KEGG   DRUG: Sertraline hydrochlorideHelp
Entry
D00825                      Drug                                   

Name
Sertraline hydrochloride (JAN/USAN);
Zoloft (TN)
Product
  Generic
SERTRALINE (A-S Medication Solutions), SERTRALINE (A-S Medication Solutions), SERTRALINE (A-S Medication Solutions), SERTRALINE (Aidarex Pharmaceuticals LLC), SERTRALINE (Aidarex Pharmaceuticals LLC), SERTRALINE (Aphena Pharma Solutions - Tennessee), SERTRALINE (Bryant Ranch Prepack), SERTRALINE (Contract Pharmacy Services-PA), SERTRALINE (DIRECT RX), SERTRALINE (Exelan Pharmaceuticals), SERTRALINE (LUPIN LIMITED), SERTRALINE (Lake Erie Medical DBA Quality Care Products LLC), SERTRALINE (Lupin Pharmaceuticals), SERTRALINE (NCS HealthCare of KY), SERTRALINE (Northwind Pharmaceuticals), SERTRALINE (Northwind Pharmaceuticals), SERTRALINE (Northwind Pharmaceuticals), SERTRALINE (NuCare Pharmaceuticals), SERTRALINE (Proficient Rx LP), SERTRALINE (QPharma), SERTRALINE (Quality Care Products), SERTRALINE (REMEDYREPACK), SERTRALINE (REMEDYREPACK), SERTRALINE (REMEDYREPACK), SERTRALINE (REMEDYREPACK), SERTRALINE (REMEDYREPACK), SERTRALINE (REMEDYREPACK), SERTRALINE (REMEDYREPACK), SERTRALINE (REMEDYREPACK), SERTRALINE (REMEDYREPACK), SERTRALINE (RedPharm Drug), SERTRALINE (TYA Pharmaceuticals), SERTRALINE (Unit Dose Services), SERTRALINE HYDROCHLORIDE (A-S Medication Solutions), SERTRALINE HYDROCHLORIDE (A-S Medication Solutions), SERTRALINE HYDROCHLORIDE (A-S Medication Solutions), SERTRALINE HYDROCHLORIDE (A-S Medication Solutions), SERTRALINE HYDROCHLORIDE (A-S Medication Solutions), SERTRALINE HYDROCHLORIDE (A-S Medication Solutions), SERTRALINE HYDROCHLORIDE (Accord Healthcare), SERTRALINE HYDROCHLORIDE (Aidarex Pharmaceuticals LLC), SERTRALINE HYDROCHLORIDE (Aidarex Pharmaceuticals LLC), SERTRALINE HYDROCHLORIDE (Aidarex Pharmaceuticals LLC), SERTRALINE HYDROCHLORIDE (American Health Packaging), SERTRALINE HYDROCHLORIDE (Aphena Pharma Solutions - Tennessee), SERTRALINE HYDROCHLORIDE (Aphena Pharma Solutions - Tennessee), SERTRALINE HYDROCHLORIDE (Aphena Pharma Solutions - Tennessee), SERTRALINE HYDROCHLORIDE (Aurobindo Pharma Limited), SERTRALINE HYDROCHLORIDE (Aurobindo Pharma Limited), SERTRALINE HYDROCHLORIDE (Aurolife Pharma LLC), SERTRALINE HYDROCHLORIDE (Bryant Ranch Prepack), SERTRALINE HYDROCHLORIDE (Bryant Ranch Prepack), SERTRALINE HYDROCHLORIDE (Bryant Ranch Prepack), SERTRALINE HYDROCHLORIDE (Bryant Ranch Prepack), SERTRALINE HYDROCHLORIDE (Bryant Ranch Prepack), SERTRALINE HYDROCHLORIDE (Bryant Ranch Prepack), SERTRALINE HYDROCHLORIDE (Bryant Ranch Prepack), SERTRALINE HYDROCHLORIDE (Cadila Healthcare Limited), SERTRALINE HYDROCHLORIDE (Camber Pharmaceuticals), SERTRALINE HYDROCHLORIDE (Cardinal Health), SERTRALINE HYDROCHLORIDE (Cipla USA), SERTRALINE HYDROCHLORIDE (Cipla USA), SERTRALINE HYDROCHLORIDE (Clinical Solutions Wholesale), SERTRALINE HYDROCHLORIDE (Contract Pharmacy Services-PA), SERTRALINE HYDROCHLORIDE (DIRECT RX), SERTRALINE HYDROCHLORIDE (DIRECT RX), SERTRALINE HYDROCHLORIDE (DIRECT RX), SERTRALINE HYDROCHLORIDE (DIRECT RX), SERTRALINE HYDROCHLORIDE (DOH CENTRAL PHARMACY), SERTRALINE HYDROCHLORIDE (Denton Pharma), SERTRALINE HYDROCHLORIDE (Denton Pharma), SERTRALINE HYDROCHLORIDE (Denton Pharma), SERTRALINE HYDROCHLORIDE (Denton Pharma), SERTRALINE HYDROCHLORIDE (Denton Pharma), SERTRALINE HYDROCHLORIDE (Greenstone LLC), SERTRALINE HYDROCHLORIDE (H.J. Harkins Company), SERTRALINE HYDROCHLORIDE (Hikma Pharmaceutical), SERTRALINE HYDROCHLORIDE (Keltman Pharmaceuticals), SERTRALINE HYDROCHLORIDE (Lake Erie Medical & Surgical Supply DBA Quality Care Products LLC), SERTRALINE HYDROCHLORIDE (Lake Erie Medical DBA Quality Care Products LLC), SERTRALINE HYDROCHLORIDE (Lake Erie Medical DBA Quality Care Products LLC), SERTRALINE HYDROCHLORIDE (Lake Erie Medical DBA Quality Care Products LLC), SERTRALINE HYDROCHLORIDE (Lake Erie Medical DBA Quality Care Products LLC), SERTRALINE HYDROCHLORIDE (Legacy Pharmaceutical Packaging), SERTRALINE HYDROCHLORIDE (McKesson Packaging Services Business Unit of McKesson Corporation), SERTRALINE HYDROCHLORIDE (Med-Health Pharma), SERTRALINE HYDROCHLORIDE (MedVantx), SERTRALINE HYDROCHLORIDE (MedVantx), SERTRALINE HYDROCHLORIDE (MedVantx), SERTRALINE HYDROCHLORIDE (Medsource Pharmaceuticals), SERTRALINE HYDROCHLORIDE (Medsource Pharmaceuticals), SERTRALINE (NCS HealthCare of KY), SERTRALINE HYDROCHLORIDE (NorthStar Rx LLC), SERTRALINE HYDROCHLORIDE (NorthStar Rx LLC), SERTRALINE HYDROCHLORIDE (NuCare Pharmaceuticals), SERTRALINE HYDROCHLORIDE (NuCare Pharmaceuticals), SERTRALINE HYDROCHLORIDE (NuCare Pharmaceuticals), SERTRALINE HYDROCHLORIDE (NuCare Pharmaceuticals), SERTRALINE HYDROCHLORIDE (NuCare Pharmaceuticals), SERTRALINE HYDROCHLORIDE (NuCare Pharmaceuticals), SERTRALINE HYDROCHLORIDE (NuCare Pharmaceuticals), SERTRALINE HYDROCHLORIDE (NuCare Pharmaceuticals), SERTRALINE HYDROCHLORIDE (NuCare Pharmaceuticals), SERTRALINE HYDROCHLORIDE (NuCare Pharmaceuticals), SERTRALINE HYDROCHLORIDE (NuCare Pharmaceuticals), SERTRALINE HYDROCHLORIDE (NuCare Pharmaceuticals), SERTRALINE HYDROCHLORIDE (NuCare Pharmaceuticals), SERTRALINE HYDROCHLORIDE (NuCare pharmaceuticals), SERTRALINE HYDROCHLORIDE (PD-Rx Pharmaceuticals), SERTRALINE HYDROCHLORIDE (PD-Rx Pharmaceuticals), SERTRALINE HYDROCHLORIDE (PD-Rx Pharmaceuticals), SERTRALINE HYDROCHLORIDE (PD-Rx Pharmaceuticals), SERTRALINE HYDROCHLORIDE (PD-Rx Pharmaceuticals), SERTRALINE HYDROCHLORIDE (Preferred Pharmaceuticals), SERTRALINE HYDROCHLORIDE (Preferred Pharmaceuticals), SERTRALINE HYDROCHLORIDE (Preferred Pharmaceuticals), SERTRALINE HYDROCHLORIDE (Preferred Pharmaceuticals), SERTRALINE HYDROCHLORIDE (Preferred Pharmaceuticals), SERTRALINE HYDROCHLORIDE (Preferred Pharmaceuticals), SERTRALINE HYDROCHLORIDE (Preferred Pharmaceuticals), SERTRALINE HYDROCHLORIDE (Preferred Pharmaceuticals), SERTRALINE HYDROCHLORIDE (Proficient Rx LP), SERTRALINE HYDROCHLORIDE (Proficient Rx LP), SERTRALINE HYDROCHLORIDE (Proficient Rx LP), SERTRALINE HYDROCHLORIDE (Proficient Rx LP), SERTRALINE HYDROCHLORIDE (Proficient Rx LP), SERTRALINE HYDROCHLORIDE (QPharma), SERTRALINE HYDROCHLORIDE (QPharma), SERTRALINE HYDROCHLORIDE (QPharma), SERTRALINE HYDROCHLORIDE (REMEDYREPACK), SERTRALINE HYDROCHLORIDE (REMEDYREPACK), SERTRALINE HYDROCHLORIDE (REMEDYREPACK), SERTRALINE HYDROCHLORIDE (REMEDYREPACK), SERTRALINE HYDROCHLORIDE (REMEDYREPACK), SERTRALINE HYDROCHLORIDE (REMEDYREPACK), SERTRALINE HYDROCHLORIDE (RPK Pharmaceuticals), SERTRALINE HYDROCHLORIDE (Ranbaxy Pharmaceuticals), SERTRALINE (ReadyMeds), SERTRALINE HYDROCHLORIDE (Rebel Distributors Corp), SERTRALINE HYDROCHLORIDE (RedPharm Drug), SERTRALINE HYDROCHLORIDE (Rising Pharmaceuticals), SERTRALINE HYDROCHLORIDE (St Marys Medical Park Pharmacy), SERTRALINE HYDROCHLORIDE (St. Mary's Medical Park Pharmacy), SERTRALINE HYDROCHLORIDE (St. Mary's Medical Park Pharmacy), SERTRALINE HYDROCHLORIDE (St. Mary's Medical Park Pharmacy), SERTRALINE HYDROCHLORIDE (St. Mary's Medical Park Pharmacy), SERTRALINE HYDROCHLORIDE (St. Mary's Medical Park Pharmacy), SERTRALINE HYDROCHLORIDE (St. Mary's Medical Park Pharmacy), SERTRALINE HYDROCHLORIDE (State of Florida DOH Central Pharmacy), SERTRALINE HYDROCHLORIDE (State of Florida DOH Central Pharmacy), SERTRALINE HYDROCHLORIDE (TYA Pharmaceuticals), SERTRALINE HYDROCHLORIDE (Torrent Pharmaceuticals Limited), SERTRALINE HYDROCHLORIDE (Unit Dose Services), SERTRALINE HYDROCHLORIDE (Unit Dose Services), SERTRALINE HYDROCHLORIDE (Unit Dose Services), SERTRALINE (Unit Dose Services), SERTRALINE HYDROCHLORIDE (Unit Dose Services), SERTRALINE HYDROCHLORIDE (Unit Dose Services), SERTRALINE HYDROCHLORIDE (Unit Dose Services), SERTRALINE (West-Ward Pharmaceutical Corp), SERTRALINE HYDROCHLORIDE (West-ward Pharmaceutical Corp), SERTRALINE HYDROCHLORIDE (Zydus Pharmaceuticals (USA))
Formula
C17H17Cl2N. HCl
Exact mass
341.0505
Mol weight
342.6905
Structure
Mol fileKCF fileDB search
Simcomp SIMCOMP
Class
Neuropsychiatric agent
 DG01659  Selective serotonin reuptake inhibitor (SSRI)
Metabolizing enzyme substrate
 DG02919  CYP2B6 substrate
 DG01642  CYP2C9 substrate
 DG01639  CYP2C19 substrate
 DG02913  CYP3A4 substrate
Remark
Therapeutic category: 1179
ATC code: N06AB06
Chemical structure group: DG00945
Product (DG00945): D00825<JP/US>
Efficacy
Antidepressant, Selective serotonin reuptake inhibitor (SSRI)
  Disease
Major depressive disorder [DS:H01646]
Obsessive-compulsive disorder [DS:H01450]
Panic disorder [DS:H01664]
Social anxiety disorder [DS:H01670]
Target
SLC6A4 (HTT) [HSA:6532] [KO:K05037]
  Pathway
hsa04726  Serotonergic synapse
Metabolism
Enzyme: CYP2C19 [HSA:1557], CYP2C9 [HSA:1559], CYP2B6 [HSA:1555], CYP3A4 [HSA:1576]
Interaction
Drug interaction
Structure map
map07027  Antidepressants
map07234  Neurotransmitter transporter inhibitors
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 N NERVOUS SYSTEM
  N06 PSYCHOANALEPTICS
   N06A ANTIDEPRESSANTS
    N06AB Selective serotonin reuptake inhibitors
     N06AB06 Sertraline
      D00825  Sertraline hydrochloride (JAN/USAN) <JP/US>
USP drug classification [BR:br08302]
 Antidepressants
  SSRIs/SNRIs (Selective Serotonin Reuptake Inhibitors/Serotonin and Norepinephrine Reuptake Inhibitors)
   Sertraline
    D00825  Sertraline hydrochloride (JAN/USAN)
 Anxiolytics
  SSRIs/SNRIs (Selective Serotonin Reuptake Inhibitors/Serotonin and Norepinephrine Reuptake Inhibitors)
   Sertraline
    D00825  Sertraline hydrochloride (JAN/USAN)
Therapeutic category of drugs in Japan [BR:br08301]
 1  Agents affecting nervous system and sensory organs
  11  Agents affecting central nervous system
   117  Psychotropics
    1179  Others
     D00825  Sertraline hydrochloride (JAN/USAN)
Target-based classification of drugs [BR:br08310]
 Transporters
  Solute carrier family
   SLC6
    SLC6A4 (HTT)
     D00825  Sertraline hydrochloride (JAN/USAN) <JP/US>
New drug approvals in Japan [br08318.html]
 Drugs with new active ingredients
  D00825
BRITE hierarchy
Other DBs
CAS: 79559-97-0
PubChem: 7847890
ChEBI: 9124
ChEMBL: CHEMBL1709
DrugBank: DB01104
LigandBox: D00825
NIKKAJI: J535.137E
LinkDB All DBs
KCF data Show

ATOM        21
            1   C8y C    25.3101  -16.0857
            2   C1y C    26.5154  -16.7935
            3   C8y C    25.3160  -14.6932
            4   C8x C    24.1107  -16.7877
            5   C8y C    26.5095  -18.1919
            6   C1x C    27.7382  -16.0974
            7   C1y C    26.5271  -13.9969
            8   C8x C    24.1107  -13.9912
            9   C8x C    22.8939  -16.0857
            10  C8x C    25.3043  -18.8822
            11  C8x C    27.7322  -18.8938
            12  C1x C    27.7439  -14.6990
            13  N1b N    26.5329  -12.5930
            14  C8x C    22.8939  -14.6932
            15  C8y C    25.2984  -20.2862
            16  C8x C    27.7265  -20.2979
            17  C1a C    27.7556  -11.8967
            18  C8y C    26.5037  -20.9883
            19  X   Cl   24.0816  -20.9825
            20  X   Cl   26.4977  -22.3867
            21  X   Cl   31.2546  -18.4534
BOND        22
            1     1   2 1
            2     1   3 1
            3     1   4 2
            4     2   5 1 #Up
            5     2   6 1
            6     3   7 1
            7     3   8 2
            8     4   9 1
            9     5  10 2
            10    5  11 1
            11    6  12 1
            12    7  13 1 #Up
            13    8  14 1
            14   10  15 1
            15   11  16 2
            16   13  17 1
            17   15  18 2
            18   15  19 1
            19   18  20 1
            20    7  12 1
            21    9  14 2
            22   16  18 1

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