KEGG   DRUG: Fluoxetine hydrochlorideHelp
Entry
D00823                      Drug                                   

Name
Fluoxetine hydrochloride (JAN/USP);
Prozac (TN)
Product
  Generic
FLUOXETINE (A-S Medication Solutions), FLUOXETINE (A-S Medication Solutions), FLUOXETINE (Aidarex Pharmaceuticals LLC), FLUOXETINE (Aidarex Pharmaceuticals LLC), FLUOXETINE (Aidarex Pharmaceuticals LLC), FLUOXETINE (Alembic Pharmaceuticals), FLUOXETINE (Alembic Pharmaceuticals), FLUOXETINE (Alembic Pharmaceuticals Limited), FLUOXETINE (Aphena Pharma Solutions - Tennessee), FLUOXETINE (Aphena Pharma Solutions - Tennessee), FLUOXETINE (Appco Pharma LLC), FLUOXETINE (Aurobindo Pharma Limited), FLUOXETINE (AvKARE), FLUOXETINE (AvKARE), FLUOXETINE (BluePoint Laboratories), FLUOXETINE (Bryant Ranch Prepack), FLUOXETINE (Bryant Ranch Prepack), FLUOXETINE (Bryant Ranch Prepack), FLUOXETINE (Bryant Ranch Prepack), FLUOXETINE (Bryant Ranch Prepack), FLUOXETINE (Cadila Pharmaceuticals Limited), FLUOXETINE (Cardinal Health), FLUOXETINE (Clinical Solutions Wholesale), FLUOXETINE (Contract Pharmacy Services-PA), FLUOXETINE (Denton Pharma), FLUOXETINE (Direct_Rx), FLUOXETINE (Direct_Rx), FLUOXETINE (Direct_Rx), FLUOXETINE (Direct_Rx), FLUOXETINE (Dr.Reddy's Laboratories Limited), FLUOXETINE (Heritage Pharmaceuticals), FLUOXETINE (Lake Erie Medical DBA Quality Care Products LLC), FLUOXETINE (Legacy Pharmaceutical Packaging), FLUOXETINE (Major Pharmaceuticals), FLUOXETINE (Mylan Pharmaceuticals), FLUOXETINE (NCS HealthCare of KY), FLUOXETINE (NorthStar Rx LLC), FLUOXETINE (NorthStar RxLLC), FLUOXETINE (NuCare Pharmaceuticals), FLUOXETINE (NuCare Pharmaceuticals), FLUOXETINE (NuCare Pharmaceuticals), FLUOXETINE (NuCare Pharmaceuticals), FLUOXETINE (PD-Rx Pharmaceuticals), FLUOXETINE (Par Pharmaceutical), FLUOXETINE (Preferred Pharmaceuticals), FLUOXETINE (Preferred Pharmaceuticals), FLUOXETINE (Proficient Rx LP), FLUOXETINE (Proficient Rx LP), FLUOXETINE (Proficient Rx LP), FLUOXETINE (Proficient Rx LP), FLUOXETINE (QPharma), FLUOXETINE (REMEDYREPACK), FLUOXETINE (REMEDYREPACK), FLUOXETINE (REMEDYREPACK), FLUOXETINE (REMEDYREPACK), FLUOXETINE (REMEDYREPACK), FLUOXETINE (REMEDYREPACK), FLUOXETINE (REMEDYREPACK), FLUOXETINE (REMEDYREPACK), FLUOXETINE (REMEDYREPACK), FLUOXETINE (RPK Pharmaceuticals), FLUOXETINE (ScieGen Pharmaceuticals), FLUOXETINE (State of Florida DOH Central Pharmacy), FLUOXETINE (Sun Pharmaceutical Industries), FLUOXETINE (TORRENT PHARMACEUTICALS LIMITED), FLUOXETINE (Teva Pharmaceuticals USA), FLUOXETINE (Teva Pharmaceuticals USA), FLUOXETINE (Teva Pharmaceuticals USA), FLUOXETINE (Teva Pharmaceuticals USA), FLUOXETINE (medsource pharmaceuticals), FLUOXETINE (A-S Medication Solutions), FLUOXETINE (A-S Medication Solutions), FLUOXETINE (A-S Medication Solutions), FLUOXETINE (Aidarex Pharmaceuticals LLC), FLUOXETINE HYDROCHLORIDE (Alembic Pharmaceuticals Limited), FLUOXETINE (American Health Packaging), FLUOXETINE (American Health Packaging), FLUOXETINE HYDROCHLORIDE (Aphena Pharma Solutions - Tennessee), FLUOXETINE HYDROCHLORIDE (Aphena Pharma Solutions - Tennessee), FLUOXETINE (Aurobindo Pharma Limited), FLUOXETINE (AvPAK), FLUOXETINE (BluePoint Laboratories), FLUOXETINE (Bryant Ranch Prepack), FLUOXETINE (Bryant Ranch Prepack), FLUOXETINE (Bryant Ranch Prepack), FLUOXETINE (Bryant Ranch Prepack), FLUOXETINE HYDROCHLORIDE (Bryant Ranch Prepack), FLUOXETINE (Cardinal Health), FLUOXETINE (Contract Pharmacy Services-PA), FLUOXETINE (Denton Pharma), FLUOXETINE HYDROCHLORIDE (Denton Pharma), FLUOXETINE HYDROCHLORIDE (Dr. Reddy's Laboratories), FLUOXETINE HYDROCHLORIDE (Dr.Reddy's Laboratories Limited), FLUOXETINE (Golden State Medical Supply), FLUOXETINE (Lake Erie Medical DBA Quality Care Products LLC), FLUOXETINE (Lake Erie Medical DBA Quality Care Products LLC), FLUOXETINE (Lake Erie Medical DBA Quality Care Products LLC), FLUOXETINE (Lannett Company), FLUOXETINE HYDROCHLORIDE (Lupin Pharmaceuticals), FLUOXETINE HYDROCHLORIDE (Lupin Pharmaceuticals), FLUOXETINE (Medsource Pharmaceuticals), FLUOXETINE (Medsource Pharmaceuticals), FLUOXETINE (NCS HealthCare of KY), FLUOXETINE (Nivagen Pharmaceuticals), FLUOXETINE HYDROCHLORIDE (NorthStar Rx LLC), FLUOXETINE HYDROCHLORIDE (Northwind Pharmaceuticals), FLUOXETINE (NuCare Pharmaceuticals), FLUOXETINE (NuCare Pharmaceuticals), FLUOXETINE (NuCare Pharmaceuticals), FLUOXETINE (NuCare Pharmaceuticals), FLUOXETINE (NuCare Pharmaceuticals), FLUOXETINE (NuCare Pharmaceuticals), FLUOXETINE (NuCare Pharmaceuticals), FLUOXETINE (NuCare Pharmaceuticals), FLUOXETINE (NuCare Pharmaceuticals), FLUOXETINE (NuCare Pharmaceuticals), FLUOXETINE (PD-Rx Pharmaceuticals), FLUOXETINE (PD-Rx Pharmaceuticals), FLUOXETINE (PD-Rx Pharmaceuticals), FLUOXETINE (PD-Rx Pharmaceuticals), FLUOXETINE (PD-Rx Pharmaceuticals), FLUOXETINE (Par Pharmaceutical), FLUOXETINE (Pharmaceutical Associates), FLUOXETINE (Preferred Pharmaceuticals), FLUOXETINE (Preferred Pharmaceuticals), FLUOXETINE (Preferred Pharmaceuticals), FLUOXETINE (Preferred Pharmaceuticals), FLUOXETINE (Proficient Rx LP), FLUOXETINE (Proficient Rx LP), FLUOXETINE (Proficient Rx LP), FLUOXETINE (Proficient Rx LP), FLUOXETINE HYDROCHLORIDE (Quality Care Products), FLUOXETINE (REMEDYREPACK), FLUOXETINE (REMEDYREPACK), FLUOXETINE (REMEDYREPACK), FLUOXETINE (REMEDYREPACK), FLUOXETINE (REMEDYREPACK), FLUOXETINE (REMEDYREPACK), FLUOXETINE HYDROCHLORIDE (REMEDYREPACK), FLUOXETINE HYDROCHLORIDE (REMEDYREPACK), FLUOXETINE (REMEDYREPACK), FLUOXETINE HYDROCHLORIDE (REMEDYREPACK), FLUOXETINE (RPK Pharmaceuticals), FLUOXETINE (RPK Pharmaceuticals), FLUOXETINE (RedPharm Drug), FLUOXETINE (RedPharm Drug), FLUOXETINE HYDROCHLORIDE (Sandoz), FLUOXETINE (ScieGen Pharmaceuticals), FLUOXETINE (ScieGen Pharmaceuticals), FLUOXETINE (St. Mary's Medical Park Pharmacy), FLUOXETINE HYDROCHLORIDE (St. Marys Medical Park Pharmacy), FLUOXETINE (State of Florida DOH Central Pharmacy), FLUOXETINE HYDROCHLORIDE (Taro Pharmaceuticals U.S.A.), FLUOXETINE (Unit Dose Services), FLUOXETINE (Unit Dose Services), FLUOXETINE (Unit Dose Services), FLUOXETINE HYDROCHLORIDE (Upsher-Smith Laboratories), FLUOXETINE (Vensun Pharmaceuticals), FLUOXETINE (Westminster Pharmaceuticals)
Formula
C17H18F3NO. HCl
Exact mass
345.1107
Mol weight
345.7871
Structure
Mol fileKCF fileDB search
Simcomp SIMCOMP
Class
Neuropsychiatric agent
 DG01659  Selective serotonin reuptake inhibitor (SSRI)
Metabolizing enzyme substrate
 DG01642  CYP2C9 substrate
 DG01644  CYP2D6 substrate
Metabolizing enzyme inhibitor
 DG01933  CYP2C19 inhibitor
 DG01645  CYP2D6 inhibitor
 DG02852  CYP3A inhibitor
Transporter inhibitor
 DG01622  ABCB1 (P-GP) inhibitor
Remark
ATC code: N06AB03
Chemical structure group: DG00942
Product (DG00942): D00823<US>
Product (mixture): D10206<US>
Efficacy
Antidepressant, Selective serotonin reuptake inhibitor (SSRI)
  Disease
Major depressive disorder [DS:H01646]
Obsessive compulsive disorder [DS:H01450]
Bulimia nervosa [DS:H01703]
Panic disorder [DS:H01664]
Target
SLC6A4 (HTT) [HSA:6532] [KO:K05037]
  Pathway
hsa04726  Serotonergic synapse
Metabolism
Enzyme: CYP2C9 [HSA:1559], CYP2D6 [HSA:1565]
Interaction
CYP inhibition: CYP2C19 [HSA:1557], CYP2D6 [HSA:1565], CYP3A [HSA:1576 1577 1551]
Transporter inhibition: ABCB1 [HSA:5243]
Drug interaction
Structure map
map07027  Antidepressants
map07234  Neurotransmitter transporter inhibitors
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 N NERVOUS SYSTEM
  N06 PSYCHOANALEPTICS
   N06A ANTIDEPRESSANTS
    N06AB Selective serotonin reuptake inhibitors
     N06AB03 Fluoxetine
      D00823  Fluoxetine hydrochloride (JAN/USP) <US>
USP drug classification [BR:br08302]
 Antidepressants
  SSRIs/SNRIs (Selective Serotonin Reuptake Inhibitors/Serotonin and Norepinephrine Reuptake Inhibitors)
   Fluoxetine
    D00823  Fluoxetine hydrochloride (JAN/USP)
Target-based classification of drugs [BR:br08310]
 Transporters
  Solute carrier family
   SLC6
    SLC6A4 (HTT)
     D00823  Fluoxetine hydrochloride (JAN/USP) <US>
Pharmacogenomic biomarkers [br08341.html]
 Polymorphisms and mutations affecting drug response
  D00823
BRITE hierarchy
Other DBs
CAS: 56296-78-7
PubChem: 7847888
ChEBI: 5119
ChEMBL: CHEMBL1201082
DrugBank: DB00472
LigandBox: D00823
NIKKAJI: J300.115F
LinkDB All DBs
KCF data Show

ATOM        23
            1   C1c C    20.5485  -17.8188
            2   C8y C    20.5485  -19.2271
            3   O2a O    21.7758  -17.1117
            4   C1b C    19.3215  -17.1117
            5   C8x C    19.3155  -19.9342
            6   C8x C    21.7698  -19.9342
            7   C8y C    22.9971  -17.8188
            8   C1b C    18.1061  -17.8129
            9   C8x C    19.3155  -21.3482
            10  C8x C    21.7698  -21.3482
            11  C8x C    22.9971  -19.2271
            12  C8x C    24.2182  -17.1117
            13  N1b N    16.8788  -17.1059
            14  C8x C    20.5485  -22.0554
            15  C8x C    24.2125  -19.9342
            16  C8x C    25.4395  -17.8188
            17  C1a C    15.6575  -17.8129
            18  C8y C    25.4395  -19.2330
            19  C1d C    26.6609  -19.9400
            20  X   F    27.9757  -20.5770
            21  X   F    27.2511  -18.9409
            22  X   F    25.9713  -21.0737
            23  X   Cl   30.6600  -18.6900
BOND        23
            1     1   2 1
            2     1   3 1
            3     1   4 1
            4     2   5 1
            5     2   6 2
            6     3   7 1
            7     4   8 1
            8     5   9 2
            9     6  10 1
            10    7  11 2
            11    7  12 1
            12    8  13 1
            13    9  14 1
            14   11  15 1
            15   12  16 2
            16   13  17 1
            17   15  18 2
            18   18  19 1
            19   19  20 1
            20   19  21 1
            21   19  22 1
            22   10  14 2
            23   16  18 1

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