROMETHAMINE (Medical Purchasing Solutions), KETOROLAC TROMETHAMINE (Medical Purchasing Solutions), KETOROLAC TROMETHAMINE (Medical Purchasing Solutions), KETOROLAC TROMETHAMINE (Medical Purchasing Solutions), KETOROLAC TROMETHAMINE (Medical Purchasing Solutions), KETOROLAC TROMETHAMINE (Medical Purchasing Solutions), KETOROLAC TROMETHAMINE (Medical Purchasing Solutions), KETOROLAC TROMETHAMINE (Medsource Pharmaceuticals), KETOROLAC TROMETHAMINE (Micro Labs Limited), KETOROLAC TROMETHAMINE (Mylan Pharmaceuticals), KETOROLAC TROMETHAMINE (NuCare Pharmaceuticals), KETOROLAC TROMETHAMINE (NuCare Pharmaceuticals), KETOROLAC TROMETHAMINE (NuCare Pharmaceuticals), KETOROLAC TROMETHAMINE (NuCare Pharmaceuticals), KETOROLAC TROMETHAMINE (NuCare Pharmaceuticals), KETOROLAC TROMETHAMINE (PD-Rx Pharmaceuticals), KETOROLAC TROMETHAMINE (PD-Rx Pharmaceuticals), KETOROLAC TROMETHAMINE (Pacific Pharma), KETOROLAC TROMETHAMINE (Preferred Pharmaceuticals), KETOROLAC TROMETHAMINE (Preferred Pharmaceuticals), READYSHARP KETOROLAC (Preferred Pharmaceuticals), KETOROLAC TROMETHAMINE (Proficient Rx LP), KETOROLAC TROMETHAMINE (Proficient Rx LP), KETOROLAC TROMETHAMINE (Proficient Rx LP), KETOROLAC TROMETHAMINE (Proficient Rx LP), KETOROLAC TROMETHAMINE (Proficient Rx LP), KETOROLAC TROMETHAMINE (REMEDYREPACK), KETOROLAC TROMETHAMINE (REMEDYREPACK), KETOROLAC TROMETHAMINE (REMEDYREPACK), KETOROLAC TROMETHAMINE (REMEDYREPACK), KETOROLAC TROMETHAMINE (Sagent Pharmaceuticals), KETOROLAC TROMETHAMINE (Sandoz), KETOROLAC TROMETHAMINE (St. Mary's Medical Park Pharmacy), KETOROLAC TROMETHAMINE (Sun Pharmaceutical Industries), READYSHARP KETOROLAC (Terrain Pharmaceuticals), KETOROLAC TROMETHAMINE (Teva Pharmaceuticals USA), KETOROLAC TROMETHAMINE (Virtus Pharmaceuticals), KETOROLAC TROMETHAMINE (West-Ward Pharmaceuticals Corp.), KETOROLAC TROMETHAMINE (Wockhardt USA LLC.)
Formula
C15H13NO3. C4H11NO3
Exact mass
376.1634
Mol weight
376.4037
Structure
Class
Anti-inflammatory
 DG01906  Anti-inflammatory drug, acetic acid derivatives
 DG01504  Nonsteroidal anti-inflammatory drug (NSAID)
  DG01906  Anti-inflammatory drug, acetic acid derivatives
Remark
ATC code: M01AB15 S01BC05
Chemical structure group: DG00751
Product (DG00751): D00813<US>
Efficacy
Analgesic, Anti-inflammatory, COX inhibitor
Comment
Non-steroidal anti-inflammatory drug (NSAID)
Target
PTGS1 (COX1) [HSA:5742] [KO:K00509]
PTGS2 (COX2) [HSA:5743] [KO:K11987]
  Pathway
hsa00590  Arachidonic acid metabolism
Interaction
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 M MUSCULO-SKELETAL SYSTEM
  M01 ANTIINFLAMMATORY AND ANTIRHEUMATIC PRODUCTS
   M01A ANTIINFLAMMATORY AND ANTIRHEUMATIC PRODUCTS, NON-STEROIDS
    M01AB Acetic acid derivatives and related substances
     M01AB15 Ketorolac
      D00813  Ketorolac tromethamine (USP) <US>
 S SENSORY ORGANS
  S01 OPHTHALMOLOGICALS
   S01B ANTIINFLAMMATORY AGENTS
    S01BC Antiinflammatory agents, non-steroids
     S01BC05 Ketorolac
      D00813  Ketorolac tromethamine (USP) <US>
USP drug classification [BR:br08302]
 Analgesics
  Nonsteroidal Anti-inflammatory Drugs
   Ketorolac
    D00813  Ketorolac tromethamine (USP)
 Ophthalmic Agents
  Ophthalmic Anti-inflammatories
   Nonsteroidal Anti-Inflammatory Drugs, Ophthalmic
    Ketorolac
     D00813  Ketorolac tromethamine (USP)
Target-based classification of drugs [BR:br08310]
 Enzymes
  Oxidoreductases (EC1)
   Prostaglandin synthase
    PTGS1 (COX1)
     D00813  Ketorolac tromethamine (USP) <US>
    PTGS2 (COX2)
     D00813  Ketorolac tromethamine (USP) <US>
Other DBs
CAS: 74103-07-4
PubChem: 7847878
ChEBI: 6130
ChEMBL: CHEMBL1201124
DrugBank: DB00465
LigandBox: D00813
NIKKAJI: J363.314D
LinkDB
KCF data

ATOM        27
            1   N4y N    19.2154  -20.8285
            2   C8y C    20.3375  -21.6701
            3   C8y C    18.0933  -21.6701
            4   C1x C    19.6362  -19.4961
            5   C1y C    21.5297  -20.8285
            6   C8x C    19.9167  -23.0025
            7   C5a C    16.9011  -20.9688
            8   C8x C    18.5141  -23.0025
            9   C1x C    21.0388  -19.4961
            10  C6a C    22.7219  -21.5298
            11  C8y C    15.6388  -21.6701
            12  O5a O    16.9011  -19.5662
            13  O6a O    23.9141  -20.8285
            14  O6a O    22.7219  -22.9324
            15  C8x C    15.6388  -23.0726
            16  C8x C    14.4466  -20.9688
            17  C8x C    14.4466  -23.7739
            18  C8x C    13.2544  -21.6701
            19  C8x C    13.2544  -23.0726
            20  C1d C    28.9634  -21.5999
            21  C1b C    27.7010  -20.8986
            22  C1b C    30.1556  -20.8986
            23  C1b C    28.9634  -23.0025
            24  N1a N    28.9634  -20.1973
            25  O1a O    26.5088  -21.5999
            26  O1a O    31.3478  -21.5999
            27  O1a O    30.1556  -23.7038
BOND        28
            1     1   2 1
            2     1   3 1
            3     1   4 1
            4     2   5 1
            5     2   6 2
            6     3   7 1
            7     3   8 2
            8     4   9 1
            9     5  10 1
            10    7  11 1
            11    7  12 2
            12   10  13 1
            13   10  14 2
            14   11  15 2
            15   11  16 1
            16   15  17 1
            17   16  18 2
            18   17  19 2
            19    5   9 1
            20    6   8 1
            21   18  19 1
            22   20  21 1
            23   20  22 1
            24   20  23 1
            25   20  24 1
            26   21  25 1
            27   22  26 1
            28   23  27 1

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