KEGG   DRUG: Oxycodone hydrochloride
Entry
D00847                      Drug                                   

Name
Oxycodone hydrochloride (USP);
Oxecta (TN);
Oxycontin (TN);
Roxicodone (TN)
Product
  Generic
OXYCODONE HYDROCHLORIDE (Amneal Pharmaceuticals LLC), OXYCODONE (Ascend Laboratories), OXYCODONE (Ascend Laboratories), OXYCODONE HYDROCHLORIDE (Bryant Ranch Prepack), OXYCODONE HYDROCHLORIDE (Major Pharmaceuticals), OXYCODONE HYDROCHLORIDE (NuCare Pharmaceuticals), OXYCODONE HCL (DIRECT RX), OXYCODONE HCL (DIRECT RX), OXYCODONE HCL (KVK-Tech), OXYCODONE HCL (Quality Care Products), OXYCODONE HYDCHLORIDE (Lake Erie Medical DBA Quality Care Products LLC), OXYCODONE HYDCHLORIDE (Lake Erie Medical DBA Quality Care Products LLC), OXYCODONE HYDROCHLORIDE (ANI Pharmaceuticals), OXYCODONE HYDROCHLORIDE (ANI Pharmaceuticals), OXYCODONE HYDROCHLORIDE (ATLANTIC BIOLOGICALS CORP.), OXYCODONE HYDROCHLORIDE (Actavis Pharma), OXYCODONE HYDROCHLORIDE (Actavis Pharma), OXYCODONE HYDROCHLORIDE (Alvogen), OXYCODONE HYDROCHLORIDE (American Health Packaging), OXYCODONE HYDROCHLORIDE (American Health Packaging), OXYCODONE HYDROCHLORIDE (American Health Packaging), OXYCODONE HYDROCHLORIDE (Amneal Pharmaceuticals of New York LLC), OXYCODONE HYDROCHLORIDE (Aurolife Pharma), OXYCODONE HYDROCHLORIDE (Bryant Ranch Prepack), OXYCODONE HYDROCHLORIDE (Bryant Ranch Prepack), OXYCODONE HYDROCHLORIDE (Bryant Ranch Prepack), OXYCODONE HYDROCHLORIDE (Bryant Ranch Prepack), OXYCODONE HYDROCHLORIDE (Bryant Ranch Prepack), OXYCODONE HYDROCHLORIDE (Bryant Ranch Prepack), OXYCODONE HYDROCHLORIDE (Bryant Ranch Prepack), OXYCODONE HYDROCHLORIDE (Bryant Ranch Prepack), OXYCODONE HYDROCHLORIDE (Camber Pharmaceuticals), OXYCODONE HYDROCHLORIDE (DIRECT RX), OXYCODONE HYDROCHLORIDE (DIRECT RX), OXYCODONE HYDROCHLORIDE (DIRECT RX), OXYCODONE HYDROCHLORIDE (Direct_Rx), OXYCODONE HYDROCHLORIDE (Direct_Rx), OXYCODONE HYDROCHLORIDE (Direct_Rx), OXYCODONE HYDROCHLORIDE (Direct_Rx), OXYCODONE HYDROCHLORIDE (Epic Pharma), OXYCODONE HYDROCHLORIDE (Eywa Pharma), OXYCODONE HYDROCHLORIDE (Eywa Pharma), OXYCODONE HYDROCHLORIDE (Glenmark Pharmaceuticals), OXYCODONE HYDROCHLORIDE (Glenmark Pharmaceuticals), OXYCODONE HYDROCHLORIDE (Golden State Medical Supply), OXYCODONE HYDROCHLORIDE (Golden State Medical Supply), OXYCODONE HYDROCHLORIDE (Hi-Tech Pharmacal), OXYCODONE HYDROCHLORIDE (Hi-Tech Pharmacal), OXYCODONE HYDROCHLORIDE (KVK-TECH), OXYCODONE HYDROCHLORIDE (KVK-TECH), OXYCODONE HYDROCHLORIDE (KVK-Tech), OXYCODONE HYDROCHLORIDE (Lake Erie Medical DBA Quality Care Products LLC), OXYCODONE HYDROCHLORIDE (Lake Erie Medical DBA Quality Care Products LLC), OXYCODONE HYDROCHLORIDE (Lannett Company), OXYCODONE HYDROCHLORIDE (Lupin Pharmaceuticals), OXYCODONE HYDROCHLORIDE (Lupin Pharmaceuticals), OXYCODONE HYDROCHLORIDE (MAJOR PHARMACEUTICALS), OXYCODONE HYDROCHLORIDE (MAJOR PHARMACEUTICALS), OXYCODONE HYDROCHLORIDE (Major Pharmaceuticals), OXYCODONE HYDROCHLORIDE (Major Pharmaceuticals), OXYCODONE HYDROCHLORIDE (Major Pharmaceuticals), OXYCODONE HYDROCHLORIDE (Major Pharmaceuticals), OXYCODONE HYDROCHLORIDE (Mayne Pharma), OXYCODONE HYDROCHLORIDE (Mayne Pharma), OXYCODONE HYDROCHLORIDE (Morton Grove Pharmaceuticals), OXYCODONE HYDROCHLORIDE (Par Pharmaceutical), OXYCODONE HYDROCHLORIDE (Pharmaceutical Associates), OXYCODONE HYDROCHLORIDE (Pharmaceutical Associates), OXYCODONE HYDROCHLORIDE (Pharmaceutical Associates), OXYCODONE HYDROCHLORIDE (Precision Dose), OXYCODONE HYDROCHLORIDE (Precision Dose), OXYCODONE HYDROCHLORIDE (Quality Care Products), OXYCODONE HYDROCHLORIDE (RedPharm Drug), OXYCODONE HYDROCHLORIDE (RedPharm Drug), OXYCODONE HYDROCHLORIDE (RedPharm Drug), OXYCODONE HYDROCHLORIDE (RedPharm Drug), OXYCODONE HYDROCHLORIDE (RedPharm Drug), OXYCODONE HYDROCHLORIDE (Rhodes Pharmaceuticals L.P.), OXYCODONE HYDROCHLORIDE (Rhodes Pharmaceuticals L.P.), OXYCODONE HYDROCHLORIDE (Safecor Health), OXYCODONE HYDROCHLORIDE (SpecGx LLC), OXYCODONE HYDROCHLORIDE (SpecGx LLC), OXYCODONE HYDROCHLORIDE (Sun Pharmaceutical Industries), OXYCODONE HYDROCHLORIDE (Teva Pharmaceuticals USA), OXYCODONE HYDROCHLORIDE (VistaPharm), OXYCODONE HYDROCHLORIDE (West-Ward Pharmaceuticals Corp.), OXYCODONE HYDROCHLORIDE (XLCare Pharmaceuticals), OXYCODONE HYDROCHLORIDE (Zydus Pharmaceuticals (USA)), OXYCODONE HYDROCHLORIDE ORAL SOLUTION (Aurolife Pharma)
Formula
C18H21NO4. HCl
Exact mass
351.1237
Mol weight
351.8246
Structure
Simcomp
Class
Neuropsychiatric agent
 DG01564  Opioid receptor agonist
  DG01563  mu-Opioid receptor agonist
Analgesic
 DG01984  Opioid analgesics
Metabolizing enzyme substrate
 DG01644  CYP2D6 substrate
 DG02913  CYP3A4 substrate
Remark
Same as: C08026
ATC code: N02AA05
Chemical structure group: DG00813
Product (DG00813): D00847<US> D05462<JP>
Product (mixture): D02153<US> D11176<US> D11573<US>
Efficacy
Analgesic (narcotic), Opioid receptor agonist
Comment
Opium alkaloid
Target
OPRM1 [HSA:4988] [KO:K04215]
OPRK1 [HSA:4986] [KO:K04214]
OPRD1 [HSA:4985] [KO:K04213]
  Pathway
hsa04080  Neuroactive ligand-receptor interaction
Metabolism
Enzyme: CYP3A4 [HSA:1576]; CYP2D6 [HSA:1565]
Interaction
Structure map
map07039  Opioid analgesics
map07224  Opioid receptor agonists/antagonists
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 N NERVOUS SYSTEM
  N02 ANALGESICS
   N02A OPIOIDS
    N02AA Natural opium alkaloids
     N02AA05 Oxycodone
      D00847  Oxycodone hydrochloride (USP) <US>
USP drug classification [BR:br08302]
 Analgesics
  Opioid Analgesics, Long-acting
   Oxycodone
    D00847  Oxycodone hydrochloride (USP)
  Opioid Analgesics, Short-acting
   Oxycodone
    D00847  Oxycodone hydrochloride (USP)
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Opioid
    OPRM1
     D00847  Oxycodone hydrochloride (USP) <US>
    OPRK1
     D00847  Oxycodone hydrochloride (USP) <US>
    OPRD1
     D00847  Oxycodone hydrochloride (USP) <US>
Drug metabolizing enzymes and transporters [br08309.html]
 Drug metabolizing enzymes
  D00847
Other DBs
CAS: 124-90-3
PubChem: 7847912
ChEBI: 7859
ChEMBL: CHEMBL1200890 CHEMBL1734772
LigandBox: D00847
NIKKAJI: J281.239H
LinkDB
KCF data

ATOM        24
            1   C1z C    24.4381  -17.6672
            2   C8y C    24.4321  -16.3168
            3   C1z C    25.6030  -18.3338
            4   C1y C    23.2847  -18.3454
            5   C8y C    23.2672  -15.6445
            6   C8y C    25.5972  -15.6445
            7   C1y C    26.7623  -17.6499
            8   C1x C    25.6087  -19.6668
            9   O1a O    26.7623  -19.2729
            10  O2x O    22.5833  -17.0126
            11  C5x C    23.2905  -19.6784
            12  C8y C    23.2672  -14.2999
            13  C1x C    26.7623  -16.3109
            14  C8x C    25.5972  -14.2999
            15  N1y N    27.9213  -18.3221
            16  C1x C    24.4554  -20.3450
            17  O5x O    22.1139  -20.3391
            18  C8x C    24.4321  -13.6277
            19  O2a O    22.0966  -13.6277
            20  C1a C    29.2659  -18.3221
            21  C1x C    27.9213  -16.9998
            22  C1x C    25.6435  -17.0412
            23  C1a C    20.8657  -14.3423
            24  X   Cl   29.6100  -14.9100
BOND        27
            1     1   2 1
            2     1   3 1
            3     1   4 1
            4     2   5 1
            5     2   6 2
            6     3   7 1
            7     3   8 1
            8     3   9 1 #Up
            9     4  10 1 #Down
            10    4  11 1
            11    5  12 2
            12    6  13 1
            13    6  14 1
            14    7  15 1 #Up
            15    8  16 1
            16   11  17 2
            17   12  18 1
            18   12  19 1
            19   15  20 1
            20    5  10 1
            21    7  13 1
            22   11  16 1
            23   14  18 2
            24   15  21 1
            25    1  22 1 #Up
            26   22  21 1
            27   19  23 1

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