| Entry |
|
|---|
| Name |
Levomethadyl acetate hydrochloride (USAN);
Orlaam (TN) |
|---|
| Formula |
C23H31NO2. HCl
|
|---|
| Exact mass |
389.2122
|
|---|
| Mol weight |
389.9587
|
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| Structure |
|
|---|
| Simcomp |
|
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| Class |
Neuropsychiatric agent
DG01564 Opioid receptor agonist
DG01563 mu-Opioid receptor agonist
Analgesic
DG01984 Opioid analgesics
Metabolizing enzyme substrate
DG01633 CYP3A/CYP3A4 substrate
DG02913 CYP3A4 substrate
|
|---|
| Remark |
|
|---|
| Efficacy |
Analgesic (narcotic), Opioid receptor agonist |
|---|
| Target |
|
|---|
| Pathway |
| hsa04080 | Neuroactive ligand-receptor interaction |
|
|---|
| Metabolism |
Enzyme: CYP3A4 [HSA: 1576]
|
|---|
| Interaction |
|
|---|
| Structure map |
| map07224 | Opioid receptor agonists/antagonists |
|
|---|
| Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
N NERVOUS SYSTEM
N07 OTHER NERVOUS SYSTEM DRUGS
N07B DRUGS USED IN ADDICTIVE DISORDERS
N07BC Drugs used in opioid dependence
N07BC03 Levacetylmethadol
D00840 Levomethadyl acetate hydrochloride (USAN)
Drug groups [BR:br08330]
Neuropsychiatric agent
DG01564 Opioid receptor agonist
DG01563 mu-Opioid receptor agonist
DG01000 Levacetylmethadol
D00840 Levomethadyl acetate hydrochloride
Analgesic
DG01984 Opioid analgesics
DG01000 Levacetylmethadol
D00840 Levomethadyl acetate hydrochloride
Metabolizing enzyme substrate
DG01633 CYP3A/CYP3A4 substrate
DG02913 CYP3A4 substrate
DG01000 Levacetylmethadol
D00840 Levomethadyl acetate hydrochloride
Target-based classification of drugs [BR:br08310]
G Protein-coupled receptors
Rhodopsin family
Opioid
OPRM1
D00840 Levomethadyl acetate hydrochloride (USAN)
Drug metabolizing enzymes and transporters [br08309.html]
Drug metabolizing enzymes
D00840
Drug groups [BR:br08330]
Neuropsychiatric agent
DG01564 Opioid receptor agonist
DG01563 mu-Opioid receptor agonist
DG01000 Levacetylmethadol
Analgesic
DG01984 Opioid analgesics
DG01000 Levacetylmethadol
Metabolizing enzyme substrate
DG01633 CYP3A/CYP3A4 substrate
DG02913 CYP3A4 substrate
DG01000 Levacetylmethadol
|
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| Other DBs |
|
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| LinkDB |
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| KCF data |
ATOM 27
1 X Cl 34.4704 -21.9382
2 C8x C 24.5000 -22.8200
3 C8x C 24.5000 -24.1500
4 C8x C 25.6900 -24.8500
5 C8x C 26.8800 -24.1500
6 C8y C 26.8800 -22.8200
7 C8x C 25.6900 -22.1200
8 C8x C 29.2600 -24.1500
9 C8y C 29.2600 -22.8200
10 C1d C 28.0700 -22.1200
11 C8x C 30.3800 -24.8500
12 C8x C 31.5700 -24.1500
13 C8x C 31.5700 -22.8200
14 C8x C 30.3800 -22.1200
15 C1b C 28.0700 -20.7200
16 C1c C 29.2600 -20.0900
17 C1c C 26.0400 -21.0000
18 C1a C 30.3800 -20.7200
19 N1c N 29.2600 -18.6200
20 C1a C 30.3800 -17.9200
21 C1a C 28.0000 -17.9200
22 O7a O 26.0400 -19.6700
23 C1b C 24.8500 -21.7000
24 C1a C 23.7300 -21.0000
25 C7a C 24.8500 -18.9700
26 C1a C 23.6600 -19.6700
27 O6a O 24.8500 -17.5000
BOND 27
1 2 3 2
2 3 4 1
3 4 5 2
4 5 6 1
5 6 7 2
6 2 7 1
7 8 9 1
8 9 10 1
9 6 10 1
10 8 11 2
11 11 12 1
12 12 13 2
13 13 14 1
14 9 14 2
15 10 15 1
16 15 16 1
17 10 17 1
18 16 18 1
19 16 19 1 #Up
20 19 20 1
21 19 21 1
22 17 22 1 #Down
23 17 23 1
24 23 24 1
25 22 25 1
26 25 26 1
27 25 27 2
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