KEGG   DRUG: Imipramine hydrochlorideHelp
Entry
D00815                      Drug                                   

Name
Imipramine hydrochloride (JP17/USP);
Tofranil (TN)
Product
  Generic
IMIPRAMINE HYDROCHLORIDE (A-S Medication Solutions), IMIPRAMINE HYDROCHLORIDE (A-S Medication Solutions), IMIPRAMINE HYDROCHLORIDE (A-S Medication Solutions), IMIPRAMINE HYDROCHLORIDE (AvKARE), IMIPRAMINE HYDROCHLORIDE (Bryant Ranch Prepack), IMIPRAMINE HYDROCHLORIDE (Carilion Materials Management), IMIPRAMINE HYDROCHLORIDE (Excellium Pharmaceutical), IMIPRAMINE HYDROCHLORIDE (Golden State Medical Supply), IMIPRAMINE HYDROCHLORIDE (KAISER FOUNDATION HOSPITALS), IMIPRAMINE HYDROCHLORIDE (Leading Pharma), IMIPRAMINE HYDROCHLORIDE (Lupin Pharmaceuticals), IMIPRAMINE HYDROCHLORIDE (Northwind Pharmaceuticals), IMIPRAMINE HYDROCHLORIDE (PD-Rx Pharmaceuticals), IMIPRAMINE HYDROCHLORIDE (Par Pharmaceutical), IMIPRAMINE HYDROCHLORIDE (Physicians Total Care), IMIPRAMINE HYDROCHLORIDE (REMEDYREPACK), IMIPRAMINE HYDROCHLORIDE (REMEDYREPACK), IMIPRAMINE HYDROCHLORIDE (REMEDYREPACK), IMIPRAMINE HYDROCHLORIDE (REMEDYREPACK), IMIPRAMINE HYDROCHLORIDE (REMEDYREPACK), IMIPRAMINE HYDROCHLORIDE (Richmond Pharmaceuticals), IMIPRAMINE HYDROCHLORIDE (Sandoz), TOFRANIL (SpecGx LLC), IMIPRAMINE HYDROCHLORIDE (Sun Pharmaceutical Industries), TOFRANIL (Thompson Medical Solutions LLC)
Formula
C19H24N2. HCl
Exact mass
316.1706
Mol weight
316.8682
Structure
Mol fileKCF fileDB search
Simcomp SIMCOMP
Class
Neuropsychiatric agent
 DG01730  Non-selective monoamine reuptake inhibitor
 DG01728  Tricyclic antidepressant
Cyp substrate
 DG01892  CYP1A2 substrate
 DG01639  CYP2C19 substrate
 DG01644  CYP2D6 substrate
 DG01633  CYP3A substrate
Remark
Same as: C07982
Therapeutic category: 1174
ATC code: N06AA02
Chemical structure group: DG00928
Product (DG00928): D00815<JP/US>
Efficacy
Antidepressant, Serotonin-noradrenaline reuptake inhibitor (SNRI)
  Disease
Depression [DS:H01646]
Comment
Active form of prodrug: Desipramine [DR:D07791]
Target
SLC6A4 (HTT) [HSA:6532] [KO:K05037]
SLC6A2 (NAT1) [HSA:6530] [KO:K05035]
  Pathway
hsa04726  Serotonergic synapse
Metabolism
Enzyme: CYP2D6 [HSA:1565]; CYP1A2 [HSA:1544], CYP3A4 [HSA:1576], CYP2C19 [HSA:1557]
Interaction
Drug interaction
Structure map
map07027  Antidepressants
map07213  Dopamine receptor agonists/antagonists
map07234  Neurotransmitter transporter inhibitors
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 N NERVOUS SYSTEM
  N06 PSYCHOANALEPTICS
   N06A ANTIDEPRESSANTS
    N06AA Non-selective monoamine reuptake inhibitors
     N06AA02 Imipramine
      D00815  Imipramine hydrochloride (JP17/USP) <JP/US>
USP drug classification [BR:br08302]
 Antidepressants
  Tricyclics
   Imipramine
    D00815  Imipramine hydrochloride (JP17/USP)
Therapeutic category of drugs in Japan [BR:br08301]
 1  Agents affecting nervous system and sensory organs
  11  Agents affecting central nervous system
   117  Psychotropics
    1174  Imipramines
     D00815  Imipramine hydrochloride (JP17/USP)
Target-based classification of drugs [BR:br08310]
 Transporters
  Solute carrier family
   SLC6
    SLC6A2 (NAT1)
     D00815  Imipramine hydrochloride (JP17/USP) <JP/US>
    SLC6A4 (HTT)
     D00815  Imipramine hydrochloride (JP17/USP) <JP/US>
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D00815  Imipramine hydrochloride
  D00815  Imipramine hydrochloride tablets
Drug classes of therapeutic agents [br08360.html]
 Psychiatric agents
  D00815
Pharmacogenomic biomarkers in FDA drug labels [br08341.html]
 Polymorphisms and germline mutations
  D00815
Prodrugs [br08324.html]
 DG00928
BRITE hierarchy
Other DBs
CAS: 113-52-0
PubChem: 7847880
ChEBI: 5882
ChEMBL: CHEMBL1692
DrugBank: DB00458
LigandBox: D00815
NIKKAJI: J243.988C
LinkDB All DBs
KCF data Show

ATOM        22
            1   C1x C    12.8734  -13.8694
            2   C8y C    12.0313  -12.7598
            3   C8y C    12.3665  -11.4030
            4   N1y N    13.6275  -10.8249
            5   C1x C    14.2792  -13.8946
            6   C8y C    14.8811  -11.4472
            7   C8y C    15.1676  -12.8159
            8   C8x C    11.3594  -10.4346
            9   C8x C    10.0174  -10.8227
            10  C8x C     9.6822  -12.1795
            11  C8x C    10.6893  -13.1476
            12  C8x C    16.4988  -13.2530
            13  C8x C    17.5430  -12.3186
            14  C8x C    17.2566  -10.9499
            15  C8x C    15.9252  -10.5128
            16  C1b C    13.6492   -9.4500
            17  C1b C    14.8732   -8.7689
            18  C1b C    16.0416   -9.4684
            19  N1c N    17.2637   -8.7883
            20  C1a C    18.4984   -9.5269
            21  C1a C    17.2857   -7.4200
            22  X   Cl   20.1600  -11.7600
BOND        23
            1     3   4 1
            2     1   5 1
            3     4   6 1
            4     2   3 1
            5     5   7 1
            6     1   2 1
            7     6   7 1
            8     3   8 2
            9     8   9 1
            10    9  10 2
            11   10  11 1
            12    2  11 2
            13    7  12 2
            14   12  13 1
            15   13  14 2
            16   14  15 1
            17    6  15 2
            18    4  16 1
            19   16  17 1
            20   17  18 1
            21   18  19 1
            22   19  20 1
            23   19  21 1

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