KEGG   DRUG: Naproxen sodiumHelp
Entry
D00970                      Drug                                   

Name
Naproxen sodium (USP);
Anaprox (TN)
Product
  Generic
NAPROXEN (Altura Pharmaceuticals), NAPROXEN SODIUM (H.J. Harkins Company), NAPROXEN SODIUM (Northwind Pharmaceuticals), NAPROXEN SODIUM (A-S Medication Solutions), NAPROXEN SODIUM (Actavis Pharma), NAPROXEN SODIUM (Aidarex Pharmaceuticals LLC), NAPROXEN SODIUM (Alvogen), NAPROXEN SODIUM (Amneal Pharmaceuticals of New York LLC), NAPROXEN SODIUM (Atlantic Biologicals Corps), NAPROXEN SODIUM (Aurobindo Pharma Limited), NAPROXEN SODIUM (AvKARE), NAPROXEN SODIUM (AvKARE), NAPROXEN SODIUM (AvPAK), NAPROXEN SODIUM (Blenheim Pharmacal), NAPROXEN (Blenheim Pharmacal), NAPROXEN SODIUM (Blenheim Pharmacal), NAPROXEN SODIUM (Blenheim Pharmacal), NAPROXEN SODIUM (Bryant Ranch Prepack), GOOD SENSE ALL DAY PAIN RELIEF (Bryant Ranch Prepack), NAPROXEN SODIUM (Bryant Ranch Prepack), NAPROXEN SODIUM (DIRECT RX), NAPROXEN SODIUM (DIRECT RX), ANAPROX (DIRECT RX), NAPROXEN SODIUM (Dr. Reddy's Laboratories), NAPROXEN SODIUM (Glenmark Pharmaceuticals Limited), NAPROXEN SODIUM (Hikma Pharmaceutical), NAPROXEN SODIUM (Keltman Pharmaceuticals), NAPROXEN SODIUM (Lake Erie Medical DBA Quality Care Products LLC), NAPROXEN SODIUM (Lake Erie Medical DBA Quality Care Products LLC), NAPROXEN SODIUM (Medsource Pharmaceuticals), NAPROXEN SODIUM (Medsource Pharmaceuticals), NAPROXEN SODIUM (New Horizon Rx Group), NAPROXEN SODIUM (Northwind Pharmaceuticals), NAPROXEN SODIUM (NuCare Pharmaceuticals), NAPROXEN SODIUM (NuCare Pharmaceuticals), NAPROXEN SODIUM (PD-Rx Pharmaceuticals), NAPROXEN SODIUM (PD-Rx Pharmaceuticals), NAPROXEN SODIUM (Preferred Pharmaceuticals), NAPROXEN SODIUM (Preferred Pharmaceuticals), NAPROXEN SODIUM (Preferred Pharmaceuticals), NAPROXEN SODIUM (Proficient Rx LP), NAPROXEN SODIUM (REMEDYREPACK), NAPROXEN SODIUM (REMEDYREPACK), NAPROXEN SODIUM (REMEDYREPACK), NAPROXEN SODIUM (REMEDYREPACK), NAPROXEN SODIUM (Rebel Distributors Corp), NAPROXEN SODIUM (RxChange), NAPROXEN SODIUM (SA3), NAPROXEN SODIUM (State of Florida DOH Central Pharmacy), NAPROXEN SODIUM (State of Florida DOH Central Pharmacy), NAPROXEN (West-Ward Pharmaceuticals Corp)
Formula
C14H13O3. Na
Exact mass
252.0762
Mol weight
252.241
Structure
Mol fileKCF fileDB search
Simcomp SIMCOMP
Class
Anti-inflammatory
 DG01908  Anti-inflammatory drug, propionic acid derivatives
 DG01504  Nonsteroidal anti-inflammatory drug (NSAID)
  DG01908  Anti-inflammatory drug, propionic acid derivatives
Remark
ATC code: G02CC02 M01AE02 M02AA12
Chemical structure group: DG00455
Product (DG00455): D00118<JP/US> D00970<US>
Product (mixture): D11577<US>
Efficacy
Analgesic, Anti-inflammatory, Antipyretic, COX inhibitor
Comment
Propionic acid derivative
Target
PTGS1 (COX1) [HSA:5742] [KO:K00509]
PTGS2 (COX2) [HSA:5743] [KO:K11987]
  Pathway
hsa00590  Arachidonic acid metabolism
Interaction
Drug interaction
Structure map
map07048  Antimigraines
map07114  Naphthalene family
map07219  Cyclooxygenase inhibitors
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 G GENITO URINARY SYSTEM AND SEX HORMONES
  G02 OTHER GYNECOLOGICALS
   G02C OTHER GYNECOLOGICALS
    G02CC Antiinflammatory products for vaginal administration
     G02CC02 Naproxen
      D00970  Naproxen sodium (USP) <US>
 M MUSCULO-SKELETAL SYSTEM
  M01 ANTIINFLAMMATORY AND ANTIRHEUMATIC PRODUCTS
   M01A ANTIINFLAMMATORY AND ANTIRHEUMATIC PRODUCTS, NON-STEROIDS
    M01AE Propionic acid derivatives
     M01AE02 Naproxen
      D00970  Naproxen sodium (USP) <US>
  M02 TOPICAL PRODUCTS FOR JOINT AND MUSCULAR PAIN
   M02A TOPICAL PRODUCTS FOR JOINT AND MUSCULAR PAIN
    M02AA Antiinflammatory preparations, non-steroids for topical use
     M02AA12 Naproxen
      D00970  Naproxen sodium (USP) <US>
USP drug classification [BR:br08302]
 Analgesics
  Nonsteroidal Anti-inflammatory Drugs
   Naproxen
    D00970  Naproxen sodium (USP)
 Anti-inflammatory Agents
  Nonsteroidal Anti-inflammatory Drugs
   Naproxen
    D00970  Naproxen sodium (USP)
Target-based classification of drugs [BR:br08310]
 Enzymes
  Oxidoreductases (EC1)
   Prostaglandin synthase
    PTGS1 (COX1)
     D00970  Naproxen sodium (USP) <US>
    PTGS2 (COX2)
     D00970  Naproxen sodium (USP) <US>
Rx-to-OTC switch list in the USA [br08315.html]
 D00970
BRITE hierarchy
Other DBs
CAS: 26159-34-2
PubChem: 7848033
ChEBI: 7477
ChEMBL: CHEMBL1200806
LigandBox: D00970
NIKKAJI: J17.059C
LinkDB All DBs
KCF data Show

ATOM        18
            1   C8y C    23.5997  -20.0988
            2   C8y C    23.5997  -21.4993
            3   C8x C    24.7901  -19.3985
            4   C8x C    22.3393  -19.3985
            5   C8x C    22.3393  -22.1995
            6   C8x C    24.7901  -22.1995
            7   C8y C    25.9806  -20.0988
            8   C8x C    21.1489  -20.0988
            9   C8y C    21.1489  -21.4993
            10  C8x C    25.9806  -21.4993
            11  C1c C    27.2410  -19.3985
            12  O2a O    19.9584  -22.1995
            13  C6a C    28.4314  -20.0988
            14  C1a C    27.2410  -17.9980
            15  C1a C    18.6980  -21.4993
            16  O6a O    28.4314  -21.4993
            17  O6a O    29.6219  -19.3985 #-
            18  Z   Na   31.5125  -19.3985 #+
BOND        18
            1     1   2 2
            2     1   3 1
            3     1   4 1
            4     2   5 1
            5     2   6 1
            6     3   7 2
            7     4   8 2
            8     5   9 2
            9     6  10 2
            10    7  11 1
            11    9  12 1
            12   11  13 1
            13   11  14 1 #Down
            14   12  15 1
            15   13  16 2
            16   13  17 1
            17    7  10 1
            18    8   9 1

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